British journal of hospital medicine最新文献

{"title":"Breaking Barriers: Achieving Equity in Acute Stroke Care.","authors":"Ranvir S P Cheema, Philip M White, Nasar Ahmad, Randeep Mullhi, Tonny Veenith","doi":"10.12968/hmed.2025.0022","DOIUrl":"https://doi.org/10.12968/hmed.2025.0022","url":null,"abstract":"<p><p>Stroke is a leading cause of morbidity and mortality worldwide but there are significant differences in access to acute stroke care between geographical regions. Indeed, inequalities in acute stroke care continue to exist within the UK. Reperfusion therapies including mechanical thrombectomy (MT) are now the established standard of care for acute ischaemic stroke. However, availability of these therapies remains variable across the UK, with patients in rural areas potentially facing a poorer outcome. Reasons for this include delayed ambulance response times for both primary transfer to an acute stroke centre (ASC) and secondary transfers to comprehensive stroke centres (CSCs), MT only being available in CSCs and consequently neurointerventionists are disproportionately concentrated in the London/South of England, where a greater number of these centres are located. Furthermore, there has been a lack of investment in stroke care outside of comprehensive stroke centres, with imaging facilities in ASCs often suboptimal, and variability in consultant stroke physician staffing/presence, delaying decision making. The neurointerventionist workforce is undergoing a rapid expansion, however, further investment is required to ensure equity of access to acute stroke care across the UK and across the world.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-6"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal Cardiopulmonary Resuscitation: Reviewing the Evidence and Exploring Its Equitable Implementation in the UK National Health Service.","authors":"Waqas Akhtar, Nicholas A Barrett","doi":"10.12968/hmed.2024.0792","DOIUrl":"https://doi.org/10.12968/hmed.2024.0792","url":null,"abstract":"<p><p>Extracorporeal cardiopulmonary resuscitation offers a potentially revolutionary improvement in the historically poor outcomes for refractory cardiac arrest. Current evidence has only demonstrated efficacy in single high volume centres in Europe and the USA and important logistical and health economic considerations remain for a country wide roll out. In this article we will review the evidence and equitable delivery of extracorporeal cardiopulmonary resuscitation in the context of the principles of the United Kingdom healthcare system for a general medical audience.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrice-Weekly Insulin Degludec Versus Once-Daily Insulin Glargine in Insulin-Naïve Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.","authors":"A B M Kamrul-Hasan, Sanja Borozan, Cornelius J Fernandez, Deep Dutta, Lakshmi Nagendra, Joseph M Pappachan","doi":"10.12968/hmed.2024.0716","DOIUrl":"https://doi.org/10.12968/hmed.2024.0716","url":null,"abstract":"<p><p><b>Aims/Background</b> Data from randomized controlled trials (RCTs) comparing the efficacy and safety of thrice-weekly insulin degludec (IDeg 3TW) versus once-daily insulin glargine (IGlar OD) in patients with type 2 diabetes mellitus (T2DM) are scarce and not uniform. Moreover, no systematic review and meta-analysis (SRM) is available for such a comparison. This SRM aimed to compare the effectiveness and safety of IDeg 3TW versus IGlar OD in the available RCTs in T2DM. <b>Methods</b> Electronic databases and registers, which include MEDLINE (via PubMed), Scopus, Cochrane Central Register, and ClinicalTrials.gov, were searched for RCTs conducted among T2DM subjects with IDeg 3TW as intervention and IGlar OD as control from inception to 30 July 2024. The primary outcome was glycated haemoglobin (HbA1c) reduction from baseline; secondary outcomes were the changes in other glycemic parameters and adverse events (AEs). RevMan web was used to conduct meta-analysis using random-effects models. Outcomes were presented as mean difference (MD), odds ratio (OR), or risk ratio (RR) with 95% confidence intervals (CIs). <b>Results</b> Three RCTs (N = 1171) with study durations ranging from 16-26 weeks and minimal risk of bias were included. IDeg 3TW was less effective than IGlar OD in HbA1c reduction (MD 0.27%, 95% CI [0.14, 0.39], <i>p</i> < 0.0001), reduction in mean nine-point self-monitored capillary blood glucose profile (MD 0.45 mmol/L, 95% CI [0.22, 0.67], <i>p</i> < 0.0001), and HbA1c reduction <7% (OR 0.69, 95% [0.53, 0.89], <i>p</i> = 0.005). IDeg 3TW outperformed IGlar OD regarding the mean daily insulin dose (MD -0.07 U, 95% CI [-0.13, -0.01], <i>p</i> = 0.02). However, both groups achieved comparable fasting plasma glucose reduction (MD 0.37 mmol/L, 95% [-0.19, 0.93], <i>p =</i> 0.19), changes in body weight (MD 0.04 kg, 95% CI [-0.46, 0.55], <i>p =</i> 0.86), and overall physical (MD 0.21, 95% CI [-0.62, 1.04], <i>p</i> = 0.62) and mental health scores (MD -0.02, 95% CI [-1.05, 1.01], <i>p</i> = 0.97). The risks for confirmed hypoglycemia (RR 1.16, 95% CI [0.83, 1.62], <i>p</i> = 0.38), nocturnal hypoglycemia (RR 1.18, 95% CI [0.49, 2.84], <i>p</i> = 0.71), any AEs (RR 1.04, 95% CI [0.84, 1.30], <i>p</i> = 0.71), serious AEs (RR 1.43, 95% CI [0.77, 2.65], <i>p</i> = 0.25), and injection-site reactions (RR 1.29, 95% CI [0.56, 2.96], <i>p</i> = 0.55) were identical in the two groups. <b>Conclusion</b> In short-term follow-up, IDeg 3TW was less effective than IGlar OD in glycaemic control; however, their safety profile was comparable. Larger multicenter RCTs comparing the overall benefit-risk ratio are necessary for appropriate clinical practice decisions. <b>Systematic Review Registeration</b> PROSPERO: CRD42024593493.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-16"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating Opioid Dependence in Orthopaedic Surgery: Current Strategies and Future Directions.","authors":"Hugo Humphries, Andreas Fontalis, Warran Wignadasan, Fares S Haddad","doi":"10.12968/hmed.2024.1022","DOIUrl":"https://doi.org/10.12968/hmed.2024.1022","url":null,"abstract":"<p><p>The opioid crisis presents a significant burden to patients and healthcare systems. Orthopaedic surgery involves treating patients with significant pain demands, therefore opioid stewardship in this specialty is an important area in targeting the opioid crisis. A number of strategies have been outlined in the literature to help reduce prescription of opioids for patients with painful orthopaedic conditions. Enhanced recovery after surgery (ERAS) protocols involving multimodal analgesia (MMA) and multi-disciplinary team (MDT) involvement have been proven effective. Pre-operative counselling of patients with clear communication and educational resources helps to educate patients on the negative effects overuse of opioids can have post-operatively. Novel strategies are being investigated to reduce opioid dependence, particularly in the areas of artificial intelligence (AI) and machine learning (ML), which can help predict patients at increased risk of opioid dependence post-operatively and therefore provide personalised treatment to prevent the harmful sequelae.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-7"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Myopia Among Children and Adolescents Aged 5-17: A Cross-Sectional Study in Haishu District, Ningbo City, China.","authors":"Xinru Jia, Shuang Wang, Jixiang Zhu, Dongwei Yao, Yan Shi, Chengfei Lin","doi":"10.12968/hmed.2025.0241","DOIUrl":"https://doi.org/10.12968/hmed.2025.0241","url":null,"abstract":"<p><p><b>Aims/Background</b> The rising incidence of myopia in children and adolescents represents a significant global public health concern in the domain of vision health and issues, especially in Asian countries like China. This study aims to investigate the prevalence and influencing factors of myopia among children and adolescents aged 5-17 in Haishu District, Ningbo City, China. <b>Methods</b> A cross-sectional study was conducted using visual acuity data from 95,985 participants collected between July and December 2023. The participants included children and adolescents from senior kindergarten, primary and secondary schools. <b>Results</b> The overall prevalence of myopia was 51.09%, with higher rates in urban (52.71%) than suburban areas (49.18%). Among males, the prevalence was 48.80%, while among females, it was higher at 53.68%. Prevalence rate increased significantly with age, particularly among individuals aged between 8 and 13 years, with girls surpassing boys from age 9. By ages 14-17, the prevalence among girls reached a plateau, while the boys' rates continued to rise. The median spherical equivalent was -2.00 D (right eye) and -1.88 D (left eye). <b>Conclusion</b> The findings highlight the need for targeted, age- and region-specific vision protection measures to address the rising myopia burden among children and adolescents.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-15"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Analyses Identify Human Serum Metabolites Associated With Risk of Gastroesophageal Reflux Disease: A Mendelian Randomization Study.","authors":"Xiang Shi, Lu Zhang, Wei Huang, Min Li, Yuyan Chen, Yilin Hu, Cuihua Lu, Chenzhou Xu, Zhaoxiu Liu","doi":"10.12968/hmed.2025.0067","DOIUrl":"https://doi.org/10.12968/hmed.2025.0067","url":null,"abstract":"<p><p><b>Aims/Background</b> Gastroesophageal reflux disease (GERD) is a widespread upper esophagogastric disease with incompletely understood biological mechanisms. Emerging evidence supports a complex link between GERD and metabolic markers. Therefore, Mendelian randomization (MR), an innovative genomic approach, was used to evaluate the causal impacts of serum metabolites on GERD, aiming to identify novel biomarkers and elucidate underlying metabolic pathways. <b>Methods</b> A two-sample MR framework was employed to examine causal relationships between circulating metabolites and GERD. Genetic instruments for 486 metabolic traits were derived from a comprehensive metabolomics genome-wide association study (GWAS), with disease outcome data from GERD cohorts. Primary causal inference was conducted using the inverse variance weighted (IVW) method, supported by complementary and sensitivity analyses to validate the reliability of the findings. The analytical framework incorporated multiple validation approaches, including replication, meta-analysis, linkage disequilibrium score regression, colocalization analysis, reverse MR analysis, and multivariable MR analysis. Systematic pathway analysis was employed to elucidate associated pathways and underlying disease mechanisms. <b>Results</b> The IVW analysis identified 32 causal associations between serum metabolites and GERD. Through subsequent sensitive analyses, robust causal links were identified between 13 metabolites and GERD. By applying several advanced approaches, such as replication, meta-analysis, linkage disequilibrium score regression, colocalization analyses, reverse MR analysis, and multivariable MR analysis, two metabolites, adrenate (22:4n6) and 2-palmitoylglycerophosphocholine, were confirmed to have stable and independent impacts on GERD. Pathway analysis revealed that three metabolic pathways, such as tryptophan metabolism, bile acid biosynthesis, and carnitine synthesis, exhibited significant association with GERD. <b>Conclusion</b> Using integrative genomics and metabolomics approaches, this study provides evidence supporting the causal influence of two serum metabolites and three metabolic pathways on GERD, highlighting the potential of these metabolites as promising biomarkers for early screening, diagnosis, and targeted treatment strategies. Moreover, these findings underscore the significance of integrating genomics and metabolomics in understanding disease pathophysiology.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-19"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Risk Factors Impacting the Severity of Coronary Artery Lesions in Kawasaki Disease.","authors":"Guangli Zhu, Ping Zhang","doi":"10.12968/hmed.2025.0047","DOIUrl":"https://doi.org/10.12968/hmed.2025.0047","url":null,"abstract":"<p><p><b>Aims/Background</b> Kawasaki disease (KD) is a systemic vasculitis primarily affecting children under five. Coronary artery lesions (CAL), a severe complication associated with KD, can lead to long-term cardiovascular problems and even life-threatening conditions. However, the pathological mechanisms underlying CAL in KD patients remain unexplored. Therefore, this study aims to investigate the risk factors affecting the severity of CAL in KD patients, providing valuable insights for early identification and clinical intervention of KD. <b>Methods</b> This single-center retrospective study included 326 KD patients treated at the pediatric clinic of The Second People's Hospital of Changzhou between January 2016 and December 2023. Baseline data, clinical characteristics, cardiac function-related indicators, and CAL severity-related information were retrieved from the hospital's electronic record system. Furthermore, risk factors affecting CAL severity were identified using logistic regression analysis. <b>Results</b> Among the 326 patients, 51 (15.64%) developed varying degrees of CAL, with 3.07% exhibiting severe CAL. KD patients were presented with clinical symptoms, such as fever, rash, oral mucosal changes, lymphadenopathy, and swelling of the hands and feet. Univariate analysis revealed younger age, longer fever duration, higher platelet count (PLT), elevated C-reactive protein (CRP) levels, faster erythrocyte sedimentation rate (ESR), increased white blood cell (WBC) count, elevated lactate dehydrogenase (LDH) levels, lower left ventricular ejection fraction (LVEF), and lower cardiac indices as significant risk factors for CAL development (<i>p</i> < 0.05). Furthermore, multivariate logistic regression analysis identified longer fever duration, higher PLT levels, increased CRP levels, and lower LVEF as independent risk factors for CAL development (<i>p</i> < 0.05). <b>Conclusion</b> Evaluating CAL development in KD patients requires a comprehensive assessment of clinical characteristics, inflammatory indicators, and cardiac function indices.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Prescribing: What It Is and What It Can Do.","authors":"Joelle Bradly, Monica Boulton","doi":"10.12968/hmed.2025.0007","DOIUrl":"https://doi.org/10.12968/hmed.2025.0007","url":null,"abstract":"<p><p>Social prescribing is proposed as a way to address social determinates of health and improve health and well-being outcomes and increasingly, acute hospitals, secondary and specialist care services are also implementing the approach. There are many local small-scale studies that have explored the benefits of social prescribing and, more recently, larger scale evaluations have brought together evidence across different areas. These studies suggest that social prescribing is able to reach those facing inequalities and can lead to economic benefits to health services as well as social and health related outcomes for individuals. However, it is also important to consider the systems that link workers fit into and how this contributes to addressing social determinates of health.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Correlation Analysis of Early Sepsis Recognition and Patient Prognosis: A Single-Center Retrospective Study.","authors":"Yingxia Jing, Yunlong Wu","doi":"10.12968/hmed.2025.0166","DOIUrl":"https://doi.org/10.12968/hmed.2025.0166","url":null,"abstract":"<p><p><b>Aims/Background</b> Sepsis is a critical medical emergency with a significantly high mortality rate. This study aims to investigate the relationship between changes in early indicators and prognosis, exploring the link between early sepsis recognition and patient outcomes. <b>Methods</b> This retrospective analysis included clinical data from 183 sepsis patients admitted to the hospital between July 2021 and November 2024. Based on the recognition time, patients were divided into an early recognition group (within 6 hours after admission, n = 136) and a delayed recognition group (6 hours after admission, n = 47). The baseline characteristics, early recognition indicators, therapeutic measures, and prognostic outcomes were collected, and the relationship between these variables was analyzed using the logistic regression analysis. <b>Results</b> There were no significant differences between the early and delayed recognition groups regarding age, gender, immunity status, and the distribution of common underlying conditions (<i>p</i> > 0.05). However, the sequential organ failure assessment (SOFA) scores were significantly higher in the delayed recognition group compared to the early recognition group (<i>p</i> < 0.05). The two groups showed significant differences in key indicators such as body temperature, heart rate, respiratory rate, white blood cell count (WBC), C-reactive protein (CRP), neutrophil ratio, procalcitonin (PCT), lactate, platelet count, and D-dimer levels (<i>p</i> < 0.05). The early recognition group received anti-infective treatment timely, had reasonable fluid resuscitation, a lower proportion of vasoactive drug usage, and reduced mechanical ventilation use (<i>p</i> < 0.05). The early recognition group had a shorter duration of hospitalization, good recovery of organ function at discharge, and significantly lower mortality and complication rates than the delayed recognition group (<i>p</i> < 0.05). Logistic regression analysis revealed that heart rate, respiratory rate, CRP, PCT, neutrophil ratio, lactate, D-dimer, and SOFA score ≥8 points were independent risk factors affecting prognosis (<i>p</i> < 0.05). <b>Conclusion</b> Early sepsis recognition, followed by prompt therapeutic measures, significantly improves patient prognosis, and relevant indicators help early sepsis identification and prognosis assessment.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-12"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Maternal Autoantibody Levels and Neurodevelopmental Outcomes in Infants Born to Mothers With Rheumatic Disease.","authors":"Bingqing Liu, Jia Xu, Mengxian Liu, Xia Gu, Peijun Xu","doi":"10.12968/hmed.2024.0411","DOIUrl":"https://doi.org/10.12968/hmed.2024.0411","url":null,"abstract":"<p><p><b>Aims/Background</b> Maternal autoimmune conditions have been associated with adverse pregnancy outcomes and neonatal complications, with potential impacts on fetal neurodevelopment. However, the specific associations between maternal autoantibody levels and neurodevelopmental outcomes in the context of rheumatic diseases remain incompletely understood. Therefore, this study aimed to investigate the relationship between maternal autoantibody profiles and infant neurodevelopmental outcomes in a cohort of mothers with rheumatic diseases, and to evaluate their diagnostic value in predicting neurodevelopmental disorders. <b>Methods</b> This retrospective case-control study included patients admitted for antenatal care with rheumatic conditions from January 2017 to June 2022. Participants were categorised into the normal neurodevelopment group (n = 404) and the neurodevelopmental disorder group (n = 111) based on infant neurodevelopmental outcomes. Maternal cytokines and hormone levels, as well as autoantibody levels, were measured and analysed. Statistical analyses, including correlation and multivariable logistic regression, were employed to evaluate associations between maternal biomarkers and infant neurodevelopmental outcomes. <b>Results</b> Statistically significant differences were observed between the two groups in terms of birth length, maternal cytokine levels (interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4]), hormone levels (progesterone, thyroxine), and maternal autoantibody levels (anti-Sjögren's-syndrome-related antigen A [anti-SSA], anti-Sjögren's-syndrome-related antigen B [anti-SSB], anti-double-stranded DNA [anti-dsDNA], anti-ribonucleoprotein [anti-RNP], and anti-Smith [anti-Sm] antibodies) (<i>p</i> < 0.05). Correlation analysis revealed significant associations between specific maternal autoantibodies and neurodevelopmental parameters, as well as a positive correlation between birth length and neurodevelopmental parameters (<i>p</i> < 0.001). The multiple regression model showed that maternal autoantibody levels had a strong diagnostic value for predicting infant neurodevelopment. <b>Conclusion</b> This study provides compelling evidence supporting the relationship between maternal autoantibodies, cytokines, and hormone levels and neurodevelopmental outcomes in infants born to mothers with rheumatic disease.</p>","PeriodicalId":9256,"journal":{"name":"British journal of hospital medicine","volume":"86 7","pages":"1-15"},"PeriodicalIF":1.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}