Basic and applied pathology最新文献

{"title":"Primary adrenal Epstein–Barr virus-positive diffuse large B cell lymphoma of the elderly, mimicking pseudocyst","authors":"Soo Jeong Nam,&nbsp;Ji-Young Choe,&nbsp;Heounjeong Go,&nbsp;Yoon Kyung Jeon,&nbsp;Jin Ho Paik","doi":"10.1111/baap.12001","DOIUrl":"10.1111/baap.12001","url":null,"abstract":"<div>\u0000 \u0000 <p>Primary adrenal lymphoma is rare, but clinically important. We report a unique case of adrenal lymphoma which showed extensive cystic change mimicking a pseudocyst. Seventy-three-year-old man visited our hospital for healthcare check-up, and was found to have a large adrenal cystic mass. He was received adrenalectomy on the impression of an adrenal pseudocyst. On gross examination, the mass was a unilocular cyst with no solid mass formation. Microscopically, the cyst wall had no epithelial lining, but was infiltrated by some atypical large lymphoid tumor cells. The cystic space was filled with coagulative necrotic material with the tumor cell shadow. The most of the tumor cells expressed leukocyte common antigen, CD20, PAX5, Ki-67, and Epstein-Barr virus (EBV)-encoded RNA, which was consistent with EBV-positive diffuse large B-cell lymphoma of the elderly. No extra-adrenal involvement was observed in imaging studies. We concluded that primary adrenal lymphoma should be considered as a rare but important cause of adrenal cysts.</p>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 4","pages":"98-100"},"PeriodicalIF":0.0,"publicationDate":"2012-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/baap.12001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63264110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of anti-phosphohistone H3 immunoreactivity to determine mitotic rate in gastrointestinal stromal tumors","authors":"Ahrong Kim,&nbsp;Dong Han Im,&nbsp;Kyungbin Kim,&nbsp;Jee Yeon Kim,&nbsp;Mee Young Sol,&nbsp;Jeong Hee Lee,&nbsp;Kyung Un Choi","doi":"10.1111/baap.12003","DOIUrl":"10.1111/baap.12003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and aim</h3>\u0000 \u0000 <p>The biologic behavior of gastrointestinal stromal tumors (GIST) is a topic of continuing controversy. The assessment of accurate mitotic figures is known to be one of the major indicators for patients with GIST. However, it is not always easy to search for mitotic figures (MFs) and count them accurately on hematoxylin and eosin stained (H&amp;E) slides.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, phopho-histone H3 (PHH3), which is a recently described specific mitosis marker, was immunohistochemically examined and compared to the mitotic count on H&amp;E sections (H&amp;E-MI) and Ki-67 expression (Ki-67 PI). A hundred cases of histologically confirmed GISTs were reviewed based on counting MF on H&amp;E slides. PHH3 positive MFs (PHH3-MI) were counted in the same way, and the Ki-67 PI was calculated for each case.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A strong correlation was found between PHH3-MI and H&amp;E-MI. Recurrence-free survival was correlated with risk category by National Institutes of Health (NIH) consensus criteria (<i>P</i> = 0.017), mucosal invasion (<i>P</i> = 0.005), H&amp;E-MI (<i>P</i> = 0.002), Ki-67 PI (<i>P</i> = 0.005), and PHH3-MI (<i>P</i> = 0.000). None of these factors was an independent prognostic factor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among GISTs, PHH3 staining was primarily found to support grading by facilitating mitotic counting, and it might have a prognostic value in GISTs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 4","pages":"91-97"},"PeriodicalIF":0.0,"publicationDate":"2012-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/baap.12003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63264350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic and Applied Pathology","authors":"","doi":"10.1111/baap.12004","DOIUrl":"https://doi.org/10.1111/baap.12004","url":null,"abstract":"","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 4","pages":"i"},"PeriodicalIF":0.0,"publicationDate":"2012-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/baap.12004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137703186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-glomerular basement membrane antibody-mediated glomerulonephritis combined with non-fulminant acute viral hepatitis A","authors":"Min-Kyung Kim,&nbsp;Hoon-Kyu Oh,&nbsp;In-Hee Lee,&nbsp;Ki-Sung Ahn,&nbsp;Kwan-Kyu Park","doi":"10.1111/baap.12002","DOIUrl":"10.1111/baap.12002","url":null,"abstract":"<div>\u0000 \u0000 <p>Anti-glomerular basement membrane antibody-mediated glomerulonephritis (anti-GBM Ab-mediated GN) is a rare autoimmune disease, characterized by crescentic glomeruli and linear GBM staining with immunoglobulin G (IgG). Exposure to viruses can trigger the formation of autoantibodies to the GBM. We report the first case of anti-GBM Ab-mediated GN associated with hepatitis A virus (HAV) infection. Although the pathogenesis of HAV-related anti-GBM Ab-mediated GN has not been documented, we suggest that the immune complexes produced by HAV infection might be deposited in the glomerular capillary walls and lead to immune complex-mediated glomerular damage, resulting in exposure of the sequestered GBM antigens and the formation of anti-GBM antibodies. Under immunosuppressive and intravenous cyclophosphamide therapy, his renal function has been improving without development of pulmonary symptoms.</p>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 4","pages":"101-104"},"PeriodicalIF":0.0,"publicationDate":"2012-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/baap.12002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63264167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal morphology assessments of rats fed phytic acid extract from sweet potato (Ipomoea batatas) and IP6","authors":"Lowell Dilworth,&nbsp;Michael Gardner,&nbsp;Helen Asemota,&nbsp;Felix Omoruyi","doi":"10.1111/baap.12000","DOIUrl":"10.1111/baap.12000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and aim</h3>\u0000 \u0000 <p>Zinc deficiency due to low intake or unavailability by bioactive compounds may lead to morphological changes in the intestines resulting in disruptions in gut function. This study aims to assess effects of phytic acid on gut morphology of rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Diets supplemented with sweet potato phytate extract were fed to Wistar rats in zinc-deficient and zinc-sufficient states for 4 weeks. Similar test animals also had diets supplemented with the commercially available sodium phytate salt (IP6) for comparison. At the end of the feeding period, body weights, feed intake and markers of intestinal function were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Acute zinc deficiency adversely affected the glycocalyx, goblet and Paneth cells within the small intestine. This may eventually lead to compromisation of the gut's immune system and further reductions in its metabolic and absorptive capacity. This was further aggravated by sweet potato phytate extract consumption. IP6 supplementation on the other hand, increased surface amplification in the jejunum resulting in increased gut transit time and more efficient absorption of nutrients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>To minimize compromisation of the gut's immune, absorptive and metabolic functions, adequate zinc supplementation is necessary especially if foods rich in phytates are included in the diet. Supplementation of the diet with IP6 seems to offset some of these effects with maximum benefits observed if the diet is properly supplemented with essential minerals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 4","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2012-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/baap.12000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63264427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological study of nasal polyps with special reference to mast cells in inflammatory polyps","authors":"V. S. Shulbha,&nbsp;B. S. Dayananda","doi":"10.1111/j.1755-9294.2012.01136.x","DOIUrl":"10.1111/j.1755-9294.2012.01136.x","url":null,"abstract":"<div>\u0000 \u0000 <p><b>Background and aim:</b> Nasal polyposis is a relatively common condition found in 1–4% of the general population and in high percentages of some groups of patients. Nasal polyps diagnosed clinically are not always of inflammatory origin. A variety of non-neoplastic and neoplastic conditions can present as nasal polyps. The aim of this study was to determine the various histopathological types, the predominant cells involved in the pathogenesis of inflammatory polyps with special reference to mast cells and to correlate them clinicopathologically. <b>Methods:</b> A total of 100 cases clinically diagnosed as nasal polyp, were studied over a period of 18 months. <b>Results:</b> Out of 100 cases studied, 91% of them were non-neoplastic and 9% were neoplastic. Among the non-neoplastic conditions, non-allergic polyps accounted for 70% and allergic polyps accounted for 21% of cases. Among the neoplastic lesions, 6% were benign and 3% malignant. Squamous metaplasia was seen in 16.38% of cases. In stroma, mononuclear cells were predominant in 63.7% of inflammatory polyps, eosinophils in 19.11%, prominent edematous stroma in 26.39%, and vasculature &gt; 2/high power field (hpf) in 20.39% of inflammatory polyps. 0–5 mast cells per 10 hpf were seen in 97.8% of inflammatory polyps in epithelium, whereas 11–20 mast cells in 26.4% of inflammatory polyps were seen in stroma. <b>Conclusions:</b> Nasal polyps diagnosed clinically are not always of inflammatory origin and therefore have to be subjected for histopathology.</p>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01136.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of isolated splenic metastasis from the breast","authors":"Kirana Pailoor,&nbsp;Hilda Fernandes,&nbsp;Clement. R. S. D'Souza","doi":"10.1111/j.1755-9294.2012.01133.x","DOIUrl":"10.1111/j.1755-9294.2012.01133.x","url":null,"abstract":"<div>\u0000 \u0000 <p>A 50-year-old woman, who underwent left mastectomy 2 years ago for infiltrating ductal carcinoma, came for follow up. A routine ultrasound of the abdomen detected a lesion in the spleen, which was suspected to be an abscess/metastasis. There was no apparent involvement of other organs such as liver, bone, lungs etc. The patient underwent splenectomy and recovered without any complications. On histopathological examination, it was diagnosed to be splenic metastasis from breast carcinoma. We present this case because of the rarity of the lesion and also as a reminder to be cognizant of one of the less likely differential diagnosis of an intraparenchymal solid splenic mass.</p>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"76-78"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01133.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63686189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathologic study on a new bioelectricity circulatory system","authors":"Ran Tian,&nbsp;Yuling Wang","doi":"10.1111/j.1755-9294.2012.01135.x","DOIUrl":"10.1111/j.1755-9294.2012.01135.x","url":null,"abstract":"","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"79-80"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01135.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63686264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What the literature says on bioelectricity?","authors":"Jeong-Wook Seo \u0000 MD","doi":"10.1111/j.1755-9294.2012.01134.x","DOIUrl":"10.1111/j.1755-9294.2012.01134.x","url":null,"abstract":"","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"81-82"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01134.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63686208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary localized amyloidosis of the ureter presenting as a ureteral stone","authors":"Se Min Jang,&nbsp;Hulin Han,&nbsp;Young Jin Jun,&nbsp;Jongmin Sim,&nbsp;Hye In Ahn,&nbsp;Tchun Yong Lee,&nbsp;Ki-Seok Jang,&nbsp;Seung Sam Paik","doi":"10.1111/j.1755-9294.2012.01131.x","DOIUrl":"10.1111/j.1755-9294.2012.01131.x","url":null,"abstract":"<div>\u0000 \u0000 <p>Primary localized amyloidosis of the urinary tract is a rare disease, usually mimicking a malignancy or inflammation in its clinical presentation and in diagnostic imaging studies. We present a case of localized amyloidosis arising in the left upper ureter in a 77-year-old man. The patient visited the hospital complaining of painless gross hematuria and dysuria for 1 month. Laboratory examination revealed hematuria only. Urine cytology was unremarkable. Abdominal computed tomography revealed an obstructing mass with calcification in the ureter. The clinical impression was of a ureteral stone or malignancy. A nephroureterectomy was performed. The ureter showed segmental fibrotic thickening with luminal obstruction. Microscopic examination revealed deposition of pale-eosinophilic amorphous material with calcification and ossification. Congo-red staining showed amyloid deposits with positive polarizing microscopic findings. Although its incidence is rare, localized amyloidosis should be considered in the differential diagnosis of ureteral tumorous lesions to avoid unnecessary surgery.</p>\u0000 </div>","PeriodicalId":92990,"journal":{"name":"Basic and applied pathology","volume":"5 3","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1755-9294.2012.01131.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63685973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}