International journal of cancer research & therapy最新文献

{"title":"Pathophysiological discussions and statistical results between diabetes caused by obesity versus cancers caused by obesity via SD-VMT areas comparison using data collected from 2010 to 2023 and based on space-domain viscoplastic energy model of GH-Method: Math-Physical Medicine (No. 893, VGT #293)","authors":"","doi":"10.33140/ijcrt.08.03.05","DOIUrl":"https://doi.org/10.33140/ijcrt.08.03.05","url":null,"abstract":"The objective of this methodology article is to assess and compare the risks of developing type 2 diabetes (T2D) and cancers caused by obesity as a single input factor. The study spans a timeframe of approximately 14 years, from 2010 to 2023. The author personally collected and analyzed their input data, although there were limitations in obtaining sufficient lab-tested data between 2010 and 2012. From 2013 to 2018, the data collection methods involved more lab testing and personal data obtained through finger-piercing glucose testing. A more complete and comprehensive dataset was obtained from 2018 to 2023, utilizing laboratory tests, automated glucose sensors, and wearable health devices. Despite these limitations, the annual dataset used in this study is considered adequate for drawing useful and reasonably accurate conclusions. The author has been diagnosed with T2D since 1996 but has not received any cancer diagnoses. The assessment of cancer risk in this study is conducted using a sophisticated metabolism index (MI) model developed by the author in 2014. This model takes into account factors such as lifetime bad habits, environmental factors, genetic concerns, four metabolic disorders, and six lifestyle details. To analyze and compare the contribution of T2D (measured through HbA1C levels) and cancer risks based on the single input cause of obesity (measured through body weight, m1), this study utilizes the space-domain viscoplastic energy model from GH-Method: Math-Physical Medicine. In summary, this research presents two key findings: Firstly, the author conducts two separate analyses to evaluate the impact of obesity on his existing T2D condition and his future risks of developing cancer. The SD-VMT analysis shows that the energy level for T2D and obesity is 110.1, while the energy level for cancers and obesity is only 1.18, representing just 1% of the diabetes energy level. This finding indicates that despite being a T2D veteran of 26 years, the author has not shown any signs of developing cancer. Furthermore, his SD time-zone analysis reveals that 98% of the total energy is concentrated in the Y10-Y13 for T2D and Y10-Y17 for cancers, while only 2% falls in the Y14-Y23 for T2D and Y18-Y23 for cancers. Secondly, as an exploratory medical research methodology, he considers obesity as the output symptom, with diabetes and cancers being two separate input causes. The SD-VMT energy ratios demonstrate that diabetes accounts for 69% of the total energy, while cancers account for 31%. Although diabetes has twice as much energy as cancers, the disparity is not as substantial as the 99-fold difference observed in the first case. This finding emphasizes that the author's existing diabetes condition is significantly more severe than his risks of developing cancer.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135088423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscoelastic and viscoplastic glucose theory (VGT #121): Prevention of breast cancer via weight control, daily exercise, and food quality using a dataset over 11.5 years with 12 annual data of a hypothetic female patient based on GHmethod: math-physical medicine (No. 711)","authors":"","doi":"10.33140/ijcrt.07.03.06","DOIUrl":"https://doi.org/10.33140/ijcrt.07.03.06","url":null,"abstract":"This paper starts with a brief excerpt from Mayo Clinic’s website “Breast cancer care at Mayo Clinic “Breast cancer is cancer that forms in the cells of the breasts.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135491610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Factors Associated with Pandemic Risk Reduction, Especially During Further emergence of SARS-Cov-2 Omicron Variant On Malawi Perspective","authors":"","doi":"10.33140/ijcrt.07.01.04","DOIUrl":"https://doi.org/10.33140/ijcrt.07.01.04","url":null,"abstract":"In 2019, around December, Coronavirus disease, shortened as COVID-19, was reported in Wuhan (China) as a respiratory disease. It was also discovered that; Covid-19 is an infectious disease caused by the SARS-CoV-2 virus. As COVID-19 Virus spread globally at a faster rate, World Health Organization (WHO) declared it as a worldwide pandemic. Though it was in more than 200 countries in the world, as of 31st March 2019 Malawi was among the countries that had not registered any case. Looking at its economic, political, and health status, the authorities recommended to strengthen more preventive measures to prevent the pandemic from entering Malawi. However, on 2nd April 2020; the first 3 Covid-19 cases were confirmed in Malawi. Worse still, in Africa, on 24th November 2021, the first case of Covid -19 Omicron Variant (an updated version of covid-19) was announced by South Africa, with the first positive sample dating back to 9th November 2021. We reviewed the current factors responsible for the pandemic risk reduction, especially during the further emergence of the current SARSCov-2 Omicron Variant in Malawi, and discussed potential prevention and mitigation techniques.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41790035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Age-Dependent Effective Dose and Toxicity Risks Due To Ingestion of 226RA and 228RA in River Water Samples in a Part of Bitumen Belt, Ondo State. Nigeria","authors":"","doi":"10.33140/ijcrt.07.01.03","DOIUrl":"https://doi.org/10.33140/ijcrt.07.01.03","url":null,"abstract":"Exposure to naturally occurring radioactive chemical elements in food and water is attracting the attention of many researchers in recent times because of its deleterious health effects. In this study, the activity concentrations of natural radionuclides in some river waters in southwestern Nigeria were measured using high-purity germanium (HPGe) detector. They ranged from 0.12 to 2.31, 0.17 to 2.85, and 7.86 to 65.51 Bql-1 for 226Ra, 228Ra, and 40K respectively. Mean of the total annual effective dose were 9.86, 2.46, 1.71, 2.43, 5.74, and 0.99 mSvy-1 for age groups ≤1y, 1-2y, 2-7y, 7-12y, 12-17y, and >17y respectively. Estimated mass concentration of 226Ra and 228Ra in the samples ranged from 3.29x10-6 to 59.71x10-6 µgl-1 with a mean of 35.04x10-6 µgl-1 and 1.69x10-8 to 28.30x10-8 µgl-1 with a mean of 14.30x10-8 µgl-1 respectively. Mortality and morbidity risks ranged from 0.04x10-3 to 0.77x10-3 with a mean of 0.42x10-3 and 0.04x10-3 to 0.80x10-3 with a mean of 0.44x10-3 respectively for 226Ra while they ranged from 0.11x10-3 to 1.89x10-3 with a mean of 0.96x10-3 and 0.16x10-3 to 2.66x10-3 with a mean of 1.38x10-3 respectively for 228Ra. Lifetime average daily dose (LADD) of 226Ra and 228Ra ranged from 9.39x10-14 µgkg-1d-1 to 181.01x10-14 µgkg-1d-1 with a mean of 100.06x10-14 µgkg-1d-1 and 4.82x10-16 µgkg-1d-1 to 80.70x10-16 µgkg-1d-1 with a mean of 40.90x10-16 µgkg-1d-1 respectively. The hazard quotient (HQ) for 226Ra and 228Ra ranged from 8.38x10-14 to 161.61x10-14 with a mean of 89.33x10-14 and 4.30x10-16 to 70.09x10-16 with a mean of 36.50x10-16 respectively. Radiological hazard indicator of radium is of concern in these river water samples.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43612354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An abused body recovers in two weeks","authors":"","doi":"10.33140/ijcrt.07.01.02","DOIUrl":"https://doi.org/10.33140/ijcrt.07.01.02","url":null,"abstract":"On the 30th of December I received a Skype call from the lady friend of a patient asking if the man was alright. He was in pain, had not enough energy to walk, looked and sounded at death’s door from what I could see and had been treated by CellSonic a few days before. I knew nothing of his case. This sounded like a failure and serious complaint. I knew who had done the treatment and she is an expert having had cancer herself, was cured by CellSonic and bought a machine to cure others because she knew that oncologists were useless.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44782975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Biophysics©","authors":"小谷 正雄, 江橋 節郎","doi":"10.33140/ijcrt.07.01.01","DOIUrl":"https://doi.org/10.33140/ijcrt.07.01.01","url":null,"abstract":"There are three branches of medicine: biochemistry, biophysics and psychiatry. Modern medicine is dominated by biochemistry and psychiatry is neglected in favour of brain blocking drugs. The only biophysics treatment accepted by the medical establishment is lithotripsy which became a tool for urologists forty years ago and its many additional applications in chronic ailments have been avoided ever since. That resistance is now changing. My own company, CellSonic Limited, has modified the basic lithotripter to be smaller, weaker and lower in cost. The machine generates a very intense pressure pulse, an electrical field and a flash of light all within a billionth of a second. By aiming the pulse into the body, infection is killed, osteoblasts and fibroblasts generated, nerves repaired and body cell voltages corrected.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46577445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iterative Recurrencies of Hemangioblastoma: Stabilization after Surgery and Radiotherapy","authors":"","doi":"10.33140/ijcrt.06.03.07","DOIUrl":"https://doi.org/10.33140/ijcrt.06.03.07","url":null,"abstract":"Hemangioblastomas are rare benign tumors that present less than 2% of all CNS tumors. Lesion development may be sporadic or associated with von hippelindau disease. Its treatment is based on total surgical excision; the risk of recurrence is linked to the potential presence of latent tumor nodules, in a quiescent state which may develop later, hence the importance of regular monitoring.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43669133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Bacterial and Viral Inhibitors Involved in Gene Therapy of Hepatocellular Carcinoma (Hcc)","authors":"","doi":"10.33140/ijcrt.06.03.06","DOIUrl":"https://doi.org/10.33140/ijcrt.06.03.06","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a form of cancer that is very widespread around the world and has a high mortality rate. Extensive evidence suggests that, HCC is a multifactorial disease. Hepatic cirrhosis is present, along with systemic inflammation and viral infections such as hepatitis B or C. Thus, giving rise to genetically and phenotypically heterogeneous hepatocellular carcinoma tumors. Researchers have found that bacterial and viral inhibitors can be used to silence targeted genes in hepatocellular carcinoma. Many bacterial species such as; Salmonella, Listeria, and Escherichia, proved to have anti-tumor properties. Up till now, adenoviral, retroviral, herpes-simplex viral and adeno-associated viral vectors have been modified and are being used for HCC gene therapy. In patients, up regulation of TLR signaling have also been observed showing an interesting influence on HCC’s microenvironment. TLR 4 and TLR 9 have positive relationship with tumor whereas, TLR3 is associated with anti-tumor influence. TLRs can cause an inflammatory response in the presence of foreign pathogens including bacteria and fungi. This review reflects an insight into the biology of HCC suggesting that certain signaling pathways and molecular alterations plays a very significant role in HCC development. As well as new experimental approaches, including; anti-angiogenesis, cancer therapy, oncolytic virotherapy, and suppressing the function of oncogenes, leading to apoptosis are successively being applied. The current challenge for the researchers is to identify a medicament which is selective for tumors specific cells only, having minimal noxiousness and harmless to normal tissue. We have scrutinized research articles based on how to merge viral and bacterial anticancer therapies into a single treatment for HCC.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44824761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritization of Covid-19 Vaccination in Patients with Cancer","authors":"","doi":"10.33140/ijcrt.06.03.04","DOIUrl":"https://doi.org/10.33140/ijcrt.06.03.04","url":null,"abstract":"In patients with cancer, SARS-CoV-2 (COVID-19) can contribute to increasing morbidity and mortality and decreased survival was found in patients with hematological and intrathoracic malignancies, poor performance status, comorbidities, and increased age. Patients with hematological malignancies who were treated with stem cell transplantation and anti-CD-20 antibody demonstrated lower rates of seroconversion, compared to COVID-19-infected-cancer patients. Patients with hematological malignancies might have substantially compromised B-cell and T-cell responses.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44264578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer as a Possible Complication of Some Types of Covid.19 Vaccines","authors":"","doi":"10.33140/ijcrt.06.03.05","DOIUrl":"https://doi.org/10.33140/ijcrt.06.03.05","url":null,"abstract":"Quick development of COVID.19 vaccines, trigger a big question about validity of clinical trials conducted on it. We observed several short-term consequences of this artificial method of immunization, but no one knows the long-term outcomes of it, I regarded that exogenous estrogen constituent of it as probable cause of breast cancer, specifically among older women.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46648166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}