British journal of hospital medicine最新文献

{"title":"The Application of Concept Map Thinking Combined with Kolcaba's Comfort Nursing in the Perioperative Care of Patients Undergoing Nasal Deformity Correction.","authors":"Yunping Deng, Yu Tian, Chang Guo, Yunping Fan, Jiaoqiong Guan, Yue Wang","doi":"10.12968/hmed.2024.0562","DOIUrl":"https://doi.org/10.12968/hmed.2024.0562","url":null,"abstract":"<p><p><b>Aims/Background</b> By addressing patients' physical, psychological, social, cultural, and environmental comfort needs holistically, Kolcaba's Comfort Theory raises the standard of care and increases patient satisfaction. This study explored the combined application of these nursing models during the perioperative period for patients undergoing nasal deformity correction surgery. <b>Methods</b> 92 patients undergoing nasal deformity correction at the Seventh Affiliated Hospital of Sun Yat-sen University were randomly divided into two groups: the conventional group (46 patients), which received standard perioperative nursing care, and the experimental group (46 patients), which received concept map thinking nursing combined with Kolcaba's comfort nursing intervention during the perioperative period. Clinical indicators, including the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI), Rhinoplasty Outcome Evaluation (ROE) and General Comfort Questionnaire (GCQ), were compared between the two groups at multiple time points. <b>Results</b> The experimental group demonstrated significantly shorter operation times (<i>p</i> < 0.001), faster recovery of nasal breathing (<i>p</i> = 0.002), and shorter hospital stays (<i>p</i> < 0.001) compared to the conventional group. Additionally, the experimental group experienced less intraoperative blood loss (<i>p</i> < 0.001) and a lower incidence of complications (<i>p</i> = 0.013). At 2 days, 1 month, and 3 months post-surgery, both groups showed decreases in SAS, SDS, and PSQI scores, with the experimental group demonstrating significantly lower scores (<i>p</i> < 0.05). At these same time points, the ROE and GCQ scores increased in both groups, with the experimental group achieving significantly higher scores than the conventional group (<i>p</i> < 0.05). <b>Conclusion</b> The integration of concept map thinking with Kolcaba's comfort nursing significantly improves the postoperative recovery of patients undergoing nasal deformity correction. Reduced surgical trauma, enhanced psychological health, better sleep, increased comfort, and quicker nasal function recovery are all results of this method. <b>Clinical Trial Registration</b> China Clinical Trial Registration Center (https://www.chictr.org.cn/showproj.html?proj=191278).</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-17"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Clinical Implications of pro-BNP and Soluble ST2 in Chronic Heart Failure.","authors":"Xing Meng, Kai Zhang, Wan-Jie Zeng, Zhen-Hua Hu","doi":"10.12968/hmed.2024.0465","DOIUrl":"https://doi.org/10.12968/hmed.2024.0465","url":null,"abstract":"<p><p><b>Aims/Background</b> Chronic heart failure (CHF) is a complex clinical syndrome resulting from various cardiac diseases, characterized by weakened cardiac pumping capacity and inadequate blood supply to body tissues. This study aims to investigate the expression and clinical implications of pro-B-type natriuretic peptide (pro-BNP) and soluble suppression of tumorigenicity 2 (sST2) in CHF to explore their potential in early diagnosis and severity assessment of the pathological condition. <b>Methods</b> This study included 146 CHF patients treated at our hospital from January 2022 to December 2023, who were classified in the observation group, and 150 concurrent healthy people categorized in the control group. pro-BNP and sST2 levels in the observation and control groups were compared. The diagnostic value of pro-BNP and sST2 in CHF was determined using receiver operating characteristic (ROC) curves. Besides, pro-BNP and sST2 levels in patients with different New York Heart Association (NYHA) grades were compared, and their relationships with left ventricular ejection fraction (LVEF), left atrial diameter (LAD), and left ventricular end-diastolic diameter (LVEDD) were assessed by means of Pearson's correlation. <b>Results</b> CHF cases showed markedly higher pro-BNP and sST2 levels than healthy controls (<i>p</i> < 0.05). The area under the ROC curves for pro-BNP and sST2 in diagnosing CHF was 0.826 (95% CI: 0.778-0.875) and 0.733 (95% CI: 0.674-0.791), respectively. pro-BNP and sST2 levels were similar in grades I and II patients (<i>p</i> > 0.05), but lower when compared with those in grades III and IV patients (<i>p</i> < 0.05). Grade III patients showed lower pro-BNP and sST2 expression than grade Ⅳ patients (<i>p</i> < 0.05). Additionally, pro-BNP and sST2 had an inverse connection with LVEF (r = -0.764 and r = -0.535, respectively) and a positive correlation with LAD (r = 0.752 and r = 0.535, respectively) and LVEDD (r = 0.721 and r = 0.544, respectively). <b>Conclusion</b> pro-BNP and sST2 exhibit good diagnostic value for CHF, owing to their close association with patients' cardiac function. These biomarkers can be used as effective indicators to evaluate the severity of heart failure.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-13"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Safety and Efficacy of α-n-Butyl-2-cyanoacrylate Glue versus Traditional Embolization Materials in the Treatment of Acute Renal Hemorrhage.","authors":"Liping Jiang, Xu Wang, Youting Zhang, Qibin Wang, Hongmei Zhang, Luoyi Ren","doi":"10.12968/hmed.2024.0514","DOIUrl":"https://doi.org/10.12968/hmed.2024.0514","url":null,"abstract":"<p><p><b>Aims/Background</b> This study aims to evaluate the safety and efficacy of α-n-butyl-2-cyanoacrylate (NBCA) glue in comparison with traditional embolization materials for the treatment of acute renal hemorrhage. <b>Methods</b> A total of 105 patients with the acute renal hemorrhage who underwent superselective renal artery embolization were enrolled. The patients were divided into two groups based on the embolization materials used: the traditional group (43 cases, control group) and the medical glue group (62 cases, observation group). Demographic characteristics, medical history, preoperative and postoperative 24-hour blood counts, renal function, and other clinical data were collected. The safety and efficacy of the two treatment methods were then compared between the groups. <b>Results</b> No significant difference in efficacy was observed between the traditional group and the medical glue group (<i>p</i> > 0.05). However, significant differences were found between the two groups in terms of embolization vessel grade, systemic immune-inflammation index (SII) difference, estimated glomerular filtration rate (eGFR) difference, and combined eGFR difference (<i>p</i> < 0.05). The traditional group exhibited a higher postoperative inflammatory response and greater renal function damage compared to the medical glue group. The degree of vascular embolization also influenced the extent of postoperative inflammatory response and renal function damage in patients with acute renal hemorrhage. <b>Conclusion</b> Compared to traditional embolization materials, NBCA glue demonstrates a clear hemostatic effect in the treatment of patients with acute renal hemorrhage, while also leading to reduced postoperative inflammatory response and renal function damage. NBCA adhesive is both safe and effective for treating acute renal hemorrhage.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-16"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Sepsis Severity Using Combined High-Density Lipoprotein and Red Cell Distribution Width Indicators.","authors":"Yan Gao, Yao Chen, Li Gao","doi":"10.12968/hmed.2024.0473","DOIUrl":"https://doi.org/10.12968/hmed.2024.0473","url":null,"abstract":"<p><p><b>Aims/Background</b> Sepsis is a life-threatening condition resulting from dysregulated immune responses to infection, leading to organ dysfunction. High-density lipoprotein (HDL) and red cell distribution width (RDW) have shown significant correlations with sepsis severity, yet the combined prognostic value of HDL and RDW in evaluating sepsis severity and outcomes remains unclear. This study examines the relationship between HDL and RDW levels and sepsis severity, as well as evaluates the combined utility of these markers in predicting disease severity and patient outcomes. <b>Methods</b> This retrospective study included 103 patients diagnosed with sepsis. Clinical data, including HDL and RDW levels, were collected for analysis. Patients were divided into shock and non-shock groups based on the presence of septic shock and into survival and death groups based on 30-day in-hospital mortality. Multivariate logistic regression was used to identify factors influencing sepsis severity and prognosis, while the predictive value of HDL in combination with RDW was evaluated using receiver operating characteristic (ROC) curve analysis. <b>Results</b> Multivariate analysis identified sequential organ failure assessment (SOFA) score (OR = 6.566), interleukin-6 (IL-6) (OR = 2.568), HDL (OR = 0.864), and RDW (OR = 4.052) as independent predictors of sepsis severity (<i>p</i> < 0.05 for all). ROC analysis demonstrated that HDL combined with RDW yielded the highest diagnostic accuracy for sepsis severity, with an area under curve (AUC) of 0.962, sensitivity of 97.56%, and specificity of 91.94%. Additionally, SOFA score (OR = 2.354), interleukin-6 (IL-6) (OR = 1.446), HDL (OR = 0.870), and RDW (OR = 3.502) were independent prognostic indicators (<i>p</i> < 0.05 for all). ROC analysis for prognosis showed that HDL combined with RDW had the highest predictive efficacy for the prognosis of sepsis, with an AUC of 0.922, sensitivity of 79.31%, and specificity of 93.24%. <b>Conclusion</b> The combination of HDL and RDW is a robust indicator for the evaluation of sepsis severity and is a valuable prognostic tool for assessing 30-day mortality risk in sepsis patients.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity in Cardiovascular Care: Advancing Health Equity.","authors":"David R Thompson, Chantal F Ski","doi":"10.12968/hmed.2024.0690","DOIUrl":"10.12968/hmed.2024.0690","url":null,"abstract":"<p><p>Health inequities exist in cardiovascular care and outcomes, especially among women, older people, individuals from racial and ethnic minorities, lower income and rural communities often those most vulnerable to adverse health outcomes. Such diverse groups form most of the patient population but they are rarely reflected in the composition of the cardiovascular care workforce. Yet a diverse cardiovascular health care workforce can enhance access to care, reduce health disparities and inequities, and improve quality of care and research for such underserved populations. Such diversity also benefits student and staff development and strengthens organizational performance. A work environment and culture that embraces and celebrates diversity will likely advance health equity.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity of Functional Arterial Spin Labelling in Detecting Cerebral Blood Flow Changes.","authors":"Qing Li, Shan Shen, Ming Lei","doi":"10.12968/hmed.2024.0433","DOIUrl":"https://doi.org/10.12968/hmed.2024.0433","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Aims/Background&lt;/b&gt; Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) method. ASL techniques can quantitatively measure cerebral perfusion by fitting a kinetic model to the difference between labelled images (tag images) and ones which are acquired without labelling (control images). ASL functional MRI (fMRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer instead of depending on vascular blood oxygenation level.This study aimed to assess the number of pulsed ASL blocks that were needed to provide accurate and reliable regional estimates of cerebral blood flow (CBF) changes when participants engaged in visually guided saccade and fixation task; evaluate the localization to cortical control saccade versus fixation; investigate the relationship between the sensitivity of ASL fMRI and the number of blocks; and compare the sensitivity of blood oxygen level-dependent (BOLD) fMRI and ASL fMRI. &lt;b&gt;Methods&lt;/b&gt; The experiment was a block-design paradigm consisting of two conditions: fixation and saccade. No response other than the eye movements of the participants was recorded during the scans. ASL and BOLD fMRI scans were conducted on all participants during the same session. The fMRI study consisted of two functional experiments: a CBF contrast was provided using the ASL sequence, and an optimized BOLD contrast was provided using the BOLD sequence. &lt;b&gt;Results&lt;/b&gt; From group analysis in all divided blocks of ASL sessions (4, 6, 8...... 14, 16, 18......26, 28, 30), ASL yielded significant activation clusters in the visual cortex of the bilateral hemisphere from block 4. There was no false activation from block 4. No activation cluster was found by reversing analysis of block 2. Robust and consistent activation in the visual cortex was observed in each of the 14 divided blocks group analysis, and no activation was found in the eye field of the brain. The sensitivity of 4-block was found to be better than that of 8-block. More significant activation clusters of the visual cortex were found in BOLD than in ASL. No activation cluster of parietal eye field (PEF), frontal eye field (FEF) and supplementary eye field (SEF) was detected in ASL. The voxel size of the activation cluster increased with the increasing number of blocks, and the percent signal change in the activation cluster decreased with the escalating block number. The voxel size was positively correlated with the number of blocks (correlation coefficient = 0.98, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001), and the percent signal change negatively correlated with the number of blocks (correlation coefficient = -0.90, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001). &lt;b&gt;Conclusion&lt;/b&gt; The 4-block pulsed functional ASL (fASL) presents accurate and reliable activation, with minimal time-on-task effect and little adverse impact of time, in participants engaging in visually guided saccade and fixation tasks. Despite having lower sensitivity than BOLD fMRI, ASL can determine accurate","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-21"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Showing the Best Version of Yourself\": The Importance of Dynamic Assessment for Trainees Undergoing Workplace-Based Assessments in Postgraduate Training.","authors":"John Sandars, Dario Cecilio-Fernandes, Rakesh Patel","doi":"10.12968/hmed.2024.0489","DOIUrl":"https://doi.org/10.12968/hmed.2024.0489","url":null,"abstract":"<p><p>Workplace-based assessments (WPBAs) in postgraduate training may not always provide an accurate representation of a trainee's capability to perform a given task, or a true measure of a trainee's overall competence in clinical practice settings. This article describes how trainers can use a theory-driven and evidence-based intervention called dynamic assessment for providing an individual with the best opportunity to demonstrate a more accurate representation of their performance, and ultimately present the best version of themselves when undergoing an observed WPBA, such as a Direct Observation of Procedural Skills (DOPS) or Mini Consultation Evaluation Exercise (MiniCEX). Dynamic assessment simultaneously combines educational support with assessment as the trainee undergoes the WPBA by using focussed questions as prompts to facilitate an individual trainee's essential coordination of their motivational and thinking processes since this is often challenged during assessments. In addition, the response to the prompts can also provide trainers with information to inform specific feedback for future professional development.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Carotid Plaque Features in Symptomatic and Asymptomatic Ischemic Stroke.","authors":"Shili Zhou, Yanhong Yan, Pinjing Hui","doi":"10.12968/hmed.2024.0406","DOIUrl":"https://doi.org/10.12968/hmed.2024.0406","url":null,"abstract":"<p><p><b>Aims/Background</b> Ischemic stroke (IS), a cerebrovascular condition, is commonly detected by evaluating carotid intima-media (CIA) stenosis. Symptomatic CIA stenosis carries a high risk (up to 32%) of another ischemic event within 12 weeks, while asymptomatic CIA stenosis has an annual risk ranging from 1% to 2%. Therefore, this study aims to explore the diagnostic value of clinical features and carotid plaque characteristics in both symptomatic and asymptomatic IS. <b>Methods</b> This study enrolled 543 consecutive patients with internal carotid artery stenosis confirmed by carotid ultrasonography. Participants were categorized into the symptomatic group (n = 356) and the asymptomatic group (n = 187) by clinical symptoms and computed tomography (CT)/magnetic resonance imaging (MRI) of the brain. Demographic data, clinical features, and ultrasonographic characteristics of the carotid plaque were collected, and logistics regression analysis was carried out to explore the predictive risk factors of IS. <b>Results</b> According to the differences in clinical and carotid plaque characteristics between the two groups, coronary heart disease (CHD), stenosis degree, plaque diameter, plaque length, plaque vulnerability, and plaque echo type were included. The results of the multivariate logistics regression analysis showed that plaque vulnerability, CHD, and plaque hypoechogenicity were independent predictors of symptomatic stroke. The clinical-ultrasonographic prediction model showed an area under the curve (AUC) of 0.85 [95% confidence interval (CI): 0.82-0.88], a sensitivity of 0.74 (95% CI: 0.69-0.78), and a specificity of 0.81 (95% CI: 0.76-0.87), with a good performance in the model prediction. <b>Conclusion</b> Plaque vulnerability, CHD, and plaque hypoechogenicity are meaningful predictors of symptomatic ischemic stroke and deserve attention in the future.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-13"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Serum Biomarkers and Disease Progression of Chronic Kidney Disease.","authors":"Junyue Xu, Xingwang Jia, Xueguang Zhang, Xiaocui Jiao, Shana Zhang, Yahong Zhao, Xiaohong Wu, Yi Li, Xuetong Liu, Qian Yu","doi":"10.12968/hmed.2024.0474","DOIUrl":"https://doi.org/10.12968/hmed.2024.0474","url":null,"abstract":"<p><p><b>Aims/Background</b> The present study aimed to assess the capability of biomarkers, including inflammatory indicators, anaemic markers, lipid markers, and renal function indices, to differentiate between different stages of chronic kidney disease (CKD). Expected to provide a new strategy for monitoring the development of CKD and stratified treatment management, providing valuable insights for future biomarker studies to explore early detection of CKD. <b>Methods</b> The changes in inflammatory markers (interferon gamma [IFN-γ], interleukin [IL]-17A, IL-10, IL-6, IL-4, IL-2, IL-1 and white blood cells [WBC]), lipid markers (high-density lipoprotein cholesterol [HDL-c], low-density lipoprotein cholesterol [LDL-c], and triglyceride [TG]), indicators of kidney injury (serum creatinine [Scr] and blood urea nitrogen [BUN]) in 451 patients with different stages of CKD were examined. Furthermore, these markers were compared between 299 anemic patients and 53 non-anemic patients. Univariate and multivariate regression analyses were employed to analyze the association between these biomarkers and estimated glomerular filtration rate (eGFR). To identify risk factors associated with the development of CKD, we utilized principal component analysis to evaluate their utility as potential diagnostic and prognostic markers for the disease. <b>Results</b> Significant differences were found in IL-6, BUN, and hemoglobin (Hb) levels across CKD stages 2 to 5. Anaemic individuals had elevated levels of IL-6, Scr, and BUN compared to non-anaemic individuals. In addition, the multivariate linear regression analysis revealed that IL-1 (<i>p</i> = 0.022), IL-6 (<i>p</i> = 0.022), Hb (<i>p</i> < 0.001), and BUN (<i>p</i> < 0.001) were statistically significant predictors of eGFR. Furthermore, it was discovered that the blood levels of IL-6 (<i>p</i> = 0.012), BUN (<i>p</i> < 0.001), and Hb (<i>p</i> < 0.001) were risk factors associated with the stages of CKD. <b>Conclusion</b> Serum levels of IL-6, BUN and Hb have been associated with the progression of CKD. Using a combination of serum biomarkers is a potential strategy for tracking the development of CKD, facilitating stratified management and early intervention.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-14"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Gabapentin versus Pregabalin in the Treatment of Postherpetic Neuralgia: A Retrospective Cohort Study.","authors":"Yi Shi, Chunhong Song","doi":"10.12968/hmed.2024.0485","DOIUrl":"https://doi.org/10.12968/hmed.2024.0485","url":null,"abstract":"<p><p><b>Aims/Background</b> Postherpetic neuralgia (PHN) is a common chronic pain disease that persists after the rash (clusters of clear blisters on the surface of the skin) has healed, adversely affecting the quality of life of affected patients. Gabapentin (GPT) and pregabalin (PGB) are two commonly used drugs for the treatment of PHN, but there have been broad concerns regarding their efficacy and safety. Thus, this retrospective cohort study was conducted to investigate the effectiveness and safety of GPT versus PGB in the treatment of PHN. <b>Methods</b> A total of 150 patients with PHN receiving routine antiviral and neurotrophic therapies, admitted between January 2022 and November 2023, were selected. 71 patients who were treated with GPT were included in the control group, while the remaining 79 patients who were given PGB were categorized in the observation group. Information on clinical effectiveness, safety (xerostomia, drowsiness, blurred vision, ataxia, and dizziness), analgesic effect (Visual Analogue Scale [VAS] and time to pain relief), sleep quality (Sleep Quality Scale [SQS] and Pittsburgh Sleep Quality Index [PSQI]), and adverse emotions (Self-rating Anxiety/Depression Scale [SAS/SDS]) was collected for analysis. <b>Results</b> Compared to the control group, the observation group exhibited significantly higher clinical effectiveness of PGB in the treatment of PHN (<i>p</i> < 0.05). In other aspects, the overall incidence of adverse events such as xerostomia, drowsiness, blurred vision, ataxia, and dizziness (<i>p</i> > 0.05) was equivalent in these two groups. In addition, significantly lower VAS, SQS, PSQI, SAS, and SDS scores were observed in the observation group after treatment, compared with the control group (<i>p</i> < 0.05). The observation group showed evidently shorter time to pain relief than the other group (<i>p</i> < 0.05). <b>Conclusion</b> PGB is an effective and safe medication for the treatment of PHN, by improving the analgesic effect and sleep quality, and alleviating negative emotions.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"85 12","pages":"1-11"},"PeriodicalIF":1.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}