British Journal of Radiology最新文献

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Impact of steatotic liver disease on hepatitis B-related hepatocellular carcinoma: MRI manifestation and prognostic potential. 脂肪变性肝病对乙型肝炎相关肝细胞癌的影响:MRI表现和预后潜力
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf121
Beixuan Zheng, Yuyao Xiao, Fei Wu, Chun Yang, Ruofan Sheng, Mengsu Zeng
{"title":"Impact of steatotic liver disease on hepatitis B-related hepatocellular carcinoma: MRI manifestation and prognostic potential.","authors":"Beixuan Zheng, Yuyao Xiao, Fei Wu, Chun Yang, Ruofan Sheng, Mengsu Zeng","doi":"10.1093/bjr/tqaf121","DOIUrl":"10.1093/bjr/tqaf121","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the impact of steatotic liver disease (SLD) on hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) in clinical and MRI manifestations and prognostic potential.</p><p><strong>Methods: </strong>Four hundred and forty-one HBV-related HCC patients were retrospectively enrolled (mean age 55.5 years ±10.8, 366 males, 237 without and 204 with concurrent SLD). Kaplan-Meier analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS). Clinical and MRI characteristics were compared. Univariate and multivariate analyses were used to identify the different imaging features between patients with and without concurrent SLD.</p><p><strong>Results: </strong>Patients with concurrent SLD had a better OS (P = .047). Except for metabolism-related indicators, the level of alpha fetoprotein (Z = 7.82, P = .007), the grade of tumour lesion (χ2 = 6.567, P = .035) and microvascular invasion (χ2 = 6.252, P = .044) appeared to be lower in patients with SLD. According to the multivariate analysis, non-adjacent to porta hepatis or confluence of hepatic veins (odds ratio [OR] = 1.624, P = .041), absent washout appearance (OR = 2.047, P = .001) and intact enhancing capsule (OR = 2.584, P = .003) were significantly different MRI manifestations between tumours with and without SLD.</p><p><strong>Conclusions: </strong>For HBV-related HCC, concurrent SLD tended to be associated with better OS. The clinical and radiological characteristics were different, which seemed to be less aggressive for those with concurrent SLD.</p><p><strong>Advances in knowledge: </strong>Concurrent SLD in HBV-related HCC patients may be associated with better overall survival, and it exhibits distinct clinical and radiological features, which seem to be less aggressive.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1313-1320"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI-based distal femur cortical thickness analysis for osteoporosis detection. 基于mri的股骨远端皮质厚度分析用于骨质疏松症检测。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf132
Sevde Nur Emir, Servet Emir
{"title":"MRI-based distal femur cortical thickness analysis for osteoporosis detection.","authors":"Sevde Nur Emir, Servet Emir","doi":"10.1093/bjr/tqaf132","DOIUrl":"10.1093/bjr/tqaf132","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the presence of osteoporosis by measuring the distal femur cortex thickness on routine knee MRI performed for any reason. We aim to determine if these measurements can serve as a reliable indicator of bone mineral density (BMD) and thus facilitate early diagnosis of osteoporosis.</p><p><strong>Methods: </strong>A retrospective study was conducted with approval from the hospital's Ethics Committee. Patients who underwent dual-energy X-ray absorptiometry (DXA) and knee MRI within 6 months were included. Exclusion criteria were patients under 18, those with a gap of more than 6 months between scans, prior knee surgeries, trauma, bone tumours, or non-diagnostic MRI results. MRI examinations were performed on a 1.5 Tesla scanner. Measurements included average cortical bone thickness (CBTavg), distal femoral cortical index-1 (DFCI-1), and distal femoral cortical index-2 (DFCI-2). A radiologist blinded to DXA scores conducted the measurements. Statistical analyses were performed using the Mann-Whitney U test and receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>A total of 74 patients were included. Significant differences were found between the normal BMD group and the osteopenia/osteoporosis group for CBTavg, DFCI-1, and DFCI-2 (P < 0.01). ROC analysis showed high diagnostic accuracy with an area under the curve (AUC) of 0.92 for CBTavg, 0.90 for DFCI-1, and 0.91 for DFCI-2. Optimal cut-off values were determined as 4.52 mm for CBTavg, 2.58 mm for DFCI-1, and 1.12 mm for DFCI-2.</p><p><strong>Conclusion: </strong>The study demonstrates that osteopenia/osteoporosis can be effectively diagnosed using distal femur cortex thickness measurements on routine knee MRI. These measurements provide a simple, fast, and practical method for opportunistically detecting osteoporosis, facilitating early intervention and management.</p><p><strong>Advances in knowledge: </strong>This study is the first to demonstrate that distal femur cortex thickness measurements on routine knee MRI can effectively predict osteoporosis, offering a novel, opportunistic screening method that enhances early detection and intervention strategies.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1327-1332"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High resolution-dynamic characterization of cardiac masses: radio-frequency spoiled 3D gradient echo sequence. 高分辨率-心脏肿块的动态特征-射频破坏三维梯度回波序列。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf093
Elif Peker, Sena Ünal, Ruhi Erdem Ergüden, Nil Sezer Yılmazer Zorlu, Sena Bozer Uludağ
{"title":"High resolution-dynamic characterization of cardiac masses: radio-frequency spoiled 3D gradient echo sequence.","authors":"Elif Peker, Sena Ünal, Ruhi Erdem Ergüden, Nil Sezer Yılmazer Zorlu, Sena Bozer Uludağ","doi":"10.1093/bjr/tqaf093","DOIUrl":"10.1093/bjr/tqaf093","url":null,"abstract":"<p><strong>Objectives: </strong>Volumetric interpolated breath-hold examination (VIBE) sequence is a radio-frequency-spoiled gradient echo sequence that is mostly used in the evaluation of soft tissues, allows dynamic high-resolution images to be taken in 30 seconds of breath-holding time in MRI, and is used to create 3D images. In this study, we aimed to determine the detectability of cardiac masses and thrombi and their differentiation from the blood pool with the T1 VIBE imaging method.</p><p><strong>Methods: </strong>Precontrast, early and late postcontrast VIBE images were evaluated. Lesion contours were drawn with a free-hand regìon of ìnterest (ROI) in the phase in which the lesion was better depicted. All ROIs were placed in the phase where the lesion appeared best and then copied to other phases.</p><p><strong>Results: </strong>Sìgnal to noìse ratìo (SNR) was calculated as SI/SD of background intensity, CNR was calculated as SNR thrombus-SNR myocardium and SNR thrombus-SNR blood pool. SNR and CNR values of thrombus, blood pool, and myocardium measured at maps and contrast-enhanced images were compared with each other.</p><p><strong>Conclusions: </strong>There are many sequences used routinely to detect cardiac masses and thrombi. Many of these techniques require long acquisition time. With the VIBE sequence, precontrast, arterial, and venous images of the lesion can be obtained quickly. Although the SNR and CNR values obtained with VIBE images are lower than those with routine post-contrast images, our study can be considered a preliminary study for future studies to evaluate dynamic images.</p><p><strong>Advances in knowledge: </strong>For our knowledge, this is the first paper written on the visual assessment of cardiac masses on VIBE images.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1233-1235"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of contrast-enhanced agent on segmentation using a deep learning-based software "Ai-Seg" for head and neck cancer. 使用基于深度学习的软件“Ai-Seg”对头颈癌进行对比增强剂对分割的影响。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf108
Sayaka Kihara, Yoshihiro Ueda, Shuichi Harada, Akira Masaoka, Naoyuki Kanayama, Toshiki Ikawa, Shoki Inui, Takashi Akagi, Teiji Nishio, Koji Konishi
{"title":"Impact of contrast-enhanced agent on segmentation using a deep learning-based software \"Ai-Seg\" for head and neck cancer.","authors":"Sayaka Kihara, Yoshihiro Ueda, Shuichi Harada, Akira Masaoka, Naoyuki Kanayama, Toshiki Ikawa, Shoki Inui, Takashi Akagi, Teiji Nishio, Koji Konishi","doi":"10.1093/bjr/tqaf108","DOIUrl":"10.1093/bjr/tqaf108","url":null,"abstract":"<p><strong>Objectives: </strong>In radiotherapy, auto-segmentation tools using deep learning assist in contouring organs-at-risk (OARs). We developed a segmentation model for head and neck (HN) OARs dedicated to contrast-enhanced (CE) computed tomography (CT) using the segmentation software, Ai-Seg, and compared the performance between CE and non-CE (nCE) CT.</p><p><strong>Methods: </strong>The retrospective study recruited 321 patients with HN cancers and trained a segmentation model using CE CT (CE model). The CE model was installed in Ai-Seg and applied to additional 25 patients with CE and nCE CT. The Dice similarity coefficient (DSC) and average Hausdorff distance (AHD) were calculated between the ground truth and Ai-Seg contours for brain, brainstem, chiasm, optic nerves, cochleae, oral cavity, parotid glands, pharyngeal constrictor muscle, and submandibular glands (SMGs). We compared the CE model and the existing model trained with nCE CT available in Ai-Seg for 6 OARs.</p><p><strong>Results: </strong>The CE model obtained significantly higher DSCs on CE CT for parotid and SMGs compared to the existing model. The CE model provided significantly lower DSC values and higher AHD values on nCE CT for SMGs than on CE CT, but comparable values for other OARs.</p><p><strong>Conclusions: </strong>The CE model achieved significantly better performance than the existing model and can be used on nCE CT images without significant performance difference, except SMGs. Our results may facilitate the adoption of segmentation tools in clinical practice.</p><p><strong>Advances in knowledge: </strong>We developed a segmentation model for HN OARs dedicated to CE CT using Ai-Seg and evaluated its usability on nCE CT.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1272-1280"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploiting the endothelial-immune axis to improve radiotherapy efficacy. 利用内皮-免疫轴提高放疗疗效。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf114
Olivier Guipaud, Claire Lago, Lucie Portier, Vincent Paget, Agnès François, Stéphane Supiot, Fabien Milliat
{"title":"Exploiting the endothelial-immune axis to improve radiotherapy efficacy.","authors":"Olivier Guipaud, Claire Lago, Lucie Portier, Vincent Paget, Agnès François, Stéphane Supiot, Fabien Milliat","doi":"10.1093/bjr/tqaf114","DOIUrl":"10.1093/bjr/tqaf114","url":null,"abstract":"<p><p>The immune system is essential for controlling tumours and plays a crucial role in how normal and cancer tissues respond to radiotherapy. Lining the inner surface of vessels, the endothelium acts as a barrier that normally prevents the passage of cells from the bloodstream into tissues and promotes the recruitment of immune cells during stressful, injured, or infected conditions. Profound changes in endothelial function occur in response to irradiation, determining the tumour response to radiotherapy and participating in the initiation and development of adverse effects. In both normal tissues and tumours, radiation makes endothelial cells more adhesive to circulating cells, stimulates transendothelial migration and promotes immune infiltration, possibly chronic and harmful to normal tissues. Considering the active role of endothelium in immune cell recruitment, targeting endothelial cells becomes an attractive strategy to improve the therapeutic gain of radiotherapy. To this end, it is crucial to better understand how endothelial cells respond to irradiation in vivo and to determine their role in regulating immune cell recruitment. Advanced analytical technologies, such as single-cell RNA sequencing and spatial transcriptomics, now enable to uncover the molecular responses of cells in living organisms and comprehend their interactions within an organ. Here, we present the latest findings regarding the impact of radiation on the vascular endothelium and its implications for normal tissues and tumours. We also explore current research using single-cell analysis to uncover new cell types, molecular pathways, and cell-cell interactions in irradiated animal models and human patients. Additionally, we highlight how endothelial cell-mediated immune recruitment may represent a potential target for modulating the immune response.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1176-1187"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phenotyping pulmonary sarcoidosis. 肺结节病的表型分析。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf118
Hiba Abbas, Maria Kokosi, Nishanth Sivarasan
{"title":"Phenotyping pulmonary sarcoidosis.","authors":"Hiba Abbas, Maria Kokosi, Nishanth Sivarasan","doi":"10.1093/bjr/tqaf118","DOIUrl":"10.1093/bjr/tqaf118","url":null,"abstract":"<p><p>Pulmonary sarcoidosis, although generally associated with a good prognosis, remains challenging to manage in view of its unpredictable disease behaviour and outcome. Being able to phenotype patients with sarcoidosis could potentially facilitate treatment decisions and promote research anchored to disease behaviour and outcome. Efforts to phenotype sarcoidosis using imaging date back to the early 1900s when chest X-rays were the main modality for lung parenchymal evaluation. However, despite significant advances in technology, there is currently no consensus on how we should classify this disease utilizing more modern imaging techniques. In this review, we provide an overview of imaging phenotypes in sarcoidosis, discuss the challenges of disease classification, evaluate associations between imaging appearance and outcome, and explore new developments in this field.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1188-1196"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging of cancer of unknown primary: a systematic literature review of the past, present, and future. 原发不明的癌症影像学:对过去、现在和未来的系统文献综述。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf039
Sajjad Rostami, Hannah W Stutterheim, Olga Maxouri, Jeroen R J Willemse, Diana Ivonne Rodríguez Sánchez, Winnie Schats, Larissa W van Golen, Marieke A Vollebergh, Zing Cheung, Wouter V Vogel, Serena Marchetti, Petur Snaebjornsson, Max J Lahaye, Doenja M J Lambregts, Zuhir Bodalal, Regina G H Beets-Tan
{"title":"Imaging of cancer of unknown primary: a systematic literature review of the past, present, and future.","authors":"Sajjad Rostami, Hannah W Stutterheim, Olga Maxouri, Jeroen R J Willemse, Diana Ivonne Rodríguez Sánchez, Winnie Schats, Larissa W van Golen, Marieke A Vollebergh, Zing Cheung, Wouter V Vogel, Serena Marchetti, Petur Snaebjornsson, Max J Lahaye, Doenja M J Lambregts, Zuhir Bodalal, Regina G H Beets-Tan","doi":"10.1093/bjr/tqaf039","DOIUrl":"10.1093/bjr/tqaf039","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the evolution and current diagnostic capabilities of medical imaging in cancer of unknown primary (CUP) and explore promising technologies for enhancing diagnostic precision.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across MEDLINE, Embase, and Scopus in March 2023 (updated in August 2024) to identify original articles focusing on CUP imaging. Two reviewers independently selected articles and extracted data. Quality assessment was performed using QUADAS-2 and Radiomics Quality Score. Given the variability in study designs, imaging techniques, and reported outcomes, a narrative synthesis was performed. Subgroup analyses compared detection rates across modalities.</p><p><strong>Results: </strong>From 4760 de-duplicated search results, 140 original articles were included. Early CUP imaging relied on 2D modalities with notable diagnostic limitations. Modern 3D modalities have risen in prominence, though mammography and ultrasound remain in CUP guidelines. Implementing CT and MRI significantly improved primary tumour detection and disease characterization. CT is fundamental for CUP evaluation, and MRI offers superior soft tissue resolution, effective for detecting occult breast cancer, head and neck primaries, and suspected abdominopelvic neoplasms. FDG-PET/CT showed varying primary detection capabilities, adding value in identifying lesions/metastases missed by other modalities, essential for confirming locoregional treatment strategies. Emerging technologies for CUP imaging include whole-body MRI, FAPI-PET/CT, and AI/radiomics.</p><p><strong>Conclusions: </strong>Advancements in imaging have improved the diagnostic workup for CUP. Innovative approaches show potential for further improvement in diagnostic accuracy.</p><p><strong>Advances in knowledge: </strong>This study provides a comprehensive overview of CUP imaging and introduces emerging modalities that could boost diagnostic accuracy.</p><p><strong>Prospero registration: </strong>CRD42023453393.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1209-1226"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeated ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein thrombus. 肝细胞癌合并门静脉血栓的超声选择性动脉化疗栓塞治疗。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf112
Akira Yamamoto, Ken Kageyama, Atsushi Jogo, Etsuji Sohgawa, Ryuichi Kita, Sawako Uchida-Kobayashi, Shigekazu Takemura, Akihiro Tamori, Toshio Kaminou, Yukio Miki
{"title":"Repeated ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma with portal vein thrombus.","authors":"Akira Yamamoto, Ken Kageyama, Atsushi Jogo, Etsuji Sohgawa, Ryuichi Kita, Sawako Uchida-Kobayashi, Shigekazu Takemura, Akihiro Tamori, Toshio Kaminou, Yukio Miki","doi":"10.1093/bjr/tqaf112","DOIUrl":"10.1093/bjr/tqaf112","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the safety and long-term effectiveness of repeated ultraselective transarterial chemoembolization (rusTACE) using a 1.7-Fr-tip microcatheter in hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT).</p><p><strong>Methods: </strong>This retrospective analysis includes HCC patients with PVTT treated with rusTACE between May 2014 and July 2022. A 1.7-Fr-tip microcatheter was used to perform rusTACE for ultraselective embolization of the tumour-feeding artery. Treatment was repeated at least 2 times within 2 months. Treatment responses, survival rates, adverse event, liver function, and tumour-feeding arteries were assessed.</p><p><strong>Results: </strong>Twenty patients underwent rusTACE with a mean interval of 42 days between treatments. RusTACE was well-tolerated. Median survival time was 26.1 months, with 1-, 2-, 3-, and 5-year survival rates of 85.0%, 61.0%, 40.9%, and 24.6%, respectively. Complete response (CR) of PVTT was achieved in 75%. Among these, 35% maintained CR of PVTT throughout follow-up (mean, 25.0 months). Univariate analysis showed prognostic factors included Child-Pugh score 5, CR of PVTT, CR of systemic tumours at the end of rusTACE, and liver tumour burden <30%. In 17%, a peribiliary vascular plexus or communicating artery was identified as the tumour-feeding artery.</p><p><strong>Conclusions: </strong>RusTACE is a safe and effective treatment option for HCC with PVTT in selected patients (Child-Pugh class A). RusTACE showed a high CR rate and long overall survival. The short interval between treatments and ultraselective embolization of tumour-feeding arteries contributed to favourable outcomes.</p><p><strong>Advances in knowledge: </strong>RusTACE can be safely performed in HCC with PVTT and has a high local control rate.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1290-1297"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI. 定量运动在克罗恩病评估狭窄组成的电影mri。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf120
Kim J Beek, Kyra L van Rijn, Catherina S de Jonge, Floris A E de Voogd, Christianne J Buskens, Jarmila van der Bilt, Willem Bemelman, Geert D'Haens, Aart Mookhoek, E Andra Neefjes-Borst, Karin Horsthuis, Jeroen A W Tielbeek, Krisztina B Gecse, Jaap Stoker
{"title":"Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI.","authors":"Kim J Beek, Kyra L van Rijn, Catherina S de Jonge, Floris A E de Voogd, Christianne J Buskens, Jarmila van der Bilt, Willem Bemelman, Geert D'Haens, Aart Mookhoek, E Andra Neefjes-Borst, Karin Horsthuis, Jeroen A W Tielbeek, Krisztina B Gecse, Jaap Stoker","doi":"10.1093/bjr/tqaf120","DOIUrl":"10.1093/bjr/tqaf120","url":null,"abstract":"<p><strong>Objectives: </strong>The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (i.e., non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (i.e., inflammatory and mixed) from chronic (i.e., non-inflammatory) strictures using quantified motility measured on cine-MRI in Crohn's disease (CD) patients.</p><p><strong>Methods: </strong>In this prospective cross-sectional study, consecutive CD patients scheduled for small bowel resection underwent 2D cine-MRI prior to surgery. The motility of small bowel strictures and pre-stricture dilatations was quantified using a validated post-processing method (GIQuant). The resection specimens were scored by two pathologists as either: predominantly inflammatory, mixed, or predominantly chronic (i.e., non-inflammatory). For the analysis, strictures were stratified into inflammatory strictures (i.e., predominantly inflammatory and mixed) and chronic (i.e., non-inflammatory) strictures.</p><p><strong>Results: </strong>Twenty-eight patients were included with 30 strictures and 15 pre-stricture dilatations. Pre-stricture dilatation motility was higher for chronic (i.e., non-inflammatory) compared to inflammatory (i.e., inflammatory and mixed) strictures (289.5 AU [188.0-362.9] vs. 113.1 AU [83.6-142.4], P = .004). The area under the curve (AUC) for chronic (i.e., non-inflammatory) stricture detection was 0.93 (95% CI, 0.78-1.0, P = .01). Within strictures, no difference was found between motility in different histopathology categories (P = .6).</p><p><strong>Conclusion: </strong>Motility in the pre-stricture dilatations of chronic (i.e., non-inflammatory) strictures was higher compared to inflammatory (i.e., inflammatory and mixed) strictures. No difference in motility was observed in stricture motility among stricture subtypes. Our findings suggest that quantified motility-measured with cine-MRI-of pre-stricture dilatations could possibly distinguish chronic (i.e., non-inflammatory) strictures from inflammatory (i.e., inflammatory and mixed) strictures.</p><p><strong>Advances in knowledge: </strong>Motility measured with cine-MRI could provide an imaging biomarker for the distinction between chronic (i.e., non-inflammatory) and inflammatory (i.e., inflammatory and mixed) strictures in CD.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1245-1254"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factors of biochemical recurrence and impact of pre-treatment MRI for prostate cancer radiotherapy. 生化复发的预后因素及术前MRI对前列腺癌放疗的影响。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-08-01 DOI: 10.1093/bjr/tqaf122
Noah Margolese, Johanna Dahan, Damien A R Olivié, Jean-Sébastien Billiard, Guila Delouya, Daniel Taussky
{"title":"Prognostic factors of biochemical recurrence and impact of pre-treatment MRI for prostate cancer radiotherapy.","authors":"Noah Margolese, Johanna Dahan, Damien A R Olivié, Jean-Sébastien Billiard, Guila Delouya, Daniel Taussky","doi":"10.1093/bjr/tqaf122","DOIUrl":"10.1093/bjr/tqaf122","url":null,"abstract":"<p><strong>Objectives: </strong>We conducted an analysis of the prognostic implications of MRI findings prior to radiotherapy in patients diagnosed with prostate cancer.</p><p><strong>Methods: </strong>Patients from our institutional database who were treated with radiotherapy between 2014-2024 were searched for diagnostic MRI. The prognostic significance of PI-RADS score, index-lesion diameter, and Cancer of the Prostate Risk Assessment (CAPRA) score on biochemical recurrence was analysed.</p><p><strong>Results: </strong>Of the 1480 patients, 499 (33.7%) underwent a diagnostic pre-treatment MRI; 49.5% were treated with low-dose brachytherapy, 29.8% with external beam radiation therapy (EBRT) plus a high-dose rate brachytherapy boost, and 20.7% with EBRT alone. Among the patients who underwent MRI, 404 (81%) had PI-RADS 4-5, including 35% with lesions ≥15 mm and 20% with lesions ≥20 mm. The median follow-up period was 44 months (IQR:23-66). Among the 78 patients who subsequently experienced biochemical recurrence, 16 underwent a diagnostic MRI prior to treatment. CAPRA score did not correlate with lesion diameter (P = 0.4). In univariate analysis, lesions ≥15 mm (P = 0.026) and ≥20 mm (P < 0.001) were significant predictors, as was CAPRA score (P < 0.001). In multivariate analyses, lesion size ≥20 mm (hazard ratio [HR], 3.49; 95%CI:1.25-9.76, P = 0.017) but not ≥15 mm significantly predicted recurrence. Stratified by CAPRA, only in high-risk cancers (score 6-10, 21% of patients) was a lesion ≥20 mm a significant predictor (P < 0.001).</p><p><strong>Conclusions: </strong>We determined that a lesion on MRI with a diameter of ≥20 mm was an independent prognostic factor for biochemical recurrence, particularly in high-risk cancers. Whether the radiation dose-escalation of these lesions can improve clinical outcomes must be determined.</p><p><strong>Advances in knowledge: </strong>We found that a prostate lesion on MRI with a diameter ≥20 mm was associated with poorer outcomes following radiotherapy.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"1321-1326"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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