{"title":"Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata","authors":"S. Majekodunmi, Ekefre-Abasi Akpan","doi":"10.9734/BJPR/2017/33247","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33247","url":null,"abstract":"Objective: The present study investigates the capability of preparing metronidazole loaded microspheres employing a natural chitosan extracted from oyster shells of Egeria radiata. Methods: Microspheres were prepared by external gelation technique using tripolyphosphate (TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug quantities with varying amount of TPP. The prepared microspheres were characterized for % yield, drug entrapment efficiency, surface morphology and drug release profile. Results: Almost spherical, rough and porous microspheres were obtained. % yield and drug entrapment efficiency were found to be in the range of 63.5 – 70.8% and 63.4 – 77.5% respectively; and about 80% of the drug was released in about 6 hours. Conclusion: The results revealed that formulation of metronidazole loaded microspheres in natural chitosan from an oyster shell can be used as a potential oral drug delivery system. Original Research Article Majekodunmi and Akpan; BJPR, 17(1): 1-11, 2017; Article no.BJPR.33247 2","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"26 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78213451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Singh, Dhiraj Kumar, A. Mishra, S. Arora, Durgesh Kumar, Sagar Pamu, H. B. Samal, Velupula Nishanth
{"title":"Development of Validated RP-HPLC Method for Simultanious Estimation of Cefadroxil and Ambroxol in Pure and Pharmaceutical Dosage Form","authors":"T. Singh, Dhiraj Kumar, A. Mishra, S. Arora, Durgesh Kumar, Sagar Pamu, H. B. Samal, Velupula Nishanth","doi":"10.9734/bjpr/2017/32225","DOIUrl":"https://doi.org/10.9734/bjpr/2017/32225","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"24 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79291919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship between Mindfulness and Psychological Well-being and Coping Strategies with Stress among Female Basketball Athletes in Tehran","authors":"Z. Fazli, S. Ghahari","doi":"10.9734/BJPR/2017/34105","DOIUrl":"https://doi.org/10.9734/BJPR/2017/34105","url":null,"abstract":"Introduction: The well-being and satisfaction with life are two indicators of mental health. The aim of this study was to evaluate the relationship between mindfulness and psychological well-being, and coping strategies with stress in female basketball athletes in Tehran. Methods and Materials: Among all women basketball athletes in Tehran in 2016, two-hundred and fifty women were randomly selected. All samples completed Lazarus and Folkman coping strategies questionnaire, Ryff Psychological well-being Questionnaire and Freiburg Mindfulness Inventory. Data were analyzed using Pearson correlation and multiple regression inSpss-22. Original Research Article Fazli and Ghahari; BJPR, 17(2): 1-8, 2017; Article no.BJPR.34105 2 Results: The results confirmed the hypothesis of this study and suggested a significant positive relationship between the components of mindfulness and psychological well-being, and coping with stress strategies (p<0.01). Conclusion: There was a significant positive relationship between components of mindfulness and psychological well-being, and coping strategies with stress.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89685453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca","authors":"S. Meesala, Ruby Singh, M. Watve","doi":"10.9734/bjpr/2017/32881","DOIUrl":"https://doi.org/10.9734/bjpr/2017/32881","url":null,"abstract":"Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of compounds were established by 1D and 2D NMR and MS data. Compound 1 exhibited strong antibacterial activity against Mycobacterium smegmatis at MIC 116 μM. Compounds 1-3 showed neither antifungal nor cytotoxic activity.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75444865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Bahmani, S. M. Mahmoodabad, B. Enjezab, M. Askarshahi, M. Baghianimoghadam
{"title":"The Effect of Training Based on Precaution Adoption Process Model (PAPM) on Rural Females’ Participation in Pap smear","authors":"A. Bahmani, S. M. Mahmoodabad, B. Enjezab, M. Askarshahi, M. Baghianimoghadam","doi":"10.9734/BJPR/2017/32965","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32965","url":null,"abstract":"Background: Decision making for adopting a health behavior is a process involving passing through different stages. Objectives: This study was conducted to determine the decision-making stages based on Precaution Adoption Process Model (PAPM) in Pap test in rural women. Methods: This study was conducted implementing a quasi-experimental method. The participants were divided into two groups as experimental and control groups using the Precaution Adoption Process Model (PAPM) among 180 rural females in Sarvabad. In treating the experimental group, the methods of lecturing with question and answer, playing videos, specialized consulting and Original Research Article Bahmani et al.; BJPR, 16(6): 1-7, 2017; Article no.BJPR.32965 2 pamphlet were used. The data gathering tool included a questionnaire consisting a demographic variables and variables affecting the stages of PAPM. Data analysis was performed using the Mann-Whitney, chi-square and descriptive statistical methods. Results: The results showed that 45% of the participants found their way to the sixth stage, i.e., practice stage (doing Pap smear). In comparison of the means of the scores of psychological variables affecting the decision process in Pap smear test, there was a significant relationship between the experimental and control groups based on Mann-Whitney test and control groups based on variables, perceived susceptibility, perceived benefits, perceived barriers, perceived selfefficacy and awareness. But the perceived severity was not statistically significant. Chance of entering the sixth stage in the intervention group was 2.5 times higher than the control group. Conclusions: Females for Pap smear at the same stage of the decision were not on the same basis. Thus, educational interventions should be done at each stage.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"16 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78313949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-Cancerous Efficacy of Alcoholic and Aqueous Extracts from an Endemic Plant Thermopsis turcica on Liver Carcinoma","authors":"M. Ali, İ. Ciğerci","doi":"10.9734/BJPR/2017/32413","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32413","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"26 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84995330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. M. Jamil, Mahamudul Haque, M. W. Rahman, T. Emran, R. Chowdhury, F. Nasrin, Chowdhoury Hasan
{"title":"Monitoring of Pesticide Poisoning in Different Occupational Groups by the Estimation of Serum Cholinesterase (PChE), ALT, AST & Bilirubin","authors":"H. M. Jamil, Mahamudul Haque, M. W. Rahman, T. Emran, R. Chowdhury, F. Nasrin, Chowdhoury Hasan","doi":"10.9734/bjpr/2017/33468","DOIUrl":"https://doi.org/10.9734/bjpr/2017/33468","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"35 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89801855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetic Characterization of Piperaquine in Nigerian Healthy Volunteers after Co-administration with a Commercial Brand of Moringa Tea","authors":"Alero Iseh, A. Adegbola, B. Adeagbo","doi":"10.9734/BJPR/2017/32723","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32723","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"63 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74828275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Liman, F. Çoban, İ. Ciğerci, I. Bulduk, Ş. Bozkurt
{"title":"Antiangiogenic and Apoptotic Effects of Oleuropein on Breast Cancer Cells","authors":"R. Liman, F. Çoban, İ. Ciğerci, I. Bulduk, Ş. Bozkurt","doi":"10.9734/BJPR/2017/33403","DOIUrl":"https://doi.org/10.9734/BJPR/2017/33403","url":null,"abstract":"Oleuropein is a fundamental polyphenol contained in olive fruit, oil, and leaf, with a bitter taste. A decrease in its level is observed as the fruit ripens. Leaves of oil tree were used in this study as a possible origin of oleuropein. In this study, cytotoxic, genotoxic, apoptotic and antiangiogenic impacts of isolated oleuropein (0.5xIC50, IC50 and 2xIC50) on MCF-7 human breast adenocarcinoma cells were examined by means of 3-[4,5Dimethylthiazol-2-yl] 1-2,5diphenyltetrazolium bromide (XTT) kit, Comet assay, Poly (ADP-Ribose) Polymerase (PARP) cleavage ELISA Kit and Vascular Endothelial Growth Factor (VEGF) Human ELISA Kit for 24, 48 and 72 h, respectively. The IC50 value of oleuropein on MCF-7 cells was found to be 11.02±0.52, 9.43±0.41 and 6.81±0.18 μg/mL for 24, 48 and 72 h, respectively. The time and concentrationrelated cytotoxic impacts of oleuropein were determined to be significant. Cleaved PARP level was Original Research Article Liman et al.; BJPR, 16(4): 1-10, 2017; Article no.BJPR.33403 2 significantly increased especially with an increase in the concentration of oleuropein. However, a significant decrease in VEGF level was observed (p<0.05). Furthermore, oleuropein increased damage on DNA for 48 and 72 h. Findings showed oleuropein as a potential antiangiogenic, apoptotic and genotoxic agent for the breast cancer cells.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"72 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75675729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Nurten, Dalaklioğlu Selvinaz, Bigat Zekiye, Karsli Bilge, Tasatargil Arda
{"title":"Comparison of the Effects of Ropivacaine and Bupivacaine on Human Umblical Artery Vasoreactivity","authors":"K. Nurten, Dalaklioğlu Selvinaz, Bigat Zekiye, Karsli Bilge, Tasatargil Arda","doi":"10.9734/BJPR/2017/32591","DOIUrl":"https://doi.org/10.9734/BJPR/2017/32591","url":null,"abstract":"","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79395826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}