Anales de pediatria最新文献

{"title":"Plasmalyte versus saline solution for rapid rehydration in gastroenteritis: prospective observational study","authors":"Reyes Fernández Montes ,&nbsp;María Agustina Alonso Álvarez ,&nbsp;María Fernández Miaja ,&nbsp;Luis Vega López ,&nbsp;María Álvarez Merino ,&nbsp;Estíbaliz Garrido García","doi":"10.1016/j.anpede.2025.503855","DOIUrl":"10.1016/j.anpede.2025.503855","url":null,"abstract":"<div><h3>Introduction</h3><div>General recommendations suggest using physiological saline solution (PSS) in the guidelines for rapid intravenous rehydration (RIR) in children with dehydration secondary to acute gastroenteritis, although the use of a balanced crystalloid solution, such as Plasmalyte (PLA), could be more beneficial since its composition is more similar to plasma.</div></div><div><h3>Materials and methods</h3><div>Single-center prospective and observational study with two treatment groups. The sample consisted of patients aged 3 months to 13 years with mild to moderate dehydration in whom RIR was indicated based on the SEUP guideline, who visited the pediatric emergency department (PED) of a tertiary care hospital. A total of 40<!--> <!-->mL/kg of solution (PLA or PSS, at the discretion of the physician in charge) supplemented with 2.5% glucose was administered over 2<!--> <!-->h. We collected data on clinical and laboratory variables before and after RIR, length of stay, need for readmission and adverse events.</div></div><div><h3>Results</h3><div>A total of 169 patients (50.9% male; median age, 40 months) completed the study. Of these, 49.1% received PLA. The group that received PLA showed greater improvement in bicarbonate levels (3.7<!--> <!-->mmol/L vs 1.4<!--> <!-->mmol/L; <em>P</em> &lt; .001) and a lower increase in chloride levels (0.9<!--> <!-->mmol/L vs 4.1<!--> <!-->mmol/L; <em>P</em> &lt; .001). There were no differences in clinical dehydration scales, length of stay in PED or need for readmission. No serious adverse events were observed.</div></div><div><h3>Conclusions</h3><div>The use of PLA in the RIR protocol was effective and safe, showing greater recovery of bicarbonate with lesser elevation of chloride levels compared to the use of PSS. However, we did not find differences in clinical outcomes.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503855"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of digital media on development and physical health","authors":"María Angustias Salmerón-Ruiz ,&nbsp;Cristina García de Ribera ,&nbsp;Valero Sebastián Barberán ,&nbsp;Lefa Eddy Ives ,&nbsp;Julio Álvarez-Pitti","doi":"10.1016/j.anpede.2025.503876","DOIUrl":"10.1016/j.anpede.2025.503876","url":null,"abstract":"<div><div>The goal of screen health is to reduce the deleterious impact of the use of screens, digital content and connected devices (collectively known as the ‘Internet of Things’) and harmful design. That is, of any information, application, software or hardware that affects physical, mental, social, sexual or brain health. With this objective in mind, the screen health working group of the Health Promotion Committee of the Asociación Española de Pediatría (AEP, Spanish Association of Pediatrics) published the Family Digital Plan (FDP) online in 2022 based on the evidence available through 2021. The purpose of this article is to offer a review of the evidence published from 2021 and to determine whether changes need to be made to the recommendations of the FDP. It is reasonable to state that there is sufficient evidence supporting the association between screen time and the displacement of healthy lifestyle habits such as sleep, diet, physical activity and face-to-face social interactions. Furthermore, screen use also has an impact on cardiovascular risk, visual health, brain volume and quality of life. Its effects are greater in children, especially those aged less than six years, and in adolescents, as it interferes with neurodevelopment and affect integration and reduces the ability to regulate emotion. The Health Promotion Committee of the AEP considers several actions necessary: the revision of the recommendations of the FDP, declaring screen use a public health problem, improving the training of pediatricians to prevent and detect it, improving research on the use of screens in education and health care systems, the establishment of legislation by governments to protect health and development, and advocating for the requirement of rigorous research to demonstrate, from the early stages of design and development, that technological products or services are safe for the health and brain of the population.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503876"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ileocecal intussusception secondary to heterotopic pancreas","authors":"Antonio Palacios Prados ,&nbsp;Rocío Vizcaíno Pérez ,&nbsp;Ana López Prieto ,&nbsp;Madai Curbelo Rodríguez","doi":"10.1016/j.anpede.2025.503805","DOIUrl":"10.1016/j.anpede.2025.503805","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503805"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025: Another step forward","authors":"Luis Carlos Blesa Baviera ,&nbsp;Susana Blesa Chiralt","doi":"10.1016/j.anpede.2025.503892","DOIUrl":"10.1016/j.anpede.2025.503892","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 6","pages":"Article 503892"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National multicenter registry on lung ultrasound in infants born before 26 weeks’ gestational age (MINI-LUS)","authors":"Almudena Alonso-Ojembarrena ,&nbsp;Rebeca Gregorio-Hernández ,&nbsp;Manuel Sánchez-Luna","doi":"10.1016/j.anpede.2025.503837","DOIUrl":"10.1016/j.anpede.2025.503837","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503837"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the treatment of cystic fibrosis: CFTR modulators","authors":"Maria Dolores Pastor-Vivero ,&nbsp;Jordi Costa i Colomer ,&nbsp;Carlos Martín de Vicente ,&nbsp;Saioa Vicente-Santamaria ,&nbsp;Ruth Garcia Romero ,&nbsp;David González Jiménez ,&nbsp;Carmen Luna Paredes","doi":"10.1016/j.anpede.2025.503857","DOIUrl":"10.1016/j.anpede.2025.503857","url":null,"abstract":"<div><div>Cystic fibrosis is a severe genetic disease caused by variants in the <em>CFTR</em> gene. Although it is a multisystem disease, respiratory involvement is the main cause of morbidity and mortality. Cystic fibrosis transmembrane conductance regulator modulator (CFTRm) therapies have advanced the treatment of this disease by improving function of this protein. Ivacaftor, the first CFTRm, has been found to significantly improve lung function and quality of life in patients with certain gating variants. However, only a small percentage of patients in Spain are eligible for this treatment. Combinations of correctors and potentiators, such as lumacaftor-ivacaftor or tezacaftor-ivacaftor, have been developed for treatment of patients with the most frequent variant (F508del), although with limited benefits. Triple therapy with elexacaftor-tezacaftor-ivacaftor has been found to significantly improve respiratory, gastrointestinal and nutritional outcomes as well as quality of life, thus changing the management of CF in eligible patients. The impact of triple therapy is also reflected in an increase in life expectancy and a decrease in mortality and lung transplantation. As regards hepatic and pancreatic involvement, while CFTR modulators have exhibited promising effects, further research is required. The use of CFTR modulators has also shifted nutritional status trends in patients with CF, reducing the risk of undernutrition but increasing the risk of obesity. The use of these drugs for treatment of less frequent variants and for potential antenatal treatment is currently being investigated. Despite these advances, there is still a subset of patients who are ineligible for treatment with modulators or highly effective therapy.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503857"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN)","authors":"Carlos Marcilla Vázquez ,&nbsp;Juan Ríos Laorden ,&nbsp;Ángeles Lloret Callejo ,&nbsp;Francisco Tejada Cifuentes ,&nbsp;María José Tirado Peláez ,&nbsp;Ignacio Párraga-Martínez","doi":"10.1016/j.anpede.2025.503840","DOIUrl":"10.1016/j.anpede.2025.503840","url":null,"abstract":"<div><h3>Introduction</h3><div>Spain is the fourth European country with the highest antibiotic consumption at the community level, being children aged 0-4 years one of the age groups with the highest amount of consumption. The aim of this study was to analyze the evolution of antibiotic prescription of the pediatric population in a Primary Health Care area according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN) in a period of ten years (2014-2023), as well as to evaluate the impact of the COVID-19 pandemic by the comparison between 2020-2021 years and a previous (2014-2019) and a later periods of time (2022-2023).</div></div><div><h3>Material and methods</h3><div>Retrospective observational study of the prescription of antibiotics for systemic use (J01 group of the Anatomical Therapeutic Chemical Classification) in pediatric patients (0-14 years) belonging to the Primary Health Care area of the Gerencia de Atención Integrada (GAI) de Albacete between 2014 and 2023.</div></div><div><h3>Results</h3><div>Mean antibiotic prescription was 16.90 defined daily doses per 1000 inhabitants per day (DID) and 12.10 DOT (days of therapy). Pre-pandemic data (2014-2019) was 19.32 DID and 13.92 DOT, being reduced during the two years of the pandemic (2020-2021) to 8.30 DID and 6.05 DOT and subsequently increased to 18.05 DID and 12.40 DOT in post-pandemic years (2022-2023). An improvement in the adequacy of antibiotic prescription was observed after the COVID-19 pandemic, with a reduction of the consumption of amoxicillin-clavulanate and a greater consumption of penicillin and amoxicillin during pre-pandemic and pandemic years (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Thoughout the period of years analysed, an improvement in the consumption indicators proposed by the PRAN, with a higher use of beta-lactamase sensitive penicillins and amoxicillin and a reduced consumption of amoxicillin-clavulanate.</div></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503840"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital syphilis on the rise. Review of a five-year period in a referral hospital in Portugal","authors":"Sara Catarino ,&nbsp;Lídia Carvalho ,&nbsp;Angélica Ramos ,&nbsp;Manuela Rodrigues ,&nbsp;Ana Reis-Melo","doi":"10.1016/j.anpede.2025.503800","DOIUrl":"10.1016/j.anpede.2025.503800","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503800"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herpes-zoster en un paciente vacunado recientemente de varicela","authors":"Omar Al-wattar-Ceballos,&nbsp;Marina Montero-García,&nbsp;Mónica Gómez-Manzanares,&nbsp;Carlos Mendoza-Chaparro","doi":"10.1016/j.anpede.2025.503723","DOIUrl":"10.1016/j.anpede.2025.503723","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503723"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradox of MBD, we know how to treat it but we don’t know how to diagnose it","authors":"Clara Chover Martínez,&nbsp;María Portolés Morales,&nbsp;Pilar Sáenz González,&nbsp;Álvaro Solaz García","doi":"10.1016/j.anpede.2025.503801","DOIUrl":"10.1016/j.anpede.2025.503801","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"102 5","pages":"Article 503801"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}