British medical bulletin最新文献_第2页

Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. 使用骨髓抽吸物浓缩液治疗膝骨关节炎：系统性综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-11-07 DOI: 10.1093/bmb/ldae016

Filippo Migliorini, Marco Pilone, Jacopo Ascani, Luise Schäfer, Madhan Jeyaraman, Nicola Maffulli

{"title":"Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.","authors":"Filippo Migliorini, Marco Pilone, Jacopo Ascani, Luise Schäfer, Madhan Jeyaraman, Nicola Maffulli","doi":"10.1093/bmb/ldae016","DOIUrl":"10.1093/bmb/ldae016","url":null,"abstract":"Introduction: Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population.Source of data: Recent published literature identified from PubMed, EMBASE, Google Scholar, and Scopus.Areas of agreement: Orthobiological therapies try to regenerate articular cartilage and stop the progression of the degenerative lesion. Intra-articular injections of biological derivates have been increasingly used in the last decade.Areas of controversy: The indications for the use of bone marrow aspirate concentrate (BMAC) are still unclear.Growing points: We systematically reviewed the current literature on BMAC in the management of knee OA, giving an update on the current indications for the selection of the ideal patient and the preparations and efficacy of BMAC compared to other biological alternatives.Areas timely for developing research: BMAC is a valuable source of mesenchymal stem cells, offering potential benefits in attenuating the inflammatory pathway associated with knee OA. Intra-articular injection of BMAC has shown effectiveness in clinical trials improving functional outcomes of knee OA patients. The superiority of BMAC over other orthobiological treatments cannot be assessed because of conflicting results.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long COVID among healthcare workers: a narrative review of definitions, prevalence, symptoms, risk factors and impacts. 医护人员中的长期 COVID：关于定义、流行率、症状、风险因素和影响的叙述性综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-09-27 DOI: 10.1093/bmb/ldae008

Brendan Dempsey, Ira Madan, Sharon A M Stevelink, Danielle Lamb

{"title":"Long COVID among healthcare workers: a narrative review of definitions, prevalence, symptoms, risk factors and impacts.","authors":"Brendan Dempsey, Ira Madan, Sharon A M Stevelink, Danielle Lamb","doi":"10.1093/bmb/ldae008","DOIUrl":"10.1093/bmb/ldae008","url":null,"abstract":"Introduction: Long COVID (LC) occurs when people experience symptoms for weeks, months or even years after a COVID-19 infection. This review looks at research exploring the LC definitions, prevalence, symptoms, risk factors, and associated impacts in research on healthcare workers (HCWs).Data sources: We systematically searched five electronic databases (CINAHL, EMBASE, Medline, PsycInfo and PubMed) and compiled a narrative literature review based on 56 relevant studies.Areas of agreement: LC is prevalent among HCWs who become infected by COVID-19. Many of the most frequent symptoms associated with LC in the general population are also reported among HCWs. Some risk factors for LC are also similar to those in the general population, such as female sex, older age, and having a pre-existing respiratory illness.Areas of controversy: The mechanism(s) responsible for LC remains unknown. A variety of terms, timeframes and symptoms are used to define LC, creating difficulties in comparing results across studies. Much of the research is cross-sectional and fails to explore the impacts that prolonged symptoms have on HCWs' personal and professional lives.Growing points: The need to support HCWs with LC is clear. Identifying the mechanism(s) responsible for LC is a key priority, as this will inform treatments.Areas for developing research: Future research should move towards a standard definition for LC. Greater attention should be paid to longitudinal and qualitative studies, which could give insights into prognosis, lived experience and work participation. Finally, studies evaluating treatments suitable for people with LC are timely.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"16-35"},"PeriodicalIF":6.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of acute severe ulcerative colitis-an update for generalist and specialist clinicians. 急性重度溃疡性结肠炎的治疗--面向全科和专科临床医生的最新进展。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-09-27 DOI: 10.1093/bmb/ldae006

Anish J Kuriakose Kuzhiyanjal, Jimmy K Limdi

{"title":"Management of acute severe ulcerative colitis-an update for generalist and specialist clinicians.","authors":"Anish J Kuriakose Kuzhiyanjal, Jimmy K Limdi","doi":"10.1093/bmb/ldae006","DOIUrl":"10.1093/bmb/ldae006","url":null,"abstract":"Background: Acute severe ulcerative colitis (ASUC) is a potentially life-threatening medical emergency that occurs in up to 25% of patients with ulcerative colitis. Although intravenous corticosteroids remain the cornerstone of therapy, 30-40% of patients will not respond and need timely consideration of rescue therapy with (currently) either infliximab or ciclosporin or indeed colectomy, underscoring the importance of multidisciplinary care to ensure favourable outcomes for patients. We discuss the current evidence and present an approach to the management of ASUC for general and specialist clinicians caring for patients with ASUC.Sources of data: The information in this review is derived from data published in peer- reviewed academic journals and registered clinical trials.Areas of agreement: Management of acute severe colitis requires a multidisciplinary approach with early initiation with steroids and timely escalation of treatment to either medical rescue therapy or surgery.Areas of controversy: Balancing the risks of delayed surgery vs. optimizing medical therapy, including accelerated dosing schedules for biologics, remains ambiguous.Growing points: The position on newer molecules like Janus Kinase inhibitors, such as tofacitinib, is a growing area with early real-world data showing promise for steroid refractory ASUC.Areas timely for developing research: Developing predictive biomarkers and clinical risk scores for personalized rescue therapy selection is an evolving area of research.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"3-15"},"PeriodicalIF":6.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological management of secondary chronic spinal cord injury: a systematic review. 继发性慢性脊髓损伤的药物治疗：系统综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-09-27 DOI: 10.1093/bmb/ldae009

Filippo Migliorini, Federico Cocconi, Luise Schäfer, Francesco Simeone, Madhan Jeyaraman, Nicola Maffulli

{"title":"Pharmacological management of secondary chronic spinal cord injury: a systematic review.","authors":"Filippo Migliorini, Federico Cocconi, Luise Schäfer, Francesco Simeone, Madhan Jeyaraman, Nicola Maffulli","doi":"10.1093/bmb/ldae009","DOIUrl":"10.1093/bmb/ldae009","url":null,"abstract":"Introduction: Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system.Source of data: Published peer-reviewed scientific articles identified from EMBASE, Google Scholar, PubMed and Scopus.Areas of agreement: Surgery and blood pressure management are the main targets in acute SCI to avoid secondary damage.Areas of controversy: The management of secondary chronic SCI is challenging, with unpredictable outcomes.Growing points: Given the lack of consensus on pharmacological therapy for acute and secondary chronic SCI, the present study analyses the currently available drugs and treatment options to manage secondary chronic SCI.Areas timely for developing research: Different approaches exist for the pharmacological management of secondary chronic SCI. One of the most investigated drugs, 4-aminopyridine, improves central motor conduction and shows improvement in neurological signs. Positive results in different areas have been observed in patients receiving the anti-spastic drugs tizanidine and baclofen or Granulocyte colony-stimulating factor. Growth hormone showed only minimal or no significant effects, and the therapy of secondary chronic SCI with riluzole has been poorly researched to date.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"49-68"},"PeriodicalIF":6.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tribute to Norman Vetter. 向诺曼-维特致敬

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-09-27 DOI: 10.1093/bmb/ldae013

Nicola Maffulli

引用次数: 0

The effectiveness of digital interventions for self-management of chronic pain in employment settings: a systematic review. 就业环境中自我管理慢性疼痛的数字干预措施的有效性：系统综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-09-27 DOI: 10.1093/bmb/ldae007

Holly Blake, Wendy J Chaplin, Alisha Gupta

{"title":"The effectiveness of digital interventions for self-management of chronic pain in employment settings: a systematic review.","authors":"Holly Blake, Wendy J Chaplin, Alisha Gupta","doi":"10.1093/bmb/ldae007","DOIUrl":"10.1093/bmb/ldae007","url":null,"abstract":"Introduction: Chronic pain affects over a quarter of the workforce with high economic burden for individuals, employers and healthcare services. Access to work-related advice for people with chronic pain is variable. This systematic review aims to explore the effectiveness of workplace-delivered digital interventions for the self-management of chronic pain.Source of data: MEDLINE, EMBASE, CINAHL, PsycINFO, the Cochrane Library, JBI, Open Science Framework, Epistemonikos and Google Scholar. Articles published between January 2001 and December 2023 were included. Searches were conducted between October 2023 and December 2023.Areas of agreement: Workplace-delivered digital interventions to support self-management of chronic pain at work may improve pain and health-related quality of life in vocationally active adults. Delivering interventions outside of clinical services, through the workplace setting, may help to reduce inequity in access to work-related advice for people with chronic pain, and ultimately reduce the burden on individuals, employers and healthcare services. Interventions include mobile apps and web-based programmes.Areas of controversy: Studies were moderate-to-low quality. Most studies focused on exercise, few considered other aspects of pain self-management. Given the limited evidence in the current literature, consensus on best intervention format and delivery is lacking.Growing points: More high-quality studies are needed given the heterogeneity in study design, interventions and outcome measures.Areas timely for developing research: No interventions included advice on work-related adjustments or support. Few studies included work-related outcomes, despite the known impact of pain on work and work on health.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"36-48"},"PeriodicalIF":6.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mind the implementation gap: a systems analysis of the NHS Long Term Workforce Plan to increase the number of doctors trained in the UK raises many questions. 注意实施差距：对英国国家医疗服务系统（NHS）旨在增加在英国培训的医生数量的长期劳动力计划进行系统分析，提出了许多问题。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-06-10 DOI: 10.1093/bmb/ldae002

Una Geary, Martin McKee, Katie Petty-Saphon

{"title":"Mind the implementation gap: a systems analysis of the NHS Long Term Workforce Plan to increase the number of doctors trained in the UK raises many questions.","authors":"Una Geary, Martin McKee, Katie Petty-Saphon","doi":"10.1093/bmb/ldae002","DOIUrl":"10.1093/bmb/ldae002","url":null,"abstract":"Background: The National Health Service (NHS) in England is facing a workforce crisis. A new Long Term Workforce Plan (LTWP) seeks to address this, setting out ambitious proposals to expand and reform domestic medical education and training in England. However, there are concerns about their feasibility.Sources of data: In September 2023, over 60 individuals representing medical education and training in the UK participated in an exercise run by UK Medical Schools Council by using systems theory to identify risks.Areas of agreement: The UK does need more 'home grown' doctors, but the LTWP has important gaps, including lack of attention to postgraduate training, absence of reference to the need for more educators and capital investment and risk of inadequate clinical placement capacity, particularly in primary care settings.Areas of controversy: There are unresolved differences in the understanding of a proposed medical apprenticeship model and no scheme has, as yet, been approved by the General Medical Council. Participants were unable to determine who the beneficiaries of this scheme will be (apart from the apprentices themselves).Growing points: While the LTWP represents a welcome, although overdue, commitment to address the NHS workforce crisis, we identified significant gaps that must be resolved.Areas timely for developing research: First, the development of the LTWP provides a case study that adds to literature on policymaking in the UK. Second, while we only examined the expansion of medical training, the method could be applied to other parts of the LTWP. Third, a prospective evaluation of its implementation is necessary.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"1-10"},"PeriodicalIF":6.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development of inherited cardiac conditions services: current position and future perspectives. 遗传性心脏病服务的发展：现状与未来展望。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-06-10 DOI: 10.1093/bmb/ldae003

Thomas Alway, Rachel Bastiaenen, Antonis Pantazis, Leema Robert, Rhoda Akilapa, John Whitaker, Stephen P Page, Gerald Carr-White

{"title":"The development of inherited cardiac conditions services: current position and future perspectives.","authors":"Thomas Alway, Rachel Bastiaenen, Antonis Pantazis, Leema Robert, Rhoda Akilapa, John Whitaker, Stephen P Page, Gerald Carr-White","doi":"10.1093/bmb/ldae003","DOIUrl":"10.1093/bmb/ldae003","url":null,"abstract":"Background: Over the last two decades, inherited cardiac conditions (ICC) centres have emerged with the aim of improving outcomes for patients and their families, through early diagnosis, genetic testing, risk assessment and specialist treatment.Sources of data: A literature search was performed using PubMed (https://pubmed.ncbi.nlm.nih.gov/). Commissioned ICC service reviews from NHS England, NHS Improvement and PHG Foundation were evaluated.Areas of agreement: ICC patient management requires a multi-disciplinary approach. ICC services are predominantly based within tertiary centres. Despite expansion, provision of care remains inadequate to meet rising demands. Access to services is inconsistent, partly due to geographic variation and lack of standardized pathways.Areas of controversy: The optimal ICC care model remains undecided, although there is growing interest in 'hub-and-spoke' networks, which could aid secondary and tertiary service integration and repatriation of care.Growing points: Genetic mainstreaming is a priority for the Genomic Medicine Service Alliance. The benefits of telehealth and virtual clinics have been validated by their use during the COVID-19 pandemic. Other innovations to improve resource efficiency, such as clinical scientist-led and nurse-led clinics, show promise.Areas timely for developing research: An update for the NHS ICC service specifications is planned that appears well timed given the rapid evolution of the ICC landscape in the decade since last review. This has the potential to address needs including national audit, standardized pathways and ICC networks to improve governance and equity of care. Delegation of commissioning for specialist services to integrated care systems may also provide opportunity for increased regional direction.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"11-22"},"PeriodicalIF":6.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disclosing non-visible disabilities in educational workplaces: a scoping review. 在教育工作场所披露非可视残疾：范围界定审查。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-06-10 DOI: 10.1093/bmb/ldae004

Juliet Hassard, Mehmet Yildrim, Louise Thomson, Holly Blake

{"title":"Disclosing non-visible disabilities in educational workplaces: a scoping review.","authors":"Juliet Hassard, Mehmet Yildrim, Louise Thomson, Holly Blake","doi":"10.1093/bmb/ldae004","DOIUrl":"10.1093/bmb/ldae004","url":null,"abstract":"Introduction: a sizable proportion of the working population has a disability that is not visible. Many choose not to disclose this at work, particularly in educational workplaces where disability is underrepresented. A better understanding of the barriers and facilitators to disclosure is needed.Sources of data: this scoping review is based on studies published in scientific journals.Areas of agreement: the reasons underpinning disclosure are complex and emotive-in-nature. Both individual and socio-environmental factors influence this decision and process. Stigma and perceived discrimination are key barriers to disclosure and, conversely, personal agency a key enabler.Areas of controversy: there is a growing trend of non-visible disabilities within the workplace, largely because of the increasing prevalence of mental ill health. Understanding the barriers and facilitators to disability disclosure is key to the provision of appropriate workplace support.Growing points: our review shows that both individual and socio-environmental factors influence choice and experience of disclosure of non-visible disabilities in educational workplaces. Ongoing stigma and ableism in the workplace, in particular, strongly influence disabled employees' decision to disclose (or not), to whom, how and when.Areas timely for developing research: developing workplace interventions that can support employees with non-visible disabilities and key stakeholders during and beyond reasonable adjustments is imperative.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"23-41"},"PeriodicalIF":6.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cultural competency training to address health disparities in surgical settings. 文化能力培训在解决外科手术环境中的健康差异方面的作用。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-06-10 DOI: 10.1093/bmb/ldae005

Roberto Mora, Mervyn Maze

{"title":"The role of cultural competency training to address health disparities in surgical settings.","authors":"Roberto Mora, Mervyn Maze","doi":"10.1093/bmb/ldae005","DOIUrl":"10.1093/bmb/ldae005","url":null,"abstract":"Background: Disparities in health care delivered to marginalized groups are unjust and result in poor health outcomes that increase the cost of care for everyone. These disparities are largely avoidable and health care providers, have been targeted with education and specialised training to address these disparities.Sources of data: In this manuscript we have sought out both peer-reviewed material on Pubmed, as well as policy statements on the potential role of cultural competency training (CCT) for providers in the surgical care setting. The goal of undertaking this work was to determine whether there is evidence that these endeavours are effective at reducing disparities.Areas of agreement: The unjustness of health care disparities is universally accepted.Areas of controversy: Whether the outcome of CCT justifies the cost has not been effectively answered.Growing points: These include the structure/content of the CCT and whether the training should be delivered to teams in the surgical setting.Areas timely for developing research: Because health outcomes are affected by many different inputs, should the effectiveness of CCT be improvement in health outcomes or should we use a proxy or a surrogate of health outcomes.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"42-59"},"PeriodicalIF":6.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0