[Rinsho ketsueki] The Japanese journal of clinical hematology最新文献_第4页

[Successful intensive treatment for severe fever with thrombocytopenia syndrome complicated by virus-associated hemophagocytic syndrome in a very elderly patient]. [一例高龄重症发热伴血小板减少综合征合并病毒相关噬血细胞综合征的强化治疗成功]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.233

Riichiro Ikeda, Yu Kochi, Takuya Nunomura, Kenjiro Hino, Takeshi Okatani, Ryota Imanaka, Kohei Kyo, Mitsuhiro Itagaki, Shinya Katsutani, Tsuyoshi Muta, Yuta Katayama

{"title":"[Successful intensive treatment for severe fever with thrombocytopenia syndrome complicated by virus-associated hemophagocytic syndrome in a very elderly patient].","authors":"Riichiro Ikeda, Yu Kochi, Takuya Nunomura, Kenjiro Hino, Takeshi Okatani, Ryota Imanaka, Kohei Kyo, Mitsuhiro Itagaki, Shinya Katsutani, Tsuyoshi Muta, Yuta Katayama","doi":"10.11406/rinketsu.66.233","DOIUrl":"https://doi.org/10.11406/rinketsu.66.233","url":null,"abstract":"The patient was an 89-year-old man who had been doing farm work for several days. He had previously visited a doctor with complaints of fever and nausea. He was referred to our hospital after pancytopenia was confirmed. On the 7th day after onset, he was found to have consciousness disturbances, liver dysfunction, and worsening pancytopenia, which led to a diagnosis of hemophagocytic syndrome by bone marrow examination. Considering the patient's history of outdoor activities and the presence of crusts on the right lower leg, we suspected severe fever with thrombocytopenia syndrome (SFTS). Reverse transcription polymerase chain reaction of peripheral blood was positive for the SFTS virus, confirming the diagnosis. Epstein-Barr virus reactivation was also observed. Steroid pulse therapy and plasma exchange led to prompt clinical improvement and hematopoietic recovery. The patient recovered without sequelae and was discharged home. Few reports have described the use of plasma exchange and steroid therapy in severe cases of SFTS. This case illustrates that early detection and aggressive treatment for elderly patients contributes to early symptom improvement and survival.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 4","pages":"233-237"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Outcome of allogeneic hematopoietic stem cell transplantation for myelofibrosis]. [同种异体造血干细胞移植治疗骨髓纤维化的疗效]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.111

Takumi Nishikawa, Masuho Saburi, Kuniaki Maehara, Keiichi Uraisami, Hiroyuki Takata, Yasuhiko Miyazaki, Eiichi Ohtsuka

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.303

引用次数: 0

[Drug-induced sarcoidosis-like reaction due to dasatinib in the lung of a patient with chronic myeloid leukemia]. [1例慢性髓性白血病患者肺部达沙替尼引起的药物性结节病样反应]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.324

Takumi Kimura, Yoshimi Nabe, Hiroki Yoshino, Ryota Urushihara, Noriaki Tsuji, Yukio Kondo

引用次数: 0

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.54

引用次数: 0

[Intravascular large B-cell lymphoma presenting as subacute progressive myelopathy]. [血管内大b细胞淋巴瘤表现为亚急性进行性脊髓病]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.12

Kiwamu Doi, Yosuke Nonohara, Soichiro Sakamoto, Toshiyuki Kitano

{"title":"[Intravascular large B-cell lymphoma presenting as subacute progressive myelopathy].","authors":"Kiwamu Doi, Yosuke Nonohara, Soichiro Sakamoto, Toshiyuki Kitano","doi":"10.11406/rinketsu.66.12","DOIUrl":"10.11406/rinketsu.66.12","url":null,"abstract":"The clinical manifestations of intravascular large B-cell lymphoma (IVLBCL) are highly variable and include constitutional B symptoms, neurological findings, and skin lesions. We report the case of a 64-year-old male patient who presented with myelopathy as a sole manifestation of IVLBCL. He had experienced progressive bilateral leg weakness along with bladder and rectal dysfunction for several months. He did not have non-neurological symptoms such as fever, night sweats, and weight loss at presentation. Blood tests, cerebrospinal fluid analysis, random skin biopsy, and bone marrow biopsy showed no evidence of lymphoproliferative disease. Subsequently, the patient developed a fever, and his LDH and soluble interleukin-2 receptor levels were elevated. PET/CT showed ground-glass opacity of the lung with associated FDG avidity. Transbronchial lung biopsy confirmed a diagnosis of IVLBCL. The patient received 6 cycles of R-CHOP combined with 2 cycles of high-dose methotrexate. His symptoms gradually improved with the chemotherapy, and PET/CT after completion of the treatment showed a complete metabolic response.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Good's syndrome complicated with pure white cell aplasia]. [古德氏综合征合并纯白细胞发育不全]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.106

Yukiko Nishizaki, Yuki Osada, Hikari Kanai-Sudo, Taro Mizuki, Sakae Tanosaki, Ken Suzuki

引用次数: 0

[Campylobacter lari bacteremia during treatment of pure red cell aplasia following major ABO-mismatched hematopoietic stem cell transplantation]. [abo -错配造血干细胞移植后治疗纯红细胞发育不全期间的拉里弯曲杆菌菌血症]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.238

Ryo Yoshimaru, Hirotaka Nakamura, Yony-Mei Guo, Song-Gi Chi, Yousuke Minami, Yusuke Ainoda, Keiji Okinaka, Junichiro Yuda

引用次数: 0

[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma]. [由亚洲诺卡菌感染引起的肌肉内脓肿和多发性淋巴结炎需要与阴烧成人t细胞白血病/淋巴瘤鉴别诊断]。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.121

Mahito Yamashiro, Tomo Nakajima, Yuka Irei, Riko Miyagi, Sakiko Kitamura, Keita Tamaki, Yukiko Nishi, Kazuho Morichika, Sawako Nakachi, Hiroki Maehara, Takuya Fukushima, Hiroaki Masuzaki

{"title":"[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma].","authors":"Mahito Yamashiro, Tomo Nakajima, Yuka Irei, Riko Miyagi, Sakiko Kitamura, Keita Tamaki, Yukiko Nishi, Kazuho Morichika, Sawako Nakachi, Hiroki Maehara, Takuya Fukushima, Hiroaki Masuzaki","doi":"10.11406/rinketsu.66.121","DOIUrl":"10.11406/rinketsu.66.121","url":null,"abstract":"A 72-year-old male engaged in horticulture developed a progressively enlarging painful mass in the left upper arm. The first biopsy revealed no malignancy or pathogenic bacteria. He completed an adequate course of antibiotics for infectious lymphadenitis, but showed no apparent improvement. Computed tomography demonstrated systemic lymphadenopathy, suggesting malignant lymphoma. Monoclonal integration of the HTLV-1 proviral genome in peripheral blood cells was confirmed by Southern blot analysis, but repeated lymph node biopsies identified no malignant cells. Based on these findings, a diagnosis of smoldering adult T-cell leukemia/lymphoma was made. After prolonged culture of the specimen, Nocardia sp. were detected and 16S rRNA sequencing confirmed infection by Nocardia asiatica. Combination therapy with sulfamethoxazole-trimethoprim and minocycline was started, and the systemic lymphadenopathy improved within 3 months. Although Nocardia asiatica infection manifesting as systemic lymphadenitis is extremely rare, it should be considered as a possibility in immunocompromised patients to ensure an accurate diagnosis.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 2","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronic graft-versus-host disease manifesting as isolated myositis]. 慢性移植物抗宿主病，表现为孤立性肌炎。

[Rinsho ketsueki] The Japanese journal of clinical hematology Pub Date : 2025-01-01 DOI: 10.11406/rinketsu.66.318

Ayako Yamamura, Takashi Hanada, Taichi Hirano, Kazuhito Tanaka, Nao Nishimura, Shinya Endo, Kenji Tokunaga, Yoshiki Mikami, Jun-Ichirou Yasunaga

{"title":"[Chronic graft-versus-host disease manifesting as isolated myositis].","authors":"Ayako Yamamura, Takashi Hanada, Taichi Hirano, Kazuhito Tanaka, Nao Nishimura, Shinya Endo, Kenji Tokunaga, Yoshiki Mikami, Jun-Ichirou Yasunaga","doi":"10.11406/rinketsu.66.318","DOIUrl":"https://doi.org/10.11406/rinketsu.66.318","url":null,"abstract":"A 26-year-old man underwent HLA-matched sibling allogeneic peripheral blood stem cell transplantation for acute myeloid leukemia with KMT2A rearrangement and maintained complete remission. On day338 post-transplant, he developed fever, myalgia, and markedly elevated creatinine kinase. We initially suspected drug-induced rhabdomyolysis and stopped the offending drugs, but his symptoms did not improve. Immunohistological findings with PD-1 staining in a muscle biopsy led to the diagnosis of graft versus host disease (GVHD)-associated myositis. The myositis resolved with prednisolone treatment based on the conventional chronic GVHD treatment protocol. Chronic GVHD with myositis alone is rare, and GVHD-associated myositis has been difficult to differentiate from other forms of myositis due to its lack of specific pathological features. Recently, PD-1 and HLA-DR expression have been reported as characteristic features of chronic GVHD-associated myositis. The pathological finding of PD-1-positive cell infiltration was useful in diagnosis and treatment in our case.","PeriodicalId":93844,"journal":{"name":"[Rinsho ketsueki] The Japanese journal of clinical hematology","volume":"66 5","pages":"318-323"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0