British Journal of Radiology最新文献

{"title":"Air embolism after CT-guided transthoracic interventional operation: Is it necessary to change the patient's position to prevent embolized air from entering the systemic circulation.","authors":"Ran Yan, Zeng-Jian Yang, Zhen-Guo Huang, Hong-Liang Sun, Yan-Yan Xu, Yu-Li Wang, Bao-Xiang Gao, Chuan-Dong Li, Shi-Long Sun, Tong-Yin Zhang, Hao-Yu Li, Yu-Wan Hu","doi":"10.1093/bjr/tqaf078","DOIUrl":"https://doi.org/10.1093/bjr/tqaf078","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the influence of the patient's position on the entry of embolized air into the systemic circulation after air embolism (AE).</p><p><strong>Materials and methods: </strong>116 patients with AE were selected as study subjects, including 81 patients undergoing CT-guided transthoracic biopsy and 35 patients undergoing CT-guided localization of pulmonary nodule before video-assisted thoracoscopic surgery. While maintaining the patient's original position, 94 out of 116 patients underwent at least one follow-up CT within 5 to 15 minutes after AE. The following two situations were considered as embolized air entering into systemic circulation: (1) CT showed air in the aorta and/or branches; (2) Follow-up CT showed a decrease or disappearance of air in the left heart.</p><p><strong>Results: </strong>The positions of the 116 patients with AE included 6 in supine position (SP), 70 in prone position (PP), 20 in left lateral decubitus position (LLDP) and 20 in right lateral decubitus position (RLDP). Embolized air entering the systemic circulation occurred in 33.3% (2/6) patients in SP, 47.1% (33/70) patients in PP, 70% (14/20) patients in LLDP, and 55% (11/20) patients in RLDP. The difference is not statistically significant (χ2=4.16, p = 0.24).</p><p><strong>Conclusions: </strong>The proportion of embolized air entering the systemic circulation is similar among patients in SP, PP, LLDP and RLDP within 5-15 minutes after AE. The above four positions can not effectively prevent the embolized air from entering the systemic circulation.</p><p><strong>Advances in knowledge: </strong>Embolized air enters the systemic circulation within a few minutes in about half of patients with AE. Within 5-15 minutes after AE, the proportion of embolized air entering the systemic circulation is similar among patients in SP, PP, LLDP, and RLDP. Changing the patient's position after AE can not prevent embolized air from entering the systemic circulation.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative CT imaging: Where are we, and what is missing?","authors":"Kevin J Treb, Ahmed O El Sadaney, Andrea Ferrero, Francis I Baffour, Shuai Leng, Lifeng Yu, Prabhakar Shantha Rajiah, Joel G Fletcher, Cynthia H McCollough, Kishore Rajendran","doi":"10.1093/bjr/tqaf075","DOIUrl":"https://doi.org/10.1093/bjr/tqaf075","url":null,"abstract":"<p><p>Quantitative computed tomography (CT) enables the measurement of biophysical processes characterized by morphology, composition, flow and/or motion to aid in clinical diagnosis and intervention. Since its initial application for determining bone mineral density for skeletal fragility assessment, quantitative CT has continued to evolve alongside CT's technological advancements. A key challenge facing quantitative CT is the lack of standardization pertinent to image acquisition, reconstruction and image analysis. With the introduction of spectral CT involving dual-energy approaches and photon-counting detectors (PCD), we are now able to obtain detailed information regarding mass densities of endogenous and exogeneous materials. Further, energy-resolved CT yields spectral image types (e.g. virtual monoenergetic image) that are, in principle, independent of tube potential and patient size. This paves the way for workflow standardization and to improve the consistency and reproducibility of CT-derived measurements. In this article, we review clinical applications of quantitative CT, discuss key challenges associated with quantitative CT and its adoption into routine practice, and outline the unique benefits ushered by new CT technologies such as PCD-CT towards improving quantitative imaging.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic relevance of CT-defined body composition in patients with acute bleeding undergoing endovascular embolization.","authors":"Simon Riegelbauer, Matthias Mehdorn, Manuel Florian Struck, Hans-Michael Tautenhahn, Uwe Scheuermann, Sebastian Ebel, Timm Denecke, Hans-Jonas Meyer","doi":"10.1093/bjr/tqaf011","DOIUrl":"10.1093/bjr/tqaf011","url":null,"abstract":"<p><strong>Objectives: </strong>Body composition assessment includes the parameter skeletal muscle mass, subcutaneous and visceral adipose tissue (SAT and VAT). The purpose of this study was to elucidate associations of body composition parameters with mortality in patients with acute bleeding undergoing transarterial embolization (TAE).</p><p><strong>Methods: </strong>A mixed cohort of patients from 2018 to 2022 with acute bleeding requiring treatment with a TAE was retrospectively evaluated. In every case, the triphasic CT to diagnose the source of bleeding was used to calculate the body composition parameters.</p><p><strong>Results: </strong>A total of 251 patients (93 female, 37.1%) with a mean age of 65.5 ± 14.3 years, 30-d mortality of 40.2%, and 24-h mortality of 7.6% were included in the analysis. In the Cox regression analysis, no statistically significant correlations were found between the body composition parameters and 24-h or 30-day mortality. In the subgroup analysis of patients aged older than 65 years, skeletal muscle index was associated with short-term 24-h mortality HR of 0.95 (95% CI 0.90; 0.99, P = .035).</p><p><strong>Conclusions: </strong>The present study demonstrated the prognostic impact of clinical, laboratory, aniography-related, and CT-defined body composition in patients with acute haemorrhage undergoing endovascular therapy. Although the overall effect of CT-defined body composition appears to be small, skeletal muscle index was a prognostic factor in the age group over 65 years.</p><p><strong>Advances in knowledge: </strong>This is a large single-centre study to investigate the prognostic relevance of CT-defined body composition in patients undergoing TAE. The effect is overall small but might be further investigated in older patients in further trials.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"571-577"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal infections update: how radiologists can contribute to patient care.","authors":"Jorge Abreu-Gomez, Vanessa Murad, Shereen Ezzat, Patrick J Navin, Antonio C Westphalen","doi":"10.1093/bjr/tqaf025","DOIUrl":"10.1093/bjr/tqaf025","url":null,"abstract":"<p><p>Adrenal infections are considered clinically important but often go unrecognized, with a significant number of cases only diagnosed post-mortem. The limited evidence regarding imaging findings in the literature emphasizes the need to detect and diagnose these infections early in disease course to improve patient outcomes. A range of microorganisms, including fungi, viruses, parasites, and bacteria, can directly or indirectly affect the morphology and function of the adrenal glands. When evaluating a patient with adrenal infection, several immunological and hormonal factors should be considered, such as the status of the hypothalamic-pituitary-adreno cortical axis and the serum cortisol level. Moreover, certain microorganisms specifically target one of the zones of the adrenal glands or vascular supply, resulting in distinct imaging manifestations. The purpose of this article is to describe the fundamental clinical features and imaging manifestations associated with adrenal infections, enabling radiologists to make informed interpretations and contribute to accurate diagnostic assessments.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"496-508"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurrence of CT-based radiological sarcopenia and frailty are related to impaired survival in surgical oncology.","authors":"Linda B M Weerink, Barbara L van Leeuwen, Thomas C Kwee, Claudine J C Lamoth, Barbara C van Munster, Geertruida H de Bock","doi":"10.1093/bjr/tqaf023","DOIUrl":"10.1093/bjr/tqaf023","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to investigate the association of radiological sarcopenia and frailty with postoperative outcomes in adult patients undergoing oncological surgery.</p><p><strong>Methods: </strong>Data were derived from the PICNIC study, consisting of two consecutive series of patients undergoing surgical cancer treatment. Radiological sarcopenia was assessed based on CT imaging. The presence of low muscle mass and/or low muscle density was determined based on lowest quartile gender specific cut-off values. Frailty was defined by a score of ≥4 on the Groningen frailty index. Postoperative overall survival was analysed with Kaplan-Meier curves and Logrank testing. Multivariable Cox regression analyses adjusted for age and gender were performed to calculate adjusted hazard ratios (HR).</p><p><strong>Results: </strong>A total of 372 patients were included. Median age was 69 (28-86) years, 77 patients (23.5%) were frail and radiological sarcopenia was present in 134 patients (41.0%). Combined radiological sarcopenia and frailty was present in 35 patients (10.7%). One-year (65.6% versus 87.0%) and three-year survival (31.4% versus 66.8%) were significantly worse in patients with combined radiological sarcopenia and frailty. The combined presence of radiological sarcopenia and frailty was associated with significantly decreased overall survival (HRadjusted: 2.06, 95% CI: 1.39-3.05, P < .001).</p><p><strong>Conclusion: </strong>Co-occurrence of radiological sarcopenia and frailty is strongly related to impaired survival in surgical cancer patients.</p><p><strong>Advances in knowledge: </strong>The combined presence of radiological sarcopenia and frailty is associated with decreased postoperative survival, strongly exceeding the effects of both risk factors separately. The use of radiological sarcopenia in addition to frailty screening can further optimize preoperative risk stratification.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"607-613"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion-weighted imaging to predict longer-term response in Crohn's disease patients commencing biological therapy: results from the MOTILITY trial.","authors":"Maira Hameed, Stuart A Taylor, Norin Ahmed, Kashfia Chowdhury, Anisha Patel, Emma Helbren, Anisha Bhagwanani, Rachel Hyland, Gauraang Bhatnagar, Harbir Sidhu, Hannah Lambie, James Franklin, Maryam Mohsin, Elen Thomson, Darren Boone, Damian Tolan, Safi Rahman, Naomi S Sakai, Gordon W Moran, Alisa Hart, Stuart Bloom, Alex Menys, Ilan Jacobs, Steve Halligan, Andrew A Plumb","doi":"10.1093/bjr/tqaf013","DOIUrl":"10.1093/bjr/tqaf013","url":null,"abstract":"<p><strong>Objectives: </strong>Predicting longer-term response to biological therapy for small bowel Crohn's disease (SBCD) is an unmet clinical need. Diffusion-weighted magnetic resonance (MR) imaging (DWI) may indicate disease activity, but its predictive ability, if any, is unknown. We investigated the prognostic value of DWI for 1 year response or remission (RoR) in SBCD patients commencing biologic therapy, including incremental value over C-reactive protein (CRP) and faecal calprotectin (FC).</p><p><strong>Methods: </strong>A subset of participants in a prospective, multicentre study investigating the predictive ability of motility MRI for 1-year RoR in patients starting biologic therapy for active SBCD, underwent additional DWI at baseline and post-induction (12-30 weeks). CRP and FC were collected in a subgroup. RoR at 1 year was evaluated using clinical and morphological MR enterography (MRE) parameters. We calculated sensitivity and specificity to predict RoR and quality of life (QoL) at 1 year, comparing apparent diffusion coefficient (ADC) value, Clermont score, and CRP using multivariable logistic regression.</p><p><strong>Results: </strong>A total of 25 participants were included (mean 36.9 years, 32% female). ADC changes and Clermont score had poor sensitivity (30.0% [95% CI, 6.7-65.2] and 40.0% [95% CI, 12.2-73.8], respectively) and poor-to-modest specificity (50.0 [95% CI, 27.2-72.8] and 65.0% [95% CI, 40.8-84.6]) for RoR. None of Clermont score, CRP, or FC predicted QoL.</p><p><strong>Conclusions: </strong>DWI has inadequate sensitivity and specificity for RoR at 1 year. There is no significant incremental prognostic value of DWI over CRP and FC to predict RoR and/or QoL at 1 year.</p><p><strong>Advances in knowledge: </strong>Early post-induction DWI has no prognostic value for RoR at 1 year.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"527-534"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adaptive statistical iterative reconstruction-V algorithm and deep learning image reconstruction algorithm on image quality and emphysema quantification in COPD patients under ultra-low-dose conditions.","authors":"Guangming Ma, Yuequn Dou, Shan Dang, Nan Yu, Yanbing Guo, Dong Han, Chenwang Jin","doi":"10.1093/bjr/tqae251","DOIUrl":"10.1093/bjr/tqae251","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the effect of different reconstruction algorithms (ASIR-V and DLIR) on image quality and emphysema quantification in chronic obstructive pulmonary disease (COPD) patients under ultra-low-dose scanning conditions.</p><p><strong>Materials and methods: </strong>This prospective study with patient consent included 62 COPD patients. Patients were examined by pulmonary function test (PFT), standard-dose CT (SDCT) and ultra-low-dose CT (ULDCT). SDCT images were reconstructed with filtered-back-projection (FBP), while ULDCT images were reconstructed using FBP, 30%ASIR-V, 60%ASIR-V, 90%ASIR-V, low-strength (DLIR-L), medium-strength (DLIR-M) and high-strength DLIR (DLIR-H) to form 8 image sets. Images were analysed using a commercial computer aided diagnosis (CAD) software. Parameters such as image noise, lung volume (LV), emphysema index (EI), mean lung density (MLD) and 15th percentile of lung density (PD15) were measured. Two radiologists evaluated tracheal and pulmonary artery image quality using a 5-point scale. Measurements were compared and the correlation between EI and PFT indices was analysed.</p><p><strong>Result: </strong>ULDCT used 0.46 ± 0.22 mSv in radiation dose, 93.8% lower than SDCT (P < .001). There was no difference in LV and MLD among image groups (P > .05). ULDCT-ASIR-V90% and ULDCT-DLIR-M had similar image noise and EI and PD15 values to SDCT-FBP, and ULDCT-DLIR-M and ULDCT-DLIR-H had similar subjective scores to SDCT-FBP (all P > .05). ULDCT-DLIR-M provided the best correlation between EI and the FEV1/FVC and FEV1% indices in PFT, and the lowest deviations with SDCT-FBP in both EI and PD15.</p><p><strong>Conclusion: </strong>DLIR-M provides the best image quality and emphysema quantification for COPD patients in ULDCT.</p><p><strong>Advances in knowledge: </strong>Ultra-low-dose CT scanning combined with DLIR-M reconstruction is comparable to standard dose images for quantitative analysis of emphysema and image quality.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"535-543"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a scoring system to predict endovascular crossing of femoropopliteal artery chronic total occlusions: the Endo VAscular CROSsing Score for Chronic Total Occlusions (EVACROSS-CTO).","authors":"Nikolas Matthaiou, Michail E Klontzas, Konstantina Kasioumi, George A Kakkos, Elias Kehagias, Dimitrios Tsetis","doi":"10.1093/bjr/tqaf004","DOIUrl":"10.1093/bjr/tqaf004","url":null,"abstract":"<p><strong>Objectives: </strong>To develop a predictive score for the prediction of successful endovascular crossing in femoropopliteal artery chronic total occlusions (CTOs).</p><p><strong>Methods: </strong>In this retrospective study, 84 patients were divided 70%:30% into a training and a testing cohort. Parameters such as cap morphology, side branches, bridging collaterals, flush occlusion, and length were derived from pre-procedural CT angiography. Lesions were segmented and calcification burden was assessed by thresholding. A score (EndoVAscular CROSsing Score for Chronic Total Occlusion [EVACROSS-CTO]) was built based on multivariate logistic regression. Receiver operating characteristics (ROC) curve analysis determined the optimal score threshold, with reported accuracy, sensitivity, specificity, and area under the curve (AUC).</p><p><strong>Results: </strong>Factors including age > 50 years (P = .036, odds ratio (OR) = 53.7), calcification percentage >10% (P = .011, OR = 16.63), the presence of a flush occlusion (P = .02, OR = 15.564), the presence of a distal side branch (P = .018, OR = 9.879), and the presence of a proximal side branch (P = 0.064, OR = 23.369) were identified as suitable for inclusion in the score. Score values were assigned based on the relative odds ratio for each factor with a maximum score of 22. EVACROSS-CTO was able to predict the success of endovascular recanalization with an AUC-ROC of 79.8% (95% CI, 58.5%-100%). A score >16 yielded a sensitivity of 75% with a specificity of 70.6% for the prediction of treatment failure.</p><p><strong>Conclusions: </strong>A score was developed by incorporating variables derived from pre-procedural CT angiography, demonstrating promising predictive capacity in determining the success of endovascular recanalization of CTOs.</p><p><strong>Advances in knowledge: </strong>EVACROSS-CTO incorporates imaging variables for the prediction of endovascular recanalization success. This score will allow improved pre-procedural planning for femoropopliteal CTO management.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"551-555"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-in-the-loop machine learning-based quantitative assessment of hemifacial spasm based on volumetric interpolated breath-hold examination MR.","authors":"Zengan Huang, Xinyi Wang, Xiaoming Liu, Jingwen Li, Xinyu Hu, Qinwei Yu, Guiying Kuang, Nian Xiong, Yi Gao","doi":"10.1093/bjr/tqaf010","DOIUrl":"10.1093/bjr/tqaf010","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to assess the severity of hemifacial spasm (HFS) through quantitative measures that associated it with neurovascular contact (NVC).</p><p><strong>Methods: </strong>We enrolled 108 HFS patients (63 severe and 45 mild cases) and implemented a human-in-the-loop approach to develop a quantitative NVC feature package. This process involved using interactive segmentation on 3D volumetric interpolated breath-hold examination (VIBE) MR images to delineate vascular and nerve structures. From these segmentations, we extracted quantitative NVC features, forming an NVC feature package, and applied a support vector machine model to assess HFS severity.</p><p><strong>Results: </strong>Our interactive segmentation technique achieved high accuracy (Dice similarity coefficients of 0.905 ± 0.030 for vascular structures and 0.922 ± 0.086 for nerves). The NVC feature package, comprising distance between vascular structures and nerves, vascular diameter, their ratio, and clinical characteristics, enabled our model to assess HFS severity with an AUC of 0.823 (95% CI: 0.714-0.932, P < .001).</p><p><strong>Conclusions: </strong>This study introduced a quantitative approach in understanding the relationship between HFS severity and NVC, using VIBE MR imaging. Our model offers a promising tool for enhancing clinical decision-making and offers deeper insights into the impact of NVCon HFS, aiming to improve patient outcomes.</p><p><strong>Advances in knowledge: </strong>Microvascular decompression is well-established as a safe and effective treatment for HFS. However, there is a gap assessing the severity of HFS using quantitative measures that directly link it to NVC. Our method introduced a quantitative and objective alternative for assessing the severity of HFS to addressing this gap.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"562-570"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between sarcopenia and hypertrophy of the future liver remnant in patients undergoing portal vein embolization before liver resection.","authors":"Akhil Baby, Yashwant Patidar, Amar Mukund, Amol Srivastava, Niraj Kumar, Shridhar Vasantrao Sasturkar, Harsh Vardhan Tevethia, Viniyendra Pamecha","doi":"10.1093/bjr/tqaf003","DOIUrl":"10.1093/bjr/tqaf003","url":null,"abstract":"<p><strong>Objectives: </strong>To study the correlation between sarcopenia and hypertrophy of the future liver remnant (FLR) in patients undergoing portal vein embolization (PVE) before liver resection, and to assess the outcomes after resection.</p><p><strong>Methods: </strong>This retrospective study examined patients underwent PVE from May 2012 to May 2023. Demographic, clinical, and laboratory features were documented and total liver volumes and FLR volumes were measured before and 2-4 weeks after PVE. Degree of hypertrophy (DH), percentage hypertrophy (PH), and kinetic growth rate (KGR) of the FLR were calculated. Sarcopenia was defined using the skeletal muscle index (SMI) at the L3 vertebral level. Subcutaneous adipose index, visceral adipose index (VAI), cross-sectional area of psoas muscle at the largest diameter, and L3 vertebral level mean muscle attenuation (MA) were also assessed.</p><p><strong>Results: </strong>Forty patients were included in the analysis and the median age was 57.5 (IQR 51-64) and majority were males 27/40(67.5%). Twenty-two patients were non-sarcopenics and 18 were sarcopenics. All patients showed hypertrophy of FLR (P = 0.001). SMI demonstrated moderate positive correlations with DH (r = 0.46, P = 0.003), PH (r = 0.47, P = 0.002), and KGR (r = 0.44, P = 0.004). VAI showed weak positive correlations with DH (r = 0.22, P = 0.17), PH (r = 0.18, P = 0.27), and KGR (r = 0.14, P = 0.37). Pre-PVE FLR demonstrated a weak negative correlation with PH (r = -0.35, P = 0.03) and KGR (r = -0.12, P = 0.47).</p><p><strong>Conclusions: </strong>Sarcopenia, specifically SMI, significantly correlates with FLR hypertrophy after PVE. Assessment of sarcopenia and body compartments prior to PVE could help in stratifying and treats patients with impaired FLR growth.</p><p><strong>Advances in knowledge: </strong>This study with data spanning over 11 years, is the first in the Indian population to demonstrate a significant correlation between SMI, a marker of sarcopenia, and FLR hypertrophy following PVE.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"544-550"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}