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Global journal of medical research最新文献

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Bilateral Internal Carotid Artery Agenesis : Very Rare Cause of Bilateral Pulsatile Tinnitus 双侧颈内动脉发育不全:双侧搏动性耳鸣的罕见病因
Global journal of medical research Pub Date : 2023-04-04 DOI: 10.34257/gjmrjvol23is1pg5
A. Aliyeva, Ziya Karimov, O. Yagiz, F. R. Alekberli
{"title":"Bilateral Internal Carotid Artery Agenesis : Very Rare Cause of Bilateral Pulsatile Tinnitus","authors":"A. Aliyeva, Ziya Karimov, O. Yagiz, F. R. Alekberli","doi":"10.34257/gjmrjvol23is1pg5","DOIUrl":"https://doi.org/10.34257/gjmrjvol23is1pg5","url":null,"abstract":"Bilateral internal carotid artery agenesis is a very rare congenital anomaly. Intracranial blood circulation in the affected internal carotid artery side is provided by collateral vasculature, contralateral internal carotid artery through the anterior communicating artery, and from the vertebrobasilar system through the posterior communicating artery. People with this abnormality may be asymptomatic for many years. However, patients may also be present with ischemic stroke orsubarachnoid hemorrhage, headache, and blurred vision. Diagnosis is usually incidental by the performance of carotid artery doppler ultrasonography or cervical/cranial magnetic resonance imaging owing to other symptoms. We report a case of bilateral internal carotid artery agenesis with pulsatile tinnitus lasting five years in the light of clinical presentation and imaging findings.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From the Thyroid to the Heart 从甲状腺到心脏
Global journal of medical research Pub Date : 2023-03-16 DOI: 10.34257/gjmrkvol23is1pg1
R. Moncayo, H. Moncayo
{"title":"From the Thyroid to the Heart","authors":"R. Moncayo, H. Moncayo","doi":"10.34257/gjmrkvol23is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrkvol23is1pg1","url":null,"abstract":"The pathogenesis of human disease is commonly considered to be unique to each organ or system. This has led to specialization in medical practice leaving little space for global pathogenesis concepts. In this review we have departed from a biochemical concept of coenzyme Q10 (CoQ10) deficiency and its relation to the initiation of hypoxia response in a systemic way. Several conditions of secondary CoQ10 deficiency are known in the literature by which the organs involved could be affected by hypoxia and switch to glycolytic metabolism. The most salient biomarkers of this situation are the low T3 syndrome and the elevation of IL-6. These parameters together with CoQ10 deficiency delineate a condition of acquired mitochondrial dysfunction. Additional related biochemical deficiency conditions affect magnesium, selenium, and iron levels. Visualization of glycolysis can be clearly achieved by diagnostic imaging methods based on the use of 18F-fluoro-deoxyglucose (18F-FDG). We present several examples of diagnostic imaging with 18F-FDG to demonstrate our model of acquired mitochondrial dysfunction and disease.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48724102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Markers and Risk Factors in Hypertensive Patients: A Cross-Sectional Study 高血压患者炎症标志物和危险因素的横断面研究
Global journal of medical research Pub Date : 2023-02-23 DOI: 10.34257/gjmrfvol23is2pg29
Bettanin, Francelise Susan Mihara, Bacci, Marcelo Rodrigues, Fonseca, Fernando Luiz Affonso
{"title":"Inflammatory Markers and Risk Factors in Hypertensive Patients: A Cross-Sectional Study","authors":"Bettanin, Francelise Susan Mihara, Bacci, Marcelo Rodrigues, Fonseca, Fernando Luiz Affonso","doi":"10.34257/gjmrfvol23is2pg29","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is2pg29","url":null,"abstract":"Objective: To observe risk factors that hypertensive patients present in the outpatient segment from the nursing perspective care. \u0000Method: Cross-sectional study where essential hypertensives of legal age belonging to the hypertension program of a municipality in Bahia were included. Those with cancer, hepatitis, HIV, lupus, arthritis, pregnant women, and chronic corticosteroid users were excluded. Collected patient demographic information and cardiovascular risk factors. \u0000Results: Included 61 patients with a mean age of 58±11, 56% women. A relationship was established between age/glucose; IL6/LDL; vitamin D/ferritin; waist circumference/BMI; BMI/CRP; smoking, age, blood pressure, LDL, and neutrophil/lymphocyte ratio. The statistical analysis evaluated predictive variables for developing hypertension and high cardiovascular risk. In the cardiovascular risk stratification, 09 patients had low chance; one was intermediate, 37 high risk, and 02 very high risk.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46471996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer Stem Cells as the Key to Cancer: Special Emphasis on Prostate Cancer 癌症干细胞是癌症的关键：特别关注癌症
Global journal of medical research Pub Date : 2023-02-23 DOI: 10.34257/gjmrfvol23is2pg17
Ghayeel Abo Kassm, Gaelle Antar, Maya Atwi, Tony Butrus, Elias Hajjar, Osamah Jaafar, Marita Machrekeki, Eddy Mikhael, Jessica Swesa, Fadi Mikhae, Muriel T. Zaata
{"title":"Cancer Stem Cells as the Key to Cancer: Special Emphasis on Prostate Cancer","authors":"Ghayeel Abo Kassm, Gaelle Antar, Maya Atwi, Tony Butrus, Elias Hajjar, Osamah Jaafar, Marita Machrekeki, Eddy Mikhael, Jessica Swesa, Fadi Mikhae, Muriel T. Zaata","doi":"10.34257/gjmrfvol23is2pg17","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is2pg17","url":null,"abstract":"Recent research into cancer stem cells has refined our knowledge of the origins, maintenance, and progression of cancer. The characteristics of tumor initiating cells and the stem-like properties of tumor side populations that appear to be responsible for tumor maintenance and metastasis have given insights into potential targets for the elimination of treatment-resistant and residual tumor cells. These insights have also provided inroads to understanding and preventing invasive and metastatic progression of cancer. In this review, we discuss recent advancements in understanding of tumor initiating cells and cancer stem cells and their implications on cancer pathobiology and treatment. The role of tumor initiating cell phenotypes on routes of metastasis and the use of stemness markers to guide prognosis and treatment are also discussed. Particular emphasis sections are included that focus on the role of stemness in the pathobiology and treatment of prostate cancer. Of particular interest is the correlation of stemness with decreased androgen receptor expression and resistance to anti-androgen therapy. The overview provided herein represents a primer for the understanding of current knowledge regarding cancer stem cells and their clinical implications in prostate and other cancer types.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46711411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cancer Prevention and Treatment Opportunity 癌症预防和治疗的机会
Global journal of medical research Pub Date : 2023-02-23 DOI: 10.34257/gjmrfvol23is2pg7
Vladimir N Pak
{"title":"A Cancer Prevention and Treatment Opportunity","authors":"Vladimir N Pak","doi":"10.34257/gjmrfvol23is2pg7","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is2pg7","url":null,"abstract":"Cancer disease results from mutations leading to apoptosis failure and immune system dysfunction. Because one in two people in developed counties will be diagnosed with cancer in their lifetimes, cancer and metastasis prevention should be ahead of therapies.The immune system in cancer patients is compromised and can be fixed with a reboot. The major oncofetal protein –alpha-feto protein –can deliver toxins instead of nutrients to the immune suppressor cells and kill them. The death of myeloid suppressor cells unleashes the immune attack on cancer cells, cancer stem cells, and metastases. Injectable and oral formulations of alpha-feto protein with toxins provide an opportunity to prevent and treat the disease.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48338777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between COVID-19 and use of Chlorine Dioxide Gas-Releasing Agents in Elementary Schools 新冠肺炎与小学使用二氧化氯气体释放剂的关系
Global journal of medical research Pub Date : 2023-02-23 DOI: 10.34257/gjmrfvol23is2pg1
Yoshinori Kubo, T. Miura, K. Obinata, K. Hisata, Mitsuyoshi Suzuki, Eisuke Inage, N. Yanagisawa, H. Shoji, N. Ogata, Jo Shibata, T. Shibata, T. Shimizu
{"title":"Relationship between COVID-19 and use of Chlorine Dioxide Gas-Releasing Agents in Elementary Schools","authors":"Yoshinori Kubo, T. Miura, K. Obinata, K. Hisata, Mitsuyoshi Suzuki, Eisuke Inage, N. Yanagisawa, H. Shoji, N. Ogata, Jo Shibata, T. Shibata, T. Shimizu","doi":"10.34257/gjmrfvol23is2pg1","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is2pg1","url":null,"abstract":"Chlorine dioxide has an inactivating effect on various types of viruses in vitro, including severe acute respiratory syndrome coronavirus 2. Therefore, chlorine dioxide gas can be used as a new preventive measure against coronavirus disease 19 (COVID-19). However, no studies have been conducted to investigate the relationship between the incidence of COVID-19 and chlorine dioxide. We retrospectively studied the occurrence of COVID-19 in 164 public elementary schools under the jurisdiction of boards of education located in urban areas in Japan, provided with chlorine dioxide gas-releasing agents or not, from January to March 2022. The odds of developing COVID-19 were lower (odds ratio: 0.934, 95% confidence interval: 0.895–0.975) in schools provided with chlorine dioxide gas-releasing agents than in schools without them. This suggested a relationship between the use of chlorine dioxide-releasing agents and the incidence of COVID-19. Further studies are needed to prove a causal relationship between them.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45706821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Resilience of 3rd and 4th Grade Students. Semester, in Times of Covid 19, at the Autonomous University of Chihuahua. Case: Faculty of Accounting and Administration 三、四年级学生的心理弹性。新冠肺炎疫情期间，奇瓦瓦自治大学的学期。案例:会计与管理学院
Global journal of medical research Pub Date : 2023-02-22 DOI: 10.34257/gjmrcvol23is1pg11
Dra. Myrna Isela García Bencomo, Dra. Brenda Guadalupe Burciaga Sánchez, Dr. Jesús Robles Villa, M. A. K. I. Holguín Magallane
{"title":"The Resilience of 3rd and 4th Grade Students. Semester, in Times of Covid 19, at the Autonomous University of Chihuahua. Case: Faculty of Accounting and Administration","authors":"Dra. Myrna Isela García Bencomo, Dra. Brenda Guadalupe Burciaga Sánchez, Dr. Jesús Robles Villa, M. A. K. I. Holguín Magallane","doi":"10.34257/gjmrcvol23is1pg11","DOIUrl":"https://doi.org/10.34257/gjmrcvol23is1pg11","url":null,"abstract":"The general objective was to identify the resilience of 3rd and 4th grade students. Semester in time of Covid 19 at the Faculty of Accounting and Administration of the Autonomous University of Chihuahua. It was carried out from March to December 2021. It was a mixed research, of an applied, non-experimental, transactional, hypothetical-deductive, field type with bibliographic support, with a sampling frame obtained from the list of students from the periods January-June and August-December 2021 for the 3rd and 4th semester, provided by the Academic Secretary of the Faculty of Accounting and Administration of the Autonomous University of Chihuahua. Non-probabilistic sampling, for convenience.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47709550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review 一例乳腺癌症患者并发孤立性声带麻痹的重症肌无力副肿瘤综合征：病例报告和文献回顾
Global journal of medical research Pub Date : 2023-02-08 DOI: 10.34257/gjmravol23is1pg27
David G. Morrison, Chrystina Castellon
{"title":"Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review","authors":"David G. Morrison, Chrystina Castellon","doi":"10.34257/gjmravol23is1pg27","DOIUrl":"https://doi.org/10.34257/gjmravol23is1pg27","url":null,"abstract":"53-year-old lady presented with progressively worsening loss of voice. Over time she could only be heard upon speaking directly into the ears of her family or physicians. She lost her job as a receptionist due to her loss of voice. She was still on adjuvant treatment for breast cancer. She underwent CT/PET, ENT consultation and a battery of paraneoplastic antibody tests. ENT consultation confirmed vocal cord paralysis. ENT exam and CT/PET found no evidence of vocal cord mass or any lesion compressing the laryngeal nerves. No mass was found in the superior mediastinum. She had a positive antibody test for anti-acetylcholine receptors. Treatment with pyridostigmine reversed her vocal cord paralysis. This is the first report of a patient with breast cancer associated paraneoplastic myasthenia gravis syndrome.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48053522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theuse of LCZ-696(Sacubitril/Valsartan) and SGLT2inhibitors: A Real World Experience in a Rural African Patient with Heart Failure with Reduced Ejection Fraction (HFrEF). A Case Series LCZ-696(Sacubitril/缬沙坦)和sgl2抑制剂的使用:非洲农村心力衰竭伴射血分数降低(HFrEF)患者的真实世界经验案例系列
Global journal of medical research Pub Date : 2023-02-06 DOI: 10.34257/gjmrfvol23is1pg1
D. Raphael, G. Makuka, Abdu Hussein Mogella, Beatrice Kabuka, Rosemary T. Mushi, Collins Boamah
{"title":"Theuse of LCZ-696(Sacubitril/Valsartan) and SGLT2inhibitors: A Real World Experience in a Rural African Patient with Heart Failure with Reduced Ejection Fraction (HFrEF). A Case Series","authors":"D. Raphael, G. Makuka, Abdu Hussein Mogella, Beatrice Kabuka, Rosemary T. Mushi, Collins Boamah","doi":"10.34257/gjmrfvol23is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is1pg1","url":null,"abstract":"Objective: To observe the outcomes of the use of both Angiotensin Receptor-Neprilysin inhibitor (ARNI) and sodium-glucose cotransport 2-inhibitor (SGLT2Ii) in terms of echocardiographic parameters, clinical symptoms, cardiovascular death, and Heart failure hospitalization in patient with heart failure reduced ejection fraction (HFrEF) in the hard-to-reach rural area of Africa.\u0000Background: Angiotensin Receptor-Neprilysin inhibitor (ARNI) is preferred over angiotensin-converting enzymes inhibitor or an angiotensin II receptor blocker as foundation therapy for patients with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death, Heart failure hospitalization, and Heart failure symptoms. SGLT2 inhibitor (Dapagliflozin and Empagliflozin) is among the four foundation drugs in managing HFrEF.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43966929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Subjective Dizziness, Tinnitus, Headache, Taste, and Smell Results by Age Group in Yakumo Town Residents Health Checkup Conducted in 2019 with Measured Taste and Smell Test Results 2019年屋云镇居民健康体检中各年龄组主观头晕、耳鸣、头痛、味觉、嗅觉结果与味觉、嗅觉实测结果的比较
Global journal of medical research Pub Date : 2023-01-16 DOI: 10.34257/gjmrlvol22is3pg1
N. Katayama
{"title":"Comparison of Subjective Dizziness, Tinnitus, Headache, Taste, and Smell Results by Age Group in Yakumo Town Residents Health Checkup Conducted in 2019 with Measured Taste and Smell Test Results","authors":"N. Katayama","doi":"10.34257/gjmrlvol22is3pg1","DOIUrl":"https://doi.org/10.34257/gjmrlvol22is3pg1","url":null,"abstract":"A self-administered questionnaire survey is conducted on various items related to health at the residents’ examination conducted in Yakumo Town, Nikai-gun, Hokkaido, where population migration is small. \u0000We will report on the results of the otolaryngology questionnaire survey conducted in 2019.\u0000The target population is 128 males and 169 females who are residents of Yakumo Town over 40 years old, for a total of 297 people.\u0000Self-administered questionnaire survey (feeling conscious: vertigo, tinnitus, headache, hearing, taste, smell), taste test (Salt taste: Salseve; manufactured by Advantech), and smell test (12 kinds of odors: Smell sticks; Daiichi Factory C0., Ltd).","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42484802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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