Annales de biologie clinique最新文献_第9页

Low-density lipoprotein triglycerides: A marker for metabolic diseases. 低密度脂蛋白甘油三酯:代谢疾病的标志物。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1840

Xiangxiang Li, Hao Shen

引用次数: 0

[Point-of-care testing for D-dimer in the exclusion of venous thromboembolism: a critical analysis]. [d -二聚体在排除静脉血栓栓塞中的即时检测:一项关键分析]。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1839

François Grand, Florence Blanc-Jouvan, Céline Delassasseigne, Hubert Galinat, Pierre-Marie Roy, Laurie Talon, Marie Toussaint-Hacquard, Laurent Macchi

{"title":"[Point-of-care testing for D-dimer in the exclusion of venous thromboembolism: a critical analysis].","authors":"François Grand, Florence Blanc-Jouvan, Céline Delassasseigne, Hubert Galinat, Pierre-Marie Roy, Laurie Talon, Marie Toussaint-Hacquard, Laurent Macchi","doi":"10.1684/abc.2023.1839","DOIUrl":"https://doi.org/10.1684/abc.2023.1839","url":null,"abstract":"Point-of-care testing (POCT) for D-dimer is an alternative to -laboratory testing for the exclusion of venous thromboembolism (VTE). This critical review by the \"CEC et biologie délocalisée\" working group of the \"Société Française de Thrombose et d'Hémostase\" (French Society of -Thrombosis and Haemostasis) aims to present the characteristics of six POCT D-dimer assays available in France in 2023. The article highlights the need to define VTE -exclusion thresholds specific to each technique and validated by clinical studies. There is insufficient data to validate the use of cut off suggested by manufacturers, and age-adjusted thresholds. The article discusses the role of laboratories in justifying and prescribing POCT D-dimer, according to objective criteria, such as the availability and turnaround time of classical laboratory tests. They should also encourage rational prescribing, limited to patients with low risk of venous thromboembolism, following an assessment of clinical probability according to national and international guidelines.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[François Rousselet (1929-2023) and Jean-Pierre Bali (1941-2023)]. [弗朗索瓦-卢塞莱（1929-2023 年）和让-皮埃尔-巴利（1941-2023 年）]。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1842

Jean-Louis Beaudeux, Alain Legrand

引用次数: 0

[Hemolytic anemia in a two-year-old child: A case of multiple red blood cell abnormalities]. [2岁儿童溶血性贫血1例:多发性红细胞异常]。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1843

Romain Ravel-Chapuis, Léo Mottin, Maïssa Souissi, Agnès Lahary, Victor Bobée

引用次数: 0

[Proinsulin: physiology, measurement, and interest in clinical biology]. [胰岛素原:生理学，测量和临床生物学的兴趣]。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1838

Katia Carvalho Alves, Fidéline Bonnet-Serrano, Christelle Laguillier, Vanessa Akiki, Léa Dehghani, Étienne Larger, Marie-Clémence Leguy, Jean Guibourdenche

{"title":"[Proinsulin: physiology, measurement, and interest in clinical biology].","authors":"Katia Carvalho Alves, Fidéline Bonnet-Serrano, Christelle Laguillier, Vanessa Akiki, Léa Dehghani, Étienne Larger, Marie-Clémence Leguy, Jean Guibourdenche","doi":"10.1684/abc.2023.1838","DOIUrl":"https://doi.org/10.1684/abc.2023.1838","url":null,"abstract":"The proinsulin molecule results from the cleavage of pre-pro-insulin, produced in pancreatic beta cells. Its subsequent -cleavage allows the release of insulin, the key hormone of glycemia regulation and C-peptide in equimolar proportions. During fasting trial, insulinoma diagnosis relies on inadequately high insulin and C-peptide serum levels concomitant with an hypoglycemia. In this context, proinsulin assay can be interesting in the cases of discrepancy between the two parameters. In diabetes, endoplasmic reticulum stress and beta cells inflammation, lead to the secretion of misfolded proinsulin molecules. Thus, in type 2 diabetes, proinsulin/insulin ratio increases with the degree of insulin resistance. In type 1 diabetes, proinsulin/C-peptide ratio could predict the onset of diabetes in relatives. In our practice, serum pro-insulin determined using an Elisa immunoassay (Millipore®) during fasting trial can be complementary to C-peptide and insulin assays in relation to glycemia to label an hypoglycemia. In case of glucose intolerance and diabetes, proinsulin could thus be measured.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Reports of the Match 180 seconds from the French-speaking Days of Medical Biology]. [医学生物学法语日180秒比赛报道]。

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1846

Marie-Hélène Tournoys, Marie-Christine Beauvieux, Valéry Brunel, Nicolas Collet, Samuel Cutullic, Yohan Darrieux, Tarik Es Sadki, Valentin Faivre, Pierre Yves Guyot, Mathilde Iberti, Felipe Le Divenah, Charles René Lefèvre, Nathalie Terrier, Jérôme Grosjean, Carole Poupon

引用次数: 0

[The ADLM Annual Meeting 2023 at a glance!] [ADLM 2023 年年会一览！]

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1845

Guillaume Grzych, Damien Gruson, Joe El Khoury, Bernard Gouget

引用次数: 0

[Evaluation of blood cell morphology with the RBC Advanced Application: Which cut-offs are most needed for which specific abnormalities?] 红细胞形态学评价的高级应用:哪种异常最需要切断?］

Annales de biologie clinique Pub Date : 2023-11-29 DOI: 10.1684/abc.2023.1837

Rhita Bennis, Francois Mullier, Pascale Saussoy

{"title":"[Evaluation of blood cell morphology with the RBC Advanced Application: Which cut-offs are most needed for which specific abnormalities?]","authors":"Rhita Bennis, Francois Mullier, Pascale Saussoy","doi":"10.1684/abc.2023.1837","DOIUrl":"https://doi.org/10.1684/abc.2023.1837","url":null,"abstract":"The detection of erythrocyte morphological abnormalities is a valuable and sometimes overlooked element in the diagnostic management of anemias. The aim of this article is to evaluate the clinical performance of the different detection thresholds tested by our laboratory using the Cellavision RBC Advanced module, after manual reclassification by an experienced operator, and comparing them to the guidelines by the ICSH (International Council for Standardization in Haematology). We arbitrarily set thresholds at 1% for \"critical\" abnormalities (tear drop cells, target cells, schizocytes and spherocytes) except for sickle cells (threshold set at 0.01%). Our data show excellent sensitivity of 100% for the cut-offs defined by the investigation for tear drop cells and sickle cells, but low specificity for detection of associated clinical pathology compared with ICSH cut-offs, varying from 4% for teardrop cells (detection of myelofibrosis), 26% for target cells (detection of martial deficiency) to 55% for schizyocytes (presence of hemolytic anemia). Our results show a better specificity of the thresholds established by ICSH than our studied thresholds for the detection of the pathologies of concern, suggesting a better clinical relevance.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"81 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Severe thrombopenia with iron deficiency anemia: about a case and literature review]. [严重血小板减少伴缺铁性贫血1例及文献复习]。

Annales de biologie clinique Pub Date : 2023-11-01 DOI: 10.1684/abc.2023.1833

Nassim Boutouchent, Maïssa Souissi, Gérard Buchonnet, Muriel Quillard, Victor Bobée

引用次数: 0

[The lactate dehydrogenase to lymphocyte ratio in evaluating the prognosis of patients with severe COVID-19]. [乳酸脱氢酶与淋巴细胞比值评价重症COVID-19患者预后]。

Annales de biologie clinique Pub Date : 2023-11-01 DOI: 10.1684/abc.2023.1836

Redouane Mammar Bennai, Mounya Boudbellah, Nada Benabdelouahab, Badr-Eddine El Amri, Laila Benchekroun

{"title":"[The lactate dehydrogenase to lymphocyte ratio in evaluating the prognosis of patients with severe COVID-19].","authors":"Redouane Mammar Bennai, Mounya Boudbellah, Nada Benabdelouahab, Badr-Eddine El Amri, Laila Benchekroun","doi":"10.1684/abc.2023.1836","DOIUrl":"https://doi.org/10.1684/abc.2023.1836","url":null,"abstract":"Inflammatory biological parameters are altered in patients with COVID-19 depending on its severity. The objective of our study is to find a score to assess the prognosis of patients with severe COVID-19. This is a retrospective study of patients with severe COVID-19 hospitalized in the intensive care units of Ibn Sina Hospital in Rabat. The study involves a total of 197 patients. The biological parameters were collected and evaluated in order to recognize the factors of poor prognosis of severe COVID-19. In our cohort, 133 patients died (67.51%) and had a higher average age (p < 0.001). A statistically significant correlation was found in this group of patients for procalcitonin (p = 0.005), lactate dehydrogenase (p = 0.02) and ferritin (p = 0.017). The lactate dehydrogenase/lymphocyte ratio (LLR) had the highest accuracy among the calculated combined scores. The LLR AUC was 0.628 (95% CI: 0.549-0.708) and the optimal cut-off value was 341, which gave a sensitivity of 91 % and a specificity of 84 %. The LLR is a good predictor of the poor prognosis of patients with severe COVID-19.","PeriodicalId":93870,"journal":{"name":"Annales de biologie clinique","volume":"0 0","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138178253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0