激素替代对性发育障碍的长期影响。

IF 6.1 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Anna Nordenström , Alessandra Mangone , Giovanna Mantovani
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引用次数: 0

摘要

性发育障碍(DSD)在大多数情况下是由影响类固醇激素合成或作用的性腺或肾上腺功能的改变引起的。性腺功能缺陷导致需要睾酮或雌二醇替代来实现青春期发育,以及持续终生更换性激素。在肾上腺酶缺乏的情况下,可能需要糖皮质激素和有时矿皮质激素替代来使激素状况正常化。与生长、骨密度、心血管和代谢健康以及心理社会健康相关的长期结果越来越多地被报道,这既与不同的治疗策略有关,也与治疗不足或缺乏治疗有关。从儿科到成人护理的过渡是一个脆弱的时期,需要组织和个性化定制,以确保终身治疗和优化一般健康。患有DSD的个体应由各年龄段的多学科团队进行诊断评估、治疗和长期临床随访。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hormone replacement in disorders of sex development, and long-term effects
Disorders of sex development, DSD, are in the majority of cases caused by alterations in the gonadal or adrenal function that affect steroid hormone synthesis or action. Gonadal deficiencies result in a need for testosterone or estradiol replacement to achieve pubertal development as well as for continuous life-long replacement with sex hormones. In cases with adrenal enzyme deficiencies, glucocorticoid and sometimes mineralocorticoid replacement may be required to normalize the hormonal situation. Long-term outcomes related to growth, bone mineral density, cardiovascular and metabolic health, as well as psychosocial wellbeing, are increasingly being reported, both in relation to different treatment strategies and as a consequence of insufficient or absent treatment. Transition from pediatric to adult care is a vulnerable period which needs to be organized and individually tailored to ensure lifelong treatment and optimized general health. Individuals with a DSD should be seen by multidisciplinary teams at all ages, for diagnostic evaluation, for treatment and for long-term clinical follow-up.
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来源期刊
CiteScore
11.90
自引率
0.00%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Best Practice & Research Clinical Endocrinology & Metabolism is a serial publication that integrates the latest original research findings into evidence-based review articles. These articles aim to address key clinical issues related to diagnosis, treatment, and patient management. Each issue adopts a problem-oriented approach, focusing on key questions and clearly outlining what is known while identifying areas for future research. Practical management strategies are described to facilitate application to individual patients. The series targets physicians in practice or training.
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