British journal of experimental pathology最新文献_第7页

Reactive oxygen products in heterologous anti-glomerular basement membrane nephritis in rats. 大鼠异源抗肾小球基底膜肾炎的活性氧产物。

British journal of experimental pathology Pub Date : 1989-04-01

R J Birtwistle, J Michael, A J Howie, D Adu

{"title":"Reactive oxygen products in heterologous anti-glomerular basement membrane nephritis in rats.","authors":"R J Birtwistle, J Michael, A J Howie, D Adu","doi":"","DOIUrl":"","url":null,"abstract":"The effect of 'scavengers' of reactive oxygen products (ROPs) was studied in the heterologous phase of anti-glomerular basement (anti-GBM) nephritis induced in rats. Glomerulonephritis was induced by the intravenous administration of sheep anti-GBM antibody (5 mg/100 g) to rats on day 0. The intraperitoneal administration of superoxide dismutase (SOD) 30 mg/kg/day or 150 mg/kg/day leads to a significant reduction in proteinuria on day 1 and also on day 3 in animals given SOD 30 mg/kg/day. Proteinuria was not significantly reduced by the intraperitoneal administration of inactivated SOD (150 mg/kg/day). In rats given polyethylene glycol coupled catalase (PEG-catalase) intraperitoneally at a dose of 10,000 iu/kg/day and 100,000 iu/kg/day proteinuria was lower than in rats with unmodified anti-GBM nephritis. These differences were significant on day 1 (P less than 0.05) in rats given PEG-catalase 100,000 iu/kg/day and on days 3 and 5 in rats treated with either dose of PEG-catalase (P less than 0.01). These data suggest a role for superoxide anion and hydrogen peroxide, or a product of their interaction such as hydroxyl radical, in glomerular injury induced by anti-GBM antibody.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 2","pages":"207-13"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040539/pdf/brjexppathol00146-0097.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13925132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of vitamin D treatment on decreased levels of ATP and energy charge in the thoracic aorta of uraemic rats. 维生素D处理对尿毒症大鼠胸主动脉ATP和能量电荷水平降低的影响。

British journal of experimental pathology Pub Date : 1989-04-01

M Krog, S Ejerblad, H Johansson, G Ronquist

引用次数: 0

Lymphohaemopoietic antigens of cultured human glomerular epithelial cells. 培养人肾小球上皮细胞的淋巴造血抗原。

British journal of experimental pathology Pub Date : 1989-02-01

F J van der Woude, A F Michael, E Muller, G K van der Hem, R L Vernier, Y Kim

{"title":"Lymphohaemopoietic antigens of cultured human glomerular epithelial cells.","authors":"F J van der Woude, A F Michael, E Muller, G K van der Hem, R L Vernier, Y Kim","doi":"","DOIUrl":"","url":null,"abstract":"Glomerular visceral epithelial cells (GVEC) from normal human glomeruli were grown in tissue culture. Cell surface markers were studied by immunofluorescence microscopy using antibodies against lymphohaemopoietic differentiation antigens which are known to be present early (BA-1, OKB2, BA-2) and late (J5, anti CR1) in renal ontogenesis. Like foetal human glomerular epithelium, the cultured cells reacted with BA-1 and OKB2 (identifying an antigen expressed on B cells and polymorphonuclear leucocytes), and BA-2 (leukaemia-associated antigen), but were consistently negative for CR1 (C3b receptor); J5 which identifies the common acute lymphoblastic leukaemia antigen (CALLA) stained variably. Reactivity with antimyosin or anti factor VIII were absent. The cells produced an extracellular matrix containing laminin, type IV collagen, and fibronectin. This study supports the notion that GVEC undergo dedifferentiation as shown by the acquisition of lymphohaemopoietic differentiation antigens present early in renal ontogeny. In addition, the production of extracellular matrix constituents in vitro may be useful for the investigation of human glomerular basement membranes.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040536/pdf/brjexppathol00145-0081.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13788061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tooth root resorption induced in rats by diphenylhydantoin and parathyroidectomy. 二苯基苯妥英联合甲状旁腺切除术对大鼠牙根吸收的影响。

British journal of experimental pathology Pub Date : 1989-02-01

P B Robinson, W Harvey

引用次数: 0

Enhanced adhesion of autologous lymphocytes to gamma-interferon-treated human endothelial cells in vitro. 体外增强自体淋巴细胞对γ -干扰素处理的人内皮细胞的粘附。

British journal of experimental pathology Pub Date : 1989-02-01

M H Thornhill, D M Williams, P M Speight

引用次数: 0

Connective tissue responses to some heavy metals. III. Silver and dietary supplements of ascorbic acid. Histology and ultrastructure. 结缔组织对某些重金属的反应。3银和抗坏血酸的膳食补充剂。组织学和超微结构。

British journal of experimental pathology Pub Date : 1989-02-01

G Ellender, K N Ham

{"title":"Connective tissue responses to some heavy metals. III. Silver and dietary supplements of ascorbic acid. Histology and ultrastructure.","authors":"G Ellender, K N Ham","doi":"","DOIUrl":"","url":null,"abstract":"Silver-loaded ion exchange resin beads implanted into loose connective tissue of the rat pinna produced a local reaction. Initially the lesion comprised local necrosis and tissue disruption with predominantly small round cell infiltration. The subsequent organization was delayed and disordered. Fibroblasts developed grossly dilated cisternae of the rough endoplasmic reticulum. The matrix contained poorly orientated collagen fibrils of varying size and ground substance appeared condensed and granular. Distorted collagen fibrils were identified within membrane-bound vacuoles in the cytoplasm of both fibroblasts and macrophages. Abnormalities of the silver lesion were indicative of disordered collagen biosynthesis. Silver interfered with the biosynthesis and assembly of matrix components of the connective tissue. The reaction to silver beads in rats maintained on a diet heavily supplemented with ascorbic acid approached that of the control (sodium-loaded bead) with respect to the time scale, tissue reaction and tissue organization. The collagen matrix which formed was more organized and of greater density than that in the rat maintained on a normal diet. However, the repair tissue retained some of the morphological features of the legacy of silver toxicity, in particular delayed repair and dense intracellular fibrils within fibroblasts and macrophages. The excess of ascorbic acid partially ameliorated the effect of silver, possibly by compensating catabolysis of ascorbic acid caused by the presence of the released silver.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 1","pages":"21-39"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040522/pdf/brjexppathol00145-0032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14059621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vivo blockage of neutrophil migration by LPS is mimicked by a factor released from LPS-stimulated macrophages. LPS刺激的巨噬细胞释放的一种因子模拟了体内中性粒细胞迁移的阻断。

British journal of experimental pathology Pub Date : 1989-02-01

F Q Cunha, G E Souza, C A Souza, B C Cerqueira, S H Ferreira

{"title":"In-vivo blockage of neutrophil migration by LPS is mimicked by a factor released from LPS-stimulated macrophages.","authors":"F Q Cunha, G E Souza, C A Souza, B C Cerqueira, S H Ferreira","doi":"","DOIUrl":"","url":null,"abstract":"The present study was performed to determine the effect of an intravenous injection of the macrophage-derived neutrophil chemotactic factor (MNCF) (Cunha & Ferreira 1986) on neutrophil migration to rat peritoneal cavities, which were challenged with chemotactic stimuli. Macrophage monolayers stimulated by LPS release a factor (MW greater than 10,000 D) which, when injected intravenously, blocked neutrophil migration in carrageenin-induced peritonitis. This inhibition was dependent on dose and lasted more than 2 h. It was not due to neutropaenia, hypotension or LPS contamination. Neutrophil migration induced by LPS, MNCF, the Gram-negative bacterium Pseudomonas aeruginosa was also blocked by intravenous administration of the factor. Intravenous injection of recombinant interleukin 1 beta or tumour necrosis factor-alpha, present in the samples of the factor, failed to reproduce the described inhibitory effect on neutrophil migration. The release of this factor by LPS-stimulated macrophage monolayers was inhibited by dexamethasone but not by indomethacin. It is suggested that the failure of neutrophils to migrate during septicaemia may be the result of a continuous release of chemotactic factors in the circulation, particularly of the macrophage-derived neutrophil chemotactic factor(s).","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040534/pdf/brjexppathol00145-0013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13788060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental frost-bite in Hanford Miniature Swine. II. Vascular changes. 汉福德迷你猪冻伤实验。2血管的变化。

British journal of experimental pathology Pub Date : 1989-02-01

P Schoning, M P Hamlet

引用次数: 0

The effect of carbon tetrachloride on the copper-laden rat liver. 四氯化碳对含铜大鼠肝脏的影响。

British journal of experimental pathology Pub Date : 1989-02-01

L Barrow, M S Tanner

{"title":"The effect of carbon tetrachloride on the copper-laden rat liver.","authors":"L Barrow, M S Tanner","doi":"","DOIUrl":"","url":null,"abstract":"Copper is believed to be hepatotoxic in Indian Childhood Cirrhosis and Wilson's disease. However, copper-loading causes only minimal hepatic damage in animal models. The hypothesis was therefore proposed that a second hepatic insult may precipitate or perpetuate liver injury in a copper-laden liver. In non-copper-dosed rats CCl4 (10 mmol/kg, i.p.) produced elevated serum AST (809 +/- 298 IU/l, normal 20 +/- 5) and ALT (295 +/- 157 IU/l, normal 6 +/- 1) and extensive liver cell necrosis, portal tract inflammation, fat deposition, and perilobular hepatocyte ballooning. In rats whose liver copper was elevated from 75 +/- 13 to 461 +/- 13 micrograms/g by oral copper supplementation, CCl4 produced much smaller increases in AST (492 +/- 80 IU/l) and ALT (172 +/- 57 IU/l) and mild focal liver cell necrosis. Fat deposition and perilobular vacuolation were not reduced. Prior copper-loading of rats unequivocally protected against the CCl4-induced liver injury. Triglyceride accumulation, however, was apparently unaffected. The possible interactions of copper with prostaglandin-mediated inflammation and with free-radical-induced liver damage are discussed.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 1","pages":"9-19"},"PeriodicalIF":0.0,"publicationDate":"1989-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040525/pdf/brjexppathol00145-0021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14059628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of BCG-induced immunity on the bactericidal activity of isoniazid and rifampicin in experimental tuberculosis of the mouse and guinea-pig. bcg诱导免疫对异烟肼和利福平对实验性肺结核小鼠和豚鼠杀菌活性的影响。

British journal of experimental pathology Pub Date : 1989-02-01

J Dhillon, D A Mitchison

引用次数: 0