British medical bulletin最新文献

All-inside arthroscopic procedures for chronic lateral ankle instability: evidence-based clinical practice guidelines. 慢性外侧踝关节不稳定的全内关节镜手术：循证临床实践指南。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-04-04 DOI: 10.1093/bmb/ldaf001

Shi-Ming Feng, Nicola Maffulli, C Niek van Dijk, Hai-Lin Xu, Kai Fehske, Christian Plaass, Francesco Oliva, Thomas Karius, Shun-Hong Gao, Wei Xu, Lu Bai, Run-Lai Song, Yue-Feng Hao, Hui Zhang, Yang-Bo Xu, Ning Zhang, Lei Lou, Tian-Tian Ren, Guo-Dong Wang, Qi Li, Jian-Hua Wu, Yong-Zhan Zhu, Gang Yin, Tong-Fu Wang, Jian-Zhong Qin, Amol Saxena, Chao Ma

{"title":"All-inside arthroscopic procedures for chronic lateral ankle instability: evidence-based clinical practice guidelines.","authors":"Shi-Ming Feng, Nicola Maffulli, C Niek van Dijk, Hai-Lin Xu, Kai Fehske, Christian Plaass, Francesco Oliva, Thomas Karius, Shun-Hong Gao, Wei Xu, Lu Bai, Run-Lai Song, Yue-Feng Hao, Hui Zhang, Yang-Bo Xu, Ning Zhang, Lei Lou, Tian-Tian Ren, Guo-Dong Wang, Qi Li, Jian-Hua Wu, Yong-Zhan Zhu, Gang Yin, Tong-Fu Wang, Jian-Zhong Qin, Amol Saxena, Chao Ma","doi":"10.1093/bmb/ldaf001","DOIUrl":"10.1093/bmb/ldaf001","url":null,"abstract":"Background: All-inside arthroscopic procedures are now frequently employed to manage chronic lateral ankle instability (CLAI) with satisfactory functional outcomes. Currently, no evidence-based guidelines exist for all-inside arthroscopic procedures for CLAI. Many surgical decisions remain uncertain and challenging.Sources of data: Published scientific literature in PubMed, MEDLINE, Web of Science, EMBASE, and Cochrane databases.Areas of agreement: All-inside arthroscopic repair and reconstruction procedures are reliable treatments for CLAI.Areas of controversy: The all-inside arthroscopic procedures for CLAI present significant challenges, particularly in the following aspects.Growing points: Given the lack of guidelines for the all-inside arthroscopic procedures for CLAI, this evidence-based clinical practice guideline provides 11 recommendations to address the controversy.Areas timely for developing research: In patients with CLAI undergoing all-inside arthroscopic procedures, comparative studies are urgently needed to establish the optimal timing for weight-bearing, as well as return to work and sports.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"154 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. 使用骨髓抽吸物浓缩液治疗膝骨关节炎：系统性综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae016

Filippo Migliorini, Marco Pilone, Jacopo Ascani, Luise Schäfer, Madhan Jeyaraman, Nicola Maffulli

{"title":"Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.","authors":"Filippo Migliorini, Marco Pilone, Jacopo Ascani, Luise Schäfer, Madhan Jeyaraman, Nicola Maffulli","doi":"10.1093/bmb/ldae016","DOIUrl":"10.1093/bmb/ldae016","url":null,"abstract":"Introduction: Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population.Source of data: Recent published literature identified from PubMed, EMBASE, Google Scholar, and Scopus.Areas of agreement: Orthobiological therapies try to regenerate articular cartilage and stop the progression of the degenerative lesion. Intra-articular injections of biological derivates have been increasingly used in the last decade.Areas of controversy: The indications for the use of bone marrow aspirate concentrate (BMAC) are still unclear.Growing points: We systematically reviewed the current literature on BMAC in the management of knee OA, giving an update on the current indications for the selection of the ideal patient and the preparations and efficacy of BMAC compared to other biological alternatives.Areas timely for developing research: BMAC is a valuable source of mesenchymal stem cells, offering potential benefits in attenuating the inflammatory pathway associated with knee OA. Intra-articular injection of BMAC has shown effectiveness in clinical trials improving functional outcomes of knee OA patients. The superiority of BMAC over other orthobiological treatments cannot be assessed because of conflicting results.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The athletes heart-from acute stimulus to chronic adaptation. 运动员的心脏从急性刺激到慢性适应。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae021

Joseph D Maxwell, David Oxborough

{"title":"The athletes heart-from acute stimulus to chronic adaptation.","authors":"Joseph D Maxwell, David Oxborough","doi":"10.1093/bmb/ldae021","DOIUrl":"10.1093/bmb/ldae021","url":null,"abstract":"Introduction: The complex phenomenon of the athlete's heart (AH) describes the chronic physiological structural and functional adaptation secondary to repeated exposure of an acute exercise stimulus.Sources of data: This narrative review is based on published evidence.Areas of agreement: Highly trained athletic individuals frequently display cardiac parameters which are suggestive of an AH and can exceed the traditional 'normal' limits.Area of controversy: The physiological processes underpinning the extent of cardiac adaption and how this is closely linked to exercise type, but also sex, ethnicity, and body size.Growing points: Since its seminal description by Morganroth and colleagues in 1975, our understanding of the AH has evolved in tandem with improvements in cardiac imaging techniques alongside the exploration of more diverse athletic populations. This narrative review aims to provide a balanced discussion of the multi-factorial nature of structure and function of the AH with specific reference to the unique physiological exercise stimuli.Areas timely for developing research: Despite great interest in cardiac adaptations across a broad spectrum of athletic populations, future research designs should consider the use of new and novel imaging techniques to enhance our understanding of the acute cardiovascular responses which ultimately mediates such adaptations, especially in athletic populations underrepresented in the literature.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity: ethical issues. 肥胖：伦理问题。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae022

Christopher Mayes, Jane Williams

引用次数: 0

Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. 用一个绳结经皮修复跟腱与用两个绳结修复跟腱的效果相当。前瞻性对比研究。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae019

Nicola Maffulli, George Christidis, Nikolaos Gougoulias, Panagiotis Christidis, Daryl Poku, Rifat Hassan, Filippo Migliorini, Francesco Oliva

{"title":"Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study.","authors":"Nicola Maffulli, George Christidis, Nikolaos Gougoulias, Panagiotis Christidis, Daryl Poku, Rifat Hassan, Filippo Migliorini, Francesco Oliva","doi":"10.1093/bmb/ldae019","DOIUrl":"10.1093/bmb/ldae019","url":null,"abstract":"Purpose: The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots.Methods: All patients underwent the procedure under local anesthesia. A total of 29 patients underwent percutaneous repair with two knots (Group A), and 33 patients underwent percutaneous repair with one knot (Group B). All patients were treated by a single surgeon between 2019 and 2021 and were followed prospectively for 24 months.Results: Patients' characteristics at baseline were similar between the two groups, except for age [38.0(15.0) vs 32.0(15.0) years, P = 0.028]. The procedure took longer for the two knots technique [19.0(4.0) vs 13.0(3.0) min, P < 0.001]. The Achilles tendon total rupture score was not different between the two techniques (90.7 ± 3.26 vs 90.5 ± 2.18, P = 0.737), as was the elongation of the gastrosoleus-Achilles tendon complex measured by the Achilles tendon resting angle [-1.0(2.0) vs - 1.0(2.0), P < 0.380]. The calf circumference of the injured and non-injured leg did not differ between the groups. Plantarflexion strength of the operated leg was significantly weaker than the non-operated leg in both groups. The European Foot and Ankle Society and patient reported outcome measures score by Piedade et al. scores were not statistically significant different between the two groups. No patient experienced a re-rupture, a venous thrombo-embolism episode, or injury to the sural nerve.Conclusion: The modified technique offered similar objective and subjective outcome measures, in addition to reduced operative time.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and performance of a novel synthetic biomimetic scaffold for iliac crest defect reconstruction during surgical treatment of pelvic girdle pain: a first-in-human trial. 一种新型合成仿生支架用于骨盆带痛手术治疗中髂骨缺损重建的安全性和性能：首次人体试验。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae023

Peter V Giannoudis, Paul Andrzejwski, George Chloros, Elizabeth M A Hensor

{"title":"Safety and performance of a novel synthetic biomimetic scaffold for iliac crest defect reconstruction during surgical treatment of pelvic girdle pain: a first-in-human trial.","authors":"Peter V Giannoudis, Paul Andrzejwski, George Chloros, Elizabeth M A Hensor","doi":"10.1093/bmb/ldae023","DOIUrl":"10.1093/bmb/ldae023","url":null,"abstract":"Introduction: Surgical treatment of pelvic girdle pain (PGP) involves arthrodesis of sacroiliac (SI) and pubic symphysis joints. Fusion of pubic symphysis involves the implantation of an autologous iliac crest tricortical graft harvested from the iliac crest. The objective was to assess the safety of a novel synthetic graft substitute (b.Bone) for iliac crest reconstruction and to evaluate the results of PGP surgical treatment.Sources of data: Consecutive participants undergoing pelvic fusion and requiring iliac crest reconstruction were enrolled and followed-up for 12 months in a prospective first-in-human clinical investigation. Adverse events were documented, and health-related quality of life was evaluated using EuroQol-5D-5L questionnaire. Iliac crest defect healing was evaluated by the Modified Lane and Sandhu radiological scoring system. In addition, relevant published peer-reviewed scientific articles identified from PubMed.Areas of agreement: The EQ-5D-5L scores improved steadily reaching the highest point at 365 days. By 365 days complete healing of the bone defect was observed.Areas of controversy: The management of PGP remains challenging with mixed results reported in the literature.Growing points: While there is lack of consensus on how to manage PGP, the present study shows improved outcomes at one year following surgery. The synthetic b.Bone scaffold is a safe option with good healing outcomes for iliac crest defect reconstruction.Areas timely for developing research: Although b.Bone synthetic scaffold found to be safe, further studies reporting on surgical treatment of PGP are required to confirm the findings in comparative trials.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"153 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicians' required competencies in AI-assisted clinical settings: a systematic review. 医生在人工智能辅助临床环境中所需的能力：系统回顾。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae025

Lotte Schuitmaker, Jojanneke Drogt, Manon Benders, Karin Jongsma

{"title":"Physicians' required competencies in AI-assisted clinical settings: a systematic review.","authors":"Lotte Schuitmaker, Jojanneke Drogt, Manon Benders, Karin Jongsma","doi":"10.1093/bmb/ldae025","DOIUrl":"10.1093/bmb/ldae025","url":null,"abstract":"Background: Utilizing Artificial Intelligence (AI) in clinical settings may offer significant benefits. A roadblock to the responsible implementation of medical AI is the remaining uncertainty regarding requirements for AI users at the bedside. An overview of the academic literature on human requirements for the adequate use of AI in clinical settings is therefore of significant value.Sources of data: A systematic review of the potential implications of medical AI for the required competencies of physicians as mentioned in the academic literature.Areas of agreement: Our findings emphasize the importance of physicians' critical human skills, alongside the growing demand for technical and digital competencies.Areas of controversy: Concrete guidance on physicians' required competencies in AI-assisted clinical settings remains ambiguous and requires further clarification and specification. Dissensus remains over whether physicians are adequately equipped to use and monitor AI in clinical settings in terms of competencies, skills and expertise, issues of ownership regarding normative guidance, and training of physicians' skills.Growing points: Our review offers a basis for subsequent further research and normative analysis on the responsible use of AI in clinical settings.Areas timely for developing research: Future research should clearly outline (i) how physicians must be(come) competent in working with AI in clinical settings, (ii) who or what should take ownership of embedding these competencies in a normative and regulatory framework, (iii) investigate conditions for achieving a reasonable amount of trust in AI, and (iv) assess the connection between trust and efficiency in patient care.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"153 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review. 骨骼不成熟患者的同种异体移植与自体移植前交叉韧带重建：系统性综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae020

Filippo Migliorini, Marco Pilone, Luise Schäfer, Francesca Alzira Bertini, Riccardo Giorgino, Nicola Maffulli

{"title":"Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.","authors":"Filippo Migliorini, Marco Pilone, Luise Schäfer, Francesca Alzira Bertini, Riccardo Giorgino, Nicola Maffulli","doi":"10.1093/bmb/ldae020","DOIUrl":"10.1093/bmb/ldae020","url":null,"abstract":"Introduction: Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common.Areas of agreement: Evidence of ACL reconstruction using allografts in children with open physes is limited.Areas of controversy: Whether the outcomes of ACL allograft reconstruction in children and adolescents with open physes are superior to autograft ACL reconstruction is unclear, with contrasting evidence.Source of data: In October 2024, the Web of Science, PubMed, and Embase were accessed with no additional filters. Only clinical investigations evaluating ACL reconstruction in children or adolescents with open physes were eligible. Only studies reporting a minimum length of 24 months of follow-up were included.Areas timely for developing research: Children who undergo allograft ACL reconstruction demonstrate similar functional outcomes to those who undergo autograft ACL reconstruction. Although allografts allow a faster return to sport, the greater laxity, the reduced activity level, and the higher failure and reoperation rates make their use dubious as a first-choice option for ACL reconstruction in skeletally immature patients.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circular RNAs in the management of human osteoporosis. 环状rna在人类骨质疏松症治疗中的应用。

IF 6.7 2区医学

British medical bulletin Pub Date : 2025-01-16 DOI: 10.1093/bmb/ldae024

Giuseppe Gargano, Simona M Pagano, Nicola Maffulli

{"title":"Circular RNAs in the management of human osteoporosis.","authors":"Giuseppe Gargano, Simona M Pagano, Nicola Maffulli","doi":"10.1093/bmb/ldae024","DOIUrl":"https://doi.org/10.1093/bmb/ldae024","url":null,"abstract":"Background: Osteoporosis (OP) is a metabolic bone disease producing reduction in bone mass with consequent bone fragility. Circular ribonucleic acid (CircRNA) is a form of RNA that forms a loop structure rather than a linear one. CircRNA can be used for therapeutic purposes, including molecular targets or to test new therapies.Sources of data: A systematic search of different databases to July 2024 was performed to define the role of circRNA in OP therapy. Seventeen suitable studies were identified.Areas of agreement: CircRNAs may be useful in studying metabolic processes in OP and identify possible therapeutic targets and new drug therapies.Areas of controversy: The metabolic processes involved in OP are regulated by many genes and cytokines that can be targeted by CircRNAs. However, it is not easy to predict whether the in vitro responses of the studied CircRNAs and their interaction with drugs are also applicable in vivo.Growing points: Metabolic processes can be affected by gene dysregulation of CircRNAs on various growth factors. Areas timely for developing research: Despite the predictability of CircRNA pharmacological response in vitro, such pharmacological response cannot be expected to be replicated in vivo.Data availability: The data that support the findings of this study are available from the corresponding author.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":"153 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-volume injections in Achilles tendinopathy: a systematic review. 跟腱病的大容量注射：系统性综述。

IF 6.7 2区医学

British medical bulletin Pub Date : 2024-12-12 DOI: 10.1093/bmb/ldae015

Rifat Hassan, Daryl Poku, Nafisa Miah, Nicola Maffulli

{"title":"High-volume injections in Achilles tendinopathy: a systematic review.","authors":"Rifat Hassan, Daryl Poku, Nafisa Miah, Nicola Maffulli","doi":"10.1093/bmb/ldae015","DOIUrl":"10.1093/bmb/ldae015","url":null,"abstract":"Introduction: Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (PRP) injections, and extracorporeal shockwave therapy. The published research on the effectiveness of HVI in the treatment of AT was evaluated in this systematic review.Sources of data: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed when conducting this systematic review. The electronic databases PubMed, Embase, Cochrane, Web of Science, CINAHL, and OVID were thoroughly searched, from inception to 13 September 2023, for articles assessing HVI for AT.Areas of agreement: A total of 10 studies with 460 participants met the inclusion criteria. HVI typically consisted of saline, local anaesthetic, and corticosteroids. HVI combined with corticosteroids demonstrated immediate and long-term improvements in ankle function. Compared to HVI without corticosteroids, HVI with corticosteroids exhibited greater, early improvements in pain and function, with no significant differences at later follow-up points. Significant reductions in tendon thickness and neovascularity were also found with HVI treatment over time.Areas of controversy: No adverse events were reported with HVI, despite the use of corticosteroids.Growing points: HVI is an effective and safe modality, particularly in the short term, to significantly reduce pain and discomfort in the Achilles tendon, especially when supplemented with corticosteroids.Areas timely for developing research: More robust randomized controlled trials, with longer-term follow-ups and homogeneity, are needed to fully establish its efficacy for AT.","PeriodicalId":9280,"journal":{"name":"British medical bulletin","volume":" ","pages":"35-47"},"PeriodicalIF":6.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0