[与骨髓增生性肿瘤相关的肾脏损害]。

Yasutaka Fukuda
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引用次数: 0

摘要

骨髓增生性肿瘤(mpn),包括真性红细胞增多症、原发性血小板增多症和原发性骨髓纤维化(PMF),已被确定与肾脏损害有显著关联。其中,mpn相关肾小球病因其在PMF患者中的患病率而引起了特别的关注。慢性肾脏疾病对一般人群有显著影响,也与MPN患者血栓形成的重大风险和较差的总生存率相关。新出现的证据表明,细胞减少疗法和ruxolitinib等治疗可能有助于改善这些患者的肾功能。鉴于肾功能损害对预后和疾病结局的重要影响,在mpn的临床管理中,全面的肾功能评估是必不可少的。强烈建议与肾病专家合作,以确保全面的护理,特别是在确诊或疑似肾脏并发症的患者中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Renal impairment associated with myeloproliferative neoplasms].

Myeloproliferative neoplasms (MPNs), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF), have been identified as having a notable association with renal impairment. Among these, MPN-related glomerulopathy has garnered particular attention due to its prevalence in patients with PMF. Chronic kidney disease has a significant impact on the general population and is also associated with a substantial risk of thrombosis and poorer overall survival in MPN patients. Emerging evidence suggests that treatments such as cytoreductive therapy and ruxolitinib may help improve renal function in these patients. Given the significant implications of renal impairment on prognosis and disease outcomes, thorough renal function assessment is essential in the clinical management of MPNs. Collaboration with nephrologists is strongly recommended to ensure comprehensive care, particularly in patients with confirmed or suspected renal complications.

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