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Immunothérapie et allergie alimentaire 免疫治疗和食物过敏
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-06 DOI: 10.1016/j.allerg.2008.01.030
F. Rancé
{"title":"Immunothérapie et allergie alimentaire","authors":"F. Rancé","doi":"10.1016/j.allerg.2008.01.030","DOIUrl":"10.1016/j.allerg.2008.01.030","url":null,"abstract":"<div><p>Immunotherapy trials on food allergy were published some years ago and few of them were randomized. The protocols used varied and IgE-mediated food allergies were the first studied. Immunotherapy is mainly indicated for persistent food allergy after the usual age of recovery. Other factors, such as the dose of the allergen and the nature of the symptoms due to food allergy, are less well-defined with regard to indications for immunotherapy. Different techniques are available: the subcutaneous route, with well-known adverse effects when currently available extracts are used; the oral route, with efficacy in a third of the cases and the sublingual route, which seems to be promising. The real effect of immunotherapy, whether persistent, transitory or merely an increase in the amount of food tolerated, remains to be defined.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 123-126"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84578332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bronchite à éosinophiles 嗜绿支气管炎
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-11 DOI: 10.1016/j.allerg.2008.01.024
V. Cottin
{"title":"Bronchite à éosinophiles","authors":"V. Cottin","doi":"10.1016/j.allerg.2008.01.024","DOIUrl":"10.1016/j.allerg.2008.01.024","url":null,"abstract":"<div><p>Eosinophilic airway inflammation may be encountered in asthma and in non asthmatic eosinophilic bronchitis, which is a recently identified and common cause of chronic cough. Non asthmatic eosinophilic bronchitis may be differentiated from asthma by the absence of airflow limitation and of bronchial hyperreactiveness (potentially reflecting the different localization of mast cells within the airway wall). Diagnosis is based on the confirmation of eosinophilic airway inflammation, usually by induced sputum, in the absence of other causes of chronic cough or of radiological and lung function abnormality. The cough is generally improved by inhaled corticosteroids. The long-term outcome is still not known; non asthmatic eosinophilic bronchitis may lead to the onset of fixed airway obstruction or asthma.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 196-200"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86094145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piqûres d’insectes et voyages 昆虫叮咬和旅行
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-05 DOI: 10.1016/j.allerg.2008.01.004
J.-L. Brunet
{"title":"Piqûres d’insectes et voyages","authors":"J.-L. Brunet","doi":"10.1016/j.allerg.2008.01.004","DOIUrl":"10.1016/j.allerg.2008.01.004","url":null,"abstract":"<div><p>Insects can be found in any areas in the world, so that it will be practically impossible to avoid them in a journey. They are the cause of many different pathologies, minor at large, but potentially severe sometimes, because a large number of them are part of epidemiological cycles, and are likely to transmit different pathogenic agents. A journey, especially in tropical areas, will have to be prepared so as to clarify the measures vital to take (vaccines, precautions of hygiene, protection equipment, preventive medicines…). Nowadays it represents a serious problem, considering the constant increase in world-wide tourism and trades.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 204-213"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85432733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergènes de contact forts
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-10 DOI: 10.1016/j.allerg.2008.01.021
J.-P. Lepoittevin
{"title":"Allergènes de contact forts","authors":"J.-P. Lepoittevin","doi":"10.1016/j.allerg.2008.01.021","DOIUrl":"10.1016/j.allerg.2008.01.021","url":null,"abstract":"<div><p>Two important parameters control skin sensitization to a xenobiotic molecule: its sensitizing potential, an intrinsic property of each chemical, and exposure. It is often difficult to quantify a patient's exposure to a given allergen, which makes it difficult to define strong allergens. Indeed, the prevalence of an allergen, as determined by patch testing, reflects not its strength but a combination of sensitizing potential and exposure. The definition of strong sensitizers is therefore mainly derived from animal experiments where it is possible to assess a sensitization threshold or the dose per square centimeter that is able to induce significant sensitization. It has been shown in a limited number of case studies, that there is a good correlation between sensitization thresholds assessed in mice by the Local Lymph Node Assay (LLNA) and those obtained in humans with the Human Repeated Insult Patch Test (HRIPT). Based on this classification, one can recognize that strong sensitizers are quite common and that the general population is exposed regularly to them. Although the strong sensitizers include a broad diversity of chemicals, they have in common the ability to rapidly modify nucleophilic residues of proteins.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 120-122"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89094233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aspects cliniques des allergies cutanées graves (toxidermies exclues) 严重皮肤过敏的临床方面(毒性皮炎除外)
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-07 DOI: 10.1016/j.allerg.2008.02.006
E. Collet, G. Jeudy
{"title":"Aspects cliniques des allergies cutanées graves (toxidermies exclues)","authors":"E. Collet,&nbsp;G. Jeudy","doi":"10.1016/j.allerg.2008.02.006","DOIUrl":"10.1016/j.allerg.2008.02.006","url":null,"abstract":"<div><p>Some skin diseases require emergency medical intervention when they are life-threatening or when the eruption is spectacular and brutal and the patient has an elevated temperature. We will discuss the clinical presentations of these conditions, excluding cutaneous drugs eruptions. Patients with severe atopic dermatitis may require brief hospitalisation if their eczema is generalized, refractory to classical therapy, or there are infectious complications, as in the Kaposi-Juliusberg syndrome when the condition is associated with a secondary herpetic infection. Acute urticaria and angioedema are frequent causes of emergency room-visits. They can be the result of drug allergy, food allergy, allergy to stinging insects or contact urticaria. However, the cause is not always identified, even after a complete allergy work-up. Some cases of contact eczema are spectacular, in particular when the face is severely oedematous. Paraphenylenediamine, topical corticosteroids and topical non-steroidal anti-inflammatory drugs are often the cause of severe delayed-type hypersensitivity reactions.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 115-119"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87815851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Poussées de dermatite atopique : définitions et causes 特应性皮炎发作:定义和原因
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-05 DOI: 10.1016/j.allerg.2008.01.002
A. Taieb
{"title":"Poussées de dermatite atopique : définitions et causes","authors":"A. Taieb","doi":"10.1016/j.allerg.2008.01.002","DOIUrl":"10.1016/j.allerg.2008.01.002","url":null,"abstract":"<div><p>Atopic dermatitis (AD) is by definition a chronic pruritic skin disease characterised by a history of flares and remissions. Genetic studies have recently demonstrated a link of causality between an impaired permeability barrier defect and both AD and mucosal allergic disorders, putting the skin stratum corneum at the centre of the pathophysiology of these disorders. The respective importance of flare factors is difficult to sort out in published papers. Some of them, such as temperature, irritants and aeroallergens have a demonstrated impact on the permeability barrier anomaly, based on epidemiological or experimental evidence. However, a better methodology and terminology are needed to identify the most significant flare factors and promote an efficient prevention.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 192-195"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86140031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Intérêt des allergènes recombinants dans le diagnostic de l’allergie alimentaire 重组过敏原在食物过敏诊断中的作用
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-14 DOI: 10.1016/j.allerg.2008.01.029
M. Morisset , F. Codreanu , C. Astier , R. Olivier , S. Jacquenet , B. Bihain , D.-A. Moneret-Vautrin , G. Kanny
{"title":"Intérêt des allergènes recombinants dans le diagnostic de l’allergie alimentaire","authors":"M. Morisset ,&nbsp;F. Codreanu ,&nbsp;C. Astier ,&nbsp;R. Olivier ,&nbsp;S. Jacquenet ,&nbsp;B. Bihain ,&nbsp;D.-A. Moneret-Vautrin ,&nbsp;G. Kanny","doi":"10.1016/j.allerg.2008.01.029","DOIUrl":"10.1016/j.allerg.2008.01.029","url":null,"abstract":"<div><p>To date, neither in vitro nor in vivo tests can establish with reliability the diagnosis of food allergy. The availability of recombinant allergens (RA) has led to improvement in the standardization of allergenic extracts and enrichment of natural extracts, resulting in more sensitive screening tests. These biotechnological advances facilitate the diagnostic approach which now rests on an individual reaction profile (component resolved diagnosis) with well-characterized allergens classified on a molecular basis. Development of diagnostic tests using RA or peptides expressing some distinctive epitopes of interest may improve the prediction of severe and/or persistent food allergies and guide the choice of the therapeutic measures that follow.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 242-245"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72408861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Caractéristiques non allergéniques des allergènes 过敏原的非致敏特性
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-03 DOI: 10.1016/j.allerg.2008.01.014
C. Duez
{"title":"Caractéristiques non allergéniques des allergènes","authors":"C. Duez","doi":"10.1016/j.allerg.2008.01.014","DOIUrl":"10.1016/j.allerg.2008.01.014","url":null,"abstract":"<div><p>Allergens are capable of inducing specific IgE production and are recognized by IgE-receptor bearing cells, more particularly mast cells and basophils expressing FcɛRI, the high affinity IgE receptor. However, they are also capable of directly stimulating certain cells of the bronchial mucosa, especially in a protease-dependent way. For example, many allergens such as those from house dust mites (<em>Dermatophagoides pteronyssinus</em> et <em>Dermatophagoides farinae</em>) have protease activity which is involved in the activation of bronchial epithelial cells, dendritic cells, T lymphocytes, B cells, eosinophils and airway smooth muscle cells. Overall, these activations amplify Th2 polarization, recruitment and activation of inflammatory cells, and airway smooth muscle cell contraction. Receptors such as the protease-activated receptor (PAR) have been involved in these functions. PAR-2, which has a role in protease-dependent activation by many allergens, is over-expressed in bronchial biopsies from asthmatic patients. Both phenomena may be involved in the development and amplification of allergic asthma.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 143-146"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86696919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mesure des allergènes de pollens d’arbre dans l’air (bouleau, olivier) 测量空气中树木花粉过敏原(桦树、橄榄树)
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-14 DOI: 10.1016/j.allerg.2008.01.022
M. Thibaudon, C. Sindt
{"title":"Mesure des allergènes de pollens d’arbre dans l’air (bouleau, olivier)","authors":"M. Thibaudon,&nbsp;C. Sindt","doi":"10.1016/j.allerg.2008.01.022","DOIUrl":"10.1016/j.allerg.2008.01.022","url":null,"abstract":"<div><p>The information provided by pollen counts cannot be ignored by allergists and allergic individuals, but the divergence sometimes observed with clinical observations has led the réseau national de la surveillance aérobiologique (RNSA) to initiate the monitoring network of allergens by immunosampling (Monalisa) project. Moreover, some recent papers has shown the influence of pollution in the region and even of the year on the content in pollen allergens, particularly that of birch pollen. Thus, the goal of the Monalisa project was to set up a measuring system based on an immunological method that would result in validation of this new way of measuring airborne pollen counts. This European Life Environment project includes nine partners: Bertin Technologies (France), RNSA (France), NPARU (England), UCO (Spain), UTU (Finland), UAM (Poland), UEVORA (Portugal), AIA (Italy), and Meteoswiss (Switzerland). The results obtained during the 2006 season and then in the 2007 campaign, after modifications made in the sampler, were not very good. The principal results concern the measurement of birch and olive allergens, captured essentially in the prepollination period and sometimes in the postpollination period. Detection of these allergens may be due either to their presence on submicroscopic particles emitted independently of pollination, these allergens cross-reacting with birch and olive allergens. The difficulties encountered in this study lead us to say that pollen counts, phenological observations and clinical data are still the best way to assess the effects of airborne pollen.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 179-186"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84991558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Cas difficiles d’allergie aux insectes piqueurs : expérience du groupe de travail 刺虫过敏的疑难病例:工作组的经验
Revue francaise d'allergologie et d'immunologie clinique Pub Date : 2008-04-01 Epub Date: 2008-03-04 DOI: 10.1016/j.allerg.2008.01.010
J.-M. Rame
{"title":"Cas difficiles d’allergie aux insectes piqueurs : expérience du groupe de travail","authors":"J.-M. Rame","doi":"10.1016/j.allerg.2008.01.010","DOIUrl":"10.1016/j.allerg.2008.01.010","url":null,"abstract":"<div><p>This article describes the function of a forum (operating by means of an exchange of correspondence) devoted to difficult cases of insect allergy, essentially to hymenoptera venoms. The principal results of this forum as well as its evolution are presented. We hope that all concerned physicians will benefit from this tool.</p></div>","PeriodicalId":92953,"journal":{"name":"Revue francaise d'allergologie et d'immunologie clinique","volume":"48 3","pages":"Pages 201-203"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.allerg.2008.01.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83688182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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