Journal of Health Science and Medical Research (JHSMR)最新文献_第2页

Microbial Characteristics of Lower Respiratory Tract Infections in Patients Referred from Primary Care Hospitals 基层医院转诊患者下呼吸道感染的微生物特征

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-31 DOI: 10.31584/jhsmr.20231004

Thanh Nguyen-Van, Van Pham-Hung, Ngoc Tran-Van,, Duy Nguyen-Dinh, Thuy Cao-Thi-My, Huong Le-Thi-Thu, Thu Vo-Pham-Minh, Phu Tran-Nguyen Trong, Van Duong-Thi-Thanh

{"title":"Microbial Characteristics of Lower Respiratory Tract Infections in Patients Referred from Primary Care Hospitals","authors":"Thanh Nguyen-Van, Van Pham-Hung, Ngoc Tran-Van,, Duy Nguyen-Dinh, Thuy Cao-Thi-My, Huong Le-Thi-Thu, Thu Vo-Pham-Minh, Phu Tran-Nguyen Trong, Van Duong-Thi-Thanh","doi":"10.31584/jhsmr.20231004","DOIUrl":"https://doi.org/10.31584/jhsmr.20231004","url":null,"abstract":"Objective: This study investigated the microbiological characteristics of severe lower respiratory tract infection patients not respond to initial treatment, and were transferred to a tertiary-level hospital.Material and Methods: This was a multicenter, prospective study conducted across four hospitals: Cho Ray, Pham Ngoc Thach, Gia Dinh People’s Hospital, and Can Tho Central General Hospital. Sputum specimens were collected shortly after admission and subjected to culture and real-time PCR testing.Results: Out of the 252 patients, 170 (67.4%) met the criteria for analysis and identification of pathogenic microorganisms. The most frequently isolated pathogens were Streptococcus pneumoniae (S. pneumonia) and Haemophilus influenzae (H. influenzae), comprising of 27.0% and 13.1%, respectively. Antibiotic susceptibility testing was conducted on 55 patients (32.3%). Among these cases, there were 16 instances of S. pneumoniae, 10 cases of Staphylococcus aureus (S. aureus), 10 cases of Pseudomonas aeruginosa (P. aeruginosa), 14 cases of gram-negative enteric bacteria, 2 cases of H. influenzae, 1 case of Moraxella catarrhalis (M. catarrhalis), 1 case of Enterococcus faecium, and 1 case of M. pneumoniae. The antibiogram results revealed significant findings; including a 70% prevalence of extended-spectrum beta-lactamase and 90% occurrence of Methicillin-Resistant Staphylococcus aureus. The data also indicated high resistance rates; such as 90% resistance to erythromycin, 40-80% to ciprofloxacin, 30-80% to ceftazidime, and 30-40% to imipenem.Conclusion: Pathogens associated with LRTIs referred from primary care hospitals encompass S. pneumonia, H. influenza, and S. aureus. At our facility, piperacillin, imipenem, amikacin, vancomycin, and linezolid emerged as the most effective antibiotics for addressing these LRTIs.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"89 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Property Determination of Antidiarrheal Remedy of Ya-Gae-Bid-Na-Ron 亚开比德纳荣止泻剂理化性质的测定

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-26 DOI: 10.31584/jhsmr.20231001

Suhaila Doloh, Siprapha Naknoi, Dujhathai Anekchai, Juraithip Wungsintaweekul

{"title":"Physicochemical Property Determination of Antidiarrheal Remedy of Ya-Gae-Bid-Na-Ron","authors":"Suhaila Doloh, Siprapha Naknoi, Dujhathai Anekchai, Juraithip Wungsintaweekul","doi":"10.31584/jhsmr.20231001","DOIUrl":"https://doi.org/10.31584/jhsmr.20231001","url":null,"abstract":"Objective: This study aimed to determine the physicochemical properties of Ya-Gae-Bid-Na-Ron (YGBNR); according to the Thai Herbal Pharmacopoeia (THP) guidelines.Material and Methods: Kratom, ginger, Java long pepper, and chilli were collected from different sources, authenticated, and prepared for crude drugs. From this, twelve YGNBR recipes were formulated, and the physicochemical properties of the raw materials and recipes were determined. The thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) fingerprints were investigated, and the microbial limits and heavy metal contamination were determined.Results: YGBNR was prepared by mixing dry powders of kratom: ginger: Java long pepper; chilli in the ratio of 72:5:13:10. The phytochemical properties; including loss on drying, total ash, acid-insoluble ash, ethanol (80% v/v)-soluble extractive, water-soluble extractive, volatile oil, and mitragynine content were: 7.68±0.04%w/w, 5.72±0.06%w/w, 0.26±0.02%w/w, 28.99±0.17%w/w, 21.98±0.21%w/w, 0.40±0.00%v/w, and 0.58±0.28 %w/w, respectively. The microbial limits and heavy metal contaminations were under the THP requirements. Conclusion: The physicochemical properties of YGNBR, an antidiarrheal recipe, was determined according to THP. The specification is essential information for the establishment for the herbal monograph of YGBNR.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vincristine and Peripheral Neuropathy in Acute Lymphoblastic Leukemia Children 长春新碱与急性淋巴细胞白血病患儿周围神经病变

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-18 DOI: 10.31584/jhsmr.2023989

Tipaporn Thongmak, Najwa Yuthasompop

{"title":"Vincristine and Peripheral Neuropathy in Acute Lymphoblastic Leukemia Children","authors":"Tipaporn Thongmak, Najwa Yuthasompop","doi":"10.31584/jhsmr.2023989","DOIUrl":"https://doi.org/10.31584/jhsmr.2023989","url":null,"abstract":"Objective: Peripheral neuropathy is a common neurological side effect in acute lymphoblastic leukemia (ALL) pediatric patients, receiving vincristine treatment. This study aims to explore the frequency, clinical, and electrodiagnosis of peripheral neuropathy of ALL patients.Material and Methods: This study was a retrospective cohort study, using medical record reviews of children who, diagnosed and undergoing treatment for acute lymphoblastic leukemia, from 1st January 2018 till 31st December 2022.Results: One hundred and ninety-seven patients were diagnosed with ALL and received chemotherapy. Ten patients had clinical and electrodiagnostic studies of peripheral neuropathy. B-cell type and high- risk classification were the most common in these patients. The most common symptom was bilateral foot drop and all patients had hyporeflexia. The mean cumulative dose of vincristine was 13.35±2.12 mg/m2. The axonal neuropathy, with motor dominantly and the peroneal nerves, were the highest abnormal finding in electrodiagnosis testing.Conclusion: This report addresses the frequent and clinical of patients with peripheral neuropathy. Foot drop and hyporeflexia might be helpful in early detection of peripheral neuropathy in ALL patients.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135823135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BRCA1 expression and its combined low expression with PARP1 and ERCC1 predict chemotherapeutic response in ovarian cancer BRCA1表达及其与PARP1和ERCC1联合低表达可预测卵巢癌化疗反应

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-11 DOI: 10.31584/jhsmr.20231000

Jarukit Tantipisit, Nungrutai Saeaib, Paramee Thongsuksai

{"title":"BRCA1 expression and its combined low expression with PARP1 and ERCC1 predict chemotherapeutic response in ovarian cancer","authors":"Jarukit Tantipisit, Nungrutai Saeaib, Paramee Thongsuksai","doi":"10.31584/jhsmr.20231000","DOIUrl":"https://doi.org/10.31584/jhsmr.20231000","url":null,"abstract":"Objective: This study aimed to evaluate the associations of immunohistochemical expressions of various deoxyribonucleic acid repair proteins, either individually or combined, with the response to platinum-based chemotherapy and overall survival in epithelial ovarian cancer.Material and Methods: This retrospective cohort study included patients with epithelial ovarian cancer who were treated by primary cytoreductive surgery with adjuvant platinum-based chemotherapy at Songklanagarind Hospital between January 2008 and December 2019. Immunohistochemistry analysis of breast cancer type 1 (BRCA1), poly (ADP-ribose) polymerase 1 (PARP1), X-ray repair cross-complementing 1 (XRCC1), and excision repair cross-complementation group 1 (ERCC1) expression was performed. Logistic regression was used to evaluate factors associated with chemotherapeutic response and Cox regression was applied for survival analysis.Results: Chemotherapeutic response was achieved in 205 of 249 patients (82.3%). Low BRCA1 expression was associated with good response (odds ratio [OR] 5.01, 95% confidence interval [CI] 1.78–14.1) and favorable overall survival (hazard ratio 0.61, 95% CI 0.38–0.98). PARP1, XRCC1, and ERCC1 showed no significant predictive or prognostic roles; however, combined low expression of PARP1/BRCA1 (OR 7.62, 95% CI 1.69–34.31) and ERCC1/BRCA1 (OR 6.98, 95% CI 1.5–32.52) additively enhanced response compared to high/high expressions.Conclusion: This study provides evidence that epithelial ovarian cancer (EOC) with low BRCA1 expression is more likely to be responsive to platinum-based therapy and is associated with favorable overall survival compared to tumors with high BRCA1 expression. The study supports a potential therapeutic strategy involving co-depletion of PARP1/BRCA and ERCC1/BRCA1 expression, although additional studies are needed.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136210321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of Rectus Sheath Block and Subcostal Transversus Abdominis Plane Block as the Sole Anesthesia for an Open Gastrostomy in a High-risk Patient 腹直肌鞘阻滞联合肋下腹横面阻滞作为高危患者开放式胃造口术的单一麻醉

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-10 DOI: 10.31584/jhsmr.2023999

Aumjit Wittayapairoj, Jedniphat Intrapongpan, Saran Thanharak

引用次数: 0

In vitro Anti-Oxidation and Anti-Cholinesterase Activities of Tuna and Chicken Hydrolysates and their Maillard Reaction Products 金枪鱼和鸡肉水解物及其美拉德反应产物的体外抗氧化和抗胆碱酯酶活性研究

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-09 DOI: 10.31584/jhsmr.2023998

Metira Jongsriwattanaporn, Kasemsiri Chandarajoti, Woralak Petrat, Jiraporn Kara, Anuchit Plubrukarn, Paotep Premchai, Luelak Lomlim

{"title":"In vitro Anti-Oxidation and Anti-Cholinesterase Activities of Tuna and Chicken Hydrolysates and their Maillard Reaction Products","authors":"Metira Jongsriwattanaporn, Kasemsiri Chandarajoti, Woralak Petrat, Jiraporn Kara, Anuchit Plubrukarn, Paotep Premchai, Luelak Lomlim","doi":"10.31584/jhsmr.2023998","DOIUrl":"https://doi.org/10.31584/jhsmr.2023998","url":null,"abstract":"Objective: To evaluate the anti-oxidation and anticholinesterase activities and cell viability of chicken and tuna hydrolysates and their Maillard reaction products.Material and Methods: Maillard reaction products (MRPs) derived from chicken or tuna hydrolysates were prepared by heating the hydrolysate with glucose at 84°C for 90 minutes. Physical characteristics, ultraviolet (UV) absorbance, browning intensity, protein concentrations, molecular weight distribution, and amino acid profiles of the hydrolysates and MRPs were determined. The anti-oxidation properties of the hydrolysate and MRPs were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Anti-cholinesterase activities were evaluated using Ellman’s method. Cell viability of the samples was evaluated in RAW 264.7 cells.Results: The MRPs presented as brown to dark brown liquids with Brix values ranging from 61.33 to 64.17 °Brix. The pH value ranged from 5.31 to 6.20. The UV absorbance at 294 nm and browning intensity at 420 nm of the MRPs were less than the absorbance of the corresponding hydrolysates. The protein concentrations were 41-44% (hydrolysates) and 18-20% (MRPs). The major constituents of the hydrolysates and MRPs were small molecules (MW<300 Da). The samples exhibited anti-oxidative activity (EC50 2.03 - 3.51 mg/mL) and anti-acetylcholinesterase activity (45-52% inhibition at 0.5 mg/mL). Both hydrolysates and MRPs showed no toxicity to RAW 264.7 cells at concentrations up to 1 mg/mL.Conclusion: Chicken and tuna hydrolysates and their MRPs exhibited mild anti-oxidative and moderate acetylcholinesterase inhibitory activities.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135095504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Testing of the Quality of Nursing Work Life Scale: Thai Version 护理工作生活质量量表的心理测试:泰文版

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-05 DOI: 10.31584/jhsmr.2023997

Pattaramon Tubsoongnoen, Jintana Yunibhand, Yupin Aungsuroch

{"title":"Psychometric Testing of the Quality of Nursing Work Life Scale: Thai Version","authors":"Pattaramon Tubsoongnoen, Jintana Yunibhand, Yupin Aungsuroch","doi":"10.31584/jhsmr.2023997","DOIUrl":"https://doi.org/10.31584/jhsmr.2023997","url":null,"abstract":"Objective: The Brooks Quality of Nursing Work Life Survey has been widely used to assess the quality of nursing work life. In Thailand, this scale was translated and used by nurse practitioners. However, many items designed for use have contextual differences from the hospital and have never been tested for their construct; including issues of cultural differences. Therefore, such a scale must be revised. This study aimed to translate and test the psychometric properties to justify its use in a hospital context.Material and Methods: This was methodological research. The process consisted of two phases; including: 1) translation using the forward-backward translation method, and 2) psychometric properties testing; content validity, cognitive interview, construct validity, and reliability would be used to evaluate psychometric properties. Content validity was considered by a panel of experts. Ten registered nurses were asked to participate in a cognitive interview. Two hundred and fourteen registered nurses were recruited, using convenience sampling for conducting the construct validity and reliability testing.Results: The findings revealed excellent content validity. Twenty-three items were revised in the phase of cognitive interviews. Internal consistency was calculated: Cronbach’s alpha was 0.959. Confirmatory factor analysis yielded four factors, and was consistent with the original version.Conclusion: The scale may be utilized by registered nurses working in Thailand’s hospital context to assess the quality of nursing work life. Further study needs to test this in larger and heterogeneous samples.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134976268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Anti-inflammatory Activity of Ginger Extract and Phlai Oil on Lipopolysaccharide-induced Inflammatory Mediators 姜提取物和麻莱油对脂多糖诱导炎症介质的协同抗炎作用

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-04 DOI: 10.31584/jhsmr.2023995

Chiramet Auranwiwat, Juwainee Madardam, Titpawan Nakpheng, Somkamol Intawong, Kanyanat Kaewiad

{"title":"Synergistic Anti-inflammatory Activity of Ginger Extract and Phlai Oil on Lipopolysaccharide-induced Inflammatory Mediators","authors":"Chiramet Auranwiwat, Juwainee Madardam, Titpawan Nakpheng, Somkamol Intawong, Kanyanat Kaewiad","doi":"10.31584/jhsmr.2023995","DOIUrl":"https://doi.org/10.31584/jhsmr.2023995","url":null,"abstract":"Objective: This study aimed to evaluate the anti-inflammatory activity of the combination of ginger extract and phlai oil on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.Material and Methods: Cell viability, inhibition activity of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) were measured in vitro on RAW 264.7 cell cultures stimulated with bacterial lipopolysaccharide.Results: The IC50 values of ginger extract and phlai oil on RAW 264.7 cells were 1.37±0.112 mg/ml and 3.79±0.261 mg/ml, respectively. The production levels of NO, TNF-α and PGE2 was induced by LPS. The inhibition percentages of NO increases in the presence of ginger extract (0.313 mg/ml) and phlai oil (0.625 mg/ml) were 38.22±0.236% and 25.00±0.198% in comparison to the control cells. The combination of ginger extract and phlai oil at a ratio 1:1 w/w exhibited statistically significant inhibitory effects on NO production, having an inhibition percentage of 75.98±0.591%. In the TNF-α assay, an inhibition percentage value of ginger extract (58.74±0.136%) was higher than that of phlai oil (52.13±0.238%), while the combination of ginger extract and phlai oil had the highest inhibitory effect (70.03±0.215%). In the PGE2 assay, the inhibition percentage of the ginger extract-phlai oil combination at a ratio of 1:1 w/w (62.34±0.187%) was higher than those of both ginger extract (18.21±0.132%) and phlai oil (34.80±0.279%).Conclusion: This study provides scientific evidence in support of the efficacy of the combined use of ginger and phlai oil to reduce inflammatory processes.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"305 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Radiation Dose and Phantom Skin Dose in Transarterial Chemoembolization in a Single Center with 2 Digital Subtraction Angiography Units 单中心2台数字减影血管造影机经动脉化疗栓塞的辐射剂量和幻皮剂量评估

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-10-04 DOI: 10.31584/jhsmr.2023996

Varaporn Pong-Inwong, Woranan Kirisattayakul, Supawan Dawong, Areeya Jitvikham, Anucha Ahooja, Panuwat Pattum, Rattapong Karawek, Waraporn Sudjai, Nittima Rungpin

{"title":"Assessment of Radiation Dose and Phantom Skin Dose in Transarterial Chemoembolization in a Single Center with 2 Digital Subtraction Angiography Units","authors":"Varaporn Pong-Inwong, Woranan Kirisattayakul, Supawan Dawong, Areeya Jitvikham, Anucha Ahooja, Panuwat Pattum, Rattapong Karawek, Waraporn Sudjai, Nittima Rungpin","doi":"10.31584/jhsmr.2023996","DOIUrl":"https://doi.org/10.31584/jhsmr.2023996","url":null,"abstract":"Objectives: This study aimed to assess and compare the radiation dose and phantom skin dose in transarterial chemoembolization (TACE) of two digital subtraction angiography (DSA) units (unit A: Philips Allura Xper FD20, unit B: Artis zee biplane)Material and Methods: The dose area product (DAP), reference air kerma (RAK), number of images (NI) and fluoroscopy time (FT) of 240 cases (120 cases/DSA unit) were retrospectively reviewed and collected. To assess skin dose, 28 nanoDot optically stimulated luminescence dosimeters (OSLDs) were placed on the phantom’s back and the TACE procedure was performed with 2 DSA units.Results: The median DAP, RAK, NI, and FT of unit A were 200.49 Gy·cm2, 379.84 mGy, 115 images, and 9.04 minutes, while for unit B were 109.74 Gy·cm2, 276.55 mGy, 121 images, and 10.19 minutes, respectively. Significant differences were observed in DAP, RAK, and FT. The RAK of all patients was less than 2 Gy. The phantom skin dose obtained from unit B was significantly lower than that of unit A in all positions. The peak skin doses of the phantom studies from both units were 973.15 and 658.66 mGy, respectively.Conclusion: The median DAP of the unit A DSA was higher than the national diagnostic reference levels (DRLs). The TACE procedure from both units is safe from skin reaction. To benefit patients, the planning of a dose optimization process of unit A DSA and management of TACE cases using the existing DSA machine must be considered.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135590866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Operative Score Development: Predicting Difficulty in Elective Laparoscopic Cholecystectomy 术前评分发展:预测择期腹腔镜胆囊切除术的难度

Journal of Health Science and Medical Research (JHSMR) Pub Date : 2023-09-29 DOI: 10.31584/jhsmr.2023994

Chusaeng Teerawiwatchai, Jiratchaya Polprative, Kantapon Rattanachueskul, Ronnayong Thomtong

{"title":"Pre-Operative Score Development: Predicting Difficulty in Elective Laparoscopic Cholecystectomy","authors":"Chusaeng Teerawiwatchai, Jiratchaya Polprative, Kantapon Rattanachueskul, Ronnayong Thomtong","doi":"10.31584/jhsmr.2023994","DOIUrl":"https://doi.org/10.31584/jhsmr.2023994","url":null,"abstract":"Objective: To develop and internally validate a pre-operative scoring system to predict difficulty in elective laparoscopic cholecystectomy (LC).Material and Methods: A retrospective diagnostic prediction study was conducted. Patients undergoing elective LC; from September 2016 to January 2023, at Hatyai Hospital in Southern Thailand were included. Patients were categorized by difficultly of LC according to the Nassar scale (grades 1-2 as non-difficult LC and grades 3-4 as difficult LC). Pre-operative data were compared between both groups; utilizing multivariable logistic regression. Internal validation was performed via the bootstrapping procedure.Results: In total, three hundred and eighteen patients were categorized into either; difficult LC 121 patients or non-difficult LC 197 patients. From this, 7 variables obtained from the multivariable logistic reduced model (male, cirrhosis, history of ERCP, ASA III, gallbladder wall ≥4 mm, dilated gallbladder, contracted gallbladder) were developed as a pre-operative score. The scoring (range: 0.0-16.6) was classified into 3 groups for clinical practicability. The positive predictive values (PPV) were 18.1 for low-risk, 38.0 for moderate-risk, and 76.0 for high-risk. Internal validation, via bootstrap technique, showed a C-statistic value of 0.76, and bootstrap shrinkage was 0.995. The prediction ability (AuROC) of the pre-operative score was 0.76.Conclusion: The developed of a pre-operative score had a good predictive performance, with fewer predictors for prediction difficulty of elective LC that can assist surgeons in surgical management selection.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0