Changes in brain mitochondrial bioenergetics in protein-deficient rats.

O O Olorunsogo
{"title":"Changes in brain mitochondrial bioenergetics in protein-deficient rats.","authors":"O O Olorunsogo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>An assessment of mitochondrial bioenergetics in protein-malnourished rats indicates that there is a reduction of brain mitochondrial metabolism in protein malnutrition. Specifically, mitochondria of protein-malnourished offspring of malnourished rats exhibit (i) an enhancement of state 4 respiration, (ii) a reduction of ADP-stimulated state 3 respiration, (iii) a decrease in ADP:O ratios, (iv) reductions of FCCP-induced ATPase action and in the rates of proton and calcium ion translocation, and (v) diminished activities of redox enzymes. In general, these changes are less pronounced in malnourished weanling rats born of healthy dams. Although the exact molecular mechanism of these defects is not yet known, the alterations are definitely caused by diet-induced changes in the structure and integrity of inner mitochondrial membrane components.</p>","PeriodicalId":9248,"journal":{"name":"British journal of experimental pathology","volume":"70 6","pages":"607-19"},"PeriodicalIF":0.0000,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040717/pdf/brjexppathol00150-0015.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of experimental pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

An assessment of mitochondrial bioenergetics in protein-malnourished rats indicates that there is a reduction of brain mitochondrial metabolism in protein malnutrition. Specifically, mitochondria of protein-malnourished offspring of malnourished rats exhibit (i) an enhancement of state 4 respiration, (ii) a reduction of ADP-stimulated state 3 respiration, (iii) a decrease in ADP:O ratios, (iv) reductions of FCCP-induced ATPase action and in the rates of proton and calcium ion translocation, and (v) diminished activities of redox enzymes. In general, these changes are less pronounced in malnourished weanling rats born of healthy dams. Although the exact molecular mechanism of these defects is not yet known, the alterations are definitely caused by diet-induced changes in the structure and integrity of inner mitochondrial membrane components.

蛋白质缺乏大鼠脑线粒体生物能量学的变化。
对蛋白质营养不良大鼠线粒体生物能量学的评估表明,蛋白质营养不良会减少脑线粒体代谢。具体来说,营养不良大鼠的蛋白质营养不良后代的线粒体表现为(i)状态4呼吸增强,(ii) ADP刺激的状态3呼吸减少,(iii) ADP:O比率降低,(iv) fccp诱导的atp酶作用以及质子和钙离子易位率降低,(v)氧化还原酶活性降低。一般来说,这些变化在健康母鼠出生的营养不良断奶鼠中不太明显。虽然这些缺陷的确切分子机制尚不清楚,但这些改变肯定是由饮食引起的线粒体内膜成分结构和完整性的变化引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信