Arquivos brasileiros de cardiologia最新文献

{"title":"Twitter (X) as a Communication and Education Tool for Brazilian Cardiologists: Profile, Influence and Challenges.","authors":"Aline Goneli de Lacerda, Luana de Oliveira Ribas, Estephany de Jesus, Ronaldo Ferreira de Araújo, Thaiane Moreira de Oliveira, Claudio Tinoco Mesquita","doi":"10.36660/abc.20230694","DOIUrl":"10.36660/abc.20230694","url":null,"abstract":"<p><strong>Background: </strong>Twitter (recently renamed to X) is a popular social media that can be used for health communication. There are few studies analyzing the profile of Brazilian cardiologists active on the platform.</p><p><strong>Objectives: </strong>To identify the profile of Brazilian cardiologists on Twitter (X), their online influence and reach, as well as their bios' description.</p><p><strong>Methods: </strong>A total of 1,083 accounts of Brazilian cardiologists were created between 2006 and 2021. Data were collected using the FollowerWonk tool and analyzed using the IRAMUTEQ software.</p><p><strong>Results: </strong>Most profiles were of men (76.5%) and 0.8% was institutional profiles. Most profiles had less than 100 followers (71%) and low social authority (81.8%). The 20 most influential profiles were mostly of men (80%) and highly concentrated in the southeast of Brazil (68%).</p><p><strong>Conclusions: </strong>Brazilian cardiologists prefer a personal and direct communication in social medias, rather than an institutional representation. There is a gender disparity among Brazilian cardiologists on Twitter (X), with a predominance of men. The most influential profiles were of men, and mostly located in the southeastern Brazil.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20230694"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intraventricular Blocks on Cardiac Cycle Dynamics: An Echocardiographic and Vectorcardiographic Analysis.","authors":"Carlos Eduardo Duarte, Katia Regina Silva, Luciene Dias de Jesus, Henry Abensur, Roberto Costa","doi":"10.36660/abc.20240253","DOIUrl":"10.36660/abc.20240253","url":null,"abstract":"<p><strong>Background: </strong>Left bundle branch block (LBBB) causes delays that alter the mechanics of the ventricular cycle. The effect of other intraventricular blocks (IVB) remains little explored.</p><p><strong>Objectives: </strong>To study the phases of the cardiac cycle (CC) and ventricular synchrony in different ventricular activation patterns.</p><p><strong>Methods: </strong>Cross-sectional study with 328 consecutive individuals without structural heart disease, normal electrocardiogram or IVB, conducted in the period between August/2020 and January/2022. Echocardiogram and Vectorcardiogram were performed simultaneously to analyze the electromechanics of the CC. A one-way Analysis of Variance (ANOVA) with Bonferroni's multiple comparison test was used, with a significance level of 5%.</p><p><strong>Results: </strong>The age of the participants was 64.8±15.3 years, with 57.9% male and an ejection fraction of 67.0±6.8%. The electrocardiogram was normal for 32.3%, 18.6% had right bundle branch block (RBBB), 17.7% had left anterior fascicular block (LAFB), 15.6% had RBBB+LAFB, and 15.9% had LBBB. The echocardiogram showed an increased left ventricular pre-ejection by 18.7% (p<0.001) and 56.8% (p<0.001) in RBBB+LAFB and LBBB, respectively. There was a post-systolic myocardial contraction in all types of IVB and ventricular dyssynchrony in LBBB. Using the vectorcardiogram, initial activation of the R wave was increased by 17.4% in LAFB (p<0.001), 43.5% in RBBB+LAFB (p<0.001) and 47.4% in LBBB (p<0.001) and delayed final activation by 69.4% in LBBB (p<0.001), 73.6% in RBBB+LAFB (p<0.001) and 95.3% in RBBB (p<0.001).</p><p><strong>Conclusion: </strong>All IVBs modified the CC; however, only LBBB and RBBB+LAFB significantly changed the left ventricular cycle, thereby evidencing the greater complexity of these disorders.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240253"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Oral Nitrite Administration Decreases Arterial Stiffness in Both Trained and Sedentary Wistar Rats.","authors":"Thiago Pereira Souza, Lidieli Pazin Tardelli, Rafael Antunes Nicoletti, André Mourão Jacomini, Gabriel Francisco de Mello Martins, Lucas Cézar Pinheiro, José Eduardo Tanus-Santos, Sandra Lia do Amaral, Anderson Saranz Zago","doi":"10.36660/abc.20230783","DOIUrl":"10.36660/abc.20230783","url":null,"abstract":"<p><strong>Background: </strong>Nitric Oxide (NO) plays an important role in blood pressure (BP) regulation, acting directly on peripheral vascular resistance through vasodilation. Physical training (via eNOS/NO) and intake of nitrite have been considered major stimuli to increase NO.</p><p><strong>Objective: </strong>We examined the effects of oral nitrite administration and aerobic exercise training on BP and arterial stiffness in Wistar rats.</p><p><strong>Methods: </strong>Thirty-nine (39) young male Wistar rats were divided into the following groups (n = 9 or 10 per group): Sedentary-Control (SC), Sedentary-Nitrite (SN), Trained-Control (TC), and Trained-Nitrite (TN). They were submitted to aerobic physical training on treadmills for 8 weeks (50-60% of physical capacity, 1h/day, 5 days/week) or kept sedentary. In the last 6 days of training, oral nitrite was administered (15 mg/Kg by gavage). BP, arterial stiffness, and plasma and tissue nitrite concentrations were assessed after the training and oral nitrite administration period. The significant level was defined as p < 0.05.</p><p><strong>Results: </strong>Oral administration of nitrite was effective in reducing arterial stiffness values (TN, -23%; and SN, -15%). Both groups that had only one type of intervention showed lower systolic BP compared with control (TC vs. SC, -14.23; and SN vs. SC, - 12.46).</p><p><strong>Conclusion: </strong>We conclude that short-term oral administration for 6 days and an aerobic physical training program promote several hemodynamic benefits in male Wistar rats, such as improvements in arterial stiffness and BP. These responses suggest that physical training and sodium nitrite supplementation can be alternatives for the prevention and treatment of hypertension.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20230783"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Females are Associated with Lower Risks of Long-Term Mortality in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting.","authors":"Chen Bai, Jiangang Wang, Qing Ye, Cheng Zhao","doi":"10.36660/abc.20240221","DOIUrl":"10.36660/abc.20240221","url":null,"abstract":"<p><strong>Background: </strong>In patients who underwent off-pump coronary artery bypass grafting (OPCABG), females were reported to have lower rates of in-hospital mortality rate and postoperative atrial fibrillation than males. However, the association between gender and long-term prognosis following OPCABG is rarely reported.</p><p><strong>Objective: </strong>This study aims to determine if women benefit more from OPCABG than men by comparing the difference in the risk of long-term all-cause mortality in patients with coronary chronic total occlusion (CTO).</p><p><strong>Methods: </strong>This is an observational, retrospective cohort study conducted in adult patients (≥18 years) with coronary CTO undergoing OPCABG at our hospital from January 2011 to December 2014. A multivariate Cox proportional hazards model was employed to assess the association of gender with the risk of all-cause mortality. A p-value of <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Totally 1,256 participants were enrolled, among which 321 (25.6%) were females and 935 (74.4%) were males. During a maximum follow-up of 10 years, the all-cause mortality rate in women was significantly lower than that in men (10.3% vs. 24.3%, p<0.01). Multivariate Cox regression analysis indicated that women were significantly associated with a lower risk of all-cause mortality (HR=0.30, 95% CI: 0.20-0.44; p<0.01) after controlling for potential confounding factors.</p><p><strong>Conclusion: </strong>Women benefit more from OPCABG surgery than men, as they have a lower risk of long-term all-cause mortality in patients with coronary CTO.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240221"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NSTEMI and Ischemic Mitral Regurgitation: Incidence and Long-Term Clinical Outcomes with Respect to Management Strategy.","authors":"Pooja Vyas, Radhakishan Dake, Kewal Kanabar, Iva Patel, Ashish Mishra, Vishal Sharma, Tirth Nathwani, Kunal Parwani, Mital Rathod","doi":"10.36660/abc.20240064","DOIUrl":"10.36660/abc.20240064","url":null,"abstract":"<p><strong>Background: </strong>The optimal treatment for ischemic mitral regurgitation (IMR) in patients of non-ST elevation myocardial infarction (NSTEMI) is a debated topic.</p><p><strong>Objective: </strong>To evaluate the long term outcome on patients with NSTEMI and IMR, particularly emphasizing the comparison of treatments in those with moderate to severe MR.</p><p><strong>Methods: </strong>We enrolled patients with NSTEMI and classified non/trivial to mild regurgitation as insignificant IMR and moderate to severe regurgitation as significant IMR. Furthermore, patients with substantial IMR were assessed for long-term clinical outcomes with respect to different management strategies. A test was considered statistically significant based on the probability value p<0.05.</p><p><strong>Results: </strong>From a total of 4,189 patients of NSTEMI, significant IMR was found in 7.21% of patients. A significantly higher number of patients with death (1.21% vs. 13.24%, p<0.0001), cardiogenic shock (0.46% vs. 13.24%, p<0.0001) and heart failure (1.03% vs. 11.59%, p<0.0001) were found during hospitalization in patients with significant IMR. At a 2-year follow-up, a higher event rate was observed in the significant IMR group. Patients with significant IMR re-vascularized either by percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), or CABG+ mitral valve (MV) surgery showed substantial improvement in MR grade ( 32.65% vs. 6% vs. 16.98%, p<0.0001) and LVEF (27.55% vs. 1% vs. 1.89%, p<0.0001) at 1 year follow up and significantly improved outcomes were identified compared to refused revascularization and medical management group with (-5.10% vs. 15% vs. 13.21%, p=0.04) mortality, (-33.67% vs. 61% vs. 73.58%, p<0.0001) readmission, and (-15.31% vs. 27% vs. 33.96%, p=0.01) heart failure at 2 years follow up.</p><p><strong>Conclusion: </strong>Higher mortality and admission rates were observed in patients with significant IMR compared to those with in-significant IMR. Notably, significant IMR patients who underwent PCI, CABG, or CABG+MV surgery showed improved outcomes compared to non-revascularized counterparts.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240064"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Anti-Inflammatory Activity of D-Limonene in a Rat Model of Monocrotaline-Induced Pulmonary Hypertension: Implications to the Heart Function.","authors":"Jorge Lucas Teixeira-Fonseca, Diego Jose Belato Y Orts, Polyana Leal da Silva, Michael Ramon de Lima Conceição, Hernan Hermes, Carlos R Prudencio, Danilo Roman-Campos","doi":"10.36660/abc.20240195","DOIUrl":"10.36660/abc.20240195","url":null,"abstract":"<p><strong>Background: </strong>D-limonene (D-L) is the major monocyclic monoterpene in citrus plants with anti-inflammatory properties. Pulmonary hypertension (PH) can cause right heart dysfunction and increases the risk of death, partially due to inflammatory response in the heart.</p><p><strong>Objective: </strong>To evaluate the possible protective effect of D-L on cardiac function in a rat model of monocrotaline-induced PH (MCT-PH).</p><p><strong>Methods: </strong>Electrocardiogram was monitored in vivo. Masson Trichrome technique was deployed to verify fibrosis in the heart. Contractility function of isolated atrial tissue was studied using organ bath chamber. Real-time quantitative PCR was applied to quantify inflammation in the right ventricle.</p><p><strong>Results: </strong>The MCT-PH group showed electrical and structural heart remodeling, with the presence of fibrosis in the cardiac tissue and in vivo electrocardiographic changes. Treatment with D-L partially prevented the development of tissue fibrosis and the increase in P wave duration in the MCT-PH group. The contraction and relaxation velocity of isolated right and left atrium were accelerated in CTR and MCT-PH animals treated with D-L. Finally, D-L was able to prevent the abnormal expression of the key inflammatory cytokines (interleukin 1-β, interleukin 6 and tumor necrosis factor-α) in the right ventricle of MCT-PH animals. D-L was able to enhance the production of the anti-inflammatory cytokine Interleukin-10.</p><p><strong>Conclusion: </strong>Our results showed that in vivo administration of D-L partially prevented the molecular, structural and functional remodeling of the heart in the MCT-PH model with attenuation of the inflammatory response in the heart.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240195"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammatory Indices as New Biomarkers for Hemodynamically Significant Ductus Arteriosus.","authors":"Ufuk Cakir, Cuneyt Tayman","doi":"10.36660/abc.20240211","DOIUrl":"10.36660/abc.20240211","url":null,"abstract":"<p><strong>Background: </strong>Increased oxygen tension and decreased prostaglandin levels cause ductal closure. The diagnostic role of systemic inflammatory indices in hemodynamically significant ductus arteriosus (hsPDA) in premature infants is unknown.</p><p><strong>Objectives: </strong>We aimed to evaluate the role of systemic inflammatory indices in the predictivity of hsPDA.</p><p><strong>Methods: </strong>Premature infants with gestational weeks (GW) of <32 weeks were evaluated retrospectively. Systemic inflammatory indices neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune- inflammation value (PIV), and systemic inflammation response index (SIRI) were calculated. Systemic inflammatory indices were compared between hsPDA and non-hsPDA groups. A p <0.05 was considered as statistically significant.</p><p><strong>Results: </strong>A total of 1228 patients were included in the study, including 447 patients in the hsPDA group and 781 patients in the non-hsPDA group. The PIV value [median (Q1 - Q3): 5.18 (2.38-10.42)] in the hsPDA group was statistically significantly higher than the PIV value [median (Q1 - Q3): 3.52 (1.41-6.45)] in the non-hsPDA group (p<0.001). According to the ROC analysis, the AUC value of PIV for the predictivity of hsPDA was 0.618, and the cutoff level was >8.66. After even multiple logistic regression analyses, PIV was shown to be a significant parameter for the diagnosis of hsPDA (OR 1.972, 95% CI 1.114-3.011. p=0.001).</p><p><strong>Conclusions: </strong>A high PIV value may be a quickly used indicator with low-cost, simple, and easily accessible for the early diagnosis of hsPDA.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 11","pages":"e20240211"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Role of Exercise Training in Enhancing Life for Adult Congenital Heart Disease: Systematic Review.","authors":"Tugba Siyah, Naciye Vardar Yagli, Ilker Ertugrul, Hayrettin Hakan Aykan, Melda Saglam","doi":"10.36660/abc.20240294","DOIUrl":"10.36660/abc.20240294","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines advise exercise for most congenital heart disease patients (CHD). However, physical activity remains low in CHD individuals, with limited research on exercise's effects in adults.</p><p><strong>Objectives: </strong>The aim of this study is to evaluate the safety and efficacy of exercise training on exercise capacity and quality of life in adult congenital heart disease (ACHD) patients.</p><p><strong>Methods: </strong>We searched PubMed/Medline, Cochrane Library, Web of Science, and Scopus through December 2022 for randomized controlled trials assessing aerobic and resistance training effects on exercise capacity and quality of life in ACHD. Out of 3,517 citations, ten eligible articles were included.</p><p><strong>Results: </strong>Meta-analysis of the included randomized controlled trials (286 participants) found no significant change in peak oxygen consumption or quality of life in ACHD with exercise training (pooled mean difference = 0.33 ml/kg/min [95% CI, -0.88 to 1.54 ml/kg/min]; p = 0.60; I2= 3%). However, the increase in maximum workload was significant (pooled mean difference = 8.86 watts [95% CI, 0.78 to 16.93], p = 0.03, I2 = 0%).</p><p><strong>Conclusions: </strong>Our review confirms that exercise training increases the maximum workload in ACHD patients. However, the lack of a standardized protocol among exercise interventions in this population may have contributed to the absence of a significant change in peak VO2 and quality of life observed in the conducted studies. The heterogeneity of exercise programs could be a contributing factor to the inconsistency of the results. In this context, the implementation of standardized exercise protocols in future research, particularly with larger sample sizes, is crucial to enhance the comparability of outcomes. Well-designed randomized controlled trials studying structured exercise training in ACHD patients will provide clearer insights.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20240294"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Biomarkers in Myocardial Fibrosis: A Bioinformatic Analysis.","authors":"Wang Cheng-Mei, Gang Luo, Ping Liu, Wei Ren, Sijin Yang","doi":"10.36660/abc.20230674","DOIUrl":"10.36660/abc.20230674","url":null,"abstract":"<p><strong>Background: </strong>Myocardial fibrosis (MF) occurs throughout the onset and progression of cardiovascular disease, and early diagnosis of MF is beneficial for improving cardiac function, but there is a lack of research on early biomarkers of MF.</p><p><strong>Objectives: </strong>Utilizing bioinformatics techniques, we identified potential biomarkers for MF.</p><p><strong>Methods: </strong>Datasets related to MF were sourced from the GEO database. After processing the data, differentially expressed genes were screened. Differentially expressed genes were enriched, and subsequently, protein-protein interaction (PPI) was performed to analyze the differential genes. The associated miRNAs and transcription factors were predicted for these core genes. Finally, ROC validation was performed on the core genes to determine their specificity and sensitivity as potential biomarkers. The level of significance adopted was 5% (p < 0.05).</p><p><strong>Results: </strong>A total of 91 differentially expressed genes were identified, and PPI analysis yielded 31 central genes. Enrichment analysis showed that apoptosis, collagen, extracellular matrix, cell adhesion, and inflammation were involved in MF. One hundred and forty-two potential miRNAs were identified. the transcription factors JUN, NF-κB1, SP1, RELA, serum response factor (SRF), and STAT3 were enriched in most of the core targets. Ultimately, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8 had higher diagnostic accuracy and sensitivity in predicting MF based on ROC curve analysis.</p><p><strong>Conclusion: </strong>Eight genes, IL11, GADD45B, GDF5, NOX4, IGFBP3, ACTC1, MYOZ2, and ITGB8, can serve as candidate biomarkers for MF. Processes such as cellular apoptosis, collagen protein synthesis, extracellular matrix formation, cellular adhesion, and inflammation are implicated in the development of MF.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 12","pages":"e20230674"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors, Management, and Evolution after the First Acute Myocardial Infarction: A Real-World Study Comparing Cohorts of Women and Men in the TriNetX Network.","authors":"Camila Mota Guida, Eduardo Juvenal de Souza, Leandro Menezes Alves da Costa, Thiago Luis Scudeler, Rafael Amorim Belo Nunes, Gustavo Bernardes de Figueiredo Oliveira","doi":"10.36660/abc.20230692","DOIUrl":"10.36660/abc.20230692","url":null,"abstract":"<p><strong>Background: </strong>International cohort studies have consistently demonstrated an unfavorable prognosis in female patients after the first acute myocardial infarction (AMI) over the past decades. However, national data on this topic are limited.</p><p><strong>Objectives: </strong>This study aims to compare national cohorts of men and women hospitalized due to the first acute myocardial infarction, examining long-term outcomes.</p><p><strong>Methods: </strong>A retrospective, observational study using real-world data extracted from the global TriNetX platform, including patients of both sexes with a confirmed diagnosis of AMI according to the International Classification of Diseases (ICD), version 11, code I21. The level of statistical significance adopted in the analysis was 5% (0.05). The primary outcome assessed was a composite of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up.</p><p><strong>Results: </strong>Data from 29,041 patients were evaluated, of which 11,284 (38.4%) were women. The mean age of the female and male populations was 64.4 and 59.8 years, respectively. The group of women showed a higher occurrence of the composite outcome of death, new hospitalization for AMI, myocardial revascularization procedures, or heart failure after the hospital phase with a 5-year follow-up (OR 1.058; CI 1.005 - 1.113; p = 0.03).</p><p><strong>Conclusions: </strong>In this large Brazilian cohort, the female sex was associated with a higher occurrence of cardiovascular events within 5 years after hospital discharge.</p><p><strong>Background: </strong>Real-world study comparing female and male cohorts in the TriNetX network.</p>","PeriodicalId":93887,"journal":{"name":"Arquivos brasileiros de cardiologia","volume":"121 10","pages":"e20230692"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}