BMC Biology最新文献

{"title":"Dual urea utilization enzyme systems in Symbiodiniaceae coral symbionts under warming.","authors":"Tangcheng Li, Baoyuan Zhang, Honghao Liang, Jiahong Huang, Youfang Sun, Zhangliang Wei, Cristiana Manullang, Hui Huang, Senjie Lin","doi":"10.1186/s12915-026-02610-x","DOIUrl":"https://doi.org/10.1186/s12915-026-02610-x","url":null,"abstract":"<p><strong>Background: </strong>Urea has been shown to be important as a nitrogen (N) nutrient for coral holobionts, but the mechanism underpinning urea utilization by symbiotic algae is not fully understood. In this study, we investigated the molecular pathways underlying urea utilization in the Symbiodiniaceae family and the responses of these pathways to different N-nutrient conditions and heat stress through comprehensive genomic screening, multi-omics analysis and stable isotope pulse-chase experiments.</p><p><strong>Results: </strong>Genome screening revealed that two urea hydrolysis systems, urease (URE) and urea amidolyase (UAL), were present in Symbiodiniaceae, positioning this lineage as one of the few non-green algae that possess UAL. Furthermore, our data reveal an interesting evolutionary trajectory of UAL. While subunit DUR2 occurs in most symbiodiniacean genomes sequenced to date, only two species (Cladocopium goreaui and Cladopium c92) possess the complete UAL system (DUR1 with DUR2). In the phylogenetic tree of UAL sequences, Symbiodiniaceae clustered more closely with coral symbiotic bacteria than with other eukaryotes, but show clear distinct genetic features such as GC content and codon usage, suggesting evolutionary horizontal gene transfer from bacteria. Furthermore, ex-hospite C. goreaui exhibited better growth and achieved higher maximum specific growth rates when urea was provided as the sole nitrogen source, compared to ammonium. Notably, when experimenting on the Cladocopium-dominating Pocillopora damicornis holobiont using ¹⁵N isotope tracer, we found that under heat stress (HS) conditions, the in-hospite Symbiodiniaceae significantly increased urea uptake but decreased NO₃^- and NH₄⁺ uptake. Omics analyses suggest that responses to different nitrogen, light, and temperature conditions were more likely mediated by UAL.</p><p><strong>Conclusions: </strong>This study reveals two distinct urea utilization systems in the coral ecosystem and their differential responses to warming, highlighting the importance of urea as N-nutrient when facing global warming.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of neuropeptide networks involved in the ecdysis program of a crustacean model: Carcinus maenas reveal similarities and differences to insects that reflect evolutionary divergence in structure and function.","authors":"Jodi L Hoppes, David C Wilcockson, Michael G B Hayle, Elsa Larrad, Simon G Webster","doi":"10.1186/s12915-026-02603-w","DOIUrl":"https://doi.org/10.1186/s12915-026-02603-w","url":null,"abstract":"<p><strong>Background: </strong>Arthropods require periodic molting (ecdysis) for growth. While the neuroendocrine orchestration of ecdysis is well characterized in insects, it remains comparatively poorly understood in crustaceans. In insects, ecdysis-triggering hormone (ETH) from epitracheal cells and eclosion hormone (EH) from the brain initiate and coordinate ecdysis. ETH triggers pre-ecdysis behaviors, while EH amplifies ETH release and promotes neuropeptide secretion of crustacean cardioactive peptide (CCAP), myoinhibitory peptide (MIP) for exuviation. Definitive evidence for functional ETH and EH in crustaceans is lacking. Here, we investigate ETH and EH in the crab Carcinus maenas by functionally characterizing the ETH receptor, comprehensively mapping transcript and peptide localization of ETH and EH, and quantifying ETH neurohormone and transcript throughout the molt cycle.</p><p><strong>Results: </strong>We identified a single CamETH GPCR with high specificity for arthropod ETHs, signaling via calcium and cAMP. ETHR mRNA is expressed in multiple tissues, but ETH is restricted to the central nervous system (CNS) with a complex neuroarchitecture in pericardial organs, adjacent to the branchiocardiac veins. EH is limited to CNS, notably in the eyestalk ganglia. Of note, complex EH immunopositive fibers in the abdominal ganglion, adjacent to CCAP/allatostatin-C (AST-C)/bursicon cells, represent a novel putative neurohemal site. Measurements of ETH mRNA and peptide through the molt cycle showed that transcription peaks in late premolt, while peptide is released during active ecdysis, later than observed in insects.</p><p><strong>Conclusions: </strong>While crustacean and insect ecdysis share neuroendocrine components, reflecting common ancestry, there is clear divergence in terms of functionality. We propose a new crustacean ecdysis cascade: ETH released from pericardial organs may stimulate EH to initiate CCAP/AST-C and bursicon release from adjacent neurons.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fusion oncogenes in cancer: organoid models and novel therapeutic approaches.","authors":"Lucia Bracesco, Delilah Hendriks, Benedetta Artegiani","doi":"10.1186/s12915-026-02606-7","DOIUrl":"https://doi.org/10.1186/s12915-026-02606-7","url":null,"abstract":"<p><p>Oncogenic fusions, arising from chromosomal rearrangements, occur in several cancers, particularly in those of pediatric origin. Advances in sequencing technologies have improved fusion detection; yet, understanding their mechanisms and tumorigenic potential remains challenging. This is partly due to the limited availability of faithful human-based model systems. Organoids have emerged as a physiologically relevant model system with in vivo-like traits and have recently allowed to obtain novel mechanistic and therapeutic insights for oncogenic fusion-bearing cancers. This review discusses how, through bottom-up tumor modeling as well as tumoroid derivation, these models are being employed to increase our understanding of fusion-bearing cancers, and how they can help future therapeutic discovery for these tumors.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene loss and vesicular transport remodeling underpin heterotrophic adaptations of scleractinian corals.","authors":"Junyuan Li, Yang Li, Zifeng Zhan, Ximing Liu, Mengke Shi, Kuidong Xu","doi":"10.1186/s12915-026-02582-y","DOIUrl":"https://doi.org/10.1186/s12915-026-02582-y","url":null,"abstract":"<p><strong>Background: </strong>Azooxanthellate scleractinian corals, which lack symbiotic dinoflagellates, occur from shallow waters to deep-sea environments. In deep-sea benthic ecosystems, they serve as foundation species and are considered highly vulnerable to environmental disturbances. However, their genomic diversities and the genetic basis of their fully heterotrophic lifestyles remain poorly understood.</p><p><strong>Results: </strong>In this study, the genome of a deep-sea solitary coral, Polymyces sp., was sequenced. Integrated with the published genomes of the deep-sea colonial coral Desmophyllum pertusum and two shallow-water azooxanthellate corals Dendrophyllia cribrosa and Catalaphyllia jardinei, the adaptive mechanisms of fully heterotrophic lifestyles were investigated. For genomic diversity comparisons, Illumina short-read data for deep-sea (Polymyces sp., D. pertusum, and Madrepora oculata) and zooxanthellate corals (Porites australiensis) were generated. The results indicated that reduced genomic diversity was found in azooxanthellate scleractinians compared with zooxanthellate relatives. Signatures of recent inbreeding were detected in Polymyces sp. and D. cribrosa, potentially contributing to their low recent effective population sizes and the endangered status of D. cribrosa. Lineage-specific gene losses affecting circadian rhythm, immunity, and autophagy were also detected in the above two species, suggesting overly streamlined energy-saving trade-offs that may impair functional flexibility. Interestingly, the cosmopolitan deep-sea D. pertusum retained complete light-sensing and circadian clock complements, whereas deep-sea Polymyces sp. with evidence of recent inbreeding showed substantial reductions, suggesting that photosensitivity and biological clocks may remain important for ecological success even in the deep-sea environment. Convergent adaptations were supported by concordant patterns of gene-family contraction and positive selection shared among the four azooxanthellate scleractinians. The contractions were concentrated in functions related to photosensitivity, lipid metabolism, and mitochondrial processes, consistent with life in dark and oligotrophic habitats, whereas significant signatures of positive selection were detected on vesicle transport-related genes, highlighting the key roles of vesicle-mediated endosomal pathways in a photosymbiosis-free lifestyle.</p><p><strong>Conclusions: </strong>This study provides a genomic perspective on the evolution of heterotrophic strategies in scleractinian corals and highlights conservation concerns for nonsymbiotic corals under accelerating global stressors.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic signatures of speciation and adaptation in the ctenophore Mnemiopsis.","authors":"Remi N Ketchum, Edward G Smith, Leandra M Toledo, Whitney B Leach, Natalia E Padillo-Anthemides, Andreas D Baxevanis, Adam M Reitzel, Joseph F Ryan","doi":"10.1186/s12915-026-02578-8","DOIUrl":"https://doi.org/10.1186/s12915-026-02578-8","url":null,"abstract":"<p><strong>Background: </strong>Understanding how populations diverge is one of the most compelling questions in evolutionary biology but our grasp on the genomic mechanisms underpinning divergence is limited to a handful of species. Indeed, we know even less about divergence in the pelagic zone, where barriers to gene flow are seemingly absent. The holopelagic ctenophore Mnemiopsis leidyi is the most widely used ctenophore in experimental biology and has become an important model system in studies ranging from developmental biology to neurobiology. In addition, its relatively small and tractable genome provides a powerful foundation for genomic and evolutionary analyses. However, we still lack a clear understanding of species boundaries, population structure, and the evolutionary forces shaping divergence within Mnemiopsis, limiting both evolutionary and ecological interpretations. To expand our general understanding of divergence across novel environments as well as resolve a long-standing taxonomic debate, we generated the most comprehensive genomic study to date of the holopelagic ctenophore Mnemiopsis across a large expanse of its native range.</p><p><strong>Results: </strong>By leveraging multiple analytical approaches and generating two near-chromosome level genomes, we identify two distinct species of Mnemiopsis with high levels of genome-wide divergence along the US Atlantic coast, which correspond to M. leidyi and M. gardeni. Our demographic analyses suggest that M. leidyi and M. gardeni began to diverge during the mid-to-late Pleistocene climate transitions and were later shaped by post-glacial oceanographic changes. We highlight substantial genomic rearrangements and copy number variation between species, as well as uncover key genes under selection that are likely important for environmental adaptation.</p><p><strong>Conclusions: </strong>Together, these findings provide compelling evidence that the ctenophore currently recognized as M. leidyi represents more than one species. Recognizing cryptic species boundaries is critical for future study designs, environmental monitoring, and developing targeted management strategies. Altogether, we connect microevolutionary processes with macroevolutionary patterns and provide new insights into how ocean dynamics drive speciation and adaptation in pelagic ecosystems.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological implications of phase separation in vesicle organization and trafficking.","authors":"Che Liu, Jinbo Cheng, Xiandeng Wu","doi":"10.1186/s12915-026-02607-6","DOIUrl":"https://doi.org/10.1186/s12915-026-02607-6","url":null,"abstract":"<p><p>Phase separation has emerged as a key mechanism of cellular compartmentalization, complementing classical membrane-bound organelles. In addition to forming membraneless compartments that provide confined environments for biochemical reactions, phase separation actively organizes and regulates membrane vesicles. Protein condensates interact with vesicular organelles through defined modes of communication, influencing their assembly, trafficking, and turnover. This review highlights recent advances in understanding how phase separation contributes to vesicle biology, including synaptic vesicle cycling, COPII-mediated transport, and endocytic vesicle organization, processes essential for maintaining physiological homeostasis and efficient intracellular transport.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development.","authors":"Maria Al Nuilati, Kyungmin Kim, Jimin Kang, Min Soo Kim, Uhtaek Oh, Gyu-Sang Hong","doi":"10.1186/s12915-026-02604-9","DOIUrl":"https://doi.org/10.1186/s12915-026-02604-9","url":null,"abstract":"<p><strong>Background: </strong>Cell fate determination during brain development, encompassing both neural stem cells (NSCs) and immature neurons, is orchestrated by complex mechanical signals. While mechanical sensing during forebrain development is gaining recognition, the underlying regulatory genes remain underexplored.</p><p><strong>Results: </strong>In this study, we present a comprehensive analysis of the expression patterns of the mechanosensitive channel Tentonin 3 (TMEM150C, TTN3) across critical stages of embryonic brain development (E12.5, E14.5, E16.5, and E18.5) using RNAscope technology. We investigated Ttn3 expression in NSCs and immature neurons through co-staining with Nestin, Eomesodermin, and Doublecortin probes. Ttn3 transcripts were detected across multiple embryonic brain regions and layers, with a higher expression in the superficial layers compared to the ventricular and subventricular zones. In addition, we demonstrate that TTN3 is involved in the proliferation and migration of progenitor cells.</p><p><strong>Conclusions: </strong>Our findings suggest that TTN3 may play a critical role in embryonic brain development, potentially contributing as a mechanotransduction mediator.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic interplay of maternal and paternal contributions to offspring phenotype in Eurasian perch.","authors":"Rossella Debernardis, Abhipsa Panda, Sylwia Wałdowska, Katarzyna Palińska-Żarska, Christophe Klopp, Taina Rocha de Almeida, Sylwia Jarmołowicz, Piotr Hliwa, Daniel Żarski","doi":"10.1186/s12915-026-02602-x","DOIUrl":"https://doi.org/10.1186/s12915-026-02602-x","url":null,"abstract":"<p><strong>Background: </strong>Parental contributions to offspring phenotype extend beyond genetic inheritance, encompassing non-genetic factors that influence early development. However, the interplay between maternal and paternal effects remains poorly understood. This study investigates these contributions in Eurasian perch (Perca fluviatilis) - a valuable model to study parental effect in finfishes - by analyzing early life traits and transcriptomic profiles of larvae resulting from crosses between wild and domesticated parents.</p><p><strong>Results: </strong>Maternal effects dominated key developmental traits, including hatching success, growth, and swim bladder inflation. Transcriptomic analysis revealed a complex regulatory interplay, with 573 genes under exclusive maternal control, while no genes were solely influenced by paternal input. Maternal-effect genes were primarily associated with metabolic, developmental, and stress-response pathways, shaping early larval physiology. Further analysis identified Eurasian-perch-specific candidate maternal-effect genes, such as crtac1, slc16a7, cox5b, kdr, cald1, and bin2, highlighting their potential role in early development. Although paternal contributions were limited, a subset of genes exhibited conditional paternal influence, suggesting a nuanced parental interplay in gene expression regulation.</p><p><strong>Conclusions: </strong>These findings challenge the traditional perspective of strictly coordinated parental contributions, instead revealing a dynamic parental interplay over gene expression and offspring traits. The dominance of maternal effects suggests a primary role in shaping early development, while paternal factors may modulate expression patterns in a context-dependent manner. This study enhances our understanding of parental effects in fish, providing valuable insights for aquaculture breeding strategies and evolutionary biology research.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effete and Cullin 4 affect nuclear organization of the gypsy chromatin insulator.","authors":"Shue Chen, Dagyeong Yang, Elissa P Lei","doi":"10.1186/s12915-026-02596-6","DOIUrl":"https://doi.org/10.1186/s12915-026-02596-6","url":null,"abstract":"<p><strong>Backgound: </strong>Chromatin insulators demarcate the genome into distinct transcriptional domains and contribute to higher-order genome organization. In Drosophila, Su(Hw), CP190, and Mod(mdg4)67.2 are core protein components of the gypsy insulator complex. Multimerization of these core components contributes to the formation of large structures within the nucleus termed insulator bodies. Post-translational modifications of insulator proteins appear to affect insulator body localization and to be required for full insulator activity, but few factors involved in these processes have been identified.</p><p><strong>Results: </strong>To address this gap in understanding, we performed a high-throughput visual screen for Mod(mdg4)67.2-GFP localization using a ubiquitination-related RNAi library. We identified ubiquitination pathway proteins Effete (Eff) and Cullin 4 (Cul4), as novel regulators of CP190 localization and function. Both Eff and Cul4 physically associate with gypsy insulator proteins and promote gypsy-dependent insulator barrier activity. Moreover, Cul4 extensively colocalizes with CP190 on chromatin and assists in the recruitment of CP190 to gypsy sites. Both Eff and Cul4 affect transcription near topologically associating domain (TAD) borders, with Eff specifically altering the three-dimensional (3D) nuclear positioning of gypsy insulator sites.</p><p><strong>Conclusions: </strong>Our findings reveal a novel role for ubiquitination pathway-related enzymes in chromatin insulator activity, 3D genome organization, and gene expression.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstructing mammalian lifespan evolution reveals strong phylogenetic effects and lifespan-associated genes.","authors":"Zhen-Na Zhang, Xue Lyu, Shan-Zhuang Niu, Dong-Ming Xu, Cheng-Gang Zou","doi":"10.1186/s12915-026-02599-3","DOIUrl":"https://doi.org/10.1186/s12915-026-02599-3","url":null,"abstract":"<p><strong>Background: </strong>Despite the extraordinary diversity in mammalian lifespans, the evolutionary trajectories and underlying molecular mechanisms governing this variation remain largely uncharacterized.</p><p><strong>Results: </strong>By reconstructing maximum lifespan evolution across 968 mammalian species, we found that ~ 23 lineages evolved relatively longer lifespans, while ~ 25 evolved relatively shorter lifespans. To understand the phylogenetic influence on lifespan evolution, we tested 9 evolutionary models and found that Pagel's lambda was the most suitable, indicating a strong effect of shared evolutionary histories on the evolution of mammalian lifespans. Through comparative genomic analysis of 15,231 one-to-one ortholog genes across 122 mammalian species, we identified 628 genes associated with variation in relative lifespan (i.e., longevity quotient). Genes whose evolutionary rates negatively correlated with relative lifespans were enriched for functions related to cell division and DNA repair, whereas those with positive correlations were primarily involved in ion transport and muscle contraction. In vivo experiments further validated the functional relevance of 11 candidate genes in C. elegans. In particular, inhibition of the phi-53 gene extended lifespan, which was associated with upregulation of genes enriched in immune-related functions and downregulation of genes enriched in reproduction-related functions.</p><p><strong>Conclusions: </strong>Our findings highlight the crucial role of phylogenetic history in shaping mammalian lifespan evolution and provide important molecular insights into the mechanisms governing lifespan variations in mammals.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}