British journal of experimental pathology最新文献

Blood clearance and tissue distribution of 99Tc-labelled pneumococci following splenectomy in rabbits. 兔脾切除术后99tc标记肺炎球菌的血液清除率和组织分布。

British journal of experimental pathology Pub Date : 1989-12-01

R J Holdsworth, G D Neill, A D Irving, A Cuschieri

{"title":"Blood clearance and tissue distribution of 99Tc-labelled pneumococci following splenectomy in rabbits.","authors":"R J Holdsworth, G D Neill, A D Irving, A Cuschieri","doi":"","DOIUrl":"","url":null,"abstract":"Female New Zealand White rabbits, following sham laparotomy, total splenectomy and splenectomy with 50% splenic autotransplantation, have been injected intravenously with 99Tc-labelled type 2 Streptococcus pneumoniae. The blood clearance of isotope has been measured and the numbers of circulating bacteria quantitated by blood culture. On sacrifice of the animals the tissue uptake of the isotope has been measured. The results indicate 98% bacterial clearance from the blood within 7 min. The liver is the principal organ for reticuloendothelial uptake of the bacteria accounting for 60% of the total injected dose; 15% of the isotope clearance occurred in the lungs, and the spleen contributed only 3% of the total bacterial clearance. There was no difference in the observed pattern of clearance following splenectomy and following splenic reimplantation. Following the uptake of the bacteria in the tissues, the isotope dissociated from the bacterium and was excreted in the urine. The secondary rise in blood isotope level consequent upon this release was not accompanied by a secondary bacteraemia.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 6","pages":"669-77"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040715/pdf/brjexppathol00150-0072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13746817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiogenic stimulation compared with angiogenic reaction to injury: distinction by focal and general application of trypsin to the chick chorioallantoic membrane. 血管生成刺激与损伤后血管生成反应的比较:胰蛋白酶对鸡绒毛膜尿囊膜的局灶性和普遍应用的区别。

British journal of experimental pathology Pub Date : 1989-12-01

W D Thompson, M A Kazmi

引用次数: 0

Cytokeratin expression in cells of the rodent bile duct developing under normal and pathological conditions. 正常和病理条件下啮齿动物胆管细胞角蛋白的表达。

British journal of experimental pathology Pub Date : 1989-12-01

P Carthew, R E Edwards, R J Hill, J G Evans

{"title":"Cytokeratin expression in cells of the rodent bile duct developing under normal and pathological conditions.","authors":"P Carthew, R E Edwards, R J Hill, J G Evans","doi":"","DOIUrl":"","url":null,"abstract":"A polyclonal anti-cytokeratin antibody has been used to examine the expression of this intermediate filament both during normal development in the rat and in a variety of pathological states in the rat and mouse. Bile duct proliferation induced by the administration of alpha-naphthylisothiocyanate (ANIT) as well as the oval cell proliferation induced by 3'-methyl-4-dimethylaminoazobenzene (3-MeDAB) have been used to examine the expression of the rodent cytokeratins in the proliferating cells regarded as being of bile duct origin. Examples of cholangiofibrosis and cholangiocarcinomas were also examined for evidence of cytokeratin expression using this antibody, as well as proliferations of a morphological intermediate type between epithelial and mesenchymal. In all cases we have been able to demonstrate continuity of phenotypic expression of the cytokeratins recognized by this antibody in cells which are recognized as bile duct in origin, even where their morphological appearance does not resemble an epithelial cell type. Because this antibody can be used on formalin-fixed, paraffin-processed tissues, after trypsin treatment, it is proposed that it can be used routinely in the toxicological evaluation (even retrospectively) of bile duct related proliferations and tumours.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 6","pages":"717-25"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040731/pdf/brjexppathol00150-0117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13625895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in brain mitochondrial bioenergetics in protein-deficient rats. 蛋白质缺乏大鼠脑线粒体生物能量学的变化。

British journal of experimental pathology Pub Date : 1989-12-01

O O Olorunsogo

引用次数: 0

Lung injury and repair in rabbits from ventilation with moist air. 湿空气通气对兔肺损伤及修复的影响。

British journal of experimental pathology Pub Date : 1989-12-01

D A Todd, E John

引用次数: 0

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. 自由基、活性氧与人类疾病:特别涉及动脉粥样硬化的关键评价。

British journal of experimental pathology Pub Date : 1989-12-01

B Halliwell

引用次数: 0

Foetal and lactational exposure to alcohol increases oxidative capacity of brown adipose tissue in the rat. A possible relationship to cot death. 胎儿和哺乳期暴露于酒精会增加大鼠棕色脂肪组织的氧化能力。可能与婴儿猝死有关。

British journal of experimental pathology Pub Date : 1989-12-01

P Huttunen, M L Kortelainen, J Hirvonen

引用次数: 0

Repopulation of guinea-pig skin by melanocytes during wound healing: a morphometric study. 豚鼠皮肤在伤口愈合过程中黑色素细胞的再生:形态计量学研究。

British journal of experimental pathology Pub Date : 1989-12-01

P M Cox, A P Dhillon, S Howe, R M Pittilo, J Rode

引用次数: 0

Collagen cross-link synthesis in cultured vascular endothelium. 胶原交联在培养血管内皮中的合成。

British journal of experimental pathology Pub Date : 1989-12-01

C I Levene, G Heale, S P Robins

{"title":"Collagen cross-link synthesis in cultured vascular endothelium.","authors":"C I Levene, G Heale, S P Robins","doi":"","DOIUrl":"","url":null,"abstract":"Cultured vascular endothelium secretes the enzyme lysyl oxidase which cross-links both collagen and elastin. The major reducible cross-link synthesized by cultured human umbilical arterial and venous endothelium is dihydroxylysinonorleucine (di-OH-LNL). Treatment of the cultures with the lathyrogen beta-aminopropionitrile (BAPN), which inhibits lysyl oxidase, inhibited synthesis of this cross-link. Cultured porcine aortic endothelium synthesized three major reducible lysine-derived cross-links: dihydroxylysinonorleucine (di-OH-LNL), hydroxylysinonorleucine (OH-LNL) and lysinonorleucine (LNL); BAPN also inhibited synthesis of these three cross-links. Earlier in-vivo observations on BAPN-treated chick embryos had shown a 20% increase in the hydration of cartilage and other tissues; the likeliest explanation was that cross-link disruption permitted the proteoglycans in cartilage to express their hydrophilic nature when freed of their collagenous network. Capillary basement membrane contains laminin, proteoglycan and type IV collagen. Following the finding of oedema in lathyritic cartilage, we would propose that agents which disrupt collagen cross-links in cultured vascular endothelium, damaging capillary basement membrane, be considered as one possible mechanism in the pathogenesis of oedema.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 6","pages":"621-6"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040723/pdf/brjexppathol00150-0028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13748262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo. 乳铁蛋白可保护小鼠体内免受致死性大肠杆菌感染。

British journal of experimental pathology Pub Date : 1989-12-01

T Zagulski, P Lipiński, A Zagulska, S Broniek, Z Jarzabek

{"title":"Lactoferrin can protect mice against a lethal dose of Escherichia coli in experimental infection in vivo.","authors":"T Zagulski, P Lipiński, A Zagulska, S Broniek, Z Jarzabek","doi":"","DOIUrl":"","url":null,"abstract":"Experiments were undertaken to demonstrate and partially explain the protective effect of bovine lactoferrin (LB) when administered intravenously to mice 24 h before a challenge with a lethal dose of Escherichia coli. About 70% of mice pretreated with LB survived challenge. The survival rates in control mice treated with E. coli alone and pretreated with bovine serum albumin (BSA), were 4 and 8%, respectively. Human lactoferrin (LH) had almost the same protective effect as LB. Sufficient amounts of ferric ions were given to mice, in single and multiple doses, for full serum transferrin saturation 30 min before or after E. coli administration. The multiple dose of ferric ions did not change considerably the survival rate of mice pretreated with LB. In contrast, a single dose of ferric ions gradually decreased the survival rate of the mice after the first week of experiment. From day 14 this decrease was statistically significant in all groups of mice treated with a single dose of ferric ions when compared with mice pretreated only with LB, and the difference ranged from 25 to 35% on day 30. The possible mechanism(s) of protective effect of LB and role of iron ions are discussed.","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 6","pages":"697-704"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040730/pdf/brjexppathol00150-0097.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13832127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0