Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI.

IF 3.4 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

British Journal of Radiology Pub Date : 2025-05-28 DOI:10.1093/bjr/tqaf120

K J Beek, K L van Rijn, C S de Jonge, F A E de Voogd, C J Buskens, J van der Bilt, W Bemelman, G D'Haens, A Mookhoek, E A Neefjes-Borst, K Horsthuis, J A W Tielbeek, K B Gecse, J Stoker

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引用次数: 0

Abstract

Objectives: The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (ie non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (ie inflammatory and mixed) from chronic (ie non-inflammatory) strictures using quantified motility measured on cine-MRI in CD patients.

Methods: In this prospective cross-sectional study consecutive CD patients scheduled for small bowel resection underwent 2D cine-MRI prior to surgery. Motility of small bowel strictures and pre-stricture dilatations was quantified using a validated post-processing method (GIQuant). The resection specimens were scored by two pathologists as either: predominantly inflammatory, mixed or predominantly chronic (ie non-inflammatory). For the analysis, strictures were stratified into inflammatory strictures (ie predominantly inflammatory and mixed) and chronic (ie non-inflammatory) strictures.

Results: Twenty-eight patients were included with thirty strictures and fifteen pre-stricture dilatations. Pre-stricture dilatation motility was higher for chronic (ie non-inflammatory) compared to inflammatory (ie inflammatory and mixed) strictures (289.5AU [188.0-362.9] vs.113.1AU [83.6-142.4], p=0.004). Area under the curve (AUC) for chronic (ie non-inflammatory) stricture detection was 0.93 (95% CI 0.78-1.0, p=0.01). Within strictures, no difference was found between motility in different histopathology categories (p=0.6).

Conclusion: Motility in the pre-stricture dilatations of chronic (ie non-inflammatory) strictures was higher compared to inflammatory (ie inflammatory and mixed) strictures. No difference in motility was observed in stricture motility among stricture subtypes. Our findings suggest that quantified motility-measured with cine-MRI-of pre-stricture dilatations could possibly distinguish chronic (ie non-inflammatory) strictures from inflammatory (ie inflammatory and mixed) strictures.

Advances in knowledge: Motility measured with cine-MRI could possibly provide an imaging biomarker for the distinction between chronic (ie non-inflammatory) and inflammatory (ie inflammatory and mixed) strictures in CD.

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定量运动在克罗恩病评估狭窄组成的电影mri。

目的：狭窄的组织病理学组成影响临床治疗选择。因此，能够区分主要炎症性和慢性（即非炎症性）狭窄的成像生物标志物是高度相关的。我们研究的目的是确定是否有可能区分炎症性（即炎症性和混合性）和慢性（即非炎症性）狭窄，使用电影mri测量CD患者的量化运动性。方法：在这项前瞻性横断面研究中，计划进行小肠切除术的连续CD患者在手术前进行了2D电影mri检查。使用经过验证的后处理方法（GIQuant）量化小肠狭窄和狭窄前扩张的运动性。切除标本由两名病理学家评分：主要是炎症，混合或主要是慢性（即非炎症）。为了进行分析，将狭窄分为炎症性狭窄（即主要炎症性和混合性）和慢性（即非炎症性）狭窄。结果：28例患者狭窄30例，狭窄前扩张15例。慢性（即非炎症性）狭窄比炎症性（即炎症性和混合性）狭窄更容易扩张（289.5AU [188.0-362.9] vs.113.1AU [83.6-142.4], p=0.004）。慢性（即非炎症性）狭窄的曲线下面积（AUC）为0.93 （95% CI 0.78-1.0, p=0.01）。在狭窄范围内，不同组织病理类型的运动性无差异（p=0.6）。结论：慢性（非炎症性）狭窄的狭窄前扩张的运动性高于炎症性（炎症性和混合性）狭窄。不同结构亚型间结构运动性无差异。我们的研究结果表明，用电影磁共振定量测量狭窄前扩张的运动性可能区分慢性（即非炎症性）狭窄和炎症性（即炎症性和混合性）狭窄。知识进展：电影mri测量的运动能力可能为区分慢性（即非炎症性）和炎症性（即炎症性和混合性）CD狭窄提供一种成像生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Radiology 医学-核医学

CiteScore

5.30

自引率

3.80%

发文量

330

审稿时长

2-4 weeks

期刊介绍： BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option