Psychoradiology最新文献

{"title":"Mapping the white-matter functional connectome: a personal perspective.","authors":"Jiao Li, Huafu Chen, Wei Liao","doi":"10.1093/psyrad/kkaf028","DOIUrl":"10.1093/psyrad/kkaf028","url":null,"abstract":"<p><p>In contemporary neuroscience, mapping the human brain's functional connectomes is essential to understanding its functional organization. Functional organizations in the brain gray matter have been the subject of previous research, but the functional information in white matter (WM), the other half of the brain, has been relatively underexplored. However, the dynamics of functional magnetic resonance imaging (fMRI) have been reliably identified in the brain WM. This review summarizes current knowledge about task-free (resting-state) fMRI neuroimaging analyses for the WM functional connectome. We present comparative findings of the WM functional connectome, including its mapping, physiological underpinnings, cognitive neuroscience relationships, and clinical applications. Furthermore, we explore the emerging consensus that WM functional networks have valid topological characteristics that can distinguish between individuals with brain diseases and healthy controls, predict general intelligence, and identify inter-subject variabilities. Lastly, we emphasize the need for further studies and the limitations, challenges, and future directions for the WM functional connectome. An overview of these developments could lead to new directions for cognitive neuroscience and clinical neuropsychiatry.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf028"},"PeriodicalIF":2.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12596274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-citation analysis of molecular imaging in neuropsychiatric disorders: integrating perspectives from radiology, neuroscience, and psychiatry.","authors":"Antonio Navarro-Ballester","doi":"10.1093/psyrad/kkaf026","DOIUrl":"10.1093/psyrad/kkaf026","url":null,"abstract":"<p><strong>Background: </strong>Molecular imaging plays a key role in advancing understanding of neuropsychiatric disorders. However, the conceptual structure of this interdisciplinary field remains poorly mapped from a bibliometric perspective. The objective of this study was to explore the intellectual structure and thematic development of research on molecular imaging applied to neuropsychiatric disorders using co-citation network analysis.</p><p><strong>Methods: </strong>A bibliometric co-citation analysis was conducted using data retrieved from Scopus. A targeted search strategy identified articles from 2014 to 2023 focused on MRS, fMRI, PET, and SPECT in the context of neuropsychiatric disorders. Bibliographic data were exported, and cited references were analyzed using VOSviewer. A manually curated thesaurus was applied to unify variant citations and reduce duplication. Co-citation networks were generated, and thematic clusters were identified and interpreted based on total link strength and citation density.</p><p><strong>Results: </strong>The co-citation network included 51 documents and revealed six major thematic clusters encompassing automated anatomical labeling and brain segmentation, functional and structural connectivity, affective neuroscience, clinical biomarkers, and methodological standardization. Notable references included foundational works on resting-state functional connectivity, motion correction, and diagnostic criteria for neuropsychiatric disorders. The clustering structure highlighted the convergence of radiology, neuroscience, and psychiatry around shared methodological tools and conceptual frameworks.</p><p><strong>Conclusion: </strong>Co-citation analysis revealed a well-defined and maturing intellectual landscape in molecular imaging applied to neuropsychiatry. The identified clusters represent distinct yet interconnected research lines, reflecting methodological innovation and translational potential. These findings offer a roadmap for future research, emphasizing methodological rigor, interdisciplinary collaboration, and clinical applicability.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf026"},"PeriodicalIF":7.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-brain synchrony to delineate the social impairment in autism spectrum disorder: a systematic review on hyperscanning studies.","authors":"Yuhang Li, Shuo Guan, Dalin Yang, Dongyun Li, Qiong Xu, Yingchun Zhang, Rihui Li","doi":"10.1093/psyrad/kkaf025","DOIUrl":"10.1093/psyrad/kkaf025","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a common neurodevelopmental disorder marked by significant deficits in social interaction and restricted repetitive behaviors. Despite rigorous research efforts, the early and effective diagnosis and intervention of ASD remain challenging, due primarily to its considerable heterogeneity and complex neurobiological underpinnings. Traditional neuroimaging techniques have largely focused on individual brain responses to social stimuli, often overlooking the critical interactive dynamics that contribute to social impairments in individuals with ASD. This review explored hyperscanning, an innovative neuroimaging approach that features simultaneous recording of brain activity across multiple individuals, to enhance our understanding of the neural mechanisms underlying social difficulties in ASD. By searching published articles conducted between 2000 and 2024, we found eight empirical studies conducted between 2012 and 2024, which employed various brain imaging techniques. We analyzed and summarized participant demographics, experimental designs, and key outcomes, with a particular focus on inter-brain synchrony (IBS) as a measure of social engagement and the quality of interpersonal interactions. Our review identified specific patterns of neural synchrony that correlate with the severity of ASD symptoms. Furthermore, we critically evaluated the limitations of current studies and proposed future research directions, highlighting the need for more nuanced hyperscanning methodologies. Such advancements could significantly deepen our understanding of social impairments in ASD and inform targeted intervention strategies. This comprehensive review aimed to assess the potential of hyperscanning techniques to propel progress in ASD research and intervention, ultimately contributing to more effective clinical practices.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf025"},"PeriodicalIF":2.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.","authors":"Qing-Lin Gao, Xiao Chen, Francisco Xavier Castellanos, Bin Lu, Chao-Gan Yan","doi":"10.1093/psyrad/kkaf024","DOIUrl":"10.1093/psyrad/kkaf024","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) biomarkers have shown considerable potential in elucidating the neurobiological underpinnings of major depressive disorder (MDD). However, clinical translation of these biomarkers remains limited due to reliance on group-level analyses, which fail to capture the individual variability inherent in MDD. Precision psychiatry, which advocates for individualized approaches, offers a framework that could enhance the clinical utility of MRI biomarkers across multiple domains, including diagnostic classification, treatment response prediction, and individualized interventions. Despite this potential, current research applying MRI biomarkers to MDD within the framework of precision psychiatry remains fragmented, lacking an integrated clinical system that seamlessly combines these components. This review introduces the concept of a closed-loop clinical system, emphasizing the integration of diagnostic classification, treatment response prediction, and individualized interventions into a unified approach at the individual patient level. We summarize recent advances in these three clinical domains, highlight existing fragmentation, and discuss the challenges of achieving a cohesive system. Finally, we propose that the integration of MRI biomarkers into a closed-loop clinical system, as envisioned by precision psychiatry, holds great promise for the individualized management of MDD, improving clinical outcomes from diagnosis through recovery.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf024"},"PeriodicalIF":2.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.","authors":"Lianlian Yang, Shuai Wang, Yingying Ji, Xiaoshan Gao, Zhenru Guo, Zimo Zhou, Yuanyuan Yang, Yu Xia, Haixia Huang, Jianhua Li, Lin Tian","doi":"10.1093/psyrad/kkaf023","DOIUrl":"10.1093/psyrad/kkaf023","url":null,"abstract":"<p><strong>Background: </strong>Suicide attempts (SA) and non-suicidal self-injury (NSSI) are serious public health problems that frequently co-occur in adolescents females with major depressive disorder (MDD), yet their neurobiological distinctions remain unclear. Here, we sought to explore female adolescents' neural mechanisms via the local gyrification index (LGI) and resting-state functional connectivity (RS-FC) analysis.</p><p><strong>Methods: </strong>We compared scale scores, LGI, and seed-based RS-FC among three groups of female adolescents: MDD with both NSSI and SA (SA + NSSI, <i>n</i> = 43), MDD with NSSI only (NSSI, <i>n</i> = 28), and healthy controls (HC, <i>n</i> = 27). Exploratory correlation analysis was applied to examine associations between the neuroimaging alterations and clinical symptom severity in depressed adolescents with SA and NSSI.</p><p><strong>Results: </strong>Compared with the HC group, both SA + NSSI and NSSI groups showed significantly decreased LGI in the prefrontal cortex, including right rostral/caudal middle frontal gyrus (MFG), precentral gyrus and postcentral gyrus (po-CG.R), as well as left rostral MFG, precentral gyrus and opercular part of the inferior frontal gyrus. The brain regions with altered RS-FC (seeds based on po-CG.R and the rostral MFG.L) are mainly distributed in the anterior cingulate cortex, insula, postcentral gyrus, and occipital lobe (<i>P </i>< 0.05, FDR correction). Moreover, exploratory correlation analysis suggested no statistically significant correlations after FDR correction (α = 0.05).</p><p><strong>Conclusion: </strong>Reduced cortical folding in postcentral and middle frontal gyri was found in both patient groups, alongside distinct functional connectivity, offering deeper neurobiological insights into SA and NSSI.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf023"},"PeriodicalIF":2.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered effective connectivity in leucine-rich glioma-inactivated 1 antibody encephalitis: a spectral dynamic causal modeling study.","authors":"Jianping Qiao, Lele Zheng, Wenlong Xu, Xuefeng Zang, Hao Shang, Cuicui Li, Shengjun Wang, Anning Li","doi":"10.1093/psyrad/kkaf022","DOIUrl":"10.1093/psyrad/kkaf022","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in understanding the effective connectivity (EC) of brain networks in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis, the specific cause and underlying mechanisms of LGI1 encephalitis remain unclear.</p><p><strong>Materials and methods: </strong>The study included 27 patients with anti-LGI1 encephalitis and 28 age- and sex-matched normal controls. Amplitude of low-frequency fluctuation (ALFF) analysis identified altered brain regions. Spectral dynamic causal modeling (spDCM) then assessed EC between these regions. Relationships between EC strength and both clinical severity and cognitive function were analyzed.</p><p><strong>Results: </strong>Distinct EC patterns were found in patients versus controls. Specifically, inhibitory EC was observed from the hippocampus to the superior temporal gyrus, while excitatory EC was noted in the reverse direction. Patients also showed reduced inhibitory self-connections in the posterior cingulate cortex. Crucially, inhibitory EC from the right hippocampus to the left superior temporal gyrus correlated inversely with symptom severity and positively with cognitive performance. Conversely, reduced inhibitory self-connections in the posterior cingulate cortex correlated positively with symptom severity and negatively with cognitive function.</p><p><strong>Conclusions: </strong>These findings indicate that changes in causal connections between specific brain regions significantly contribute to neurological deficits in anti-LGI1 encephalitis. The inhibitory connectivity from the hippocampus to the superior temporal gyrus may serve as a potential biomarker for personalized diagnosis, offering new insights into the underlying pathological mechanisms of this disorder.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf022"},"PeriodicalIF":2.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin modulation of resting-state functional connectivity network topology in individuals with higher autistic traits.","authors":"Abraham Tonny Hagan, Lei Xu, Juan Kou, Yuan Hu, Benjamin Klugah-Brown, Jialin Li, Mercy Chepngetich Bore, Benjamin Becker, Keith M Kendrick, Xi Jiang","doi":"10.1093/psyrad/kkaf021","DOIUrl":"10.1093/psyrad/kkaf021","url":null,"abstract":"<p><strong>Background: </strong>Altered connectivity patterns in socio-emotional brain networks are characteristic of individuals with autism spectrum disorder. Despite recent research on intranasal oxytocin's modulation effects of network topology in autism, its specific effects on the functional connectivity network topology remain underexplored.</p><p><strong>Methods: </strong>To address this gap, we conducted an exploratory data-driven study employing a dimensional approach using data from a large cohort of 250 neurotypical adult male subjects with either high or low autistic traits and who had administered 24 IU of intranasal oxytocin or placebo in a randomized, controlled, double-blind design. Resting-state functional connectivity data were analyzed using network-based statistical methods and graph theoretical approaches.</p><p><strong>Results: </strong>The findings from treatment × autistic trait group interactions revealed significantly different effects of oxytocin in local (cluster coefficient, efficiency, nodal path length, degree and betweenness centrality) but not global graph metrics in individuals with higher autistic traits compared to those with lower ones, across multiple brain regions. Changes across multiple measures were found in the motor, auditory/language, visual, default mode and socio-emotional processing networks, all of which are influenced in autism spectrum disorder.</p><p><strong>Conclusion: </strong>Overall, findings from this dimensional approach demonstrate that oxytocin particularly targets widespread enhancement of local but not global neural network processing parameters in neurotypical individuals with higher autistic traits. This suggests that intranasal oxytocin may represent a therapeutic option for social, emotional and sensorimotor symptoms in individuals with autism spectrum disorder by modulating local integration within brain regions involved in their regulation.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf021"},"PeriodicalIF":2.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of yoga nidra for chemo brain: a complementary and integrative perspective.","authors":"Santosh Kumar Sahu, Ajit Kumar Pradhan","doi":"10.1093/psyrad/kkaf020","DOIUrl":"10.1093/psyrad/kkaf020","url":null,"abstract":"<p><p>Chemotherapy-induced cognitive impairment (CICI), commonly known as \"chemo brain,\" affects a significant proportion of cancer survivors, manifesting as memory deficits, reduced attention, and impaired executive function. Conventional pharmacological treatments offer limited efficacy, prompting interest in complementary, non-invasive interventions. Yoga nidra (YN), a structured form of guided yogic relaxation, has demonstrated potential benefits for neurocognitive and emotional regulation. Grounded in ancient Indian traditions and increasingly supported by modern neuroscientific findings, YN appears to influence brainwave activity, autonomic function, and stress-related biomarker mechanisms implicated in the pathophysiology of CICI. This perspective review explores the emerging role of YN in managing chemo brain, integrating insights from neuroimaging, cognitive neuroscience, and psychophysiology. Drawing on peer-reviewed literature from PubMed- and Scopus-indexed sources, the article highlights the need for further research, including functional imaging and biomarker-based studies, to elucidate its therapeutic mechanisms. The findings underscore YN's potential as an adjunctive tool within integrative oncology and neurorehabilitation frameworks.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf020"},"PeriodicalIF":7.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain on expert medical performance: a systematic review and activation likelihood estimation functional magentic resonance imaging meta-analysis.","authors":"Nicoletta Cera, Joana Pinto, Minghao Dong, Steven Durning, Janniko R Georgiadis","doi":"10.1093/psyrad/kkaf019","DOIUrl":"10.1093/psyrad/kkaf019","url":null,"abstract":"<p><p>Healthcare systems require the efficient development of expert performance. Several studies have explored the cognitive foundations of medical expert performance, especially in radiology. Studying at the brain level could provide further insight into specific mechanisms mediating medical expert performance. Researchers have recently begun to systematically employ neuroimaging in this field. Most studies focus on specific specializations rather than identifying shared neural substrates across disciplines. This systematic review and activation likelihood estimation (ALE) meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. A total of 297 studies examining neural correlates were identified by comparing expert and novice medical performance. After screening, 22 studies were included in the final analysis. For studies reporting three-dimensional coordinates, ALE meta-analysis revealed consistent involvement of the medial frontal lobe, including the superior frontal gyrus, dorsomedial and ventromedial prefrontal cortex, and inferior frontal and fusiform gyri. Radiology-specific analyses highlighted activation in the ventromedial prefrontal cortex, the left pre-supplementary motor area (pre-SMA), along with the fusiform and opercular inferior frontal gyri. Internal medicine-based studies highlighted involvement of the SMA, inferior frontal gyrus, and dorsomedial prefrontal cortex. Our results revealed involvement, at different levels, of the medial frontal cortex, including the SMA and superior and inferior frontal gyri, which is part of the network relevant for inhibitory control and decision-making. The development of decision-making during the diagnostic process is relevant for the training of future professionals.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf019"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7T magnetic resonance imaging-based investigation of the correlation between mammillary body structure and cognitive impairment in patients with spinocerebellar ataxia type 3.","authors":"Congwei Li, Yunsong Peng, Peiling Ou, Ru Wen, Wei Chen, Chong Tian, Zhiming Zhen, Xingang Wang, Lan Ou, Chen Liu, Bijia Wang","doi":"10.1093/psyrad/kkaf010","DOIUrl":"10.1093/psyrad/kkaf010","url":null,"abstract":"<p><strong>Background: </strong>Spinocerebellar ataxia type 3 (SCA3) is a hereditary disease characterized by cerebellar atrophy and motor dysfunction. Patients also exhibit non-ataxic symptoms such as cognitive impairment. While prior neuroimaging studies have identified multiple cognition-associated brain regions in SCA3 patients, research on Papez circuit structural damage (e.g., mammillary bodies (MBs)) remains sparse. Advancements in 7T magnetic resonance imaging (MRI) technology have enabled scanning and quantitative analysis of structures such as the MBs within the Papez circuit. In this study, we investigated the relationship between cognitive impairment in patients with SCA3 and structural changes in the three Papez circuit structures: the MBs, the mammillothalamic tract (MTT), and the post-commissural fornix (PF).</p><p><strong>Methods: </strong>This cross-sectional study included 46 SCA3 patients and 48 healthy controls undergoing 7T MRI and neuropsychological assessments. Using manual delineation and a deep learning model, we extracted the MB, MTT, and PF volumes from participants. Subsequently, we statistically analyzed the quantitative data.</p><p><strong>Results: </strong>SCA3 patients exhibited reduced MB, PF, and MTT volumes compared with those of the healthy controls. The MB, left MTT, and left PF volumes were significantly lower in cognitive impairment than in cognitive preserved. Cognitive function in SCA3 patients was positively correlated with the MB, left MTT, and left PF, whereas motor function was negatively correlated with the MB and left PF.</p><p><strong>Conclusion: </strong>Decreased cognitive and memory function in SCA3 patients is associated with MB, MTT, and PF alterations and is more pronounced on the left side. Motor dysfunction may be correlated with cognitive impairment development.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf010"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}