Impact of steatotic liver disease on hepatitis B related hepatocellular carcinoma: MRI manifestation and prognostic potential.

IF 3.4 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Beixuan Zheng, Yuyao Xiao, Fei Wu, Chun Yang, Ruofan Sheng, Mengsu Zeng
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引用次数: 0

Abstract

Objectives: To investigate the impact of steatotic liver disease (SLD) on hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) in clinical and MRI manifestations and prognostic potential.

Methods: 441 HBV-related HCC patients were retrospectively enrolled (mean age 55.5 years ±10.8, 366 males, 237 without and 204 with concurrent SLD). Kaplan-Meier analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS). Clinical and MRI characteristics were compared. Univariate and multivariate analyses were used to identify the different imaging features between patients with and without concurrent SLD.

Results: Patients with concurrent SLD had a better OS (P = 0.047). Except for metabolism-related indicators, the level of alpha fetoprotein (Z = 7.82, P = 0.007), the grade of tumor lesion (χ2= 6.567, P = 0.035) and microvascular invasion (χ2= 6.252, P = 0.044) appeared to be lower in patients with SLD. According to the multivariate analysis, non-adjacent to porta hepatis or confluence of hepatic veins (odds ratio [OR]=1.624, P = 0.041), absent washout appearance (OR = 2.047, P = 0.001) and intact enhancing capsule (OR = 2.584, P = 0.003) were significantly different MRI manifestations between tumors with and without SLD.

Conclusions: For HBV-related HCC, concurrent SLD tended to be associated with better OS. The clinical and radiological characteristics were different, which seemed to be less aggressive for those with concurrent SLD.

Advances in knowledge: Concurrent SLD in HBV-related HCC patients may be associated with better overall survival, and it exhibits distinct clinical and radiological features, which seem to be less aggressive.

脂肪变性肝病对乙型肝炎相关肝细胞癌的影响:MRI表现和预后潜力
目的:探讨脂肪变性肝病(SLD)对乙型肝炎病毒(HBV)相关肝细胞癌(HCC)临床、MRI表现及预后的影响。方法:回顾性纳入441例hbv相关HCC患者(平均年龄55.5岁±10.8岁,男性366例,无SLD 237例,合并SLD 204例)。Kaplan-Meier分析比较总生存期(OS)和无复发生存期(RFS)。比较临床和MRI特征。采用单因素和多因素分析来确定合并和不合并SLD患者的不同影像学特征。结果:并发SLD患者有较好的OS (P = 0.047)。除代谢相关指标外,SLD患者甲胎蛋白水平(Z = 7.82, P = 0.007)、肿瘤病变程度(χ2= 6.567, P = 0.035)、微血管侵犯(χ2= 6.252, P = 0.044)均低于对照组。多因素分析显示,非肝门邻近或肝静脉汇合处(优势比[or]=1.624, P = 0.041)、无洗脱样表现(or = 2.047, P = 0.001)、增强囊完整(or = 2.584, P = 0.003)是伴、不伴SLD肿瘤的MRI表现有显著差异。结论:对于hbv相关的HCC,并发SLD往往与更好的OS相关。临床和放射学特征不同,对于并发SLD的患者,其侵袭性似乎较小。知识进展:hbv相关HCC患者并发SLD可能与更好的总生存率相关,并且其表现出独特的临床和放射学特征,似乎侵袭性较小。
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来源期刊
British Journal of Radiology
British Journal of Radiology 医学-核医学
CiteScore
5.30
自引率
3.80%
发文量
330
审稿时长
2-4 weeks
期刊介绍: BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option
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