Open journal of blood diseases最新文献_第6页

A Rare Entity of Angioimmunoblastic T-Cell Lymphoma 一种罕见的血管免疫母细胞t细胞淋巴瘤

Open journal of blood diseases Pub Date : 2019-06-10 DOI: 10.4236/OJBD.2019.92005

G. Kasinathan, A. Kori

{"title":"A Rare Entity of Angioimmunoblastic T-Cell Lymphoma","authors":"G. Kasinathan, A. Kori","doi":"10.4236/OJBD.2019.92005","DOIUrl":"https://doi.org/10.4236/OJBD.2019.92005","url":null,"abstract":"Introduction: Angioimmunoblastic T Cell Lymphoma (AITL) is a well-recognized subtype of peripheral T cell lymphoma. It occurs predominantly in the lymph nodes with presence of systemic symptoms and carries a dismal prognosis. AITL accounts for about 1% - 2% of all cases of non-Hodgkin lymphoma. Case presentation: A 59-year-old gentleman of Chinese ethnicity with no prior medical illness presented to Tengku Ampuan Afzan Hospital with a two-month history of fever, anorexia, unintentional weight loss and generalized lymphadenopathies. Physical examination revealed diffuse lymphadenopathies involving the cervical, axillary and inguinal regions bilaterally. He had hepatosplenomegaly. An excisional biopsy of the cervical and inguinal lymph nodes was compatible with AITL. The bone marrow biopsy demonstrated disease infiltration. He was treated with 6 cycles of Etoposide-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) induction chemotherapy followed by consolidation high dose therapy-autologous stem cell transplant (HDT-ASCT). He achieved complete remission on 18-Fluoro- deoxyglucose Positron Emission Tomography (18-FDG-PET) imaging. His bone marrow biopsy showed disease clearance. Conclusion: The diagnosis of AITL remains challenging and often poses a dilemma to clinicians and lymphoma pathologists. The natural history of AITL remains very variable with many of them relapsing subsequently despite achieving prior complete remission.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45292097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple Red Cell Indices in Screening and Discrimination of Iron Deficiency Anemia and Beta Thalassemia Trait in Egyptian Patients 埃及患者缺铁性贫血和β地中海贫血特征的简单红细胞指数筛选和鉴别

Open journal of blood diseases Pub Date : 2019-03-01 DOI: 10.4236/ojbd.2019.91002

E. Hamed, A. El-Deen

{"title":"Simple Red Cell Indices in Screening and Discrimination of Iron Deficiency Anemia and Beta Thalassemia Trait in Egyptian Patients","authors":"E. Hamed, A. El-Deen","doi":"10.4236/ojbd.2019.91002","DOIUrl":"https://doi.org/10.4236/ojbd.2019.91002","url":null,"abstract":"Background: The most common causes of microcytic hypochromic anemia are iron deficiency anemia (IDA) and the beta-thalassemia trait (β-TT). The aim of the work is to compare the validity of the various simple indices to differentiate between iron deficiency anemia and β-thalassemia trait. Subjects and methods: A total of 2000 individuals were screened, by complete blood picture, measurement of serum iron, serum ferritin and hemoglobin separation; 224 patients were detected as having hypochromia and microcytosis. Among them 166 cases were IDA and 58 cases were β-TT. We calculated 11 discrimination indices. The number of correctly identified cases were determined, sensitivity, specificity, positive and negative predictive value and Youden’s index (YI) of each discrimination index was calculated. Results: The percentage of correctly diagnosed patients is highest for Matos and Carvalho index (MCI) (95.5%) which is closely followed by Red cell distribution width index (RDWI) (93.7%). The third high index was Green and King (GKI) (91.9%). Sensitivity, specificity of MCI for detection of IDA was found 98.8%, 87.9% respectively. For β-TT, sensitivity and specificity was found 86.2% and 98.8% respectively. The YI of MCI was found 85.9%. It is followed by RDWI; its sensitivity and specificity for detection of IDA was found 97.6%, 85.3%. For β-TT, sensitivity and specificity was found 82.7% and 97.6% respectively. The YI of RDWI was 81.6%. Conclusion: Matos and Carvalho index and RDWI are easily available automated cell-count-based indices coming out as good discriminator between IDA and β-TT in our study.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46197886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients 2型糖尿病患者血清铬水平与糖化血红蛋白(HbA1c)、总胆固醇和甘油三酯的相关性研究

Open journal of blood diseases Pub Date : 2019-01-21 DOI: 10.4236/OJBD.2019.91001

Hani M. Mohamed, I. Sadik, A. Eltom, A. Osman, Asaad Mohammed Babker

{"title":"A Study of Correlation of Serum Chromium Level with Glycosylated Haemoglobin (HbA1c), Total Cholesterol and Triglycerides, among Type 2 Diabetes Patients","authors":"Hani M. Mohamed, I. Sadik, A. Eltom, A. Osman, Asaad Mohammed Babker","doi":"10.4236/OJBD.2019.91001","DOIUrl":"https://doi.org/10.4236/OJBD.2019.91001","url":null,"abstract":"Background: Diabetes mellitus is a common disease and it is a major cause of morbidity; several studies indicate that diabetes is a likely under reported cause of death. Chromium’s is important trace element to control diabetes mellitus and metabolism of carbohydrate, lipid and protein. Objective: The purpose of this study was to understand the relationship between serum chromium, with HbA1c, Total cholesterol and Triglycerides among type 2 diabetes patients among diabetic patients. Methodology: This is cross-sectional study done in Jabber Abu Ezz Centre for treatment and care of diabetics in Khartoum—Sudan. Four hundred subjects were enrolled in this study; one hundred subjects were normal healthy as control group, and three hundred subjects diabetic patient type 2 as test group; demographic and biochemical data were collected; serum chromium, Glycosylated Haemoglobin (HbA1c), Total cholesterol Triglycerides, were determined by using NYCOCARD READER II, spectrophotometer (Biosystem 310) and spectrophotometer 210-VGP. Result: In this study there is significant parameters level means of FBS HbA1c, Total Cholesterol, Triglycerides and Chromium of the test groups when compared with healthy control groups subjects (P = 0.001, 0.018, 0.01, 0.011, 0.004), respectively. Significant negative correlation is between FBS, HbA1c, Total Cholesterol, Triglycerides and Chromium (r = ?0.555, P value = 0.003), (r = ?0.668, P value = 0.002), (r = ?0.335, P value = 0.004) and (r = ?0.774, P value = 0.002) respectively. Conclusion: There was significant correlation between serum Chromium level with fasting blood sugaer, Glycosylated Haemoglobin (HbA1c), Total cholesterol and Triglycerides among type 2 diabetes patients.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46335860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Demographic and Clinical Profiles of Blood Transfusion Recipients at a Teaching and Referral Hospital in Kenya 肯尼亚一家教学和转诊医院输血接受者的人口统计学和临床概况

Open journal of blood diseases Pub Date : 2019-01-18 DOI: 10.4236/OJBD.2019.91004

Japheth C. Kipkulei, N. Buziba, Simeon Kipkoech Mining, Hellen Jepngetich

{"title":"Demographic and Clinical Profiles of Blood Transfusion Recipients at a Teaching and Referral Hospital in Kenya","authors":"Japheth C. Kipkulei, N. Buziba, Simeon Kipkoech Mining, Hellen Jepngetich","doi":"10.4236/OJBD.2019.91004","DOIUrl":"https://doi.org/10.4236/OJBD.2019.91004","url":null,"abstract":"Background: Blood transfusion is an essential component of modern health care. It is required universally to manage various medical, surgical and obstetric conditions. Establishing the profiles of blood recipients would help in predicting the long term needs of blood transfusion as changing patterns of populations, diseases and health care will result in changing demands for blood and blood components. The objective of the study was to determine the pattern of blood use in terms of demographic and clinical profiles of the recipients. Methods: A hospital based medical chart review of 384 patients who were transfused from June 2013 to November 2013 was carried out. Systematic random sampling method was used; data were collected using a structured data collection form and was analyzed using frequency tables. Results: The median age of the recipients was 31.5 years (IQR 13, 45.8) and the range was 0 to 89 years. Females comprised 55.2% of the recipients, of which 57.7% were in the reproductive age group (15 - 49 years). The majority of the recipients (60%) were from surgical and medical wards. The main indication of the transfusion was anaemia (62.8%) and most of the transfused patients were being treated for neoplasms (23.2%), pregnancy and childbirth related conditions (11.7%), injuries (11.5%) and infections (11.4%). Conclusion: Majority of the transfused patients were relatively young and were females. Anemia was the main indication of the transfusion and most of the transfused recipients presented with neoplasms, pregnancy and childbirth related conditions, infections and injuries.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49095668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Evaluation of a Possible Effect of In-House Cryoprecipitate Transfusion on Outcome of Severe Upper Gastrointestinal Bleeding: A Retrospective Cohort Study 室内冷冻沉淀输注对严重上消化道出血预后可能影响的评估：一项回顾性队列研究

Open journal of blood diseases Pub Date : 2019-01-18 DOI: 10.4236/OJBD.2019.91003

H. Fujita, S. Nishimura, K. Sugiyama

{"title":"Evaluation of a Possible Effect of In-House Cryoprecipitate Transfusion on Outcome of Severe Upper Gastrointestinal Bleeding: A Retrospective Cohort Study","authors":"H. Fujita, S. Nishimura, K. Sugiyama","doi":"10.4236/OJBD.2019.91003","DOIUrl":"https://doi.org/10.4236/OJBD.2019.91003","url":null,"abstract":"Purposes: Hypofibrinogenemia is usually complicated with severe and massive upper gastrointestinal (GI) bleeding, especially in liver cirrhosis. In Japan, neither fibrinogen concentrate nor cryoprecipitate (CRYO) is available for cases of acquired hypofibrinogenemia to recover the hemostatic level of fibrinogen rapidly. We prepared and produced in-house CRYO from fresh frozen plasma, and compared mortality between pre-implementation and post-implementation of CRYO. Methods: We performed a retrospective cohort study of patients admitted to our single tertiary medical center with upper GI bleeding from January 2011 to December 2016. The observational control period was from January 2011 to February 2013. From March 2013 to December 2016, we implemented the transfusion of CRYO, which was prepared and produced in our hospital. Clinical outcomes were compared between the patients in the two periods. Patients: Eleven patients in the control period and 10 in the intervention period were eligible for analysis. Results: In-hospital mortality (55% vs. 20%, P = 0.238) and mortality within 24 hour after admission (27% vs. 0%, P = 0.246) tended to be lower in the intervention period than in the control period, although the patients had more severe coagulation on admission than those in the control period. The plasma fibrinogen level before the treatment of hemostasis in the intervention period was higher than that in the control period (80 ± 9 mg/dL vs. 127 ± 15 mg/dL, P Conclusion: Implementation of in-house CRYO transfusion may reduce the rate of mortality due to severe upper GI bleeding.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1