Vinícius C Fiusa, Andrea D Stephanus, Victor F Couto, Gustavo A Alexim, Thaiene M M Severino, Ana Claudia C Nogueira, Adriana J B A Guimarães, Alexandre Anderson S M Soares, Elizabeth Bilevicius, Vivian Batista, Alessandra Staffico, Andrei C Sposito, Luiz Sérgio F de Carvalho
{"title":"Clinical Predictors of Heart Failure after STEMI: Data from a Middle-Income Country with Limited Access to Percutaneous Coronary Intervention.","authors":"Vinícius C Fiusa, Andrea D Stephanus, Victor F Couto, Gustavo A Alexim, Thaiene M M Severino, Ana Claudia C Nogueira, Adriana J B A Guimarães, Alexandre Anderson S M Soares, Elizabeth Bilevicius, Vivian Batista, Alessandra Staffico, Andrei C Sposito, Luiz Sérgio F de Carvalho","doi":"10.36660/abc.20240447","DOIUrl":"10.36660/abc.20240447","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is a common complication of ST-elevation myocardial infarction (STEMI) in low- and middle-income countries (LMICs), where cardiovascular mortality is disproportionately high. Primary percutaneous coronary intervention (PCI) has reduced post-STEMI HF incidence in high-income countries. However, access to this standard of care is poor in LMICs, and data in these settings remain scarce.</p><p><strong>Objective: </strong>To identify predictors of HF following STEMI in a LMIC with limited access to PCI, aiming at better management and outcomes.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 2,467 STEMI patients admitted to two Brazilian public hospitals between January/2015 and February/2020. All participants received pharmacological thrombolysis and underwent coronarography within 48h post-admission. The primary outcome was symptomatic HF, defined as dyspnea with chest X-ray evidence of congestion, from 48h post-admission until discharge. Stepwise binary logistic regression was used to identify HF predictors. Significance was defined as p-values<0.05.</p><p><strong>Results: </strong>The population was 61.9% male, mean age was 58.3±12.6 years, and 39.9% developed post-STEMI HF. HF was more common among older men with cardiovascular-kidney-metabolic (CKM) disease, larger infarcts, and left anterior descending artery involvement. Medications were often underprescribed at discharge, especially aldosterone antagonists (11.0%). HF was notably more frequent among individuals with failed thrombolysis (47.0%).</p><p><strong>Conclusions: </strong>This regionally representative cohort from a LMIC with limited access to PCI showed that older men with CKM disease are particularly vulnerable to post-STEMI HF, and that HF pharmacotherapy at discharge needs optimization. The high HF incidence among patients with failed thrombolysis highlights the need to expand PCI availability.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"122 3","pages":"e20240447"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Addressing Gender Disparities in Cardiovascular Care: Guideline-Oriented PCI for Women and the Hua-Mulan Conundrum.","authors":"Pedro Guimarães Silva, Henrique Barbosa Ribeiro","doi":"10.36660/abc.20240824","DOIUrl":"10.36660/abc.20240824","url":null,"abstract":"","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"122 1","pages":"e20240824"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac Valve Prosthesis and Pregnancy: Challenges and Strategies.","authors":"Marcelo Luis Nomura","doi":"10.36660/abc.20240602","DOIUrl":"10.36660/abc.20240602","url":null,"abstract":"","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"122 1","pages":"e20240602"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Walkiria Samuel Avila, Daniel Vinicius Rodrigues Pinto, Jessica Sol Brugnara, Marilia Moro, Talita Carla Stratti Moreira, Isabelle Borges, Nana Miura, Flávio Tarasoutchi
{"title":"Choosing a Valve Prosthesis for a Successful Pregnancy. The \"Tip of the Iceberg\" for a Disease of Complex Evolution.","authors":"Walkiria Samuel Avila, Daniel Vinicius Rodrigues Pinto, Jessica Sol Brugnara, Marilia Moro, Talita Carla Stratti Moreira, Isabelle Borges, Nana Miura, Flávio Tarasoutchi","doi":"10.36660/abc.20240163","DOIUrl":"10.36660/abc.20240163","url":null,"abstract":"<p><strong>Background: </strong>The choice of valve prosthesis in women planning a pregnancy is still controversial. The durability of biological prostheses and the characteristic thrombogenic of mechanical prostheses are limitations to the pregnancy's successful Objectives: To study the pregnancy success rate after valve prosthesis implantation, and identify the variables related to maternal outcomes.</p><p><strong>Methods: </strong>Prospective study with 78 pregnant women with bovine pericardial prosthesis (Group BP) and 50 with a mechanical prosthesis (Group MP), who received prior guidance on the risks of pregnancy. The pregnancy success rate was considered in the absence of complications cardiac, obstetric and/or fetal complications.</p><p><strong>Results: </strong>Successful pregnancy was achieved in 64 (50.0%) patients, not differing between groups (BP 56.4% vs MP 40.0% - p=0.103). The BP group had a higher cardiac events rate and prosthesis dysfunction (43.6% vs 16.0% p<0.001; 26.9% vs 2.0% p<0.001). The frequency of fetal losses (14.1% vs 24.0% p=0.165) and obstetric complications (28.2% vs 42% p=0.127) were not different between the BP and MP groups. The pre-existence of heart failure (odds ratio 8.5; 95% CI [1.4; 50.7]; p=0.019), atrial fibrillation (odds ratio 16.7; 95% CI [5.7; 49 .1]; p<0.001) and dysfunction of the biological prosthesis (odds ratio 12.6; 95% CI [3.0; 52.7]; p=0.001) were the variables predicting complications and/or deaths.</p><p><strong>Conclusions: </strong>Patients with valve prostheses had low maternal-fetal success due to the complicating factors of valve disease, the limited structural survival of biological prostheses and the lack of anticoagulants to guarantee pregnancy. The choice of a prosthesis, whether biological or mechanical, should not be considered an isolated decision, but rather a consequence of a complex outcome of the heart disease.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"122 1","pages":"e20240163"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of Electrovectorcardiographic Assessment of Intraventricular Blocks and their Relationship with the Cardiac Cycle.","authors":"Carlos Alberto Pastore","doi":"10.36660/abc.20240767","DOIUrl":"10.36660/abc.20240767","url":null,"abstract":"","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240767"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Rodrigues Bitencourt, Ana Luiza Lima Sousa, Priscila Valverde de Oliveira Vitorino, Mikaelle Costa Correia, Alexandre Massao Yoshizumi, Weimar Kunz Sebba Barroso
{"title":"Acupuncture for Essential Hypertension and Endothelial Dysfunction: A Randomized Clinical Trial.","authors":"Amanda Rodrigues Bitencourt, Ana Luiza Lima Sousa, Priscila Valverde de Oliveira Vitorino, Mikaelle Costa Correia, Alexandre Massao Yoshizumi, Weimar Kunz Sebba Barroso","doi":"10.36660/abc.20240596","DOIUrl":"10.36660/abc.20240596","url":null,"abstract":"","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"122 1","pages":"e20240596"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}