Brazilian Journal of Psychiatry最新文献_第3页

Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results 中等收入国家青少年抑郁症的神经成像:功能磁共振成像方案的可行性和初步结果

Brazilian Journal of Psychiatry Pub Date : 2019-08-05 DOI: 10.1590/1516-4446-2019-0508

Lucas Battel, J. Swartz, M. Anés, P. Manfro, L. Rohde, A. Viduani, V. Mondelli, C. Kieling

{"title":"Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results","authors":"Lucas Battel, J. Swartz, M. Anés, P. Manfro, L. Rohde, A. Viduani, V. Mondelli, C. Kieling","doi":"10.1590/1516-4446-2019-0508","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-0508","url":null,"abstract":"Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"50 1","pages":"6 - 13"},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79126425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Difficulties in activities of daily living are associated with stigma in patients with Parkinson’s disease who are candidates for deep brain stimulation 帕金森病患者日常生活活动困难与耻辱感有关，这些患者是深部脑刺激的候选者

Brazilian Journal of Psychiatry Pub Date : 2019-08-05 DOI: 10.1590/1516-4446-2018-0333

A. D. da Silva, V. P. Leal, Paulo R da Silva, F. C. Freitas, M. Linhares, R. Walz, L. Malloy-Diniz, A. Diaz, A. Palha

{"title":"Difficulties in activities of daily living are associated with stigma in patients with Parkinson’s disease who are candidates for deep brain stimulation","authors":"A. D. da Silva, V. P. Leal, Paulo R da Silva, F. C. Freitas, M. Linhares, R. Walz, L. Malloy-Diniz, A. Diaz, A. Palha","doi":"10.1590/1516-4446-2018-0333","DOIUrl":"https://doi.org/10.1590/1516-4446-2018-0333","url":null,"abstract":"Objective: Parkinson’s disease (PD) is often accompanied by stigma, which could contribute to a worse prognosis. The objective of this study is to identify the variables associated with stigma in PD patients who are candidates for deep brain stimulation (DBS). Methods: We investigated sociodemographic and clinical variables associated with stigma in a sample of 54 PD patients indicated for DBS. The independent variables were motor symptoms assessed by the Movement Disorder Society‐sponsored revision of the Unified Parkinson Disease Rating Scale (MDS-UPDRS III), depressive symptoms measured by the Hospital Anxiety and Depression Scale, age, disease duration and the presence of a general medical condition. The Mobility, Activities of daily living and Emotional well-being domains of the 39-item Parkinson’s Disease Questionnaire (PDQ-39) were also investigated as independent variables, and the Stigma domain of the PDQ-39 scale was considered the outcome variable. Results: After multiple linear regression analysis, activities of daily living remained associated with the Stigma domain (B = 0.42 [95%CI 0.003-0.83], p = 0.048). The full model accounted for 15% of the variance in the Stigma domain (p = 0.03). Conclusions: Although causal assumptions are not appropriate for cross-sectional studies, the results suggest that ADL difficulties could contribute to greater stigma in PD patients with refractory motor symptoms who are candidates for DBS.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"47 1","pages":"190 - 194"},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80790646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Depression and quality of life in older adults on hemodialysis 老年血液透析患者的抑郁和生活质量

Brazilian Journal of Psychiatry Pub Date : 2019-08-05 DOI: 10.1590/1516-4446-2018-0345

Saulo B V de Alencar, F. M. de Lima, L. D. A. Dias, V. D. Dias, Anna C Lessa, Jéssika M Bezerra, Julianna F Apolinário, K. D. de Petribú

{"title":"Depression and quality of life in older adults on hemodialysis","authors":"Saulo B V de Alencar, F. M. de Lima, L. D. A. Dias, V. D. Dias, Anna C Lessa, Jéssika M Bezerra, Julianna F Apolinário, K. D. de Petribú","doi":"10.1590/1516-4446-2018-0345","DOIUrl":"https://doi.org/10.1590/1516-4446-2018-0345","url":null,"abstract":"Objective: Depression is highly prevalent in hemodialysis patients, but few studies have evaluated older hemodialysis patients. The aim of this study was to evaluate the prevalence of depression, its associated factors and its impact on quality of life in an older population on hemodialysis. Methods: This was a cross-sectional study including 173 hemodialysis patients aged 60 years or older in Recife, Brazil. Depression was evaluated using the Mini-International Neuropsychiatric Interview when depressive symptoms (according to the 5-item Geriatric Depression Scale) were present. Quality of life was assessed with the Control, Autonomy, Self-realization and Pleasure Questionnaire (CASP-16). Data were also collected on sociodemographic, laboratory (albumin, parathormone, hemoglobin, and phosphorus) and dialysis (dialysis vintage, vascular access and hemodialysis adequacy) characteristics. Results: Depression was present in 22.5% of the sample. Depressed patients presented low CASP-16 quality of life scores (31.6 vs. 24.2, p < 0.001), twice the odds of albumin levels < 3.8 g/dL (OR 2.36; 95%CI 1.10-5.07; p = 0.027) and higher parathormone levels (OR 1.06; 95%CI 1.00-1.13; p = 0.05). Conclusion: Older hemodialysis patients have a high prevalence of depression. Depressed patients presented poor quality of life, lower serum albumin and higher parathormone levels. Teams dealing with older hemodialysis patients should include depression and quality of life assessments in care protocols.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"23 1","pages":"195 - 200"},"PeriodicalIF":0.0,"publicationDate":"2019-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86840692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Biological bases for a possible effect of cannabidiol in Parkinson’s disease 大麻二酚对帕金森病可能影响的生物学基础

Brazilian Journal of Psychiatry Pub Date : 2019-07-15 DOI: 10.1590/1516-4446-2019-0460

N. C. Ferreira‐Junior, A. Campos, F. Guimarães, E. Del-Bel, Patrícia M Zimmermann, Liberato Brum Junior, Jaime E. C. Hallak, J. Crippa, A. Zuardi

{"title":"Biological bases for a possible effect of cannabidiol in Parkinson’s disease","authors":"N. C. Ferreira‐Junior, A. Campos, F. Guimarães, E. Del-Bel, Patrícia M Zimmermann, Liberato Brum Junior, Jaime E. C. Hallak, J. Crippa, A. Zuardi","doi":"10.1590/1516-4446-2019-0460","DOIUrl":"https://doi.org/10.1590/1516-4446-2019-0460","url":null,"abstract":"Current pharmacotherapy of Parkinson’s disease (PD) is palliative and unable to modify the progression of neurodegeneration. Treatments that can improve patients’ quality of life with fewer side effects are needed, but not yet available. Cannabidiol (CBD), the major non-psychotomimetic constituent of cannabis, has received considerable research attention in the last decade. In this context, we aimed to critically review the literature on potential therapeutic effects of CBD in PD and discuss clinical and preclinical evidence supporting the putative neuroprotective mechanisms of CBD. We searched MEDLINE (via PubMed) for indexed articles published in English from inception to 2019. The following keywords were used: cannabis; cannabidiol and neuroprotection; endocannabinoids and basal ganglia; Parkinson’s animal models; Parkinson’s history; Parkinson’s and cannabidiol. Few studies addressed the biological bases for the purported effects of CBD on PD. Six preclinical studies showed neuroprotective effects, while three targeted the antidyskinetic effects of CBD. Three human studies have tested CBD in patients with PD: an open-label study, a case series, and a randomized controlled trial. These studies reported therapeutic effects of CBD on non-motor symptoms. Additional research is needed to elucidate the potential effectiveness of CBD in PD and the underlying mechanisms involved.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"65 1","pages":"218 - 224"},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89153862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Body self-image disturbances in women with prolactinoma 催乳素瘤女性的身体自我形象障碍

Brazilian Journal of Psychiatry Pub Date : 2019-07-15 DOI: 10.1590/1516-4446-2018-0325

Helen S Pereira, E. Naliato, A. Moraes, M. Gadelha, L. Vieira Neto, Renan M Almeida, A. Nardi, A. Violante

{"title":"Body self-image disturbances in women with prolactinoma","authors":"Helen S Pereira, E. Naliato, A. Moraes, M. Gadelha, L. Vieira Neto, Renan M Almeida, A. Nardi, A. Violante","doi":"10.1590/1516-4446-2018-0325","DOIUrl":"https://doi.org/10.1590/1516-4446-2018-0325","url":null,"abstract":"Objective: To evaluate body dissatisfaction and distorted body self-image in women with prolactinoma. Methods: Body dissatisfaction and distorted body self-image were evaluated in 80 women with prolactinoma. All patients were in menacme, 34% had normal body mass index (BMI), and 66% were overweight. Most patients (56.2%) had normal prolactin (PRL) levels and no hyperprolactinemia symptoms (52.5%). The Body Shape Questionnaire (BSQ) was used to assess the patients’ dissatisfaction with and concern about their physical form, and the Stunkard Figure Rating Scale (FRS) was used to assess body dissatisfaction and distorted body self-image. The patients were divided according to PRL level (normal vs. elevated) and the presence or absence of prolactinoma symptoms. Results: The normal and elevated PRL groups had similar incidences of body dissatisfaction and distorted body self-image. However, symptomatic patients reported a higher incidence of dissatisfaction than asymptomatic patients. Distorted body self-image was less common among symptomatic patients. Conclusion: Symptomatic patients showed higher body dissatisfaction, but lower body self-image distortion. The presence of symptoms may have been responsible for increased body awareness. The perception of body shape could have triggered feelings of dissatisfaction compared to an ideal lean body. Therefore, a distorted body self-image might not necessarily result in body dissatisfaction in women with prolactinomas.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"15 1","pages":"33 - 39"},"PeriodicalIF":0.0,"publicationDate":"2019-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81412598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country 严重精神疾病患者抗精神病药物综合用药的患病率及相关因素:来自中高收入国家的横断面研究结果

Brazilian Journal of Psychiatry Pub Date : 2017-02-06 DOI: 10.1590/1516-4446-2016-2015

Kerryn S Armstrong, H. Temmingh

{"title":"Prevalence of and factors associated with antipsychotic polypharmacy in patients with serious mental illness: Findings from a cross-sectional study in an upper-middle-income country","authors":"Kerryn S Armstrong, H. Temmingh","doi":"10.1590/1516-4446-2016-2015","DOIUrl":"https://doi.org/10.1590/1516-4446-2016-2015","url":null,"abstract":"Objective: The aim of our study was to examine the prevalence of and factors associated with antipsychotic polypharmacy (APP) among patients with serious mental illness in the current South African health care context. Methods: We collected data on patient, illness, and treatment characteristics of patients discharged on one or more antipsychotic agents from January to June 2014. We analyzed the associations of APP with demographic and clinical variables using hierarchical multivariable logistic regression, and examined prescription patterns. Results: The prevalence of APP in our study population of 577 patients was 28.4%. Demographic and clinical characteristics significantly associated with APP included age > 29, male sex, diagnosis of schizophrenia, comorbid intellectual disability, comorbid substance use, greater number of hospital admissions, and high-dose prescribing. First-generation antipsychotics and long-acting injectable preparations were prominent in APP combinations. Co-prescription of anticholinergic agents and sodium valproate demonstrated a significant association with APP. Conclusion: APP appears common in our population, despite lack of evidence for the practice and possible risk of harm. Our findings suggest a complex interplay among patient, illness, and treatment factors relevant to APP in our setting that could be targeted for intervention.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"65 1","pages":"293 - 301"},"PeriodicalIF":0.0,"publicationDate":"2017-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76363347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests 对啮齿类动物在多边形竞技场和复杂迷宫中面对蛇时的惊恐发作和预期焦虑样行为的关键神经心理生物学分析:与升高的正迷宫和t迷宫行为测试的比较

Brazilian Journal of Psychiatry Pub Date : 2017-02-06 DOI: 10.1590/1516-4446-2015-1895

N. Coimbra, T. Paschoalin-Maurin, G. Bassi, A. Kanashiro, A. Biagioni, T. T. Felippotti, D. H. Elias-Filho, J. Mendes-Gomes, Jade P Cysne-Coimbra, R. C. Almada, B. Lobão-Soares

{"title":"Critical neuropsychobiological analysis of panic attack- and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex labyrinths: a comparison to the elevated plus- and T-maze behavioral tests","authors":"N. Coimbra, T. Paschoalin-Maurin, G. Bassi, A. Kanashiro, A. Biagioni, T. T. Felippotti, D. H. Elias-Filho, J. Mendes-Gomes, Jade P Cysne-Coimbra, R. C. Almada, B. Lobão-Soares","doi":"10.1590/1516-4446-2015-1895","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1895","url":null,"abstract":"Objective: To compare prey and snake paradigms performed in complex environments to the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack- and anticipatory anxiety-like behaviors in rodents. Methods: PubMed was reviewed in search of articles focusing on the plus maze test, EPM, and ETM, as well as on defensive behaviors displayed by threatened rodents. In addition, the authors’ research with polygonal arenas and complex labyrinth (designed by the first author for confrontation between snakes and small rodents) was examined. Results: The EPM and ETM tests evoke anxiety/fear-related defensive responses that are pharmacologically validated, whereas the confrontation between rodents and snakes in polygonal arenas with or without shelters or in the complex labyrinth offers ethological conditions for studying more complex defensive behaviors and the effects of anxiolytic and panicolytic drugs. Prey vs. predator paradigms also allow discrimination between non-oriented and oriented escape behavior. Conclusions: Both EPM and ETM simple labyrinths are excellent apparatuses for the study of anxiety- and instinctive fear-related responses, respectively. The confrontation between rodents and snakes in polygonal arenas, however, offers a more ethological environment for addressing both unconditioned and conditioned fear-induced behaviors and the effects of anxiolytic and panicolytic drugs.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"41 1","pages":"72 - 83"},"PeriodicalIF":0.0,"publicationDate":"2017-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86200106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults 脑源性神经营养因子(BDNF)基因Val66Met多态性影响老年人的记忆表现

Brazilian Journal of Psychiatry Pub Date : 2017-01-12 DOI: 10.1590/1516-4446-2016-1980

L. A. de Azeredo, Tatiana de Nardi, M. L. Levandowski, S. Tractenberg, Júlia Kommers-Molina, A. Wieck, T. Q. Irigaray, I. G. da Silva, R. Grassi‐Oliveira

{"title":"The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults","authors":"L. A. de Azeredo, Tatiana de Nardi, M. L. Levandowski, S. Tractenberg, Júlia Kommers-Molina, A. Wieck, T. Q. Irigaray, I. G. da Silva, R. Grassi‐Oliveira","doi":"10.1590/1516-4446-2016-1980","DOIUrl":"https://doi.org/10.1590/1516-4446-2016-1980","url":null,"abstract":"Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"57 1","pages":"90 - 94"},"PeriodicalIF":0.0,"publicationDate":"2017-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74927787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia 脑血管代谢基因型与阿尔茨海默病痴呆的神经精神症状和发病年龄的关系

Brazilian Journal of Psychiatry Pub Date : 2017-01-12 DOI: 10.1590/1516-4446-2016-1991

F. F. de Oliveira, E. Chen, Marília Cardoso Smith, P. Bertolucci

{"title":"Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia","authors":"F. F. de Oliveira, E. Chen, Marília Cardoso Smith, P. Bertolucci","doi":"10.1590/1516-4446-2016-1991","DOIUrl":"https://doi.org/10.1590/1516-4446-2016-1991","url":null,"abstract":"Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer’s disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-ɛ4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs11669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"1 1","pages":"95 - 103"},"PeriodicalIF":0.0,"publicationDate":"2017-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89623031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders 自闭症谱系障碍儿童血浆S100钙结合蛋白B和肿瘤坏死因子α浓度升高

Brazilian Journal of Psychiatry Pub Date : 2017-01-12 DOI: 10.1590/1516-4446-2015-1843

Selin Aktan Guloksuz, O. Abali, E. Cetin, S. Gazioglu, G. Deniz, Abdurrahman Yildirim, I. Kawikova, S. Guloksuz, J. Leckman

{"title":"Elevated plasma concentrations of S100 calcium-binding protein B and tumor necrosis factor alpha in children with autism spectrum disorders","authors":"Selin Aktan Guloksuz, O. Abali, E. Cetin, S. Gazioglu, G. Deniz, Abdurrahman Yildirim, I. Kawikova, S. Guloksuz, J. Leckman","doi":"10.1590/1516-4446-2015-1843","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1843","url":null,"abstract":"Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children. The severity of autism was assessed using the Childhood Autism Rating Scale (CARS). Results: Concentrations of both S100B and TNF-α were higher in children with autism before and after adjusting for a priori-selected confounders (age, sex, and body mass index). S100B concentrations were higher in children with severe autism compared to children with mild-moderate autism. However, this association remained as a trend after adjusting for confounders. S100B concentrations correlated positively with TNF-α concentrations. Conclusion: Our findings showing an increase in peripheral concentrations of S100B and TNF-α provide limited support to the hypothesis about the roles of altered immune function and S100B in autism spectrum disorder (ASD). Studies of larger numbers of well-characterized individuals with ASD are needed to clarify the potential role of the immune system in the pathophysiology of this disorder.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":"314 1","pages":"195 - 200"},"PeriodicalIF":0.0,"publicationDate":"2017-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77780843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45