Global journal of medical research最新文献

Gender Determination by Measuring the Mandibular Ramus and Body of the Mandible: A Retrospective Radiographic Study 通过测量下颌横突和下颌骨体来确定性别：一项回顾性影像学研究

Global journal of medical research Pub Date : 2024-03-06 DOI: 10.34257/gjmrjvol24is1pg5

Dr. Kirti Saharan, Dr. Shivaprasad S., Dr. Ashok L.

引用次数: 0

Hepatitis C Virus Infected Human Megakaryocytes and Platelets: Intra-and Extracellular Evaluation 受丙型肝炎病毒感染的人类巨核细胞和血小板：细胞内和细胞外评估

Global journal of medical research Pub Date : 2024-02-24 DOI: 10.34257/gjmrcvol24is1pg1

Caroline Mitiká Watanabe, Nathália Almeida Souza Tancler, Aline Márcia Marques Braz, Shelly Favorito de Carvalho, Giovanni Faria Silva, Maria Inês de Moura Campos Pardini, Maria Aparecida Custódio Domingues, Guilherme Targino Valente, Paulo Eduardo de Abreu Machado, Rejane Maria Tommasini Grotto, Marjorie de Assis Golim

引用次数: 0

Preferential Induction of Canonical IMD and Toll Innate Immune Receptors by BacterialChallenges in Triatoma Pallidipennis Primed with Gram-Negative and Gram-Positive Bacteria, Respectively 用革兰氏阴性菌和革兰氏阳性菌引诱的苍蝇蝽在细菌挑战下分别优先诱导典型 IMD 和 Toll Innate 免疫受体

Global journal of medical research Pub Date : 2024-02-23 DOI: 10.34257/ljmhrvol23is2pg1

Juárez-Palma Lilia, Alejandro Alvarado Delgado, Mario Henry Rodriguez

{"title":"Preferential Induction of Canonical IMD and Toll Innate Immune Receptors by Bacterial\u0000Challenges in Triatoma Pallidipennis Primed with Gram-Negative and Gram-Positive Bacteria, Respectively","authors":"Juárez-Palma Lilia, Alejandro Alvarado Delgado, Mario Henry Rodriguez","doi":"10.34257/ljmhrvol23is2pg1","DOIUrl":"https://doi.org/10.34257/ljmhrvol23is2pg1","url":null,"abstract":"Insects lack an adaptive immune defense against invading microorganisms, but they possess humoral and cellular response similar to that of vertebrates. The Immune Deficiency (IMD) and Toll are the major signaling pathways to produce humoral antimicrobial peptides AMPs. Pathogen molecular patterns (PAMs) of Gram-negative bacteria activate Pattern recognition receptors (PRR) of the IMD pathway, while PAMS of Gram-positive activate PRR of the Toll pathway. Although the IMD pathways is incomplete in Hemipterans, in Triatoma pallidipennis, there is a preferential participation of the IMD pgrp-lc and toll receptors in the responses to Gramnegative and Gram-positive bacteria, respectively. Still, as in other insects, cross induction was observed. An enhanced protection after a previous exposure to a pathogen, termed priming, functionally homologous to the adaptive immune memory of vertebrates, has been documented in several insect Orders but not in Hemiptera, and the participation of the components of the immune signaling cascades remains poorly explored. We present evidence for immune priming to Micrococcus luteus (Gram-positive) and Escherichia coli (Gramnegative) bacteria in T. pallidipennis. The preferential participation of receptors of the IMD and Toll pathways in the responses to each bacterial challenge was recorded","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"25 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPIB Unveiled: A Comprehensive Pan-Cancer Exploration Unraveling Immunological Signatures and Prognostic Implications PPIB 揭开面纱：揭示免疫学特征和预后意义的泛癌症综合探索

Global journal of medical research Pub Date : 2024-02-22 DOI: 10.34257/gjmrfvol24is1pg1

Ouyang Yan, Qi Dai, Shengming Lai, Haiyan Huang, Yongsheng Huang, Shuwei Ren

引用次数: 0

Self-Reported Cardiovascular Risk Factors among Medical Students 医学生自述的心血管风险因素

Global journal of medical research Pub Date : 2024-02-22 DOI: 10.34257/gjmrfvol24is1pg13

Jéssica de Paula Chalup Junqueira, Lais de Souza Rodrigues, Maria Aparecida de Almeida Souza Rodrigues, Ivana Picone Borges de Aragão

{"title":"Self-Reported Cardiovascular Risk Factors among Medical Students","authors":"Jéssica de Paula Chalup Junqueira, Lais de Souza Rodrigues, Maria Aparecida de Almeida Souza Rodrigues, Ivana Picone Borges de Aragão","doi":"10.34257/gjmrfvol24is1pg13","DOIUrl":"https://doi.org/10.34257/gjmrfvol24is1pg13","url":null,"abstract":"Cardiovascular diseases are the leading cause of death in the world, with smoking, diabetes, high blood pressure, dyslipidemia and a sedentary lifestyle being among the main risk factors. The objective of this study was to evaluate the self knowledge about cardiovascular risk factors among medical students.\u0000Methodology: Observational and cross-sectional study on students from the first to the eighth semester of medicine using anonymous questionnaires containing questions about cardiovascular risk factors.\u0000Results: A total of 288 students paticipeted. There was a higher percentage of self-declared emotional stress (p<0.001), and high blood pressure (p=0.007), family history of coronary heart disease (CAD) or stroke (0.049) in the female group; The group under 20 years old practiced more physical activity (p=0.023) and reported a balanced diet (p=0.047), the age group between 20 and 29 years old reported a higher percentage of smoking (p=0.001) and alcohol consumption (p=0.048), those older than 30 years old reported a higher knowledge about family history of CAD or stroke.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"16 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why Citicoline (A Medical Food) Should Not be Prescribed to Treat People with Acute Ischemic Stroke: The Certainty of the Evidence 为什么不应将西替考林（一种医用食品）用于治疗急性缺血性中风患者？证据的确定性

Global journal of medical research Pub Date : 2024-02-19 DOI: 10.34257/ljmhrvol24is2pg19

Prof. Arturo Martí Carvajal, MD, MSc. PhD

{"title":"Why Citicoline (A Medical Food) Should Not be Prescribed to Treat People with Acute Ischemic Stroke: The Certainty of the Evidence","authors":"Prof. Arturo Martí Carvajal, MD, MSc. PhD","doi":"10.34257/ljmhrvol24is2pg19","DOIUrl":"https://doi.org/10.34257/ljmhrvol24is2pg19","url":null,"abstract":"Background: Citicoline, a medical food prescribed for ischemic stroke, faces scrutiny due to itsb unproven ef icacy and potential harms. This essay, drawing on a recent Cochrane review and focusing solely on all-cause mortality, advocates for a critical reevaluation of its use. Rather than of ering an updated Cochrane review, this\u0000analysis provides a reflective perspective through the lens of Evidence-based Medicine and Philosophy of Science.\u0000Question Research: Why citicoline (a medical food) should not be prescribed to treat people with acute ischemic stroke: The certainty of the Evidence.?\u0000Objective: Demonstrate from evidence-based medicine and philosophy of science perspective that citicoline should not be prescribed for acute ischemic stroke due to lack of ef icacy and harm uncertainties.\u0000Search publications: We searched in PubMed and Cochrane Library from 2020 until 30 October 2023. We, furthermore, used engineering machines Bing and Google Scholar to detec additional papers. Additionally, we also reviewed reference lists of the retrieved\u0000publications and review articles and searched the websites of the U. S. Food and Drug\u0000Administration (FDA) and European Medicines Agency (EMA).\u0000Selection criteria: We included systematic reviews, meta-analyses, randomized clinical\u0000trials, clinical guidelines focused on acute ischemic stroke and comparing citicoline versus placebo or no intervention. We excluded narrative reviews, observational studies and ongoing trials.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"70 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Strategies for Dental Anatomy Education: A Qualitative Exploration of Online Learning Perceptions 牙科解剖学教育的创新策略：在线学习感知的定性探索

Global journal of medical research Pub Date : 2024-01-08 DOI: 10.34257/gjmrjvol23is4pg9

Suveer Sachdeva, Susha Rajadurai

引用次数: 0

Influence of Piperine on Collagen Color and Degree of Conversion of a Universal Adhesive System Applied to Bleached Dentin 胡椒碱对应用于漂白牙本质的通用粘合剂系统的胶原蛋白颜色和转化程度的影响

Global journal of medical research Pub Date : 2024-01-08 DOI: 10.34257/gjmrjvol23is4pg1

Flávia Maria Noronha Nigri, L. Aragão, Wildson Max Barbosa da Silva, Guida H.M. do Nascimento, Solange de Oliveira Pinheiro, Juliana Paiva Marques Lima Rolim, D. Cunha, Paulo Goberlânio de Barros Silva, Phillipe Nogueira Barbosa Alencar, J. Neri

{"title":"Influence of Piperine on Collagen Color and Degree of Conversion of a Universal Adhesive System Applied to Bleached Dentin","authors":"Flávia Maria Noronha Nigri, L. Aragão, Wildson Max Barbosa da Silva, Guida H.M. do Nascimento, Solange de Oliveira Pinheiro, Juliana Paiva Marques Lima Rolim, D. Cunha, Paulo Goberlânio de Barros Silva, Phillipe Nogueira Barbosa Alencar, J. Neri","doi":"10.34257/gjmrjvol23is4pg1","DOIUrl":"https://doi.org/10.34257/gjmrjvol23is4pg1","url":null,"abstract":"Aims: The aim was to evaluate the influence of piperine on the collagen staining and on the degree of conversion of the universal adhesive system applied to the bleached dentin. \u0000Methods: The piperine extraction process was carried out using a water reflux system and confirmed by UV-Vis spectrophotometry. For collagen staining analysis, dentin collagen disk were analyzed with a spectrophotometer. Regarding the collagen color evaluation, there was no statistically significant difference between the groups regarding ΔL, Δa, Δb e ΔE (p>0,05). \u0000Results: Regarding the degree of conversion, there was no statistically significant difference between without hydrogen peroxide, PH + 0,001% piperine, PH + 0,002% piperine and PH + 0,004% piperine (p>0,05). \u0000Conclusions: It is possible to conclude that piperine, did not change the color of the dentin collagen and avoided the reduction in the degree of conversion of a universal adhesive system applied immediately after bleaching with 35% hydrogen peroxide.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphism of Rs1800629 Gene of TNF-Α in the Pathogenesis of Acne Vulgaris TNF-Α 基因 Rs1800629 在大疱性痤疮发病机制中的多态性

Global journal of medical research Pub Date : 2024-01-02 DOI: 10.34257/gjmrfvol23is10pg1

Nilufar N. Malikova, K. Karimov, S. Arifov, K. Boboev

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Profile of Work Accidents in the Building and Public Works Sector BTP about 8 Companies in Conakry 建筑和公共工程部门工伤事故概况 BTP 关于科纳克里的 8 家公司

Global journal of medical research Pub Date : 2024-01-02 DOI: 10.34257/gjmrbvol23is3pg9

Habib Toure, Bocar Baila Diedhiou, Cheik amadou Toure, Armandine Eusebia Roseline Diatta

引用次数: 0