International journal of functional nutrition最新文献

{"title":"Coffee extracts and caffeine upregulate the expression of the immune checkpoint factors, PD‑1 and PD‑L1","authors":"Tatsushi Yoshida, Kenta Yamasaki, Mano Horinaka, K. Tadagaki","doi":"10.3892/ijfn.2024.36","DOIUrl":"https://doi.org/10.3892/ijfn.2024.36","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140685307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and anti‑inflammatory effects of a mixture of propolis, red bean and tomato extracts","authors":"Eun Kang, Se Jeong, Mi Joo, M. Kim, Yong Hur, Byoung Cho, Seon Jang","doi":"10.3892/ijfn.2024.35","DOIUrl":"https://doi.org/10.3892/ijfn.2024.35","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140713804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An antioxidant ‘database’ for local food products from the Serres region in Greece","authors":"Thomas Karampatzakis, Fotios Tekos, Periklis Vardakas, Z. Skaperda, Demetrios Kouretas","doi":"10.3892/ijfn.2023.34","DOIUrl":"https://doi.org/10.3892/ijfn.2023.34","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"22 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the polyphenolic content and the antioxidant activities of four indigenous Greek red and white wine varieties","authors":"Fotios Tekos, Maria Gkasdrogka, Periklis Vardakas, Zoi Skaperda, Demetrios Kouretas","doi":"10.3892/ijfn.2023.33","DOIUrl":"https://doi.org/10.3892/ijfn.2023.33","url":null,"abstract":"Greece has a long history in viticulture and vinification, cultivating indigenous and imported grape varietals for the production of fine wines. The dominant Greek red grape varieties are Xinomavro and Agiorgitiko, while the most recognizable Greek white grape varieties are Assyrtiko and Malagouzia. In the present study, the biological activities of monovarietal wines, derived from the aforementioned indigenous Greek grape varieties, were investigated by evaluating their polyphenolic content and antioxidant potency <em>in vitro</em>, using a well‑established panel of cell‑free assays. According to the results obtained, the red wines contained higher levels of polyphenolic compounds and exhibited more prominent antioxidant activities than the white wines. Among the different wine varieties, Xinomavro was the most potent, exhibiting a high concentration of polyphenols and notable antioxidant properties, whereas Malagouzia was the least efficacious. Finally, the correlation analysis between the total polyphenolic content and antioxidant capacity of the red and white wine varieties revealed a proportional correlation in almost all cases, indicating that the antioxidant activities strongly correlated with the phenolic content. Overall, the findings of the present study suggest that the monovarietal wines of these indigenous Greek grape varieties, and particularly Xinomavro, are highly bioactive, and their moderate consumption may be associated with health‑promoting effects.","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135617466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of the combination of <i>Citrus aurantium</i>, <i>Cistus creticus</i> and <i>Olea europaea</i> leaf extract on the lipid profiles of individuals with marginally elevated lipid levels","authors":"Annia Tsolakou, Dimitrios Konstantinidis, Vassiliki Economou, Stamatis Boulis, Evangelia Koutsogiannouli, Costas Tsioufis, Nikolaos Drakoulis","doi":"10.3892/ijfn.2023.32","DOIUrl":"https://doi.org/10.3892/ijfn.2023.32","url":null,"abstract":"Dyslipidemia includes a large range of lipid abnormalities involving increased levels of total cholesterol (TC), low‑density lipoprotein cholesterol and triglycerides (TGs), and/or decreased levels of high‑density lipoprotein (HDL) cholesterol. Individuals with marginally elevated fasting levels of cholesterol in laboratory tests may need an alternative therapeutic approach. Bitter orange, rock‑rose and olive leaf extracts have been highlighted for their antioxidant and lipid lowering properties in numerous studies. The aim of the present observational study was to evaluate the potential synergistic effects of a standardized food supplement, rich in polyphenols and flavonoids, containing a blend of <em>Citrus aurantium</em>, <em>Olea europaea</em> leaf and <em>Cistus creticus</em> extracts, chromium and vitamin B complex, on lowering the cardiovascular risk in individuals with mild dyslipidemia (TC, 190‑290 mg/dl; TG, &gt;150 mg/dl). Following 12 weeks of treatment, a statistically significant decrease in TG levels and an increase in HDL levels was recorded. On the whole, the findings presented herein support a significant decrease in TG levels, further promoting the evaluation of this supplement in a larger study population.","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135696516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbs and plants in immunomodulation (Review)","authors":"T. Kadiyska, I. Tourtourikov, Kristiyan Dabchev, A. Zlatarova, N. Stoynev, R. Hadjiolova, D. Spandidos, M. Adamaki, V. Zoumpourlis","doi":"10.3892/ijfn.2023.31","DOIUrl":"https://doi.org/10.3892/ijfn.2023.31","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90455555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of vitamin D deficiency in a Middle Eastern population: A cross‑sectional study","authors":"Dahat A. Hussein, Gasha S Ahmed, Shaho F. Ahmed, Rawezh Q. Salih, F. Kakamad, A. Salih, Bnar J. Hama Amin, Berun A. Abdalla, S. Mohammed, Rivan Salim, Sawen Hamarahim, Shaima Hamid, Awara Hamarashid, Chawan Rashid, Wafa Hamadameen, Karzan M. Salih","doi":"10.3892/ijfn.2022.30","DOIUrl":"https://doi.org/10.3892/ijfn.2022.30","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84780316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of local and systemic immune responses by fermented garlic extract","authors":"P. Gurung, J. Lim, Til Bahadur Thapa Magar, Rajeev Shrestha, Yong-Wan Kim","doi":"10.3892/ijfn.2022.29","DOIUrl":"https://doi.org/10.3892/ijfn.2022.29","url":null,"abstract":". Fermented garlic (FG), prepared by fermenting garlic with Bacillus subtilis for 3‑15 days at 20‑40˚C has been linked to immune‑boosting properties. In the present study, FG was utilized to investigate its immunomodulatory effects using RAW264.7 cells, as well as BALB/c and c3H/HeN mice. Nitric oxide (NO) and pro‑inflammatory cytokine levels were quantified in RAW264.7 cells treated with or without FG (0.016, 0.08, 0.4, 2 and 10 mg/ml), garlic extract (GE) (0.016, 0.08, 0.4, 2 and 10 mg/ml) and lipopolysaccharide (1 µg/ml). Peritoneal macrophages and splenocytes were obtained from BALB/c mice for ex vivo analyses. MTT and enzyme‑linked immunosorbent assays were used to determine splenocyte proliferation, natural killer (NK) cell activity and cytokine production. The intestinal immunostimulatory in vitro effects of FG were also investigated. In a concentration‑dependent manner, FG treatment markedly accelerated the prolifera‑ tion of RAW264.7 cells, murine peritoneal macrophages and splenocytes. Moreover, FG initiated macrophage activation by significantly increasing the NO, tumor necrosis factor‑ α , interleukin (IL)‑12 and IL‑6 levels in RAW264.7 cells and peritoneal macrophages. In contrast to FG, GE promoted RAW264.7 cell proliferation at lower concentrations and toxicity at higher concentrations, while no detectable NO synthesis was observed at the concentrations tested. Likewise, the FG extract at larger concentrations fortified the intestinal immune system and improved bone marrow cell proliferation by significantly elevating IL‑6 and granulocyte‑macrophage colony‑stimulating factor production in splenocytes and Peyer's patch cells of mice. In addition, the NK cell activities of splenocytes from FG‑treated mice at lower doses against YAC‑1 cells were significantly increased, which must have been fostered and activated by interferon‑ γ generated by sple‑ nocytes. On the whole, these findings provide relevant in vitro and ex vivo information that describes the mechanisms through which FG can strengthen a compromised immune system by influencing local and systemic gut immune responses directly or indirectly.","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89214867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of nutritional value of different ruminant milks in human nutrition","authors":"A. Arrichiello, G. Auriemma, F. Sarubbi","doi":"10.3892/ijfn.2022.28","DOIUrl":"https://doi.org/10.3892/ijfn.2022.28","url":null,"abstract":". The present study was conducted on milk samples from 30 Italian Mediterranean buffaloes, and as many goats, sheep and cattle. Milk samples were subjected to chem‑ ical‑nutritional analysis and compared with commercially available milk samples. In the experiments, the management conditions could have influenced this parameter, determining the observed values. The higher fat content in sheep's milk differed significantly from that in the milk of the other animals analyzed. A higher lactose content was found in the milk of buffaloes and sheep, than in cows and goats. The highest cholesterol content was observed in cow and buffalo milk. These differences were statistically significant. To avoid exces‑ sive cholesterol intake, it is necessary to pay attention to both the quantity and quality of fats contained in food, bearing in mind that the introduction of large quantities of dairy products in the diet can cause a significant intake in cholesterol levels. Furthermore, when selecting the type of milk to be consumed, it is necessary to consider that the amount of total cholesterol is dependent on both the animal of origin and on the integrity of the lipid fraction. To complete the study, a chemical‑nutritional analysis of milk samples normally marketed, both of vegetable and animal origin, was also included. Observing the results, some differences appear evident in the chemical‑nutritional composition of goat and cow milk compared to the raw milk analyzed. In particular, goat's milk has a higher percentage of lipids. However, the differences observed herein were not significant and could be explained by the manufacturing process the samples were subjected to from the stable to the packaging industry. From the results obtained in the present study in the compositional analyses performed, and as also obtained from previous studies, it was found that sheep and goat milk, in particular, may be a valid substitute for cow's milk.","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"71 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91485819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological effects of grape stem extracts on human cancer cell lines","authors":"Eleni Vassi, Aristidis S. Veskoukis, Fotios Tekos, Z. Skaperda, K. Poulas, S. Haroutounian, D. Kouretas","doi":"10.3892/ijfn.2022.27","DOIUrl":"https://doi.org/10.3892/ijfn.2022.27","url":null,"abstract":"","PeriodicalId":93109,"journal":{"name":"International journal of functional nutrition","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86662539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}