British Journal of Radiology最新文献

{"title":"Real world clinical experience of using Brainomix e-CTA software in a medium size acute National Health Service Trust.","authors":"Fraser Merchant, James Choulerton, Richard James, Chun Lap Pang","doi":"10.1093/bjr/tqaf019","DOIUrl":"10.1093/bjr/tqaf019","url":null,"abstract":"<p><strong>Objectives: </strong>Artificial intelligence (AI) software including Brainomix \"e-CTA\" which detect large vessel occlusions (LVO) have clinical potential. We hypothesized that in real world use where prevalence is low, its clinical utility may be overstated.</p><p><strong>Methods: </strong>In this single centre retrospective service evaluation project, data sent to Brainomix from a medium size acute National Health Service (NHS) Trust hospital between January 3, 2022 and January 3, 2023 was reviewed. 584 intracranial computed tomography angiogram (CTA) datasets were analysed for LVO by e-CTA. The e-CTA output and radiology report were compared to ground truth, defined by a consultant radiologist with fellowship neuroradiology training, with access to subsequent imaging and clinical notes. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.</p><p><strong>Results: </strong>Of 584 cases (45% female, mean age 70 ± 16 years), 9% (n = 50) had LVO. e-CTA had a sensitivity of 0.78 (95% CI 0.64-0.88), specificity of 0.93 (0.9-0.95), PPV of 0.5 (0.42-0.58), and NPV of 0.98 (0.96-0.99). e-CTA had an error rate of 9% (52/584). Erroneous cases were categorized into causes for error. Common causes for false positives included incorrect anatomy (21%, 8/39) and other pathology (13%, 5/39), with several uncategorizable cases (39%, 15/39). Common causes for false negatives included LVO within the terminal internal carotid artery (ICA) (55%, 6/11) and uncategorizable (18%, 2/11).</p><p><strong>Conclusions: </strong>We demonstrated that PPV of e-CTA is poor in consecutive cases in a real-world NHS setting. We advocate for local validation of AI software prior to clinical use.</p><p><strong>Advances in knowledge: </strong>Common AI errors were due to anatomical misidentification, presence of other pathology, and misidentifying LVO in the terminal ICA.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"592-599"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic contrast enhanced MRI in nodal lymphoma: correlation of quantitative MR perfusion parameters with lymphoma subtype, Lugano stage, and Ki-67 index.","authors":"Rohit Kataria, Rohini Gupta Ghasi, Satya Pal Kataria, Sachin Kolte","doi":"10.1093/bjr/tqaf016","DOIUrl":"10.1093/bjr/tqaf016","url":null,"abstract":"<p><strong>Background: </strong>Research into the intratumoural microenvironment in lymphoma has been escalated along with improved survival and new targeted therapies with an intent to refine risk stratification and prognostication. Various studies have reported significance of quantitative DCE-MRI parameters for predicting biological behaviour of various tumours. This study is an endeavour to supplement the existing literature on quantitative DCE-MRI in nodal lymphoma.</p><p><strong>Objectives: </strong>To study the correlation of quantitative DCE-MRI parameters of Ktrans, Kep, and Ve with subtype, Lugano stage at diagnosis and Ki-67 proliferation index (PI) in nodal lymphoma.</p><p><strong>Methods: </strong>33 patients of age >12 years with newly diagnosed nodal lymphoma underwent DCE-MRI. Ktrans, Kep, and Ve were generated from extended Tofts model and correlated with lymphoma subtype, Lugano staging, and Ki-67 PI.</p><p><strong>Results: </strong>Mean Ktrans and Kep values were significantly higher in non-Hodgkin's lymphoma than in Hodgkin's lymphoma. Considering Ki-67 PI value of >45% as aggressive lymphoma, the mean Ktrans (659.37 × 10-3 min-1 vs 288.00 × 10-3 min-1, P < .001) and Kep (1256.63 × 10-3 min-1 vs 689.82 × 10-3 min-1, P = .004) values in aggressive lymphomas were significantly higher compared to non-aggressive lymphomas. ROC curve analysis revealed a threshold Ktrans value of ≥359 × 10-3 min-1 and Kep value of ≥853 × 10-3  min-1 for diagnosing aggressive lymphomas with a sensitivity of 95%, 90%, specificity of 100%,82%, and diagnostic accuracy of 91.7%,86.7%, respectively. There was no significant difference in DCE-MRI parameters of various Lugano stage subgroups.</p><p><strong>Conclusion: </strong>DCE-MRI parameters have the potential to non-invasively predict the subtype, aggression and Ki-67 PI in nodal lymphoma.</p><p><strong>Advances in knowledge: </strong>The knowledge that Ktrans is higher in aggressive lymphomas is novel. It adds to previous literature regarding MR perfusion in various neoplasms.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"586-591"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of anti-cancer drugs: the imaging findings to watch out for in common cancers.","authors":"Vishnu Prasad Pulappadi, Krithika Rangarajan, Raja Pramanik, Mukesh K Yadav, Sanjay Thulkar","doi":"10.1093/bjr/tqaf021","DOIUrl":"10.1093/bjr/tqaf021","url":null,"abstract":"<p><p>A multitude of drugs are used for the treatment of various types of cancers. They consist of conventional cytotoxic agents and newer targeted agents. Both types of agents produce a variety of side effects by their effect on normal cells of the body. Regardless of whether they produce any symptoms or not, a proportion of these side effects can be visualized on imaging, and their identification is crucial for guiding further management. While some of the adverse effects are mild and tolerable, many others require dose reduction and even withdrawal of the drug. A few of these manifestations may resemble tumour progression or recurrence on imaging. Therefore, appropriate knowledge regarding the imaging manifestations of the adverse effects caused by the chemotherapeutic agents used for various types of cancers is an integral part of onco-radiology practice. In this review, the common adverse effects of various anti-cancer drugs have been described based on the type of malignancy in which they occur, rather than based on the organ affected. This would allow the radiologist to look for common side effects while reading the scan of a patient with a specific cancer.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"509-516"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine concentration in the lung parenchyma in relation to different inspiratory depths during CT pulmonary angiography.","authors":"Koichiro Yasaka, Hiroyuki Saigusa, Osamu Abe","doi":"10.1093/bjr/tqaf008","DOIUrl":"10.1093/bjr/tqaf008","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the impact of changing inspiratory depth from end- to mid-inspiratory level on the iodine concentration in the lung parenchyma and main pulmonary artery in dual-energy CT pulmonary angiography.</p><p><strong>Methods: </strong>This retrospective study included patients who underwent dual-energy CT pulmonary angiography from July 2020 to June 2023. Patients were instructed to hold their breath at end- and mid-inspiratory levels before and after January 2022, respectively. By placing regions of interest on the lung lobes and main pulmonary artery in the iodine map, their iodine concentration was recorded.</p><p><strong>Results: </strong>In end- and mid-inspiratory command, 173 (mean age: 63.4 ± 17.0 years; 68 males) and 179 (mean age: 65.1 ± 15.4 years; 62 males) patients, respectively, were included. The mean iodine concentrations of the right upper, right middle, right lower, left upper, and left lower lobes were 0.81/0.91, 0.67/0.74, 1.06/1.07, 0.85/0.95, and 1.07/1.11 mgI/mL, respectively, for the end-/mid-inspiratory level. The multivariable regression analysis revealed inspiratory depth as a significant factor for iodine concentration of the right upper, right middle, and left upper lobes. Main pulmonary artery iodine concentration in mid-inspiratory depth (13.21 mgI/mL) was higher than that in end-inspiratory depth (12.51 mgI/mL) (P = .129), and a statistically significant difference was observed in the patient group with a body weight of ≥70 kg (P = .015).</p><p><strong>Conclusions: </strong>Changing inspiratory depth from end- to mid-inspiratory level has a significant impact on the iodine concentration in the upper and right middle lobes in dual-energy CT pulmonary angiography.</p><p><strong>Advances in knowledge: </strong>Changing inspiratory depth from end- to mid-inspiratory level has significantly increased the iodine concentration in the right upper, right middle, and left upper lobes.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"556-561"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study of microwave ablation for Bethesda IV follicular neoplasms (≤3 cm).","authors":"Xin-Yu Yu, Xin-Yi Zhou, Ying Wei, Zhen-Long Zhao, Li-Li Peng, Yan Li, Jie Wu, Shi-Liang Cao, Ming-An Yu","doi":"10.1093/bjr/tqaf015","DOIUrl":"10.1093/bjr/tqaf015","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the feasibility, safety, and efficacy of microwave ablation (MWA) for the treatment of patients with Bethesda IV follicular neoplasms (FNs) (≤3 cm).</p><p><strong>Methods: </strong>In the retrospective study, patients who underwent MWA for Bethesda IV FNs (≤3 cm) were included. Technical success, volume reduction, disease progression, and adverse event (AE) rates were analysed postablation.</p><p><strong>Results: </strong>The study cohort consisted of 44 patients with a mean age of 48.2 ± 15.7 years. The median follow-up period was 16 months (interquartile range [IQR]: 9-24 months). The technical success rate was 100%. The median volume reduction ratio (VRR) reached 100% (IQR: 98.8%-100.0%) after the 18th month of follow-up. The disease progression rate was 4.5% (2/44), and both of those patients experienced local recurrence. The overall AE rate was 9.1% (4/44), and AEs included 3 cases of voice hoarseness and 1 case of cough.</p><p><strong>Conclusion: </strong>This study presents promising clinical outcomes regarding the feasibility, efficacy, and safety of MWA for the treatment of patients with Bethesda IV FNs ≤ 3 cm.</p><p><strong>Advances in knowledge: </strong>The study highlights the high technical success rate, low disease progression rate and AE rate of MWA for FNs, which underscores its potential for broader application. Future research should aim to validate these results in larger populations to increase the scope of therapy for FNs.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"578-585"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of non-gated 4-min delayed dual-energy CT for myocardial extracellular volume quantification.","authors":"Tsukasa Kojima, Yuzo Yamasaki, Daisuke Nishigake, Takashi Shirasaka, Masatoshi Kondo, Kazuhito Hioki, Takeshi Kamitani, Toyoyuki Kato, Kousei Ishigami","doi":"10.1093/bjr/tqaf022","DOIUrl":"10.1093/bjr/tqaf022","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate the myocardial extracellular volume (ECV) obtained from non-electrocardiography (ECG)-gated delayed CT images acquired 4 min post-contrast infusion (4-min-non-ECG-ECV) compared with the ECV obtained from ECG-gated delayed CT images acquired 10 min post-contrast infusion (Conv-ECV).</p><p><strong>Methods: </strong>We retrospectively analysed 29 patients (males: 21) after a comprehensive CT protocol of both 4-min-non-ECG-ECV and Conv-ECV on a dual-layer CT scanner. The mean volume of contrast medium administered was 90 ± 11.8 mL, and the average heart rate during the CT examinations was 74.2 ± 18.2 bpm. Two independent observers calculated the respective 4-min-non-ECG-ECV and Conv-ECV. We determined the correlation between the ECV obtained by the 2 methods and conducted a Bland-Altman analysis to identify systematic errors and determine the limits of agreement (LOA) between the 4-min-non-ECG-ECV and Conv-ECV values.</p><p><strong>Results: </strong>The respective median ECV values for observer 1 were 27.3 for 4-min-non-ECG-ECV and 26.5 for Conv-ECV; for observer 2, they were 27.8 and 27.1. The correlation between the methods was 0.97 for both observers (P < .01). The Bland-Altman plots for observers 1 and 2 demonstrated a minor bias (-0.2% and -0.5%, respectively), with the 95% LOA ranges at -4.4% to 4.0% and -5.0% to 4.0%, respectively.</p><p><strong>Conclusion: </strong>The 4-min-non-ECG-ECV provided ECV values comparable to those obtained by Conv-ECV.</p><p><strong>Advances in knowledge: </strong>Myocardial ECV quantification is feasible using a non-gated, 4-min delayed dual-energy CT scan with an already established CT acquisition method. This approach achieves ECV accuracy comparable to that of the conventional CT-ECV calculation method (gated 10-min delayed imaging) while enhancing clinical efficacy and diagnostic throughput.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"600-606"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of indocyanine green lymphography imaging for the diagnosis of primary lymphoedema.","authors":"Greta Brezgyte, Mike Mills, Malou van Zanten, Kristiana Gordon, Peter S Mortimer, Pia Ostergaard","doi":"10.1093/bjr/tqaf006","DOIUrl":"10.1093/bjr/tqaf006","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review aims to evaluate the use of indocyanine green lymphography (ICGL) for the investigation of the lymphatics in the lower limbs of primary lymphoedema patients.</p><p><strong>Methods: </strong>MEDLINE and EMBASE articles from January 1, 2000 to September 1, 2023 were searched for. A total of 11 studies were included in the review after a two-stage screening process.</p><p><strong>Results: </strong>Data on patient demographics, ICG contrast injection technique, imaging protocols, and imaging outcomes were summarized and reviewed in detail. The review highlights the lack of commonality in protocols used. Factors important for good imaging are highly variable, particularly the number of injections, their location, and whether they are delivered intradermally or subcutaneously.</p><p><strong>Conclusions: </strong>ICGL has strong potential to become a diagnostic tool to diagnose lymphoedema due to its non-ionizing nature and cost-effectiveness. However, due to the lack of thorough phenotyping and genotyping of patients included in the studies, uncertainty still exists as to the value of the described imaging features such as splash, starburst, and diffuse dermal rerouting patterns. Future studies, therefore, should aim to explore the diagnostic utility of ICGL for lymphoedema further through the imaging of primary lymphoedema patients with a confirmed genetic diagnosis and using standardized imaging protocols.</p><p><strong>Advances in knowledge: </strong>ICGL is a strong candidate for advancing the diagnosis and understanding of primary lymphoedema, and monitoring response to treatment, but protocol heterogeneity and a lack of consistency in reporting imaging details and patient phenotyping currently hold it back.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"517-526"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiology's Role in Providing and Ensuring Access to Reproductive Care.","authors":"Katherine Frederick-Dyer, Mindy M Horrow, Theresa M Caridi, Rochelle F Andreotti","doi":"10.1093/bjr/tqaf071","DOIUrl":"https://doi.org/10.1093/bjr/tqaf071","url":null,"abstract":"<p><p>The U.S. Supreme Court Dobbs decision has significantly impacted reproductive healthcare in the USA. While obstetricians are most directly affected, radiologists, radiation oncologists, and medical imaging professionals are also involved in the care of pregnant patients, and these legislative changes can alter our practices. In this commentary, we describe examples of how this reproductive legal landscape has changed the practice of interventional radiology in states affected by abortion bans, discuss some of the radiologist lead advocacy efforts for the preservation of reproductive healthcare, and review the Society of Radiologists in Ultrasound's first trimester ultrasound consensus statement clarifying and standardizing medical terminology frequently used in radiologist reports. The radiology community has a responsibility to advocate for the preservation of reproductive health and the patient-physician relationship.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous ultra-high resolution multi-energy cardiac imaging in a dual-source photon counting detector CT system.","authors":"Elisabeth Shanblatt, Kishore Rajendran, Joseph Robert Swicklik, Thomas Allmendinger, Bernhard Schmidt, Thomas Flohr, Cynthia H McCollough, Shuai Leng","doi":"10.1093/bjr/tqaf069","DOIUrl":"https://doi.org/10.1093/bjr/tqaf069","url":null,"abstract":"<p><strong>Objectives: </strong>To assess quantitative and qualitative image characteristics in phantoms and patients using a simultaneous ultra-high resolution (UHR) and multi-energy (ME) dual-source cardiac scan mode in a photon counting detector (PCD) CT scanner.</p><p><strong>Methods: </strong>UHR-ME cardiac scans were performed to determine the spatial resolution and multi-energy performance. UHR reconstructions were completed to measure transverse and axial spatial resolution in terms of modulation transfer function (MTF) and slice sensitivity profile (SSP). Virtual monoenergetic images (VMIs), virtual non-contrast (VNC) images, and iodine concentration images were created using moderately sharp reconstruction kernels to assess ME performance. With IRB approval, coronary CT angiograms were acquired in 19 patients using the UHR-ME mode, from which iodine contrast-to-noise ratio (CNR) was measured. Various ME post-processing tasks were performed to show the utility of the spectral capabilities.</p><p><strong>Results: </strong>VMIs showed a mean CT number error of 5.9%, while iodine accuracy was 0.75 mg/cc (root-mean-square-error). Spatial resolution matched well with a standard UHR mode. Patient images showed a trend of higher CNR at lower keV, while higher keV images showed decreased calcium blooming. ME techniques to separate iodine and calcium were used successfully.</p><p><strong>Conclusions: </strong>The combination of UHR-ME cardiac mode retains UHR image quality while providing flexibility for ME post-processing.</p><p><strong>Advances in knowledge: </strong>Cardiac UHR-ME scanning offers simultaneous ultra-high-resolution and ME imaging without loss of spatial or temporal resolution or quantitative accuracy.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of standardisation and challenges of dosimetry in conventional preclinical radiation biology research.","authors":"Mark A Hill, Ileana Silvestre Patallo, Adam H Aitkenhead, Magdalena Bazalova-Carter, Rebecca Carter, Simeon Nill, Andrew Nisbet, Mihaela Ghita-Pettigrew, Yannick Poirier, Kevin M Prise, Anna Subiel, Giuseppe Schettino","doi":"10.1093/bjr/tqaf066","DOIUrl":"https://doi.org/10.1093/bjr/tqaf066","url":null,"abstract":"<p><p>To fully exploit the prospects presented by the increasing focus on biological approaches for enhancing radiotherapy outcomes, improvements in repeatability and translatability of radiobiological and preclinical studies are required. This requires the development and adoption of appropriate dosimetric standards and reproducible approaches to increase confidence in the studies, enabling inter-laboratory validation and facilitating clinical translation. An IPEM Working-Party reviewed the current status and challenges associated with dosimetry of medium-energy X-rays and make recommendations with the aim to optimize the potential clinical significance of radiobiological preclinical investigations. The paper discusses the currently available resources with technical recommendations for performing dosimetry in medium-energy X-rays, along with the consequences of lack of standardization and implications of dose inhomogeneity. It is clear that there is still a gap in understanding the needs for standardisation of dosimetric aspects of preclinical and radiobiological studies. It is recommended that these radiobiology studies should be conducted in partnership with medical/radiation physicists. This collaboration ensures the correct utilization of suitable dosimetry systems, thus guaranteeing accuracy and consistency of dose delivery. Appropriate calibration and traceability to national/international standards laboratory, along with regular quality assurance of radiation devices are paramount to reproducibility. Additionally, it is critical that experimental details and associated dosimetry are sufficiently reported to ensure accurate replication that enables reanalysis including evaluation of dose distributions. Increasing awareness among the researchers and the funding bodies was identified as a crucial step to improve translatability and appropriate resources are budgeted to increase the value for money of research proposals. Advances in knowledge: The proposed recommendations will serve as a vital resource for researchers, encouraging uniformity in experimental design and improving the translatability of preclinical research to clinical settings.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}