British journal of anaesthesia最新文献

{"title":"Neuropathic pain and chronic postsurgical pain trajectories up to 12 months after surgery: a prospective observational questionnaire study.","authors":"Julia A Fischer, Markus Huber, Debora M Hofer, Michael Harnik, Janne Gierthmühlen, Ulrike M Stamer","doi":"10.1016/j.bja.2026.07.056","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.056","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotension and pulmonary atelectasis during general anaesthesia: interpreting lung protection as cardiopulmonary coupling. Comment on Br J Anaesth 2026; 137: 601-9.","authors":"Zhichao Zhao, Ting Shen","doi":"10.1016/j.bja.2026.07.059","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.059","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsible use of large language models in manuscript authorship, peer review, and editorial processes: the right framework is there-now it needs to become a requirement. Comment on Br J Anaesth 2026; 136: 1625-33.","authors":"Agnes S Meidert","doi":"10.1016/j.bja.2026.07.053","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.053","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of intraoperative dexamethasone on glycaemic responses in people with diabetes mellitus: assessment of glycaemic outcomes beyond peak blood glucose levels. Comment on Br J Anaesth 2026; 137: 460-9.","authors":"Jie Yue, Fangjie Wan, Aihua Shu, Yifei Liu","doi":"10.1016/j.bja.2026.07.063","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.063","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure: a balance between expectations and reality. Responses to Br J Anaesth 2026; 136: 1102–4 and Br J Anaesth 2026; 137, 879-80","authors":"Martin Ruste, Jean-Luc Fellahi, Matthias Jacquet-Lagrèze, Aaron D. Aguirre","doi":"10.1016/j.bja.2026.07.043","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.043","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"85 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing noninvasive blood pressure monitoring technologies: the challenge of between-arm differences","authors":"Simon T. Vistisen, Alexandre Joosten, Johannes Enevoldsen","doi":"10.1016/j.bja.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.bja.2026.08.013","url":null,"abstract":"Continuous noninvasive blood pressure monitoring technologies are increasingly being evaluated against invasive arterial pressure measurements. Berkholz and colleagues demonstrate that a finger-cuff system satisfies International Organization for Standardization (ISO) performance criteria for mean arterial and diastolic blood pressure, although not for systolic blood pressure, and it appeared to show closer agreement with invasive monitoring than oscillometric measurements. However, because oscillometric measurements were necessarily obtained from the contralateral arm, physiological inter-arm blood pressure differences may have contributed to the observed differences in agreement with the invasive reference standard. In this editorial, we describe how the study supports mean arterial pressure monitoring with a finger-cuff system and why it does not establish superiority over conventional oscillometric monitoring.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"10 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liberal liquid fasting and aspiration: a mandate for patient-centred precision care in perioperative fasting.","authors":"Anne Rüggeberg, Anne M Camilleri Podesta","doi":"10.1016/j.bja.2026.07.048","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.048","url":null,"abstract":"<p><p>Despite the recommendation for clear liquids up to 2 h before anaesthesia, the median liquid fasting time worldwide remains ∼12 h. If fasting times of <2 h for clear liquids were accepted, median liquid fasting times of 2-3 h could be achieved, but rigorous evidence synthesis on the incidence of perioperative aspiration is missing. Given that perioperative aspiration in elective patients is rare, definitive studies are practically impossible to conduct, which does not prove that aspiration risk is increased. Therefore, every aspiration event should be systematically evaluated before being attributed to the fasting strategy. Under these circumstances, it is high time that liberal liquid regimens individually assigned to each patient within institutional protocols are in line with recommendations by anaesthesia societies.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal neonatal sevoflurane exposure induces intergenerational anxiety via epididymal DNMT2-dependent sperm transfer RNA derived small RNA remodelling in rats.","authors":"Xiaoyu Hu, Qingsheng Meng, Sai Chen, Jinjin Yang, Mingming Zhao, Yangyang Shan, Jian-Jun Yang, Lei Lei","doi":"10.1016/j.bja.2026.06.057","DOIUrl":"https://doi.org/10.1016/j.bja.2026.06.057","url":null,"abstract":"<p><strong>Background: </strong>Perioperative exposures such as general anaesthesia can induce long-term neurodevelopmental changes with potential intergenerational effects, but the paternal epigenetic mechanisms remain unclear. We investigated whether neonatal sevoflurane exposure in male rats drives intergenerational anxiety through DNA methyltransferase 2 (DNMT2)-dependent remodelling of sperm transfer RNA-derived small RNAs (tsRNAs).</p><p><strong>Methods: </strong>Anxiety-like behaviours and hypothalamic-pituitary-adrenal (HPA) axis function were assessed in F0 males (sevoflurane-exposed or control generation), their offspring (F1), and grand-offspring (F2). Glucocorticoid receptor (GR)-mediated DNMT2 regulation was verified using chromatin immunoprecipitation quantitative polymerase chain reaction and primary cell assays. Sperm tsRNA profiles and 5-methylcytosine (m⁵C) methylation were analysed using small RNA sequencing and liquid chromatography-tandem mass spectrometry. Epididymal exosomes were isolated, and their role in tsRNA transfer was evaluated. Pharmacological and genetic interventions (GR blockade, DNMT2 knockdown, exosome inhibition) were used for validation of the pathway.</p><p><strong>Results: </strong>Paternal neonatal sevoflurane exposure induced anxiety-like behaviours in F0 males (open-field test, P=0.041; elevated plus maze, P=0.005) and F1 (not F2) offspring. Sevoflurane-induced HPA axis sensitisation, sustained corticosterone elevation (P=0.004), and GR-mediated DNMT2 upregulation in the cauda epididymis (P=0.014) of F0 males, with increased sperm m⁵C methylation (P=0.019) and aberrant tsRNA profiles. Epididymal exosomes mediated tsRNA transfer; DNMT2 knockdown or exosome blockade prevented tsRNA remodelling and intergenerational anxiety. Similar alleviating effects were observed after paternal treatment with the DNMT inhibitor decitabine.</p><p><strong>Conclusions: </strong>Neonatal sevoflurane exposure triggers a paternal GR-DNMT2 pathway in the epididymis, reprogramming sperm tsRNA profiles and driving intergenerational anxiety in a rat model. Epididymal DNMT2 is a key epigenetic mediator of anaesthesia-induced inheritance, and the alleviating effects of decitabine suggest additional mediating mechanisms.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of difficult airways in critical care units (ID-ACCT): surgical context contributes to defining risk. Comment on Br J Anaesth 2026; 136: 705-15.","authors":"Marco Sanvitti, Filomena Di Vezza, Federico Bilotta","doi":"10.1016/j.bja.2026.07.051","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.051","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social deprivation and morbidity and mortality after surgery: derivation of deprivation quintiles. Response to Br J Anaesth 2026; 136: 1017-8.","authors":"Eimear Lusby, Ruaraidh Campbell","doi":"10.1016/j.bja.2026.07.049","DOIUrl":"https://doi.org/10.1016/j.bja.2026.07.049","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}