Basic and applied pathology最新文献_第3页

Ameloblastic carcinoma of mandible: Report of intriguing presentation 下颌骨成釉细胞癌:一个有趣的报告

Basic and applied pathology Pub Date : 2012-01-20 DOI: 10.1111/j.1755-9294.2011.01122.x

Mahima V. Guledgud, Karthikeya Patil, Suchetha N. Malleshi

引用次数: 1

Clinicohematologic analysis of pancytopenia: Study in a tertiary care centre 全血细胞减少症的临床血液学分析:在三级保健中心的研究

Basic and applied pathology Pub Date : 2012-01-03 DOI: 10.1111/j.1755-9294.2011.01121.x

Deepak B. Kumar, A. R. Raghupathi

{"title":"Clinicohematologic analysis of pancytopenia: Study in a tertiary care centre","authors":"Deepak B. Kumar, A. R. Raghupathi","doi":"10.1111/j.1755-9294.2011.01121.x","DOIUrl":"10.1111/j.1755-9294.2011.01121.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: A study was carried out to analyze the presentation, to identify the causes and to find out the bone marrow morphology in cases of pancytopenia. Pancytopenia was an indication for bone marrow examination in 48 out of a total of 100 cases (48%) for which a bone marrow examination was requested. Methods: The data regarding the various signs and symptoms, the causes and the bone marrow findings were obtained and analyzed using simple statistical methods. All age groups were included for the study. Results: Generalized weakness (70.83%) was the commonest symptom and pallor (45.83%) was the predominant sign. Anisocytosis (79.1%) was the most important peripheral blood finding in pancytopenic patients followed by microcytosis (52.08%). The commonest cause of pancytopenia in the present study was hypoplastic marrow (33.33%), followed by normoblastic erythroid hyperplasia (27.08%), megaloblastic marrow (18.75%), and myelodysplastic syndrome (8.33%). Normal bone marrow and dry tap accounted for three cases each (6.25%). Of the various cases of myelodysplastic syndrome, one was refractory anemia; two were refractory cytopenia with multilineage dysplasia and one myelodysplastic syndrome unclassified. Dry tap was seen in three cases of pancytopenia. Bone marrow biopsy was done in one, which showed features of myelofibrosis. Conclusions: A thorough evaluation of the pancytopenic patients is necessary as it has varied causes.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2012-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01121.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Significance of epidermal growth factor receptor expression in the grading of phyllodes tumors of the breast 表皮生长因子受体表达在乳腺叶状肿瘤分级中的意义

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01116.x

Yong-Han Jung, Won-Hwa Yoon, Hye-Kyoung Yoon

{"title":"Significance of epidermal growth factor receptor expression in the grading of phyllodes tumors of the breast","authors":"Yong-Han Jung, Won-Hwa Yoon, Hye-Kyoung Yoon","doi":"10.1111/j.1755-9294.2011.01116.x","DOIUrl":"10.1111/j.1755-9294.2011.01116.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: Limited studies on the relationships between epidermal growth factor receptor (EGFR) expression and the grades of phyllodes tumors (PT) of the breast were reported. This study evaluated the significance of EGFR overexpression in the grading of PT. Methods: Immunohistochemical stain for EGFR was done in 46 PT cases. The differences of EGFR expression according to the degrees of cytologic atypia and mitotic count and between benign, borderline and malignant PTs based on Rosen or World Health Organization (WHO) criteria were analyzed. Results: Significant differences of positive (moderate membranous and cytoplasmic, more than 10% of tumor cells) and strong positive (moderate more than 50% of tumor cells) reactions for EGFR were found according to the degree of cytologic atypia (P= 0.0016 and P= 0.0122) and between the PTs showing ≤5 mitoses and >5 mitoses/10 high power field (P= 0.0230 and P= 0.0058). Positive reaction for EGFR was more common in borderline/malignant PTs than benign PTs, and strong positive reaction for EGFR was relatively common in malignant PTs. Conclusions: Epidermal growth factor receptor overexpression, more than 10% of tumor cells, could be used as an ancillary tool for the discrimination of benign from borderline and malignant PTs.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"120-124"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01116.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Xanthogranulomatous inflammatory reaction associated with endoscopic mucosal resections of gastric and colonic cancer 胃和结肠癌内镜下粘膜切除术与黄色肉芽肿性炎症反应相关

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01117.x

Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, Eun Jeong Jang, Han-Ik Bae

{"title":"Xanthogranulomatous inflammatory reaction associated with endoscopic mucosal resections of gastric and colonic cancer","authors":"Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, Eun Jeong Jang, Han-Ik Bae","doi":"10.1111/j.1755-9294.2011.01117.x","DOIUrl":"10.1111/j.1755-9294.2011.01117.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: Xanthogranulomatous inflammatory reaction (XGI) is a rare diagnosis in the gastrointestinal tract. It could be misinterpreted as an invasive cancerous lesion. The pathogenesis of XGI in the gastrointestinal tract (GIXGI) is not well understood. We clinicopathologically studied six cases of GIXGI associated with endoscopic biopsy, mucosal resection, and submucosal dissection of gastric and colonic adenocarcinoma. Methods: Immunohistochemical, special histochemical stains, and tuberculosis-polymerase chain reaction (PCR) were performed. All radiological images and medical records of the patients were reviewed. Results: All cases showed XGI with foamy histiocytes, lymphocytes, and foreign body-type giant cells, which were positive for CD68 and negative for CD117, S-100, and cytokeratin. Acid-fast, Gomori's methenamine silver, periodic acid Schiff stains, and nontuberculous Mycobacterium and Mycobacterium tuberculosis-PCR were also negative. Two of four gastric adenocarcinomas were suspected to be advanced gastric cancer by computed tomography staging. However, the microscopic examination revealed only XGI with a mucosal carcinoma or without any residual tumor cells in the gastric wall. Conclusions: GIXGI may simulate advanced carcinoma clinicoradiologically. GIXGI should be included in the differential diagnosis in the case suggestive of a rapid transition to advanced gastrointestinal carcinoma within 12 weeks from the preoperative endoscopic procedure.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"125-129"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01117.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of the human homolog of discs, large homolog 1 (Drosophila) in normal epithelium, nodule, papilloma and invasive squamous cell carcinoma of larynx 人盘状同源物、大同源物1(果蝇)在喉部正常上皮、结节、乳头状瘤和浸润性鳞癌中的表达

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01119.x

Sun-ju Byeon, Wook Youn Kim, Kyung Yeol Lee, Tae Sook Hwang, Young Ho Kim, Mee Soo Chang

{"title":"Expression of the human homolog of discs, large homolog 1 (Drosophila) in normal epithelium, nodule, papilloma and invasive squamous cell carcinoma of larynx","authors":"Sun-ju Byeon, Wook Youn Kim, Kyung Yeol Lee, Tae Sook Hwang, Young Ho Kim, Mee Soo Chang","doi":"10.1111/j.1755-9294.2011.01119.x","DOIUrl":"10.1111/j.1755-9294.2011.01119.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: The discs large 1 of Drosophila (DLG1) is a cell junction-localized protein that is required for the maintenance of cyto-architectural stability and alteration of DLG1 may be related to development of epithelial neoplasm. Methods: To determine DLG1 expression in human papillomavirus-related carcinogenesis, DLG1 expression in normal larynx (NL), laryngeal nodule (LN), laryngeal papilloma (LP), and invasive squamous cell carcinoma of larynx (SQCC) was investigated using immunohistochemistry. Results: In LN, the expression pattern of DLG1 was similar to NL showing cytoplasmic expression of basal and suprabasal cells except suprabasal membranous staining, which is observed in NL. In regard to basal cell expression, unlikely NL and LN, and the basal cells of most LPs did not express DLG1. In SQCC, the cancer cells of surface area showed strong cytoplasmic and membranous staining patterns of DLG1 in most SQCCs, whereas cells of deep invasive edge (IE) demonstrated weak cytoplasmic patterns without membranous staining. This expression pattern of DLG1 was similar to that of E-cadherin. Conclusions: Weak expression of DLG1 in IE of SQCC with a pattern similar to E-cadherin suggests that the perturbation of DLG1 as cell junction-localized cyto-architectural protein may be associated with progression of invasiveness.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01119.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinico-pathological changes in buffalo calves following oral exposure to Pasteurella multocida B:2 水牛犊牛口服多杀性巴氏杆菌B暴露后的临床病理变化

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01113.x

Muhammad Salisu Abubakar, Mohd Zamri-Saad

{"title":"Clinico-pathological changes in buffalo calves following oral exposure to Pasteurella multocida B:2","authors":"Muhammad Salisu Abubakar, Mohd Zamri-Saad","doi":"10.1111/j.1755-9294.2011.01113.x","DOIUrl":"10.1111/j.1755-9294.2011.01113.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: Pasteurella multocida B:2, which causes hemorrhagic septicemia of ruminants, is believed to enter the host via respiratory and oral routes. While the role of respiratory route of infection has been established, the present study describes the clinical and pathological alterations following oral exposure of buffalo calves to live wild-type Pasteurella multocida B:2. Methods: Nine 8-month-old buffalo calves were selected and divided into three groups. Calves of group 1 were exposed orally to 50 mL of the inoculums containing 109 colony-forming unit (CFU)/mL of live Pasteurella multocida B:2. Calves of group 2 were exposed intra-tracheal to 5 mL of the same inoculums while calves of group 3 were exposed orally to 50 mL of phosphate-buffered saline. Results: Only one calf had to be euthanized at 48 h post-intra-tracheal exposure due to persistent clinical signs of hemorrhagic septicemia. The mean respiratory rate and rectal temperature had significantly increased in calves of groups 1 and 2. The pathological alterations included submandibular and brisket edema, generalized lymphadenopathy, acute fibrinous pneumonia, acute colitis and hemorrhagic typhilitis and proctitis. Nevertheless, oral infection with 109 CFU/mL of live wild-type P. multocida B:2 failed to produce a typical clinical disease. However, P. multocida B:2 was present along the gastro-intestinal tract, including the rectum of the calf that succumbed to the infection at 48 h post-intra-tracheal exposure. Conclusions: The presence of P. multocida B:2 along the gastro-intestinal tract is of concern since transmission via the gastro-intestinal tract of diseased animals is strongly possible.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"130-135"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01113.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63684937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Atypical small acinar proliferation of prostate: Follow-up study of 114 patients 114例前列腺非典型小腺泡增生的随访研究

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01115.x

Kyoung Yul Lee, Yoomi Choi, Kyusang Lee, Sumi Yun, Gheeyoung Choe

{"title":"Atypical small acinar proliferation of prostate: Follow-up study of 114 patients","authors":"Kyoung Yul Lee, Yoomi Choi, Kyusang Lee, Sumi Yun, Gheeyoung Choe","doi":"10.1111/j.1755-9294.2011.01115.x","DOIUrl":"10.1111/j.1755-9294.2011.01115.x","url":null,"abstract":"Background and aim: Atypical small acinar proliferation (ASAP) is defined as atypical foci suspicious for but not diagnostic of malignancy. ASAP is known as a strong predictive factor associated with prostate cancer. Because the diagnostic criteria for ASAP are subjective, objective diagnostic criteria were applied for ASAP as follows: (i) total loss of basal cells confirmed by immunohistochemistry and inconspicuous nucleoli; and (ii) a minute (≤500 micrometer in length) focus of atypical glands with total loss of basal cells and prominent nucleoli. Methods: To evaluate the cancer detection rate of ASAP diagnosed by objective diagnostic criteria, 114 patients initially diagnosed with ASAP were reviewed. Results: ASAP was noted in 2.17% of prostate biopsy cases. Eighty-one patients were successfully followed up. Twenty patients (24.7%) were finally diagnosed as having adenocarcinoma by subsequent biopsy. According to the criteria, we subclassified ASAP into two groups: ASAP (not otherwise specified [NOS]) and ASAP (suspicious microscopic adenocarcinoma). ASAP (NOS) and ASAP (suspicious microscopic adenocarcinoma) showed significantly different cancer detection rates (20.3% vs 71.4%) at subsequent biopsies (P= 0.003). Sixteen patients underwent radical prostatectomy, and 13 cases (81.2%) were categorized as clinically significant prostate cancer. Conclusions: The presence of ASAP in needle biopsy was evaluated to be an important predictor of cancer.","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"116-119"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01115.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63684987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Myeloperoxidase positive histiocytes in subacute necrotizing lymphadenitis express both CD11c and CD163 亚急性坏死性淋巴结炎的髓过氧化物酶阳性组织细胞表达CD11c和CD163

Basic and applied pathology Pub Date : 2011-12-16 DOI: 10.1111/j.1755-9294.2011.01114.x

Seon Jung Jang, Hyae Min Jeon, Dowhan Kim, Woo-Ick Yang

{"title":"Myeloperoxidase positive histiocytes in subacute necrotizing lymphadenitis express both CD11c and CD163","authors":"Seon Jung Jang, Hyae Min Jeon, Dowhan Kim, Woo-Ick Yang","doi":"10.1111/j.1755-9294.2011.01114.x","DOIUrl":"10.1111/j.1755-9294.2011.01114.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: Immunophenotype analysis of lesional histiocytes in subacute necrotizing lymphadenitis (SNL) has revealed several unexpected findings. Histiocytes express myeloperoxidase (MPO), and immature dendritic cells occupy a significant proportion of the lesional cells in SNL. However, whether MPO-expressing lesional histiocytes of SNL also express immunophenotypic markers of immature dendritic cells has not been determined. Methods: The immunophenotypes of lesional histiocytes in paraffin-embedded tissue sections from 26 patients with SNL were analyzed using a panel of dendritic cell and macrophage markers. Double immunohistochemical staining was also performed to confirm coexpression of several markers. Results: CD11c-expressing histiocytes represented a major component of lesional cells (averaging 50.1% of the lesional area), surpassing CD163-positive histiocytes (averaging 32.0% of the lesional area). Double immunohistochemical staining confirmed that a significant proportion of CD11c-expressing histiocytes also coexpressed MPO as well as CD163. CD123-positive plasmacytoid dendritic cells (averaging 3.2% of the lesional area) were minor lesional cells, and fascin-positive mature dendritic cells were not present in the lesions. Conclusions: Our results demonstrate that the main lesional cells in SNL are histiocytes expressing myeloid dendritic cell and macrophage markers as well as MPO, indicating phenotypic plasticity and functional versatility of histiocyte lineage cells.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 4","pages":"110-115"},"PeriodicalIF":0.0,"publicationDate":"2011-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01114.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation 胃腺癌伴绒毛膜癌和肝样分化

Basic and applied pathology Pub Date : 2011-12-14 DOI: 10.1111/j.1755-9294.2011.01118.x

Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, Han-Ik Bae

{"title":"Gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation","authors":"Seong Wook Hwang, Sun Jae Lee, Po Eun Park, Mee Seon Kim, Han-Ik Bae","doi":"10.1111/j.1755-9294.2011.01118.x","DOIUrl":"10.1111/j.1755-9294.2011.01118.x","url":null,"abstract":"<div>\u0000 \u0000 We report a patient with gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation. A 67-year-old man visited our hospital for further evaluations due to gastric adenocarcinoma. The gastric cancer was located in the prepyloric area and appeared to be a protruding mass with an infiltrative growth pattern. Initial pancreatic and postoperative hepatic and pulmonary metastases were detected radiologically. Microscopically, choriocarcinomatous and hepatoid differentiation was observed with a moderately differentiated adenocarcinoma. The choriocarcinomatous components were positive for β-hCG and the hepatoid components were positive for α-fetoprotein (AFP). These uncommon pathological patterns are supposed to arise from the retrodifferentiation pathway of primary gastric adenocarcinoma. The preoperative laboratory data revealed elevated serum AFP (773.4 ng/mL) and carcinoembryonic antigen (62.2 ng/mL), whereas other tests were unremarkable. The prognosis of gastric adenocarcinoma with choriocarcinomatous and hepatoid differentiation is very poor; our patient died 4 months after the operation.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2011-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01118.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunohistochemical analysis of Hedgehog signaling in prostatic adenocarcinoma 前列腺腺癌中Hedgehog信号的免疫组化分析

Basic and applied pathology Pub Date : 2011-09-22 DOI: 10.1111/j.1755-9294.2011.01111.x

Tae-Jung Kim

{"title":"Immunohistochemical analysis of Hedgehog signaling in prostatic adenocarcinoma","authors":"Tae-Jung Kim","doi":"10.1111/j.1755-9294.2011.01111.x","DOIUrl":"10.1111/j.1755-9294.2011.01111.x","url":null,"abstract":"<div>\u0000 \u0000 Background and aim: The Hedgehog (Hh) signaling pathway plays an essential role in normal development of normal prostate gland. Deregulation of this pathway is responsible for carcinogenesis of prostatic adenocarcinoma. Methods: Total 176 cases of prostatic adenocarcinomas were prepared and the Hh signaling molecules including Sonic hedgehog (Shh), Patched (Ptch), Smoothened (Smo), GLIoma-associated oncogene (Gli-1) and suppressor of fused (Su[fu]) were immunohistochemically analyzed. Results: Hh signaling molecules were significantly associated with prognostic factors; High Gleason score (≥7) was significantly associated with expression of Shh, Ptch, Smo, and Gli-1; tumor, node and metastasis stages with Shh, Ptch, Smo and Gli-1; initial prostate specific antigen with Ptch and Smo; large tumor volume with Gli-1; perineural invasion with Shh, Smo and Gli-1. Su(fu) was significantly associated inversely with multiplicity of tumor. Conclusions: Hh signaling molecules including Shh, Ptch, Smo and Gli-1 were associated with high Gleason score and advanced stage even in the low Gleason score.\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"4 3","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2011-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2011.01111.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63684747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0