BMC Biology最新文献

{"title":"Ca²⁺-dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion.","authors":"Baicong Mu, David M Rutkowski, Gianluca Grenci, Dimitrios Vavylonis, Dan Zhang","doi":"10.1186/s12915-025-02309-5","DOIUrl":"10.1186/s12915-025-02309-5","url":null,"abstract":"<p><strong>Background: </strong>Robust coordination of surface and volume changes is critical for cell integrity. Few studies have elucidated the plasma membrane (PM) remodeling events during drastic cell surface and volume alteration, especially regarding PM sensing and its subsequent rearrangements.</p><p><strong>Results: </strong>In this article, using fission yeast protoplasts, we reveal a Ca²⁺-dependent mechanism for membrane addition that ensures PM integrity and allows its expansion during acute hypoosmotic cell swelling. We show that MscS-like mechanosensitive channels activated by PM tension control extracellular Ca²⁺ influx, which triggers potential direct lipid transfer at endoplasmic reticulum (ER)-PM contact sites by conserved extended-synaptotagmins and accelerates exocytosis, enabling PM expansion necessary for osmotic equilibrium. Defects in any of these key events result in rapid protoplast rupture upon severe hypotonic shock. Our numerical simulations of such hypoosmotic PM expansion further propose a cellular strategy that combines instantaneous non-vesicular lipid transfer with bulk exocytic membrane delivery to maintain PM integrity for dramatic cell surface/volume adaptation.</p><p><strong>Conclusions: </strong>We propose a cellular strategy that combines instantaneous non-vesicular lipid transfer with bulk exocytic membrane delivery to maintain PM integrity for dramatic cell surface/volume adaptation.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"207"},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungus-mediated plant-pollinator mutualism in Monoon laui (Annonaceae): functional differentiation of stigmatic exudate and petal nectar.","authors":"Yanwen Chen, Bine Xue, Juan Diego Gaitán-Espitia, Richard M K Saunders","doi":"10.1186/s12915-025-02308-6","DOIUrl":"10.1186/s12915-025-02308-6","url":null,"abstract":"<p><strong>Background: </strong>Floral nectar typically functions as a pollinator reward in mutualistic flower-pollinator interactions, with this mutualism sometimes strengthened when plants provide the pollinators with brood sites and larval food as rewards. The functional and molecular mechanisms underpinning such rewards remain unclear.</p><p><strong>Results: </strong>We present strong circumstantial evidence supporting a fungus-mediated plant-pollinator mutualism in a beetle-pollinated early-divergent angiosperm, Monoon laui (Annonaceae), which has flowers that produce exudates on both the stigmas and inner petals, with fungi that develop on the inner petals subsequently consumed by insect larvae. The identities of the pollinators and larvae, as well as the fungal communities borne on the pollinators and petals, indicate that the pollinators disperse fungi while ovipositing on the petals. The nutritional value of the two exudates reveals that the stigmatic exudate is sugar-rich, whereas the inner petal exudate has a greater amino acid content. Transcriptomic and proteomic comparisons between the two organs and their exudates corroborate the nutritional profiles, with a stronger immune response on stigmas.</p><p><strong>Conclusions: </strong>Both stigmatic exudate and petal nectar of Monoon laui function as a pollinator reward, while petals with their nectar are moreover critical in the fungus-mediated plant-pollinator mutualism, as they are likely to be closely adapted to the requirements of the pollinators by providing them with brood sites and larval food, thereby increasing their population size during the flowering season and promoting pollination success.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"206"},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reference genome enhances the power to detect signatures of recent anthropogenic impact in genomic data: a lesson learned from a stag beetle system.","authors":"Zong-Yu Shen, My-Hanh Le, Ming-Hsun Chou, Jen-Pan Huang","doi":"10.1186/s12915-025-02307-7","DOIUrl":"10.1186/s12915-025-02307-7","url":null,"abstract":"<p><strong>Background: </strong>Genomic data are vital for conservation biology and recent advances in sequencing technology have facilitated their applicability. However, the role of reference genomes in conservation planning remains largely underexplored. Specifically, while reference genomes can improve the accuracy of estimating genetic indices and help detect genomic regions under selection, they are still limited for non-model species. We explored whether a reference genome can help reveal novel insights not detected by previous genome-wide SNP analyses in a stag beetle system, especially in understanding recent demographic changes and local adaptation, which are critical information for conservation planning.</p><p><strong>Results: </strong>We used Oxford Nanopore Technology (ONT) to sequence and assemble a draft genome of an endemic stag beetle Lucanus miwai in Taiwan. With this newly generated genome map, we reanalyzed a previously published ddRADseq dataset. Our results revealed that the three geographical lineages of L. miwai exhibit varying levels of runs of homozygosity (ROH), with the lineage experiencing the most severe and recent habitat disturbance showing the longest ROH. Furthermore, the inferred timing and duration of a recent bottleneck coincide with historical records of recent habitat destruction. We also identified putative genomic regions showing signals of divergent selection between the lineages, indicating the importance of maintaining geographical lineages as separate conservation units.</p><p><strong>Conclusions: </strong>The impact of anthropogenic disturbance among different geographical lineages of L. miwai can be detected using genomic data only when a reference genome is available. Furthermore, a reference genome helps us identify a genomic region that may have experienced a recent selective sweep. Our findings thus provide empirical evidence supporting the crucial roles of reference genomes in conservation planning.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"205"},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 14-bp motif in the KIT active promoter region is critical for melanin accumulation in yaks, mice, and humans.","authors":"Xinfeng Liu, Tongcheng Wang, Zeyu Zheng, Congcong Dong, Wenyu Liu, Zhimin Niu, Yingbo Yang, Xiaoyun Wu, Qiang Qiu, Yongzhi Yang, Kexin Li, Johannes A Lenstra, Ping Yan, Minghui Kang, Bowen Li, Lingzhao Fang, Jianquan Liu","doi":"10.1186/s12915-025-02311-x","DOIUrl":"10.1186/s12915-025-02311-x","url":null,"abstract":"<p><strong>Background: </strong>Animal pigmentation serves as an excellent model for studying genetics, development, and evolution. Among yak breeds, the all-white yak breed (Bos grunniens) is the only indigenous variety with pristine white fur, in stark contrast to the black coat color of the wild yak and most domesticated yaks.</p><p><strong>Results: </strong>Using whole-genome sequencing data from 387 yaks, we analyzed the population genetic structure of all-white yaks and discovered that they clustered into two distinct genetic groups. Further, by conducting a genome-wide association study (GWAS) based on whole-genome variants (SNPs and indels) between all-white and wild-type yaks, we identified a 14-bp deletion in the promoter of KIT, which decreased its expression in all-white yaks. The following knock-in experiments in mouse confirmed that the absence of the yak 14-bp motif decreases the expression of KIT. Deletion of a human orthologue of the yak 14-bp motif by using the CRISPR/Cas9 system reduces the melanin accumulation in human melanoma cells.</p><p><strong>Conclusions: </strong>Overall, our study revealed the genetic basis of all-white yaks and underscored the importance of studying livestock phenotypes to uncover conserved genetic regulators in mammals.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"208"},"PeriodicalIF":4.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial dependence in face-gender classification revealed in low-beta frequency EEG.","authors":"Giacomo Ranieri, David C Burr, Jason Bell, Maria Concetta Morrone","doi":"10.1186/s12915-025-02289-6","DOIUrl":"10.1186/s12915-025-02289-6","url":null,"abstract":"<p><strong>Background: </strong>Perception depends not only on current sensory input but is also heavily influenced by the immediate past perceptual experience, a phenomenon known as \"serial dependence,\" particularly robust in face perception.</p><p><strong>Results: </strong>We measured discrimination of face-gender in participants to a sequence of intermingled male, female, and androgynous images, while recording EEG responses. The discriminations showed strong serial dependence (androgynous images biased towards male when preceded by male and female when preceded by female). The strength of the bias oscillated over time in the beta range, at 14 Hz for female prior stimuli, 18 Hz for male. Using classification techniques, we were able to successfully classify the previous stimulus from current EEG activity. Classification accuracy correlated well with the strength of serial dependence across individual participants, confirming that the neural signal from the past trial biased face perception. Bandpass filtering of the signal within the beta range showed that the most useful information to classify gender was around 14 Hz when the previous response was \"female,\" and around 18 Hz when it was \"male,\" reinforcing the psychophysical results showing serial dependence to be carried at those frequencies.</p><p><strong>Conclusions: </strong>Overall, the results suggest that recent experience of face-gender is selectively represented in beta-frequency (14-20 Hz) spectral components of intrinsic neural oscillations.</p><p><strong>Significance statement: </strong>The neurophysiological mechanisms of how past perceptual experience affects current perception are poorly understood. Using classification techniques, we demonstrate that the response to gender of the previous face image of a sequence can be decoded from the neural activity of the current EEG response, showing that relevant neural signals are maintained over trials. Classification accuracy was higher for participants with strong serial dependence, strongly implicating these signals as the neural substrate for serial dependence. The best information to classify gender was around 14 Hz for \"female\" faces, and around 18 Hz for \"male,\", reinforcing the psychophysical results showing serial dependence to be carried at those beta -frequencies.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"203"},"PeriodicalIF":4.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A gap-free reference genome of Populus deltoides provides insights into karyotype evolution of Salicaceae.","authors":"Changwei Bi, Ning Sun, Zhuangwei Hou, Xiaogang Dai, Huaitong Wu, Fuchuan Han, Zefu Wang, Tongming Yin","doi":"10.1186/s12915-025-02304-w","DOIUrl":"10.1186/s12915-025-02304-w","url":null,"abstract":"<p><strong>Background: </strong>As a species of poplar with significant economic and ecological value, the high-quality genome assembly of Populus deltoides (P. deltoides) is crucial for understanding its growth and development, stress resistance, and biosynthetic pathways.</p><p><strong>Results: </strong>We presented a gap-free telomere-to-telomere (T2T) assembly of the P. deltoides genome using PacBio HiFi and Hi-C sequencing data. The P. deltoides genome is 395.9 Mb in length and consists of 27 contigs (contig N50: 22.73 Mb), encompassing nearly all telomeres (36 out of 38). Following careful evaluations of genome accuracy and completeness, our assembly represents a substantial enhancement over the previously published genomes of P. deltoides, eliminating all gaps and rectifying numerous assembly errors. The expanded and contracted gene families of the P. deltoides genome were significantly enriched in functions crucial for stress and defense responses, as well as environmental adaptation. Additionally, our study confirms that all Salicaceae genomes have undergone at least two major whole genome duplication events. The most recent duplication event, shared by between Salicaceae and Manihot esculenta, is estimated to have occurred approximately 44.2 to 57.8 Mya. Most importantly, we reconstructed the ancestral karyotype of Salicaceae, which comprised 11 proto-chromosomes.</p><p><strong>Conclusions: </strong>This study provides strong evidence for comprehensive understanding of the evolutionary dynamics within Salicaceae genomes and provides valuable genomic resources for the genetic improvement and biological breeding of P. deltoides.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"201"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide identification of the interferon complex establishes IFNf in Cypriniformes.","authors":"Yu Huang, Lei Zhang, Xinyi Yang, Yuqing Li, Zeyu Li, Qianqian Zhang, Zhen Xu","doi":"10.1186/s12915-025-02319-3","DOIUrl":"10.1186/s12915-025-02319-3","url":null,"abstract":"<p><p>Type I interferons (IFNs) are pleiotropic cytokines widely recognized for their roles in the innate immunity of vertebrates, from fish to mammals. Previously, seven type I IFNs were identified in the order of Cypriniformes, the largest group of freshwater fish. Using whole genome analysis, we have identified the IFNf from this order, expanding the number of type I IFNs in this order to eight. IFNf exhibited conserved synteny across 25 Cypriniformes genomes and phylogenetically predated the divergence of group 1 and group 2 type I IFNs. Despite low sequence identity at both the nucleotide and protein levels, IFNf retained a conserved gene structure and three-dimensional conformation essential for its function. Expression analysis revealed drastic upregulation of IFNf in grass carp upon infection with hemorrhagic virus (GCRV-II), with the highest level of activation among all the eight IFNs. Additionally, four chemically synthesized α-helix peptides derived from both grass carp and zebrafish IFNfs acted as antimicrobial peptides (AMPs), displaying direct inhibitory activity against a variety of microorganisms. Thus, this study establishes IFNf as an important component of the immune system in Cypriniformes.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"202"},"PeriodicalIF":4.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate prediction of synergistic drug combination using a multi-source information fusion framework.","authors":"Shuting Jin, Huaze Long, Anqi Huang, Jianming Wang, Xuan Yu, Zhiwei Xu, Junlin Xu","doi":"10.1186/s12915-025-02302-y","DOIUrl":"10.1186/s12915-025-02302-y","url":null,"abstract":"<p><strong>Background: </strong>Accurately predicting synergistic drug combinations is critical for complex disease therapy. However, the vast search space of potential drug combinations poses significant challenges for identification through biological experiments alone. Nowadays, deep learning is widely applied in this field. However, most methods overlook the important role of protein-protein interaction networks formed by gene expression products and the pharmacophore information of drugs in predicting drug synergy.</p><p><strong>Results: </strong>We propose MultiSyn, a multi-source information integration method for the accurate prediction of synergistic drug combinations. Specifically, we design a semi-supervised learning framework using an attributed graph neural network to integrate protein-protein interaction networks of gene expression products with multi-omics data, constructing initial cell line representations that incorporate multi-source information. Furthermore, we refine the initial cell line representation by adaptively integrating it with normalized gene expression profiles, enabling the extraction of cell line features that encapsulate global information. In addition, we decompose drugs into fragments containing pharmacophore information based on chemical reaction rules and construct a heterogeneous graph comprising atomic and fragment nodes. To enhance the capture of molecular structural information, we introduce a heterogeneous graph transformer to learn multi-view representations of heterogeneous molecular graphs. Extensive experiments show that MultiSyn outperforms several classical and state-of-the-art baselines in synergistic drug combination prediction tasks.</p><p><strong>Conclusions: </strong>This study provides a powerful tool for inferring promising synergistic drug combinations. By leveraging attention mechanisms and pharmacophore information, MultiSyn identifies key substructures that are critical for synergy. Further visualization and case studies validate its effectiveness in capturing biologically meaningful features and identifying potential drug combinations.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"200"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation.","authors":"Jia Xuan Cai, Ai Wen Le, Xin Yue Han, Jie Chen, Xiao Hua Lei, Chen Huang, Jian V Zhang","doi":"10.1186/s12915-025-02294-9","DOIUrl":"10.1186/s12915-025-02294-9","url":null,"abstract":"<p><strong>Background: </strong>Placental metabolic dysfunction is associated with pregnancy complications, including preeclampsia, gestational diabetes mellitus, and fetal growth restriction. However, little is known about how the metabolic processes regulate placental development and trophoblast differentiation. The adipokine chemerin, whose serum level is elevated during pregnancy, regulates the placental lipid metabolism and may influence placental development and trophoblast differentiation.</p><p><strong>Results: </strong>In this study, we observed the increased chemerin expression in the serum and placenta of the pregnant mice. Chemerin is highly expressed in the extraembryonic primary parietal trophoblast giant cells and the ectoplacental cone (EPC) trophoblast cells. Excessive chemerin treatment in mice results in increased placental lipid accumulation, promotes the expansion of glycogen trophoblast cell (GlyT) and syncytiotrophoblast, and restricts the growth of spongiotrophoblast (SpT) and sinusoidal trophoblast giant cell (S-TGC). Chemerin deficiency led to increased expression of placental fatty acid oxidation enzymes and disrupted the proliferation of SpT and S-TGC in the labyrinth. Furthermore, we utilized the fatty acid oxidation inhibitor etomoxir and demonstrated that blocking fatty acid oxidation hinders the proliferation of SpT and S-TGC in the labyrinth.</p><p><strong>Conclusions: </strong>Our study demonstrated that chemerin-related lipid metabolism is crucial for EPC trophoblast differentiation during placental development, providing evidence that chemerin determines the growth of SpT and S-TGC through fatty acid oxidation. These findings also imply a possible pathological mechanism for pregnancy complications associated with chemerin.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"199"},"PeriodicalIF":4.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-resistant worker reproductive potential and effect of helpers on prolonged lifespan in an ant.","authors":"Kevin L Haight, Juergen Liebig","doi":"10.1186/s12915-025-02305-9","DOIUrl":"10.1186/s12915-025-02305-9","url":null,"abstract":"<p><strong>Background: </strong>Aging theory suggests that animals should reproduce early at a cost to longevity, leading to a fecundity-longevity trade-off. Social insects with long-lived reproductive queens and short-lived helper workers are notable exceptions, primarily attributed to selection on queen lifespan in the protected nest and increased extrinsic mortality of workers performing risky outside tasks. By creating different age groups of non-reproductive workers in an ant where workers can replace reproductive queens and by isolating single workers with and without helpers, we investigated the effect of age on reproductive and parenting abilities and the impact of help on reproductive worker lifespan.</p><p><strong>Results: </strong>Isolated workers could become reproductive and raise offspring to adulthood despite commencing reproduction at ages twice the median lifespan of non-reproductive worker ants. Experimentally selected old workers converged with workers half the median age to a common lifespan maximum of about 600 days in the absence of worker help. However, most reproductive workers surviving beyond this point were associated with at least one helper worker and showed a marked lifespan increase. In a separate test, helper presence increased the median life-span at least 2.6-fold in single, isolated workers compared to helperless workers.</p><p><strong>Conclusions: </strong>Helper presence may be a primary reason for the longevity differences between reproductive and non-reproductive individuals in social insects similar to cooperatively breeding birds and mammals while mechanisms associated with selection on queen lifespan have evolved secondarily. Contrary to many ant species with high extrinsic mortality, some with sexual reproduction invest in reproductive capacities until advanced age.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"23 1","pages":"198"},"PeriodicalIF":4.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}