Online journal of neurology and brain disorders最新文献

{"title":"Acquired Cumulative Systemic Neurotoxic Effect: The Future of Medicine & Biopsychology","authors":"R. Richardson","doi":"10.32474/OJNBD.2018.01.000119","DOIUrl":"https://doi.org/10.32474/OJNBD.2018.01.000119","url":null,"abstract":"As a result of working extensively with dozens of patients who had repeated exposure to toxins and solvents throughout their lifetimes, I wrote the article “Acquired Cumulative Neurotoxic Encephalopathy: Look toward the Future” which was published in the Academy of Medical Psychology Newsletter in March of 2015. Since then, I have reviewed hundreds of studies, and worked with additional patients, who have the onset of systemic disorders such as autoimmune disorders, multiple chemical sensitivity, allergic reactions, histamine intolerance, leaky gut, metabolic syndrome, and various myalgia conditions. Many of them can trace the onset of symptoms back to one point where they had, after repeated exposure to solvents or toxins, gone from relatively normal function to significant dysfunction. The premise of Acquired Cumulative Neurotoxic Encephalopathy and Acquired Cumulative Systemic Neurotoxic Effect is that there is a threshold at which the body cannot tolerate additional exposure to toxins without a significant reaction. This may be related to genetic sensitivities, failure of the body to eliminate toxins from the body, and/or cumulative damage to the physiological/biochemical systems of the body. One of the first commonly known cases is those who played the crystal armonica, a leaded-crystal musical instrument, where the musician would build up lead in their system over time to the point of risks lead poisoning.","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46082403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep is for Life: an Essential Part of Everyday Life","authors":"M. Bhatnagar, Reena Chittora","doi":"10.32474/OJNBD.2018.01.000118","DOIUrl":"https://doi.org/10.32474/OJNBD.2018.01.000118","url":null,"abstract":"Sleep is essential for basic survival as well as for optimal physical and cognitive performance in both human beings and animals. Sleep is a normal human function that is detrimental to sustaining life yet; individuals are affected differently by their sleep schedule. However, the community at large often underestimates sleep and its importance, therefore leading people to not be as concerned with a proper night’s sleep, thereby preventing them from performing at peak efficiency. Sleep plays a vital role in learning and when a person fails to obtain enough sleep the night prior, neurons in the brain might not fire properly, the body becomes out of synch, and it can even lead to accidental physical injuries. As many studies have been conducted, the majority have seemed to come to similar conclusions- a lack of sleep can have detrimental side effects on the human mind and body and by regularly obtaining enough sleep each night; a person can function more efficiently","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42763993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confrontation Naming Errors of Alzheimer’s Disease Patients","authors":"Stephen Enwefa","doi":"10.32474/OJNBD.2018.01.000117","DOIUrl":"https://doi.org/10.32474/OJNBD.2018.01.000117","url":null,"abstract":"This study investigated confrontation naming errors of Alzheimer’s disease patients. Clinicians lack a validated test battery for differentiating the communication disorders of patients with AD from either normal elderly or patients with aphasia [1,3]. The communication of AD patients is often assessed with one of the standardized test batteries for aphasia. This was done because of the marked discrepancy between language and other cognitive functions. A linguistic measure involving errors in confrontation naming was used to establish the extent of linguistic impairment of AD patients. A total of ten photographs were shown to twenty AD patients, (ten mild and ten moderate) and ten normal elderly. The results showed that naming errors increased as the disease progressed. The study concluded that the number of naming errors of AD patients increased as the severity of the disease progressed. ISSN: 2637-6628 DOI: 10.32474/OJNBD.2018.01.000117 On J Neur & Br Disord Copyrights@ Stephen C Enwefa, et al. Citation: Stephen C E, Regina E. Confrontation Naming Errors of Alzheimer’s Disease Patients. On J Neur & Br Disord 1(4)2018. OJNBD. MS.ID.000117. DOI: 10.32474/OJNBD.2018.01.000117. 62 defined as a form of dementia characterized by a gradual loss of several important mental functions that interrupts the normal flow of life. It is perhaps, the most common cause of dementia in older Americans, and goes beyond just normal forgetfulness, such as losing your car keys or forgetting where you parked. Signs of Alzheimer’s disease include language deficits, memory loss that is much more severe and more serious, such as forgetting the names of your children or perhaps where you’ve lived for the last decade or two, and remembering when you had your last meal. Numerous studies have investigated naming errors in AD by classifying errors as visual, semantic or lexical in nature [4-6]. A common finding is that AD patients produce many semantic and/or thematic naming errors (i.e. shark for dolphin). The criteria by which errors are divided can potentially overlook interactions among perceptual and lexical-semantic processes.AD can be considered a multifocal disorder; one must consider the possibility that visual perception and naming are two unrelated areas of concomitant decline. However, there is evidence of a possible link between the two processes in visual perception tasks that require discrimination of real objects according to Tippett and Blackwood [7]. Studies have found that when healthy individuals underwent fMRI while performing a visual discrimination task between line drawings, they recruited relatively more anterior regions of the fusiform gyrus when the two drawings had high structural similarity and relatively more posterior regions of the fusiform gyrus and inferior occipital cortex when the drawings were lower in structural similarity. Together these findings pose that fMRI signal in mid-anterior areas are related to processing of detailed object stru","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41249286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rett Syndrome","authors":"Rodriguez Rivera Sofia Lucila","doi":"10.32474/ojnbd.2018.01.000116","DOIUrl":"https://doi.org/10.32474/ojnbd.2018.01.000116","url":null,"abstract":"There is no specific treatment that can reverse or stop the course of the disease. The rapeutic management revolves around the restoration of synaptic function and maturation, since it has been shown that the deficitis at the level of micro circuits that involve synaptic transmission. The management is symptomatic and individualized. A multidisciplinary and dynamic approach is essential. The knowledge of the genetic causes allows a diagnostic confirmation, a family genetic counseling, an evolutionary prognosis and the application of a therapy to the disease in the very near future [7,8] (Figure 1). Abstract Rett sindrome is a severe neuro developmental disorder that is a leading cause of mental retardation in females, characterized by an apparently normal psycho motor development through the first 6 months of life, followed by stagnation and growth regression in different are as like motor, language and social skills; patients often exhibitautistic behaviors in the early stages. Other symptoms include seizures, breathing problems when awake such as hyper ventilation, apnea, and swallowing air; ataxia and stereotypich and movements. It is caused by mutations in the X-linked gene encodingmethyl-CpG-binding protein 2 (MECP2) [1,2]. One case is presented with positive molecular study.","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49350157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology of Sleep and Clinical Characteristics","authors":"M. Gabriel","doi":"10.32474/ojnbd.2018.01.000114","DOIUrl":"https://doi.org/10.32474/ojnbd.2018.01.000114","url":null,"abstract":"Sleep is defined as a natural decrease in the perception of the external environment that occurs periodically and reversibly, but retaining a certain degree of reactivity towards the environment and autonomous functions. The dream is considered an active process of biological, cyclical and, is essential for survival. Most adults require an amount of sleep between 7 8 hours per day; however, there are individual variations regarding the schedule, duration, and internal structure of the dream. In this regard, recent research has identified a possible genetic basis to explain these differences.","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46133820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of A Good Sleep” (or Also of Why the Pope Should Learn to Give Habits to Their Children)","authors":"M. Gabriel","doi":"10.32474/ojnbd.2018.01.000112","DOIUrl":"https://doi.org/10.32474/ojnbd.2018.01.000112","url":null,"abstract":"Since we become parents at the same time we become a mirror of the potential actions that our children can carry out; do not be surprised when we see our children raving at very early stages when watching a football match when we do it religiously on each Sunday, with its respective repetition on cable TV, the summary in “action†or even the controversy in “the move†. It also repeats the fact that to be drinkers or smokers our offspring by imitation do so with the typical conscience of “...if he can, why do not me ...?†And we believe that there is a genetic factor, which explains it, when the cry of the example is so strong that it silences the other voices of science","PeriodicalId":93346,"journal":{"name":"Online journal of neurology and brain disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45792245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}