International journal of cancer research & therapy最新文献

Filling the Void: The Need for Psycho-Oncology Multidisciplinary Tumour Boards in Hospitals across Pakistan 填补空白:巴基斯坦各医院对心理肿瘤学多学科肿瘤委员会的需求

International journal of cancer research & therapy Pub Date : 2023-10-30 DOI: 10.33140/ijcrt.08.04.06

引用次数: 0

Delay in First Treatment Initiation and Associated Factors among Colorectal Cancer Patients at TikurAnbessa Specialized Hospital, Addis Ababa, Ethiopia: A Retrospective Cohort Study 埃塞俄比亚亚的斯亚贝巴TikurAnbessa专科医院结直肠癌患者首次治疗开始延迟及相关因素:一项回顾性队列研究

International journal of cancer research & therapy Pub Date : 2023-10-17 DOI: 10.33140/ijcrt.08.04.04

{"title":"Delay in First Treatment Initiation and Associated Factors among Colorectal Cancer Patients at TikurAnbessa Specialized Hospital, Addis Ababa, Ethiopia: A Retrospective Cohort Study","authors":"","doi":"10.33140/ijcrt.08.04.04","DOIUrl":"https://doi.org/10.33140/ijcrt.08.04.04","url":null,"abstract":"Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality worldwide. There is a paucity of data on the clinical and demographic characteristics of CRC patients and factors associated with delayed treatment initiation. Methods: This retrospective cohort study was conducted in 274 patients with CRC from July 1st 2019 to July 1st 2022. Data were collected from medical records, including demographic and clinical characteristics, symptoms, diagnostic findings, treatment modalities, and treatment delay. Bivariate and multivariate logistic regression analysis was performed to determine factors associated with delayed treatment initiation. Results: The mean age of onset for CRC was 47.7+/- 14,7 years, with a slight male predominance. Patients experienced an average duration of complaints of 9.8 months, with bleeding per rectum, bowel habit change, and a rectal mass being the most frequently reported symptoms. Over 90% of cases were diagnosed at advanced stages, with the rectum being the most commonly affected site. Only 35% of patients received multidisciplinary team (MDT) care for the initial treatment plan, and radiotherapy was the most frequently delayed treatment modality, with a mean delay of 164.4 days. Multivariate logistic regression analysis revealed that delayed treatment initiation was significantly associated with the first treatment modality. Conclusion: This study highlights the clinical and demographic characteristics of CRC patients, and the high incidence of delayed treatment initiation, particularly for radiotherapy. Efforts should be made to increase awareness and screening for CRC, improve utilization of MDT care, and reduce delays in treatment initiation.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Epidemiological Profile of Cervical Cancer Patients Attending Nyeri County and Referral Hospital, Kenya: a Review of Records 肯尼亚尼亚里县和转诊医院宫颈癌患者的患病率和流行病学概况:对记录的回顾

International journal of cancer research & therapy Pub Date : 2023-10-17 DOI: 10.33140/ijcrt.08.04.05

{"title":"Prevalence and Epidemiological Profile of Cervical Cancer Patients Attending Nyeri County and Referral Hospital, Kenya: a Review of Records","authors":"","doi":"10.33140/ijcrt.08.04.05","DOIUrl":"https://doi.org/10.33140/ijcrt.08.04.05","url":null,"abstract":"Objective: This study aimed to establish the prevalence and epidemiological characterization of cervical cancer patients registered in Nyeri County and Referral Hospital, Kenya. Methods and analysis: This was a retrospective observational design that involved the systematic collection and analysis of data from 2328 patient records. Relevant variables, including demographic characteristics, clinical features, treatment modalities and survival outcomes, were extracted and analyzed. Descriptive statistics were used to determine the prevalence of cervical cancer, while Chi-square test was performed to assess the association between various factors and survival outcomes. Multivariate analysis was conducted to control for confounding variables and determine the independent effects of predictors. Ethical clearance was obtained and ethical principles maintained. Results: Records of 2328 cancer patients were analyzed, out of which 120 were cervical cancer. Majority of cervical cancer patients were aged 50-59 years with majority residing in Nyeri County. The prevalence of cervical cancer was 5.16%. The overall survival rate for cervical cancer patients was 58.33%. Advanced age and late-stage diagnosis were factors associated with lower survival rates. Conclusion: The study revealed a prevalence of 5.16% of cervical cancer among patients attending Nyeri County and Referral Hospital in Kenya from the year 2017 to 2022 with an overall survival rate of 58.33%. Age and latestage diagnosis were found to be influential factors in survival outcomes. Therefore, improving early detection and initiation of early treatment for all cervical cancer patients is required in order to improve survival status.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136077363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Lung Cancer Survivability: A Machine Learning Ensemble Method On Seer Data 预测肺癌生存能力:基于Seer数据的机器学习集成方法

International journal of cancer research & therapy Pub Date : 2023-10-11 DOI: 10.33140/ijcrt.08.04.03

引用次数: 2

Towards a Therapeutically Pragmatic Molecular Definition of Hepatoblastoma 肝母细胞瘤的实用分子定义

International journal of cancer research & therapy Pub Date : 2023-10-10 DOI: 10.33140/ijcrt.08.04.02

{"title":"Towards a Therapeutically Pragmatic Molecular Definition of Hepatoblastoma","authors":"","doi":"10.33140/ijcrt.08.04.02","DOIUrl":"https://doi.org/10.33140/ijcrt.08.04.02","url":null,"abstract":"Hepatoblastoma (HB) is the most common pediatric liver cancer while also holding the distinction of being the least genomically altered of all malignancies. Three major oncogenic pathways have been identified as underlying the pathogenesis of this disease. Mouse models have demonstrated that deregulating any two is the minimal requirement for generating a tumor and that deregulating all three generates particularly aggressive ones. The terminal mediators of these three pathways, namely β-catenin of the Wnt/β-catenin, YAP of the Hippo pathway and NFE2L2/NRF of the NRF2 pathway are all transcription factors (TFs) that directly regulate hundreds-thousands of both unique and common downstream targets. Different pairwise combinations of these three TFs generate HBs with distinct growth patterns, histologies and gene expression patterns. Moreover, different patient-derived mutant forms of β-catenin also generate HBs with similarly distinct profiles. Based on the analyses of numerous tumors with these various combinations of TFs, and in different genetic backgrounds, it has been possible to identify a key set of 22 so-called “BYN genes” genes that are always similarly deregulated across all experimental HB types. A subset of these can be used to classify human HBs into those with long-term favorable and unfavorable outcomes and another subset is predictive of survival in hepatocellular carcinomas and over a dozen other human cancers. None of the BYN genes encode TFs; rather they mostly encode secreted or extracellular membrane proteins or enzymes. They therefore make more appealing targets than do the more refractory upstream TFs.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Few Words about Tumoroids 关于类肿瘤几句话

International journal of cancer research & therapy Pub Date : 2023-10-10 DOI: 10.33140/ijcrt.08.04.01

引用次数: 0

Cytological Changes in Buccal Mucosa among Glue Abusers in Shendi, Sudan 苏丹申迪地区胶滥用者口腔黏膜细胞学变化

International journal of cancer research & therapy Pub Date : 2023-09-29 DOI: 10.33140/ijcrt.08.03.09

{"title":"Cytological Changes in Buccal Mucosa among Glue Abusers in Shendi, Sudan","authors":"","doi":"10.33140/ijcrt.08.03.09","DOIUrl":"https://doi.org/10.33140/ijcrt.08.03.09","url":null,"abstract":"Background: Glue sniffing among young people on the streets has gone completely out of control. The majority of street kids start out sniffing glue before moving on to other, more extreme narcotics. The organizations tackling the drug problem claim that because it is inexpensive and widely accessible, the majority of young people on the streets smell it. Objective: The purpose of this study was to assess how sniffing glue affected the buccal mucosal cells. Materials and Methods: This cross-sectional descriptive study was carried out at Shendi town between March 2021 and March 2022. The study involved 150 participants under the age of 25, of whom 50 were glue abusers. The remaining 50 participants served as the (control1) group, and their parameters were similar to those of the abusers', with the exception that they did not abuse glue. The final 50 participants served as the (control 2) group, and they appeared to be in good health and did not use tobacco, Glue sniffing, or another type of addiction. Buccal samples were taken from each group, strained by pap stain, and microscopically examined. A standardized face-to-face questionnaire was utilized to gather data, and the (SPSS) version (11.5) application was used to analyze the results. Results: The study revealed a significant P-value of nuclear atypia among study populations, inflammation, and infection was 0.000, the significant relationship of nuclear atypia with the duration of glue snuffing and dose of glue with P-value 0.000,0.001 respectively. Conclusions: The usage of glue caused considerable morphological alterations in mucosal cells, such as nuclear atypia and pre-nuclear hallo, as well as inflammations and infections (bacterial and viral)","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135343638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical Modeling of Cancers Using Machine Learning Algorithms 使用机器学习算法的癌症数学建模

International journal of cancer research & therapy Pub Date : 2023-09-22 DOI: 10.33140/ijcrt.08.03.07

引用次数: 0

Accelerating Drug Development: Regulatory and Operational Strategies for Shortening Clinical Trials 加速药物开发:缩短临床试验的管理和操作策略

International journal of cancer research & therapy Pub Date : 2023-09-22 DOI: 10.33140/ijcrt.08.03.08

引用次数: 0

Prevalence and Associated Factors of Anemia among People with Cancer in ACSH, Tigray, Ethiopia 埃塞俄比亚提格雷ACSH地区癌症患者贫血患病率及相关因素

International journal of cancer research & therapy Pub Date : 2023-09-14 DOI: 10.33140/ijcrt.08.03.06

{"title":"Prevalence and Associated Factors of Anemia among People with Cancer in ACSH, Tigray, Ethiopia","authors":"","doi":"10.33140/ijcrt.08.03.06","DOIUrl":"https://doi.org/10.33140/ijcrt.08.03.06","url":null,"abstract":"Background: anemia is becoming a tricky health problem among people suffering from different types of cancer. Objective: the aim of this study was to assess the prevalence and associated factors of anemia among people with cancer. Methods: an institution based cross-sectional study was conducted from January to June 2020 in ACSH, Tigray, Ethiopia. Medical records were systematically reviewed to get demographic and clinical characteristics of 72 study subjects. Data were entered to SPSSv25 and descriptive analysis, logistic regression, independent sample T test and ANOVA were used for analysis. Results: about 45.8% of study subjects with different types of cancer were found to have anemia. Unemployment (OR=2.167; 95%CI: 1.093, 4.294; p=0.027), rural residence (OR = 3.750; 95%CI: 1.245, 11.299; p= 0.019), advanced stages of cancer (OR = 10.771; 95%CI: 3.580, 32.405; p= 0.000), duration of cancer (OR=3.542; 95%CI: 1.289, 9.728; p=0.014) and higher (5-8) cycles of chemotherapy (OR = 3.000; 95%CI: 1.090, 8.254; p=0.033) were variables found to have statistically significant association with anemia. Conclusion: anemia is a common complication in patients with different types of cancer. Occupation, residence, duration of cancer, stage of caner, chemotherapy, and cycles of chemotherapy significantly increased the prevalence of anemia in cancer patients.","PeriodicalId":93106,"journal":{"name":"International journal of cancer research & therapy","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134990555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0