Open journal of blood diseases最新文献

{"title":"Deep Vein Thrombosis Complicating SS Sickle Cell anemia in Pregnancy: About a Case Diagnosed at the Issaka Gazobi Maternity","authors":"Chaibou-Yacouba Maimouna, Hamidou Soumana-Diaouga, Amadou Djibrilla-Almoustapha, Moctar Abdoulaye-Maliki, Mansour Sidi-Mahamane, Madeleine Garba-Rah, I. Nafiou, M. Nayama","doi":"10.4236/OJBD.2021.112004","DOIUrl":"https://doi.org/10.4236/OJBD.2021.112004","url":null,"abstract":"Pregnancy in a sickle cell patient is a source of maternal and perinatal morbidities. Thromboembolic diseases of which Deep Vein Thrombosis (DVT) is one of the complications. The frequency of the latter is poorly assessed. Very few studies have been done on this topic. We report a case of DVT in a 35-year-old patient with sickle cell SS pregnant with 27SA diagnosed and cared for at the Maternity Issaka Gazobi (MIG) in Niamey. The management was based on low molecular weight heparin combined with preventive measures against sickle cell anemia and a planned cesarean section which led to a favorable maternal and perinatal prognosis.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45951253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological and Biochemical Profile of Sickle Cell Patients in Critical and Inter-Critical Periods in Brazzaville, Republic of Congo","authors":"E. P. L. Nanitelamio, S. O. Mokono, C. J. Mbani, Olivia Firmine Galiba Atipo-Tsiba, F. R. Niama, E. Mokondjimobé, D. Moukassa, A. Abena, A. Dokekias","doi":"10.4236/ojbd.2021.112007","DOIUrl":"https://doi.org/10.4236/ojbd.2021.112007","url":null,"abstract":"Introduction: Sickle cell disease is a public health problem in \u0000the Republic of Congo where the prevalence of sickle cell trait is estimated at \u00001.25%. The objective of this study is to describe the variations of \u0000hematological and biochemical parameters of hemolysis in sickle cell patients \u0000in critical and inter-critical periods. Methods: This is a descriptive \u0000cross-sectional study including sickle cell patients followed regularly at the \u0000National Reference Center for Sickle Cell Disease (CNRDr) from November 2019 to \u0000March 2020. A sample of 167 patients (sickle cell subjects in crisis and in \u0000steady state as well as control subjects) was randomly selected during the \u0000study period. The blood count was performed using a Sysmex-XN 350 automated \u0000system and the biochemical parameters were determined using the Cobas e 311 \u0000automated system. Statistical analysis was performed with SPSS version 22 \u0000software. Results: The study showed that the mean cholesterol level in \u0000controls was 4.16 ± 0.77 ul compared with 9.64 ± 4.34 ul in sickle cell crisis \u0000subjects. Hb and HCT levels were significantly higher in controls compared with \u0000sickle cell subjects in crisis. During crisis, total bilirubin, direct \u0000bilirubin, triglycerides, LDH, AST, and CRP were significantly elevated. \u0000Hematological parameters such as Hb and HCT were elevated in controls, while \u0000the mean WBC value and RET were higher in sickle cell patients in steady state. \u0000The mean values of the biochemical parameters were higher in sickle cell \u0000patients in steady state. Conclusion: Evaluation of the influence of \u0000sickle cell trait on biochemical and hematological parameters showed \u0000significant differences between sickle cell and control subjects.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47856834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the Efficacy of Autologous Blood Transfusion Combined with Controlled Hypotension in Patients with Spinal Internal Fixation during the Outbreak of New Coronavirus Pneumonia in Western Guangxi (in Guixi)","authors":"Chengkua Huang, Guosheng Su, Zhao Yong, Chunxia Lu, Shengxiong Nong, X. Huang","doi":"10.4236/OJBD.2021.111003","DOIUrl":"https://doi.org/10.4236/OJBD.2021.111003","url":null,"abstract":"Objective: To explore the therapeutic effect of autologous blood reinfusion combined with controlled hypotension in surgical spinal fixation during the outbreak of COVID-19. Methods: 30 patients with spinal internal fixation autologous blood transfusion combined with controlled hypotension were selected as the subjects during the epidemic period from December 2019 to June 2020 in our hospital and during the operation, on the basis of routine blood pressure reduction, the American Haemonetice Corporation autologous blood continuous reinfusion system was used to infuse the blood recovered during the operation to the patient through filtration and other procedures. Results: 30 patients had no complications such as fever and hemolysis; And after the operation, the tube was dialed according to the drainage volume, the cervical thoracic and lumbar brace was customized, and the patient walked on the ground for one week; After no abnormalities, the patient was discharged. Intraoperative comparison of white blood cells (WBC), red blood cells (RBC), red blood cell pressure (HCT), hemoglobin (HGB), and coagulation time (PT) of patients with autologous blood before and after transfusion showed statistically significant differences before and after surgery (P < 0.001). Conclusion: During the new coronavirus pneumonia epidemic, the internal fixation of spinal surgery used a recovery machine to collect intraoperative blood for reinfusion. Intraoperative antihypertensive drugs were used to control blood pressure within a certain safe range. The postoperative clinical observation effect was significant and safe; especially at present the clinical significance during the epidemic was significant.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46825552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Case of Von Willebrand Disease in Niger","authors":"Amadou Djibrilla-Almoustapha, M. Maman-Brah, Moustapha Elhadji-Chefou, M. R. Badé, Amal Al-Azhari, Youssoufa Seydou-Moussa, M. Sani, M. Daou, S. Brah, B. Malam-Abdou","doi":"10.4236/OJBD.2021.111001","DOIUrl":"https://doi.org/10.4236/OJBD.2021.111001","url":null,"abstract":"Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of Niamey’s National Hospital.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49608921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Virological Markers HIV, HBV and HCV in Homozygous Sickle Cell Patients at Brazzaville University Hospital","authors":"Laure Flora Josiane Kibangou, R. Moyen, Nanikaly Moyen, I. Kocko, L. Ngolet, Ettienne Nguimbi, A. Dokekias","doi":"10.4236/ojbd.2021.114014","DOIUrl":"https://doi.org/10.4236/ojbd.2021.114014","url":null,"abstract":"In order to evaluate the seroprevalence of major viral markers, a descriptive study was carried out in homozygous sickle cell transfusion patients at the University Hospital of Brazzaville. The profiles were determined in 51 patients, 32 of whom were male and 19 female, with an age range of 17 to 51 years, admitted to the clinical hematology department of the University Hospital and to the National Reference Center for Sickle Cell Disease. The tests were performed on pre- and post-transfusion blood samples. The following reagents were used: GeenscreenTMultraHIVAg-Ab, MonolisaAg-HBs plus, Monoli-saHCV Ag-Ab Ultrade Bio-Radot for the detection of HIV, HBV and HCV by fourth generation ELISA tests (serological tests). The results showed that the indications for blood transfusion were: acute crises of anemia due to malaria and in some cases of Vaso-Occlusive Crises (VOC) resistance to analgesic treatment. The prevalence rates of the markers before the new transfusion were respectively: HIV: 0%, HBV: 1.96%, HCV: 3.92%. After transfusion, the final seroprevalence rates of the markers are: HIV: 0%, HBV: 5.88%, HCV: 3.92%. The seroconversion rate for HBV was 3.92%. One case of HBV + HCV co-infection (1.96%). Conclusion: Transfusion safety is achieved through good transfusion practices and the qualification of blood donations. Homozygous sickle cell disease, characterized by frequent anemia attacks, requires a guar-antee of efficient transfusion practices in order to limit microbial risks.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compressive Myeloradiculopathies in Multiple Myeloma: Clinical and Radiological Characteristics of a Series of 29 Patients","authors":"E. Niang, M. Bamba, K. Mamadou, F. Seynabou, Seck Moussa, M. Ababacar, Bousso Elimane, Sarr Khadim, Faye Atoumane, Ndiaye Fatou Samba Diago, N. Moustapha, Diop Saliou","doi":"10.4236/ojbd.2021.114013","DOIUrl":"https://doi.org/10.4236/ojbd.2021.114013","url":null,"abstract":"Introduction: Patients with multiple myeloma (MM) develop neurological complications such as root and/or spinal cord compression in at least 5% of cases. The aim of this work is to describe the clinical and radiological features of root and/or spinal cord compression occurring during multiple myeloma. Patients and Methods: We conducted a retrospective study in the Clinical Haematology Department of Dalal Jamm Hospital and the National Blood Transfusion Centre, the Neurological Clinic of Fann Hospital Centre and the Internal Medicine Department of Aristide Le Dantec Hospital in Dakar between January 2016 and December 2019. All patients whose multiple myeloma diagnosis was established according to the International Myeloma Working Group’s 2014 and who had root, spinal or myeloradicular compression, were included in our study. Results: A total of 29 patients were included. The average age was 54.31 years [32 76 years]. The sex ratio (M/F) was 1.6. Motor deficits were the reason for consultation in 68% of the patients and spinal pains were reported by 93% of the patients. Neurological signs revealed multiple myeloma in all our patients. 25 patients (86.2%) had paraplegia and 1 patient had tetraparesis. Hypoesthesia to a defined sensory level was noted in 8 patients (28%). 5 patients (17.24%) had sphincter disorders. The types of lesions showed by imaging were vertebral lysis in 100% of cases, vertebral compression in 37% of cases, and epidural infiltration in 34% of cases. 12 patients (41.37%) had spinal compression, 14 patients (48.27%) had root compression, and 3 patients (10.34%) had myeloradicular compression. Spinal cord compression was most often at the dorsolumbar level (91.3% of cases) and root compression was How to cite this paper: Niang, E.H.D., Bamba, M.A., Mamadou, K., Seynabou, F., Moussa, S., Ababacar, M.K., Elimane, B., Khadim, S., Atoumane, F., Diago, N.F.S., Moustapha, N. and Saliou D. (2021) Compressive Myeloradiculopathies in Multiple Myeloma: Clinical and Radiological Characteristics of a Series of 29 Patients. Open Journal of Blood Diseases, 11, 133-139. https://doi.org/10.4236/ojbd.2021.114013 Received: January 17, 2021 Accepted: November 29, 2021 Published: December 2, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Panmyelosis with Myelofibrosis: A Rare Subtype of Acute Myeloid Leukemia","authors":"A. Diallo, S. A. Touré, M. Seck, Mouhamed Keita, E. S. Bousso, B. Faye, S. Diop","doi":"10.4236/ojbd.2021.113009","DOIUrl":"https://doi.org/10.4236/ojbd.2021.113009","url":null,"abstract":"","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Complement Regulatory Proteins (CD55, CD59, and CD35) on Red Blood Cells of β-Thalassaemia Patients","authors":"H. H. Mahmoud, Nawal Mahrous Nasef, Dalia Mahmoud Eldewi, Rasha Kamel Fathy Galal","doi":"10.4236/ojbd.2021.114010","DOIUrl":"https://doi.org/10.4236/ojbd.2021.114010","url":null,"abstract":"","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Blood Donation Activities in Kyrgyzstan and General Implications for Blood Donation","authors":"N. Kurmanaliev, Baktygul Aisarieva, Iskenderbek Abdiraiimov, Zhainagul Abdirasulova, Zhypargul D. Abdullaeva, M. Karataev, Nurzhigit Kurmanbaev, M. Khan","doi":"10.4236/ojbd.2020.104012","DOIUrl":"https://doi.org/10.4236/ojbd.2020.104012","url":null,"abstract":"Objectives: This article is aiming to give an essential informative principle about \u0000the development of blood donation activities in Kyrgyzstan. Background: The \u0000sequence of blood donation procedure steps before donation, during donation, \u0000and after donation was shown and discussed. Methods/Materials: Rhesus factor \u0000determination in donors was achieved by “COLICO” method which is based on the use of \u0000monoclonal antibodies solution. Results: According to the blood \u0000donation activity of donors in Osh, Kyrgyzstan for the 2018 year, it was found \u0000that gratuitous donors who donated blood in 6 months were 269, in 9 months were \u0000366, and in 1 year were 499 people. Relative donors who donated blood in 6 \u0000months were 3480, in 9 months were 5100, and in 1 year were 6701 people. Active \u0000donors donated blood in 6 months were 12, in 9 months were 14 and in 1 year \u0000were 17 people. Conclusion: No agglutination was observed in any of the \u0000plates for the first blood group; agglutination was observed with anti-A \u0000monoclonal antibody solution for the second blood group; agglutination was \u0000observed with anti-B monoclonal antibody solution for the third blood group; \u0000agglutination was observed with both of anti-A and anti-B monoclonal antibody \u0000solutions for the fourth blood group.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42702232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Prognosis of MYD88 L265p Mutation in Diffuse Large B-Cell Lymphoma","authors":"Yiming Zhao, Rui Zhang, Ling Ge, W. Qian, Fengbo Jin, Ming-zhen Yang","doi":"10.4236/ojbd.2020.104015","DOIUrl":"https://doi.org/10.4236/ojbd.2020.104015","url":null,"abstract":"Objective: To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. Methods: In this study, 40 formalin fixed paraffin embedded tissue samples were collected from the pathology department of the Fourth Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019. The relationship between MYD88 L265p gene mutation and clinicopathological parameters of DLBCL, such as age, gender, Ann Arbor stage, site, B symptom, NCCN-IPI and IPI score, ECOG PS score, serum ferritin, β2-microglobulin and LDH levels were analyzed. Results: The positive rate of MYD88 L265p was 20% (8/40), 25.0% (6/24) in non GCB and 12.5% (2/16) in GCB. There were no significant differences in age, gender, location, extranodal invasion site, β2-microglobulin, serum ferritin and LDH between wild-type and mutant type of MYD88 gene, but had statistical significance with Han’s classification. MYD88 L265p gene mutation was associated with Ann Arbor stage, NCCN-IPI score and IPI score. Conclusion: MYD88 L265P mutation is closely related to the occurrence, development and prognosis of DLBCL. It is an adverse prognostic factor of DLBCL and may be used for the prognosis evaluation of DLBCL.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}