British Journal of Ophthalmology最新文献_第9页

Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic clinicians 全基因组关联研究，多基因风险评分和孟德尔随机化：眼科临床医生常见遗传流行病学方法概述

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2024-12-02 DOI: 10.1136/bjo-2024-326554

Samantha Sze-Yee Lee, Fiona Stapleton, Stuart MacGregor, David A Mackey

{"title":"Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic clinicians","authors":"Samantha Sze-Yee Lee, Fiona Stapleton, Stuart MacGregor, David A Mackey","doi":"10.1136/bjo-2024-326554","DOIUrl":"https://doi.org/10.1136/bjo-2024-326554","url":null,"abstract":"Genetic information will be increasingly integrated into clinical eye care within the current generation of ophthalmologists. For monogenic diseases such as retinoblastoma, genetic studies have been relatively straightforward as these conditions result from pathogenic variants in a single gene resulting in large physiological effects. However, most eye diseases result from the cumulative effects of multiple genetic variants and environmental factors. In such diseases, because each variant usually has an individually small effect, genetic studies for complex diseases are comparatively more challenging. This article aims to provide an overview of three genetic epidemiology methods for polygenic (or complex) diseases: genome-wide association studies (GWAS), Polygenic Risk Scores (PRS) and Mendelian randomisation (MR). A GWAS systematically conducts association analyses of a trait of interest against millions of genetic variants, usually in the form of single nucleotide polymorphisms, across the genome. GWAS findings can then be used for PRS construction and MR analyses. To construct a PRS, the cumulative effect of many genetic variants associated with a trait from a prior GWAS is calculated and taken as a quantitative representation of an individual’s genetic risk of a complex disease. MR studies analyse an outcome measure against the genetic variants of an exposure, and are particularly useful in investigating causal relations between two traits where randomised controlled trials are not possible or ethical. In addition to explaining the principles of these three genetic epidemiology concepts, this article provides a minimally technical description of their basic methodology that is accessible to the non-expert reader. No data are available.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"8 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142760059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights from this issue 本期亮点

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2024-12-01 DOI: 10.1136/bjo-2024-326751

Frank Larkin

引用次数: 0

Semiautomated measures of foveal immaturity from handheld swept-source optical coherence tomography are associated with retinopathy of prematurity severity. 通过手持扫源光学相干断层扫描半自动测量眼窝不成熟度与早产儿视网膜病变严重程度相关。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-27 DOI: 10.1136/bjo-2023-324220

Emily K Tam, Karen E Lee, Sumner E Lawson, Tatiana R Monger, Alex T Legocki, John P Kelly, Teng Liu, Yujiao Zheng, Leona Ding, Kristina Tarczy-Hornoch, Ruikang Wang, Michelle T Cabrera

{"title":"Semiautomated measures of foveal immaturity from handheld swept-source optical coherence tomography are associated with retinopathy of prematurity severity.","authors":"Emily K Tam, Karen E Lee, Sumner E Lawson, Tatiana R Monger, Alex T Legocki, John P Kelly, Teng Liu, Yujiao Zheng, Leona Ding, Kristina Tarczy-Hornoch, Ruikang Wang, Michelle T Cabrera","doi":"10.1136/bjo-2023-324220","DOIUrl":"https://doi.org/10.1136/bjo-2023-324220","url":null,"abstract":"Background/aims: Handheld swept-source optical coherence tomography (SS-OCT) was previously used to measure foveal maturity through semiautomated methods in awake premature infants. This study assesses the relationship between foveal maturity and retinopathy of prematurity (ROP) severity.Methods: This is a prospective, observational study using handheld SS-OCT imaging of premature infants undergoing ROP screening. A semiautomated segmentation algorithm measured foveal angle, total retinal cross-sectional area, and retinal and choroid thicknesses at the fovea and parafovea, excluding significant macular oedema. Measures were correlated with ROP severity using a mixed model approach.Results: 99 eye imaging sessions from 26 preterm infants were included. Average birth weight was 1057.6±324.8 g. Gestational age and postmenstrual age at imaging were 29.1±3.0 and 36.1±3.8 weeks, respectively. Stage 3 ROP occurred in 16/99 (16.2%) exams. Shallow foveal angle and higher inner retinal fovea/parafoveal (F/P) ratio correlated with more posterior ROP zone (zone 2: 119.2°±20.9° vs zone 3: 96.5°±16.7° and zone 2: 0.6±0.2 vs zone 3: 0.4±0.1, respectively, both p<0.001). Inner retinal F/P ratio was greater in eyes with higher ROP stage (stage 3: 0.6±0.2 vs stage 0 or mature: 0.4±0.2, p=0.03) but this relationship was not seen for outer retina (p=0.29). Larger retinal cross-sectional area coincided with worse ROP stage (stage 3: 1.9±0.06 mm2 vs stage 0 or mature: 1.6±0.04 mm2, p<0.001) and zone (zone 2: 1.6±0.04 mm2 vs zone 3: 1.7±0.04 mm2, p=0.01).Conclusions: SS-OCT semiautomated measurements of inner retinal F/P ratio, foveal angle and retinal cross-sectional area may serve as ROP severity biomarkers.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic signature of retinal ageing, polygenetic susceptibility, and major health outcomes 视网膜老化、多基因易感性和主要健康结果的代谢组特征

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-24 DOI: 10.1136/bjo-2024-325846

Riqian Liu, Shaopeng Yang, Xiaoying Zhong, Ziyu Zhu, Wenyong Huang, Wei Wang

{"title":"Metabolomic signature of retinal ageing, polygenetic susceptibility, and major health outcomes","authors":"Riqian Liu, Shaopeng Yang, Xiaoying Zhong, Ziyu Zhu, Wenyong Huang, Wei Wang","doi":"10.1136/bjo-2024-325846","DOIUrl":"https://doi.org/10.1136/bjo-2024-325846","url":null,"abstract":"Background/aims To identify the metabolic underpinnings of retinal aging and examine how it is related to mortality and morbidity of common diseases. Methods The retinal age gap has been established as essential aging indicator for mortality and systemic health. We applied neural network to train the retinal age gap among the participants in UK Biobank and used nuclear magnetic resonance (NMR) to profile plasma metabolites. The metabolomic signature of retinal ageing (MSRA) was identified using an elastic network model. Multivariable Cox regressions were used to assess associations between the signature with 12 serious health conditions. The participants in Guangzhou Diabetic Eye Study (GDES) cohort were analyzed for validation. Results This study included 110 722 participants (mean age 56.5±8.1 years at baseline, 53.8% female), and 28 plasma metabolites associated with retinal ageing were identified. The MSRA revealed significant correlations with each 12 serious health conditions beyond traditional risk factors and genetic predispositions. Each SD increase in MSRA was linked to a 24%–76% higher risk of mortality, cardiovascular diseases, dementia and diabetes mellitus. MSRA showed dose–response relationships with risks of these diseases, with seven showing non-linear and five showing linear increases. Validation in the GDES further established the relation between retinal ageing-related metabolites and increased risks of cardiovascular and chronic kidney diseases (all p<0.05). Conclusions The metabolic connections between ocular and systemic health offer a novel tool for identifying individuals at high risk of premature ageing, promoting a more holistic view of human health. All data used in this study are available from UK Biobank via data access procedures (<http://www.ukbiobank.ac.uk>). Permission to use the UK Biobank Resource was obtained via material transfer agreement as part of Application 105658. Not applicable.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"256 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes after acute primary angle closure: case series from Moorfields Eye Hospital, UK. 急性原发性角膜闭合术后的长期疗效：英国 Moorfields 眼科医院的病例系列。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-324748

Sana Hamid, Francesco Matarazzo, Zihan Sun, Sandika Baboolal, Dhakshi Muhundhakumar, Paul J Foster

{"title":"Long-term outcomes after acute primary angle closure: case series from Moorfields Eye Hospital, UK.","authors":"Sana Hamid, Francesco Matarazzo, Zihan Sun, Sandika Baboolal, Dhakshi Muhundhakumar, Paul J Foster","doi":"10.1136/bjo-2023-324748","DOIUrl":"10.1136/bjo-2023-324748","url":null,"abstract":"Background: There is limited data regarding the morbidity and progression to primary angle closure glaucoma in those presenting with acute primary angle closure (APAC) in the UK. We aim to report on the vision and intraocular pressure (IOP) outcomes and treatment required after an APAC episode and to identify any risk factors that could predict worse outcomes.Methods: A retrospective observational case series review including 117 consecutive patients (121 eyes) attending Moorfields Eye Hospital, at a tertiary referral unit in the UK, with APAC was performed.Results: Most patients (73%) had visual acuities of ≥6/12, meeting the UK driving standard, at the final follow-up. Only 15% (17 eyes) had severe visual impairment, as defined by the WHO, in the affected eye, of which 6.6% (eight eyes) were due to glaucoma. The delayed presentation was linked to a higher need for further medical treatment (OR=2.83, 95% CI 1.09 to 7.40, p=0.03). Patients who underwent phacoemulsification were at lower risk of having blindness in the affected eye (OR 0.18, 95% CI 0.05 to 0.69, p=0.01), having elevated IOP (OR 0.10, 95% CI 0.01 to 0.75, p=0.02) or requiring further medical treatment (OR 0.34, 95% CI 0.12 to 0.99, p=0.04). Older age (OR 1.26, 95% CI 1.08 to 1.48, p<0.01) was associated with worse visual outcomes.Conclusions: APAC causes low long-term visual and treatment morbidity in this largely Caucasian patient group in the UK. Phacoemulsification as a treatment may enhance visual outcomes and reduce the need for further IOP-lowering treatment.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1659-1664"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140915829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of systemic medications associated with diabetic retinopathy: a nested case-control study from the UK Biobank. 评估与糖尿病视网膜病变相关的全身用药：英国生物库的巢式病例对照研究。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-324930

Guangming Jin, Yiyuan Ma, Danying Zheng, Ling Jin, Charlotte Aimee Young, Yanyu Shen, Yuan Tan, Jiaxin Jin, Xinyu Zhang, Yue Wu, Zhenzhen Liu

{"title":"Evaluation of systemic medications associated with diabetic retinopathy: a nested case-control study from the UK Biobank.","authors":"Guangming Jin, Yiyuan Ma, Danying Zheng, Ling Jin, Charlotte Aimee Young, Yanyu Shen, Yuan Tan, Jiaxin Jin, Xinyu Zhang, Yue Wu, Zhenzhen Liu","doi":"10.1136/bjo-2023-324930","DOIUrl":"10.1136/bjo-2023-324930","url":null,"abstract":"Aims: This study aims to investigate the associations between commonly used systemic medications and diabetic retinopathy (DR).Methods: Individuals with linked primary care prescription data from the UK Biobank were included. Cases were defined as individuals with a Hospital Episode Statistics-coded or primary care recorded diagnosis of DR or self-reported DR. Controls were matched for age, sex, glycosylated haemoglobin, duration of diabetes mellitus (DM), hypertension status and cardiovascular disease status. ORs and 95% CIs were calculated using conditional univariate and multivariable logistic regression models.Results: A total of 3377 case subjects with DR were included in the study and matched with 3377 control subjects. In multivariable logistic regression, increased odds of incident DR were observed for exposure to short-acting insulins (OR 1.63; 95% CI 1.22 to 2.18), medium-acting insulins (OR 2.10; 95% CI 1.60 to 2.75), sulfonylureas (OR 1.30; 95% CI 1.16 to 1.46). Instead, the use of fibrates (OR 0.71; 95% CI 0.53 to 0.94) and Cox-2 inhibitors (OR 0.68; 95% CI 0.58 to 0.79) was associated with decreased odds of incident DR. Dose-response relationships were observed for all five drug categories (all p<0.05).Conclusions: This study comprehensively investigated the associations between systemic medication use and DR and found significant associations between the use of short-acting insulins, medium-acting insulins and sulfonylureas with increased odds of incident DR. In contrast, fibrates and Cox-2 inhibitors were associated with decreased odds of incident DR. These findings may provide valuable insights into DM medication management and serve as a reference for the prevention of DR in patients with DM.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1716-1722"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Posner-Schlossman Syndrome European Study Group: study protocol and baseline patients characteristics of a multicentre study. Posner-Schlossman 综合征欧洲研究小组：一项多中心研究的研究方案和患者基线特征。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-324900

Emanuela Interlandi, Luca Cimino, Massimo Accorinti, Elisabetta Miserocchi, Loredana Latanza, Pia Allegri, Paolo Mora, Alex Fonollosa, Alfredo Adan, Carlos Pavesio, Rocco De Marco, Stefano A Gandolfi, Paolo Nucci, Marco De Luca, Fabrizio Gozzi, Giacomo Visioli, Federico Rissotto, Roberta Rissotto, Carlo Bellucci, Josè Manuel Cachero, Francesco Pellegrini, Gaia Li Calzi, Maite Sainz de la Maza, Pasquale Cirillo, Valentina Mastrofilippo, Matteo Sacchi

{"title":"Posner-Schlossman Syndrome European Study Group: study protocol and baseline patients characteristics of a multicentre study.","authors":"Emanuela Interlandi, Luca Cimino, Massimo Accorinti, Elisabetta Miserocchi, Loredana Latanza, Pia Allegri, Paolo Mora, Alex Fonollosa, Alfredo Adan, Carlos Pavesio, Rocco De Marco, Stefano A Gandolfi, Paolo Nucci, Marco De Luca, Fabrizio Gozzi, Giacomo Visioli, Federico Rissotto, Roberta Rissotto, Carlo Bellucci, Josè Manuel Cachero, Francesco Pellegrini, Gaia Li Calzi, Maite Sainz de la Maza, Pasquale Cirillo, Valentina Mastrofilippo, Matteo Sacchi","doi":"10.1136/bjo-2023-324900","DOIUrl":"10.1136/bjo-2023-324900","url":null,"abstract":"Background: The aim of the Posner-Schlossman Syndrome European Study Group (PSS-ESG) is to acquire a comprehensive dataset of European patients with PSS. Here, we present the first report on the study protocol and the clinical findings of the patients at baseline.Methods: The PSS-ESG is a retrospective, multicentre study designed to evaluate patients with PSS. The study, designed and driven by a European Expert Committee includes three datasets: (1) the baseline, (2) the follow-up and (3) the intraocular pressure (IOP)/glaucoma dataset.Results: A total of 11 centres adhered to the PSS-ESG and 107 patients were included (68 males, 39 females) mostly Caucasian (93.4%). At uveitis onset, the patient's age ranged between 11 and 76 years, (mean age: 42±15 years).Best-corrected visual acuity was >0.5 in 80.3% of the eyes, IOP was >40 mm Hg in 44% of the eyes. Keratic precipitates were found in 78.5% of the eyes. No flare or cells in anterior chamber were detected in 56% and 53% of the cases, respectively. PCR analysis on aqueous sample was positive for cytomegalovirus-DNA in 50.6% out of the 81 tested patients.Conclusions: The PSS-ESG is the first multicentre study aimed to collect a comprehensive dataset of patients with PSS in non-Asian countries. A middlde-aged Caucasian male with a low-grade anterior chamber inflammation, keratic precipitates, preserved visual acuity and marked increased in IOP seemed to be the standard PSS patient across the 11 uveitis and glaucoma centres participating in the PSS-ESG.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1652-1658"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iris freckle: a distinct entity. 虹膜雀斑：一个独特的实体。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-325009

Yağmur Seda Yeşiltaş, Millennia Zhou, Emily C Zabor, Zackery Oakey, Nakul Singh, Ahad Sedaghat, Gabrielle Yeaney, Arun D Singh

{"title":"Iris freckle: a distinct entity.","authors":"Yağmur Seda Yeşiltaş, Millennia Zhou, Emily C Zabor, Zackery Oakey, Nakul Singh, Ahad Sedaghat, Gabrielle Yeaney, Arun D Singh","doi":"10.1136/bjo-2023-325009","DOIUrl":"10.1136/bjo-2023-325009","url":null,"abstract":"Purpose: To report distinctive clinical and imaging features of iris freckles to differentiate them from iris nevi.Design: Retrospective observational study.Subjects: 53 patients (277 freckles) with incidental iris freckles and 102 patients (104 nevi) with iris nevi that are either clinically stable or pathologically confirmed.Methods: Patient data were collected from the Department of Ophthalmic Oncology, Cleveland Clinic, Cole Eye Institute database (2012-2023). Lesion characteristics were recorded from slit-lamp examination descriptions and review of colour photographs. Ancillary imaging features observed using anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) were assessed in patients (where available).Main outcome measures: Comparison of clinical and imaging features of iris freckles and iris nevi.Results: A total of 277 iris freckles and 104 iris nevi were analysed. Iris freckles were more frequently bilateral (17%; nevi 0%) and multiple (69%; nevi 2%) and located centrally (89%; nevi 17%) compared with iris nevi (p<0.001). The median freckle largest basal diameter and thickness were 0.8 mm (nevi; 2.1 mm, p<0.001) and 0.04 mm (nevi 1.0 mm, p<0.001), respectively. All iris freckles had irregular margins without any secondary effects compared with iris nevi. Iris freckles appeared flat without effacement of iris folds compared with iris nevi on AS-OCT (p<0.001). Iris freckles were not detectable by UBM. Heat map revealed that freckles demonstrated several features with uniform or near uniform values, whereas nevi demonstrated more variability in values across features.Conclusions: Iris freckles exhibit specific clinical and imaging features reflective of their characteristic histological composition that support their classification as a distinct entity within the spectrum of iris pigmented lesions.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1749-1754"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METAVISION: a novel system for quantifying metamorphopsia in patients with myopic traction maculopathy. METAVISION：一种用于量化近视牵引性黄斑病变患者变形的新型系统。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-324175

Qi Zhang, Xiujuan Zhao, Xia Huang, Qingxiu Wu, Shida Chen, Yonghao Li, Ping Lian, Lin Lu

{"title":"METAVISION: a novel system for quantifying metamorphopsia in patients with myopic traction maculopathy.","authors":"Qi Zhang, Xiujuan Zhao, Xia Huang, Qingxiu Wu, Shida Chen, Yonghao Li, Ping Lian, Lin Lu","doi":"10.1136/bjo-2023-324175","DOIUrl":"10.1136/bjo-2023-324175","url":null,"abstract":"Purpose: To develop a novel system for quantifying metamorphopsia in patients with myopic traction maculopathy (MTM) and to explore the metamorphopsia pattern of MTM.Design: Observational, cross-sectional study.Methods: We designed a new system.Results: Of the 445 eyes tested, 188 (42.25%) were deemed by patients to have metamorphopsia impacting their daily lives while 257 (57.75%) were considered to have no metamorphopsia symptoms. The Amsler grid, M-CHARTS and METAVISION tests displayed sensitivities for metamorphopsia of 95.74%, 89.89% and 100%, respectively. The specificities of the Amsler grid, M-CHARTS and METAVISION tests are 100%. The metamorphopsia questionnaire and METAVISION scores were highly consistent (average intraclass correlation coefficient=0.951, p<0.001) and strongly correlated (R=0.879, p<0.001). The METAVISION score was highly correlated with the stages of MTM (R=0.837, p<0.001), whereas there was a moderate correlation between the M-CHARTS M-score and the stages of MTM (R=0.679, p<0.001).Conclusions: Quantification of metamorphopsia is important and useful for MTM management. The METAVISION is a clinically applicable and comprehensive approach for quantifying metamorphopsia, which can be used in clinical settings.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1723-1728"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ophthalmic quality of life in the adult Danish population: an epidemiological study. 丹麦成年人的眼科生活质量：一项流行病学研究。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-11-22 DOI: 10.1136/bjo-2023-324414

Toke Bek, Bodil Hammer Bech

{"title":"Ophthalmic quality of life in the adult Danish population: an epidemiological study.","authors":"Toke Bek, Bodil Hammer Bech","doi":"10.1136/bjo-2023-324414","DOIUrl":"10.1136/bjo-2023-324414","url":null,"abstract":"Background: Ophthalmic quality of life (OQoL) has been investigated in selected parts of general populations and in patients with ocular disease, but OQoL in unselected general populations has not been studied in detail. The present study reports OQoL obtained from a representative sample of the adult Danish population 2020-2022.Methods: The FORSYN study invited 10 350 citizen representatives for the adult Danish population for a non-mydriatic eye examination and answer the National Eye Institute Visual Function Questionnaire with 39 items in the validated Danish translation. The results from the 3384 (32.7%) persons who participated in the study were weighted on the basis of relevant socio-economic factors, and data were projected to represent the total population. Binocular visual acuity was below 0.1 corresponding to legal blindness in 0.22% of this population.Results: OQoL was positively correlated with binocular visual acuity up to better than 93 ETDRS letters, negatively correlated with age for persons younger than 60 years of age and again positively correlated with age for persons older than 60 years. OQoL was negatively correlated with increasing ametropia and refractive error above 1 dioptre and encompassed more OQoL parameters for hyperopic than for myopic persons.Conclusions: The study underlines the benefits of improving visual acuity even within the normal range and of adjusting uncorrected refraction errors in the general population. OQoL is positively correlated with age in older persons independently of visual acuity, sex, refractive power and previous cataract surgery.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"1755-1759"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0