Journal of hazardous materials letters最新文献

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Recovery of nitrate and fluoride salts from stainless steel pickling wastewater with flow-electrode capacitive deionization
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-20 DOI: 10.1016/j.hazl.2025.100148
Niklas Köller , Dustin Roedder , Christian J. Linnartz , Mark Enders , Florian Morell , Patrick Altmeier , Matthias Wessling
{"title":"Recovery of nitrate and fluoride salts from stainless steel pickling wastewater with flow-electrode capacitive deionization","authors":"Niklas Köller ,&nbsp;Dustin Roedder ,&nbsp;Christian J. Linnartz ,&nbsp;Mark Enders ,&nbsp;Florian Morell ,&nbsp;Patrick Altmeier ,&nbsp;Matthias Wessling","doi":"10.1016/j.hazl.2025.100148","DOIUrl":"10.1016/j.hazl.2025.100148","url":null,"abstract":"<div><div>Flow-electrode Capacitive Deionization (FCDI) is an innovative method for practical salt removal and recycling applications. Here, we report that FCDI facilitates the recovery of nitrate and fluoride salts from brines produced during the wastewater treatment process in a stainless steel pickling line. Laboratory-scale experiments with synthetic wastewaters were used to evaluate the influence of (a) the membrane thickness, (b) feed flow rates, and (c) applied voltage on the outlet concentrations and the average salt transfer rate. In continuous single-pass experiments, the flow rates of diluate and concentrate have the greatest influence on the resulting outlet concentrations in the FCDI process as they directly influence the residence time. The operating voltage of the FCDI process can be varied to increase the ratio of fluoride over nitrate for recycling.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100148"},"PeriodicalIF":6.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio)
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-19 DOI: 10.1016/j.hazl.2025.100143
Ba Reum Kwon , Gowoon Lee , Inae Lee , Ah-Reum Jo , Jeonghwan Lee , Na-Youn Park , Younglim Kho , Jung Pyo Lee , Kyungho Choi
{"title":"First snapshot comparison of nephrotoxic potentials of four common organic UV filters in juvenile and adult zebrafish (Danio rerio)","authors":"Ba Reum Kwon ,&nbsp;Gowoon Lee ,&nbsp;Inae Lee ,&nbsp;Ah-Reum Jo ,&nbsp;Jeonghwan Lee ,&nbsp;Na-Youn Park ,&nbsp;Younglim Kho ,&nbsp;Jung Pyo Lee ,&nbsp;Kyungho Choi","doi":"10.1016/j.hazl.2025.100143","DOIUrl":"10.1016/j.hazl.2025.100143","url":null,"abstract":"<div><div>To protect against UV light, organic UV filters (UVFs) are widely used in sunscreen and various consumer products. Concerns regarding the potential health impacts of UVFs have been raised, however, information is mostly limited to their endocrine disruptions. The present study aims to investigate nephrotoxic potentials of four major organic UVFs, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), using a zebrafish model at different life stages. Test UVFs were applied during early (0–30 days post-fertilization (dpf)), and adult life stage (&gt; 6 months old, 21 d exposure), and investigated for alterations in gene expression and/or kidney function. In juvenile fish (30 dpf), early life stage exposure to BP-3 and OMC caused significant induction of proteinuria. Moreover, regardless of life stage, key genes (<em>wt1a</em>, <em>podocin</em>, <em>nephrin</em>, <em>cdh17</em>, <em>sim1a</em>, and <em>kim-1</em>) responsible for kidney structure and function showed transcriptional alterations that support nephrotoxic potentials of the test UVFs. Our results demonstrate that exposure to widely used organic UVFs could impair normal biological processes for maintaining kidney health during both life stages. Considering the widespread use of organic UVFs among the general human population, the implication of this nephrotoxic potential warrants further investigation.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100143"},"PeriodicalIF":6.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the impact of copper oxide nanoparticles on the biocontrol activity and plant growth promotion of Trichoderma asperellum
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-19 DOI: 10.1016/j.hazl.2025.100147
Claudia A. Ramírez-Valdespino , Marlyn Morales-García , Guillermo Herrera-Pérez , Yordan J. Romero-Contreras , Enrique García-Mireles , Joan Salas-Leiva , Susana González-Chávez , Socorro Tarango-Rivero , Erasmo Orrantia-Borunda
{"title":"Exploring the impact of copper oxide nanoparticles on the biocontrol activity and plant growth promotion of Trichoderma asperellum","authors":"Claudia A. Ramírez-Valdespino ,&nbsp;Marlyn Morales-García ,&nbsp;Guillermo Herrera-Pérez ,&nbsp;Yordan J. Romero-Contreras ,&nbsp;Enrique García-Mireles ,&nbsp;Joan Salas-Leiva ,&nbsp;Susana González-Chávez ,&nbsp;Socorro Tarango-Rivero ,&nbsp;Erasmo Orrantia-Borunda","doi":"10.1016/j.hazl.2025.100147","DOIUrl":"10.1016/j.hazl.2025.100147","url":null,"abstract":"<div><div>Agriculture is constantly in the search for new alternatives to control phytopathogens and improvement of plant growth. One of its main strategies is the use of biocontrollers, among them, <em>Trichoderma</em> genus stand out for their versatility and broad spectrum phytopatogenic fungi attacked. On the other hand, nanotechnology is positioning itself as an alternative to the use of agrochemicals, especially metal oxide nanoparticles, including ZnO, TiO<sub>2</sub> and CuO. Recently, it has been seen that when <em>Trichoderma</em> is put in contact with nanoparticles, it increases its biocontrol and biostimulant activity. Therefore, in this work we performed the characterization of a <em>T. asperellum</em> strain, which was capable to grow in different concentrations of CuO nanoparticles, obtaining that, at 200 ppm, <em>Trichoderma</em> showed no changes in growth and no apparent stress. Moreover, the strain developed a higher biocontrol activity against two <em>Fusarium oxysporum</em> strains, but decreases with <em>F. fujikuroi</em>, as well as changes in the expression of genes associated to biocontrol. Finally, an enhance in alfalfa growth is reported. These results suggest that, at the tested concentrations, CuO-NPs do not interfere with the biocontrol activity of <em>T. asperellum</em>, providing the basis for the development of a bionanoformulation to control <em>F. oxysporum</em> and promotes alfalfa growth.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100147"},"PeriodicalIF":6.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental BPA exposure disrupts offspring transcriptomic profiles and impairs embryonic lineage specification during zygotic genome activation
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-18 DOI: 10.1016/j.hazl.2025.100146
Yuequn Chen , Kusheng Wu , Wenlong Huang
{"title":"Parental BPA exposure disrupts offspring transcriptomic profiles and impairs embryonic lineage specification during zygotic genome activation","authors":"Yuequn Chen ,&nbsp;Kusheng Wu ,&nbsp;Wenlong Huang","doi":"10.1016/j.hazl.2025.100146","DOIUrl":"10.1016/j.hazl.2025.100146","url":null,"abstract":"<div><div>Bisphenol A (BPA) is an endocrine-disrupting chemical known for its developmental toxicity. However, the impact of BPA on early embryonic development, particularly during zygotic genome activation (ZGA), remains underexplored. In this study, zebrafish embryos at 3.5 and 4.5 hours post-fertilization (hpf) were collected after 7-day parental exposure to 1.0 µM BPA for transcriptome sequencing. Transcriptomic data underwent differential gene expression functional enrichment and gene set enrichment analyses. Public single-cell transcriptome atlases of zebrafish embryos at different developmental stages (3.3, 4, and 4.8 hpf) were obtained to build signature matrices for digital cell type sorting of the bulk transcriptome using the CIBERSORTx algorithm. Results indicated that parental BPA exposure resulted in muted gene expression response, disturbed energy metabolism profile, and increased pro-inflammatory signatures during ZGA. Digital cell type deconvolution revealed altered cell composition, including deeper multilayer and enveloping layer cells and fewer margin cells. Furthermore, reductions in neural progenitor and heart primordium lineages, alongside expansions in primordial germ and mesendodermal lineages, potentially contribute to later-stage developmental abnormalities. This study elucidates the embryotoxic effects of BPA during the ZGA period, shedding light on the developmental perturbations from early-life exposure to this ubiquitous environmental contaminant.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100146"},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrethroids have become a barrier to the daily existence of molluscs (Review)
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-16 DOI: 10.1016/j.hazl.2025.100144
Raja Saha , Sangita Maiti Dutta
{"title":"Pyrethroids have become a barrier to the daily existence of molluscs (Review)","authors":"Raja Saha ,&nbsp;Sangita Maiti Dutta","doi":"10.1016/j.hazl.2025.100144","DOIUrl":"10.1016/j.hazl.2025.100144","url":null,"abstract":"<div><div>Molluscs are significant aquatic organisms, which serve as bioindicator species. They are crucial for maintaining ecological balance as secondary consumers. Molluscs are threatened by pesticides such as pyrethroid insecticides. Pyrethroids are increasingly utilized to control insects in agriculture and gardening. It contaminates aquatic bodies through rainwater runoff and drainage-sewage systems. The current review will focus on the issue of increasing pyrethroid use and its biological effects on molluscs. Due to their highly lipophilic nature, pyrethroids pose a significant risk to these organisms by affecting their metabolites, producing reactive oxygen species, and influencing neurotransmitter actions. The threats to the molluscs and eventually to the concerned aquatic ecosystem warrant significant discussion and attention.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100144"},"PeriodicalIF":6.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicological assessment & risk evaluation of pesticides and their mixtures through C. elegans & RISK21: A risk-based approach for sustainable agriculture
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-12 DOI: 10.1016/j.hazl.2025.100145
Mariana I. Manetti , M. Laura Migliori , M. Florencia Kronberg , Rosana Rota , Aldana Moya , Eduardo A. Pagano , Daniel H. Calvo , Sandrine Deglin , Michelle Embry , Diego A. Golombek , Eliana R. Munarriz
{"title":"Toxicological assessment & risk evaluation of pesticides and their mixtures through C. elegans & RISK21: A risk-based approach for sustainable agriculture","authors":"Mariana I. Manetti ,&nbsp;M. Laura Migliori ,&nbsp;M. Florencia Kronberg ,&nbsp;Rosana Rota ,&nbsp;Aldana Moya ,&nbsp;Eduardo A. Pagano ,&nbsp;Daniel H. Calvo ,&nbsp;Sandrine Deglin ,&nbsp;Michelle Embry ,&nbsp;Diego A. Golombek ,&nbsp;Eliana R. Munarriz","doi":"10.1016/j.hazl.2025.100145","DOIUrl":"10.1016/j.hazl.2025.100145","url":null,"abstract":"<div><div>Pesticides are extensively used in agriculture to protect crops, but their environmental release, particularly as mixtures, raises concerns about effects on non-target organisms and ecosystem health. This study aimed to evaluate the toxicity of five pesticides used extensively on soybean crops - glyphosate, 2,4-D, paraquat, chlorpyrifos, and lambda-cyhalothrin- and their binary mixtures on the nematode <em>Caenorhabditis elegans</em>, a model organism in toxicology. Locomotion and growth assays were conducted to assess acute and chronic effects, and the RISK21 matrix framework was used to convey environmental risks based on the bioassay results combined with surface water monitoring data and modeled exposure estimates. Our results demonstrate significant reductions in locomotion and body length for all tested pesticides, with synergistic effects observed in binary mixtures. However, the risk-based analysis suggests that the estimated environmental concentrations of these pesticides pose minimal ecological risks. In conclusion, our work highlights the novelty of combining <em>C. elegans</em>-based toxicity assays in a risk-based approach to evaluate pesticide mixtures, offering a practical approach for predicting environmental impacts and promoting sustainable agriculture.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100145"},"PeriodicalIF":6.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualization and spatial mapping of PFAS in the edible storage root of radish
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-02-01 DOI: 10.1016/j.hazl.2025.100141
Yuwei Zuo, Weilan Zhang
{"title":"Visualization and spatial mapping of PFAS in the edible storage root of radish","authors":"Yuwei Zuo,&nbsp;Weilan Zhang","doi":"10.1016/j.hazl.2025.100141","DOIUrl":"10.1016/j.hazl.2025.100141","url":null,"abstract":"<div><div>Plants, as key components of trophic networks, play a critical role in the bioaccumulation of PFAS and their transfer to higher trophic levels. This study introduces an innovative methodology using timsTOF fleX MALDI-2 to visualize the spatial distribution of PFAS in plant tissues. Radish was selected as the model plant due to its global popularity as a widely consumed vegetable. DAN (1,5-diaminonaphthalene) was used as the MALDI matrix, and the mass spectrometry operating conditions were optimized to acquire the best PFAS signals. The results show that long-chain PFAS predominantly accumulated in the xylem of the edible storage root, where their high hydrophobicity limits upward translocation. In contrast, short-chain PFAS and PFOA exhibited stronger signals in the cortex and periderm, likely due to alternative transport pathways. This differential distribution highlights the significant influence of PFAS physicochemical properties, such as chain length and hydrophobicity, on their in-planta transport mechanisms. By precisely mapping PFAS within plant tissues, this study provides a powerful tool for identifying high-risk edible tissues and assessing human exposure risks through PFAS-contaminated crops. It also reinforces the urgent need for sustainable remediation strategies to reduce PFAS levels in agricultural systems, thereby safeguarding food safety, ecosystem health, and human well-being.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100141"},"PeriodicalIF":6.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated concentrations of quaternary ammonium compounds in childcare centers: A pilot study
IF 6.6
Journal of hazardous materials letters Pub Date : 2025-01-02 DOI: 10.1016/j.hazl.2024.100138
Yao Cheng , Zhong Lv , Erika Schreder , Min Hu , Abby Mutic , Guomao Zheng , Amina Salamova
{"title":"Elevated concentrations of quaternary ammonium compounds in childcare centers: A pilot study","authors":"Yao Cheng ,&nbsp;Zhong Lv ,&nbsp;Erika Schreder ,&nbsp;Min Hu ,&nbsp;Abby Mutic ,&nbsp;Guomao Zheng ,&nbsp;Amina Salamova","doi":"10.1016/j.hazl.2024.100138","DOIUrl":"10.1016/j.hazl.2024.100138","url":null,"abstract":"<div><div>Quaternary ammonium compounds (QACs) are used as antimicrobials, preservatives, and antistatic agents in cleaning, disinfecting and personal care products, and textiles. High levels of QACs have been found in indoor dust in residential homes; however, there is limited information on QAC exposure in non-residential environments serving sensitive populations, such as childcare centers. In this study, we investigated the occurrence of QACs, including benzylalkyldimethyl ammonium compounds (BACs), dialkyldimethylammonium compounds (DADMACs), and alkyltrimethylammonium compounds (ATMACs), in dust from childcare centers and estimated daily intake of QACs by toddlers in chidlcare via dust ingestion. Nineteen QACs were detected in dust with a median total QAC concentration (ΣQAC) of 150 μg/g. BACs were the most abundant QAC group found at concentrations ranging from 2.67 to 1370 μg/g (median 90.4 μg/g) and constituted 64 % of the ΣQAC concentrations. The QAC levels in dust from childcare centers were significantly higher than concentrations previosly reported in homes. The EDIs for BACs, DADMACs, and ATMACs via dust ingestion calculated based on the 95th percentile concentrations in childcare dust were up to 30 times higher than those for toddlers in residential homes. These findings demonstrate high QAC exposure in childcares, posing significant early-life exposure for toddlers.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100138"},"PeriodicalIF":6.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No traces of emerging and priority organic pollutants in the muscles of Procambarus clarkii suggest the feasibility of its regulated and sustainable control from uncontaminated environments
IF 6.6
Journal of hazardous materials letters Pub Date : 2024-12-30 DOI: 10.1016/j.hazl.2024.100140
Dario Savoca , Vincenzo Arizza , Gaetano Cammilleri , Leonardo Cerasino , Antonella Maccotta , Federico Marrone , Licia Pantano , Nico Salmaso , Francesco Paolo Faraone
{"title":"No traces of emerging and priority organic pollutants in the muscles of Procambarus clarkii suggest the feasibility of its regulated and sustainable control from uncontaminated environments","authors":"Dario Savoca ,&nbsp;Vincenzo Arizza ,&nbsp;Gaetano Cammilleri ,&nbsp;Leonardo Cerasino ,&nbsp;Antonella Maccotta ,&nbsp;Federico Marrone ,&nbsp;Licia Pantano ,&nbsp;Nico Salmaso ,&nbsp;Francesco Paolo Faraone","doi":"10.1016/j.hazl.2024.100140","DOIUrl":"10.1016/j.hazl.2024.100140","url":null,"abstract":"<div><div>A monitoring of organic contaminants in the muscles of the <em>Procambarus clarkii</em> and environmental samples of water and sediment was conducted in three Sicilian wetlands (Italy). The substances investigated in the biological samples were per- and polyfluoroalkyl substances (PFAS), phthalic acid esters (PAEs), pesticides, antibiotics, and microcystins (MCs), all of which were below the detection limit. Given that the Louisiana red swamp crayfish is considered a bioaccumulator, the results of this study indicate that these environments are not significantly contaminated by the selected pollutants. Furthermore, the study suggests the potential uses of the edible portions of this alien species. Despite <em>P. clarkii</em> cannot be marketed in several countries, including Italy, it is possible that the animal biomass obtained in the frame of the monitoring, control and eradication activities carried out by local authorities, could be exploited for various purposes, such as food, feed and biotechnology. This would reduce the costs associated with disposal and make these activities more sustainable in the long term, thereby contributing to the preservation of ecosystems that are currently threatened by this invasive species.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100140"},"PeriodicalIF":6.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Approach Methodologies: Physiological responses of daphnids to pharmaceutical mixtures
IF 6.6
Journal of hazardous materials letters Pub Date : 2024-12-28 DOI: 10.1016/j.hazl.2024.100139
Emma Rowan , Anne Leung , Katie O’Rourke , Xiaofei Yin , Lorraine Brennan , Konstantinos Grintzalis
{"title":"New Approach Methodologies: Physiological responses of daphnids to pharmaceutical mixtures","authors":"Emma Rowan ,&nbsp;Anne Leung ,&nbsp;Katie O’Rourke ,&nbsp;Xiaofei Yin ,&nbsp;Lorraine Brennan ,&nbsp;Konstantinos Grintzalis","doi":"10.1016/j.hazl.2024.100139","DOIUrl":"10.1016/j.hazl.2024.100139","url":null,"abstract":"<div><div>Conventional methods for water monitoring are insufficient to capture the impacts of pollution because of their sensitivity limits, while they also fail to provide mechanistic insight regarding the actions of pollutants. On the other hand, New Approach Methodologies are more and more introduced as supplementary tools that provide sensitive metrics for pollution assessment. In this context, freshwater sentinel species commonly known as water fleas were used to assess the impact of a pharmaceutical mixture. The pharmaceutical cocktail comprised of representatives of commonly encountered pharmaceuticals and specifically diclofenac, metformin, gabapentin, amoxicillin, trimethoprim, and erythromycin. Combining toxicity, phenotypic and molecular endpoints, results showed differences in mortality, feeding, key enzyme activities and metabolic perturbations, thus supporting a distinct pattern in physiological responses of daphnids that could be used to monitor and predict pollution early.</div></div>","PeriodicalId":93463,"journal":{"name":"Journal of hazardous materials letters","volume":"6 ","pages":"Article 100139"},"PeriodicalIF":6.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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