Nanoscale最新文献

{"title":"Harnessing Atomically Precise Metal Nanoclusters as Next-Generation Photocatalysts for CO2 Reduction","authors":"Anna Sebastian,Saptarshi Roy,Tapu Raihan Gazi,Rajanya Bera,Sathi Roy,Indranath Chakraborty","doi":"10.1039/d6nr03344j","DOIUrl":"https://doi.org/10.1039/d6nr03344j","url":null,"abstract":"Photocatalytic CO₂ conversion using solar energy offers a sustainable route to value-added fuels and chemicals. Atomically precise metal nanoclusters (NCs), with discrete electronic states, abundant active sites, and well-defined structures, are promising photocatalysts for this process. This Minireview summarizes recent advances in gold, silver, copper, and bimetallic NCs for photocatalytic CO₂ reduction, focusing on their reaction products, selectivity, and catalytic mechanisms. Strategies to enhance charge separation, migration, and catalytic performance are critically discussed. Finally, key challenges and future directions toward efficient, stable, and practically viable NC-based photocatalysts are highlighted.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"102 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanochemical exfoliation and functionalization of MoS2 in one step: a quick click method","authors":"Marina Garrido,Natalia Martin Sabanes,Emilio M Perez","doi":"10.1039/d6nr02215d","DOIUrl":"https://doi.org/10.1039/d6nr02215d","url":null,"abstract":"Chemical functionalization of molybdenum disulfide (MoS2) is an effective tool to fine tune its physico-chemical properties. Typically, this process occurs in two steps, first the exfoliation of bulk MoS2 and subsequently, the obtained layers are functionalized with the desired molecular fragment. However, this implies long times for the complete sequence. Herein we report the simultaneous exfoliation and functionalization of MoS2 with different maleimides in short times (10 min.) using mechanochemistry. The resulting few-layer functionalized MoS2 materials are thoroughly characterized by TEM, AFM, Raman spectroscopy, DRIFT, XPS, and solid-state 13C-NMR, collectively confirming both the exfoliation to few-layer flakes (average thickness 5 ± 1 nm) and the formation of covalent S-C bonds. Critically, the choice of maleimide functional group allows direct tuning of the dispersibility of the functionalized material in a range of green solvents, yielding stable dispersions in isopropanol, water, or ethyl acetate depending on the substituent. This rapid, scalable, and solvent-free approach opens a practical route to covalently functionalized MoS2 powders for downstream applications.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"5 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium-Anchored Covalent Organic Framework for Cyclic Carbonate and One-Pot Oxazolidinone Synthesis","authors":"Susmitha Kumar,Bipasha Banerjee,Bidhan Kumbhakar,Swarbhanu Ghosh,Anil Chandra Kothari,Sk Manirul Islam,Asma A. Alothman","doi":"10.1039/d6nr03357a","DOIUrl":"https://doi.org/10.1039/d6nr03357a","url":null,"abstract":"The development of heterogeneous catalysts that efficiently transform carbon dioxide into value-added chemicals under mild conditions offers a sustainable approach towards chemical synthesis. Nevertheless, achieving high catalytic activity, excellent selectivity, broad applicability within a single catalyst remains a persistent challenge. In this work, an imide-linked covalent organic framework (TAPA-NDA COF) was synthesized and employed as a support for the immobilization of Pd nanoparticles, yielding Pd@TAPA-NDA COF as an efficient heterogeneous catalyst. The resulting COF-based catalyst was thoroughly characterized by PXRD, FR-IR, FE-SEM, HRTEM, TGA, BET and XPS analyses, confirming the successful formation of the imide-linked framework and the incorporation of Pd species within its porous COF architecture. Furthermore, PXRD analysis provided structural validation of the Pd6 nanoclusters@TAPA-NDA COF, while theoretical calculations identified the thermodynamically preferred adsorption site of the Pd6 nanocluster within the COF framework. The catalytic activity of Pd@TAPA-NDA COF was first assessed for the cycloaddition of CO2 with epoxides to form cyclic carbonates, delivering good to excellent yields (i.e. 72% to 96%) with up to 99% selectivity under mild and solvent-free conditions. Subsequently, the catalyst was applied to the cyclization of propargylic alcohols with phenyl isocyanate for the synthesis of 2-oxazolidinones, an important class of bioactive heterocycles, affording the desired products in yields up to 92% with 99% selectivity under optimized conditions. The outstanding catalytic efficiency is attributed to the synergistic interaction between Pd(0)/Pd(II) active sites and the porous COF framework. Moreover, Pd@TAPA-NDA COF could be readily recovered and reused over five consecutive catalytic cycles without any appreciable loss in activity, as evidenced by FT-IR and SEM analyses of the recycled catalyst. Overall, Pd@TAPA-NDA COF serves as a versatile, recyclable, and efficient heterogeneous catalyst for CO2 fixation and one pot oxazolidinone synthesis, offering a sustainable platform for value-added chemical synthesis.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"11 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149218315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light- and ROS-responsive nanomicelles enable targeted combination photothermal molecular therapy in melanoma cells and spheroids.","authors":"Irine Rose Antony, Ansuja Pulickal Mathew, Nabila Masud, Susheel Kumar Nethi, Surya K Mallapragada, Anwesha Sarkar, Rizia Bardhan","doi":"10.1039/d6nr01741j","DOIUrl":"https://doi.org/10.1039/d6nr01741j","url":null,"abstract":"<p><p>Stimuli-responsive nanocarriers that respond to both exogenous and endogenous cellular stimuli are highly desirable to enable high payload delivery. Here, we designed novel micelles that are responsive to multiple stimuli, including light (exogenous) and reactive oxygen species (ROS, endogenous). We showed that this dual-stimuli response of light and ROS-responsive micelles (LRMs) can be leveraged to reverse the resistance of melanoma cells to a small molecule drug, trametinib. LRMs were designed with hyaluronic acid (HA) that specifically targets CD44 receptors in B16F0 melanoma cells and spheroids. HA was conjugated to IR780, a dye that absorbs near-infrared light and converts it to heat enabling photothermal therapy (PTT). LRMs also incorporated a cleavable thioketal linker that responds to ROS and enables drug delivery at sites of high ROS. Our findings show that trametinib-loaded LRMs function based on a two-step mechanism, enabling combination photothermal molecular therapy that facilitates (i) high short-term cancer cell death, (ii) reduction in the long-term proliferative capacity of cancer cells, (iii) significantly decreased glycolytic function and overall survival, (iv) pronounced downregulation of phosphorylated ribosomal protein S6, and (v) significant metabolic shift in the lipid profile and downregulation of oncometabolites that promote cell growth and proliferation. Furthermore, our results also show that LRM treatment has distinct effects in lipid remodelling and triglyceride storage in 2D cells compared to 3D spheroids, emphasizing the importance of both cellular models in understanding treatment response. Our findings will ultimately enable a new generation of stimuli-responsive nanocarriers that will have a tremendous impact on many diseases beyond cancer.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-template molecular imprinting enables fully synthetic phosphatidylserine-targeted cancer therapy.","authors":"Shuhan Hu, Wenjing Yu, Luxi Chen, Muhammad Mujahid Ali, Juntao Zhou, Lei Ye, Lianghai Hu","doi":"10.1039/d6nr02739c","DOIUrl":"https://doi.org/10.1039/d6nr02739c","url":null,"abstract":"<p><p>Phosphatidylserine (PS) exposed on tumor cell membranes is an attractive target for cancer therapy, but current PS-targeting strategies depend largely on biologically derived ligands that suffer from calcium dependence, limited stability, immunogenicity risk, and manufacturing complexity. Here, we report a fully synthetic therapeutic platform based on dual-template molecular imprinting that integrates PS-targeted tumor recognition with pH-responsive doxorubicin (Dox) delivery in a single nanocarrier. By co-imprinting the PS polar head group and Dox, the resulting molecularly imprinted polymer nanoparticles (dt-MIP) generate orthogonal binding sites for membrane targeting and drug loading, achieving high binding capacities for PS and Dox (<i>Q</i>_max ∼ 180 mg g^-1 and ∼37 mg g^-1, respectively), high selectivity, minimal drug leakage at physiological pH, and accelerated release in acidic environments. The dt-MIP recognized surface-exposed PS with specificity comparable to Annexin V and enabled PS-dependent Dox delivery across multiple cell lines, with delivery efficiency correlating with the degree of PS externalization. In triple-negative breast cancer cells, Dox-loaded dt-MIP markedly enhanced intracellular drug accumulation and reduced cell viability to ∼8% at 200 μg mL^-1 dt-MIP, compared with ∼70% for free Dox at the same dose. In an MDA-MB-231 xenograft model, dt-MIP achieved tumor-selective accumulation and substantially suppressed tumor growth while maintaining a favorable safety profile. These results establish dual-template molecular imprinting as a general strategy for constructing fully synthetic, target-directed cancer therapeutics, positioning PS-imprinted nanocarriers as an alternative to biologically derived targeting systems.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Zr–O–N bonds modulated oxygen vacancies in S-scheme heterojunction for enhanced wastewater purification","authors":"Liping Liang,Zhu Zhu,Sizhuo Wang,Kailian Zhang,Weiya Huang,Kai Yang,Dan Li,Zhao-Qing Liu","doi":"10.1039/d6nr03077g","DOIUrl":"https://doi.org/10.1039/d6nr03077g","url":null,"abstract":"UiO‑66 derived oxygen‑doped g-C3N4(OCN)/t-ZrO2 heterojunctions with Zr–O–N interfacial chemical bonds were successfully prepared via a solid‑state grinding and pyrolysis method. The presence of Zr–O–N bonds induced the generation of abundant oxygen vacancies (Ov), which enhanced the surface adsorption of pollutant molecules. Meanwhile, the Zr–O–N bonds acted as \"electron channels\", optimizing the interfacial contact of the S-scheme heterojunction and suppressing the recombination of photogenerated electron-hole pairs. Moreover, Ov-mediated degradation pathway dominated by singlet oxygen (1O2) and superoxide radicals (·O2−) effectively promoted the efficient degradation and deep mineralization of pollutants, allowing for a triple synergy of “enhanced adsorption–promoted charge separation-regulated reactive species”. After 30 min of dark adsorption followed by 120 min of simulated visible-light irradiation, the optimal sample ZOCN-3 achieved a total adsorption–photocatalytic removal of 95.72% for tetracycline hydrochloride (TC) and 97.58% for methylene blue (MB). Its degradation rate constants for TC and MB were 4.56 and 2.66 times those of t-ZrO2, respectively, with a TOC removal of 61.41% for TC after 120 min. ZOCN-3 also exhibited excellent recyclability, stability, and anti-interference capability. This work offers an interfacial engineering approach to create MOF-derived S-scheme heterojunctions with superior efficacy in treating wastewater.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"31 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled vanadium-graphene hydrogels for high-capacity aqueous zinc-ion batteries.","authors":"Andrew J Sellathurai, Mahmoud Khademi, Mohammad Bandpey, Dominik P J Barz","doi":"10.1039/d6nr02910h","DOIUrl":"https://doi.org/10.1039/d6nr02910h","url":null,"abstract":"<p><p>This work presents a novel strategy for synthesizing vanadium-oxide-based cathode materials for zinc-ion batteries. The synthesis begins with the preparation of a vanadium-graphene hydrogel <i>via</i> hydrothermal reduction of a graphene oxide dispersion containing vanadyl sulfate. In a subsequent hydrothermal step, the resulting vanadate species are converted into hydrated vanadium pentoxide. The obtained vanadium pentoxide-graphene hydrogel composites are thoroughly characterized in terms of their structural and electrochemical properties. At a current density of 0.1 A g^-1, normalized to the entire cathode mass, the material delivers an impressive discharge capacity of 502 mAh g^-1. When normalized to the electroactive vanadium pentoxide content, this value increases to around 670 mAh g^-1. This exceptional performance arises not only from the reversible intercalation of zinc ions into vanadium pentoxide but also from concurrent proton intercalation and the capacitive contribution of the high-surface-area graphene host material.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering charge transfer pathways in anion exchanged CsPbBr_3-<i>x</i>Cl_<i>x</i> perovskite nanocrystals with fullerene.","authors":"Priyanka Dubey, Ambika Prasad Kar, Himanshu Kumar, Soumi Dutta, Pramit Kumar Chowdhury, Manas Kumar Sarangi","doi":"10.1039/d6nr02079h","DOIUrl":"https://doi.org/10.1039/d6nr02079h","url":null,"abstract":"<p><p>The optoelectronic efficacies of lead halide perovskite nanocrystal (PNC)-driven devices are often assessed by the interfacial charge-transfer (CT) dynamics between the active layer and the adjacent charge-transporting layers. Enhanced device performance typically requires efficient charge-carrier generation, swift CT dynamics, effective carrier extraction, and reduced recombination losses. In the current study, we have attempted to unveil the underlying photoinduced CT kinetics among the compositionally tuned CsPb(Br/Cl)₃ PNCs with fullerene (C₆₀) through a series of steady-state and time-resolved spectroscopic and conductivity measurements along with simulations. Among the investigated systems, the mixed-halide CsPb(Br/Cl)₃ PNCs exhibit a markedly higher CT rate with C₆₀ compared to their pristine CsPbBr₃ and CsPbCl₃ counterparts. The analysis further uncovers signatures of both electron and hole transfer processes at the CsPb(Br/Cl)₃-C₆₀ interface, indicating a more efficient dual-channel deactivation pathway. Conductive atomic force microscopy shows enhanced conductivity and the most significant relative resistance reduction for CsPb(Br/Cl)₃-C₆₀, evidencing superior charge injection and transport. Complementarily, a one-dimensional solar cell capacitance simulator (SCAPS-1D) further reveals that incorporation of C₆₀ enhances the photovoltaic parameters, with the CsPb(Br/Cl)₃-based device showing the most pronounced improvement, in agreement with the spectroscopic and conductance measurements. These results provide crucial insights into strategies for tailoring PNC-based optoelectronic devices towards higher efficiency while highlighting the critical influence of CT in governing charge transport and device performance.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA origami as an electronically coupled scaffold for Au nanocluster electrocatalysts.","authors":"Shikha Rai, Ritu Raj, Aneena Alottu Padikkal, Kousik Giri, Tapasi Sen, Krishna Kanta Haldar","doi":"10.1039/d6nr03032g","DOIUrl":"https://doi.org/10.1039/d6nr03032g","url":null,"abstract":"<p><p>Ultra-small, atomically precise gold nanoclusters (Au NCs) offer distinctive opportunities for electrocatalysis owing to their discrete electronic structures and high density of coordinatively unsaturated sites; however, uncontrolled aggregation and the absence of spatial control over cluster nucleation on conventional supports remain significant challenges for the rational engineering of catalytic interfaces. Herein, we report a site-directed, <i>in situ</i> strategy for the spatially controlled synthesis of Au NCs on DNA origami (Au NC@DNA) scaffolds, which function as localized nucleation and coordination platforms to afford Au NC@DNA origami hybrid architectures. The resulting hybrids exhibit a narrowly distributed Au NC size of 1.5 ± 0.2 nm, as established by complementary UV-vis and fluorescence spectroscopy, atomic force microscopy (AFM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS). When evaluated for the hydrogen evolution reaction (HER) in 0.5 M H₂SO₄, the Au NC@DNA origami hybrid exhibits a low overpotential of 87 mV at a current density of -10 mA cm^-2, together with a Tafel slope of 67 mV dec^-1, a charge-transfer resistance of 13.87 Ω, and a mass activity of 416.3 A g^-1. These electrocatalytic metrics substantially exceed those of Au NC@Poly-C, pristine DNA origami, and poly-cytosine (poly-C) controls and approach the performance of the benchmark Pt/C catalyst. Furthermore, the Au NC@DNA origami catalyst demonstrates pronounced operational durability, maintaining its electrocatalytic activity over 3000 continuous linear sweep voltammetry cycles and 36 h of chronoamperometric operation. Density functional theory (DFT) calculations identify the DNA-Au₂₁ configuration as a thermodynamically favorable catalytic motif, characterized by a near-thermoneutral Gibbs free energy of hydrogen adsorption (Δ<i>G</i>_H*). Bader charge analysis and projected density of states (PDOS) further reveal substantial electronic coupling between the Au cluster and DNA ligand, accompanied by Au-H orbital hybridization and charge redistribution involving neighbouring N/O coordination sites. These results demonstrate that DNA origami functions not merely as a structural template but as an electronically coupled and catalytically relevant scaffold that modulates the physicochemical properties of atomically precise Au nanoclusters.</p>","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-based materials in advanced oxidation processes: From electron deficiency to catalytic versatility","authors":"Yiru Xu,Bo Yang,Yang Liu,Peng Zhou","doi":"10.1039/d6nr02309f","DOIUrl":"https://doi.org/10.1039/d6nr02309f","url":null,"abstract":"Being favorable replacements for traditional metal-based catalysts, boronbased materials have gained increasing attention in advanced oxidation processes (AOPs) for water decontamination, benefiting from their unique electron-deficient 2 structure, strong covalent bonding, excellent chemical stability, and minimal metal leaching. This review comprehensively examines four representative categories of boron-based materials (including elemental boron, metal borides, boron-doped diamond (BDD), and boron nitride) from the fundamental physicochemical properties to their specific applications in various AOPs. Furthermore, the intrinsic mechanisms underlying structure-activity relationships of various boron-based materials, covering electron donation driven metal redox cycling, dual active site synergistic catalysis, and nanoconfined interfacial reactions, are critically elucidated. Finally, the critical challenges impeding the practical implementation of boron-based materials are identified and future research directions are proposed. It is expected that this review can provide a comprehensive reference framework and new inspiration for the scientific design and engineering application of boron-based materials in water remediation.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"30 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}