Brazilian Journal of Psychiatry最新文献_第6页

Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease 缩短端粒长度在双相情感障碍:早期和晚期疾病的比较

Brazilian Journal of Psychiatry Pub Date : 2016-10-01 DOI: 10.1590/1516-4446-2016-1910

F. Barbé-Tuana, M. M. Parisi, B. Panizzutti, G. Fries, L. Grun, F. Guma, F. Kapczinski, M. Berk, C. Gama, A. Rosa

{"title":"Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease","authors":"F. Barbé-Tuana, M. M. Parisi, B. Panizzutti, G. Fries, L. Grun, F. Guma, F. Kapczinski, M. Berk, C. Gama, A. Rosa","doi":"10.1590/1516-4446-2016-1910","DOIUrl":"https://doi.org/10.1590/1516-4446-2016-1910","url":null,"abstract":"Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89908174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Cessation of dangerousness status: an analysis of 224 reports from the Instituto de Perícias Heitor Carrilho, Rio de Janeiro, Brazil 停止危险状态:对巴西里约热内卢Perícias Heitor Carrilho研究所224份报告的分析

Brazilian Journal of Psychiatry Pub Date : 2016-09-29 DOI: 10.1590/1516-4446-2015-1871

Gustavo Oliveira, A. M. Valença, T. M. de Moraes, M. Mendlowicz, M. C. Forrest, F. F. Batista, Gabriella A. Mendes, Tiago N Lima, Vinicius R. Gonçalves, Kátia Mecler

{"title":"Cessation of dangerousness status: an analysis of 224 reports from the Instituto de Perícias Heitor Carrilho, Rio de Janeiro, Brazil","authors":"Gustavo Oliveira, A. M. Valença, T. M. de Moraes, M. Mendlowicz, M. C. Forrest, F. F. Batista, Gabriella A. Mendes, Tiago N Lima, Vinicius R. Gonçalves, Kátia Mecler","doi":"10.1590/1516-4446-2015-1871","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1871","url":null,"abstract":"Objectives: To evaluate factors related to dangerousness cessation at the end of involuntary commitment based on an analysis of expert reports. In light of the current legal requirement of dangerousness cessation as a pre-requisite for prison or internment release of individuals subjected to the safety measure, we sought elements to reflect on the practice of expert examiners in charge of making this decision. Methods: The authors revised 224 expert psychiatric dangerousness cessation reports released 2011 through 2014 and collected data for a statistical analysis. Results: The following variables were associated with positive risk cessation assessments: no inadequate behavior (according to the assistant professionals), no productive psychotic symptoms, no negative symptoms, presence of insight, presence of a support network, and no psychoactive substance abuse. The following variables were associated with negative dangerousness cessation decisions: early onset of malfunction, lack of insight, negative attitudes, active signs of major mental illness, presence of impulsiveness, poor response to treatment, presence of plans lacking feasibility, exposure to destabilizing factors, lack of personal support, and presence of stress. Conclusions: In this study we were able to identify factors associated with dangerousness in a sample of expert reports. The knowledge of factors linked to a higher risk of recidivism in illegal activities or violent behavior is crucial for decision-making regarding the release of offenders after their legally established period of involuntary commitment.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81382655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Spatial-temporal trends and risk of suicide in Central Brazil: an ecological study contrasting indigenous and non-indigenous populations. 巴西中部的时空趋势和自杀风险：一项对比土著和非土著居民的生态研究。

Brazilian Journal of Psychiatry Pub Date : 2016-07-01 Epub Date: 2016-01-19 DOI: 10.1590/1516-4446-2015-1720

Jesem D Orellana, Antônio A Balieiro, Fernanda R Fonseca, Paulo C Basta, Maximiliano L Ponte de Souza

{"title":"Spatial-temporal trends and risk of suicide in Central Brazil: an ecological study contrasting indigenous and non-indigenous populations.","authors":"Jesem D Orellana, Antônio A Balieiro, Fernanda R Fonseca, Paulo C Basta, Maximiliano L Ponte de Souza","doi":"10.1590/1516-4446-2015-1720","DOIUrl":"10.1590/1516-4446-2015-1720","url":null,"abstract":"Objective: To examine spatial-temporal distribution and risk of suicide, as well as trends in suicide mortality rates, in the indigenous and non-indigenous population of the state of Mato Grosso do Sul, Brazil.Methods: Data were obtained from the Information Department of the Brazilian Unified Health System. Deaths recorded as voluntary self-inflicted injuries (ICD-10 codes X60.0 to X84.9) were considered suicide. Suicide rates were estimated and adjusted by age in the population > 9 years of age. Kernel analysis was used to assess the spatial distribution of suicide cases, while trend analysis was carried out using a non-parametric test (Mann-Kendall).Results: The suicide risk among the indigenous population was 8.1 (95%CI 7.2-9.0) times higher than in the non-indigenous population. For indigenous residents in the 15-24 age group, the risk was 18.5 (95%CI 17.5-19.6) times higher than in the non-indigenous population. The majority of indigenous cases were concentrated in a few villages in reservation areas, mainly occupied by Guarani-Kaiowá and Guarani-Ñandeva groups. Rate patterns remained stable over time in both groups.Conclusion: Suicide is a serious public health problem in Mato Grosso do Sul, and has had an alarming and disproportionate impact on the indigenous population for more than a decade.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83067068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognition and functioning in bipolar depression

Brazilian Journal of Psychiatry Pub Date : 2016-05-02 DOI: 10.1590/1516-4446-2014-1558

N. S. Kapczinski, J. Narvaez, P. Magalhaes, J. Bücker, A. C. Peuker, Ana C Loredo, Federico Troiano, L. Czepielewski, A. Rosa, G. Fries, C. Gama

{"title":"Cognition and functioning in bipolar depression","authors":"N. S. Kapczinski, J. Narvaez, P. Magalhaes, J. Bücker, A. C. Peuker, Ana C Loredo, Federico Troiano, L. Czepielewski, A. Rosa, G. Fries, C. Gama","doi":"10.1590/1516-4446-2014-1558","DOIUrl":"https://doi.org/10.1590/1516-4446-2014-1558","url":null,"abstract":"Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p < 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76689352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review. 以弥散张量成像发现为重点的双相情感障碍的神经生物学基础：系统性综述。

Brazilian Journal of Psychiatry Pub Date : 2016-03-22 DOI: 10.1590/1516-4446-2015-1793

Juliana A Duarte, Jaisa Q de Araújo E Silva, André A Goldani, Raffael Massuda, Clarissa S Gama

{"title":"Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review.","authors":"Juliana A Duarte, Jaisa Q de Araújo E Silva, André A Goldani, Raffael Massuda, Clarissa S Gama","doi":"10.1590/1516-4446-2015-1793","DOIUrl":"10.1590/1516-4446-2015-1793","url":null,"abstract":"Objective: To review the available data on diffusion tensor imaging (DTI) of subjects with bipolar disorder (BD), with a particular focus on fractional anisotropy (FA) in white matter (WM) tracts.Methods: The PubMed/MEDLINE database was searched for relevant articles, which were included in a systematic review of the literature. FA reductions and WM abnormalities were divided anatomically into three groups: commissural tracts, association tracts, and projection tracts.Results: Eighteen studies met the inclusion criteria. The corpus callosum was the main impaired commissural tract as demonstrated by FA reductions. Five studies reported FA reductions in the cingulum. Two studies reported decreased FA in the anterior thalamic radiation, and one in the corticospinal tract. Conversely, three studies found increased FA values in WM tracts involved in BD pathophysiology.Conclusion: Despite considerable heterogeneity, these results indicate a direct link between executive cognitive functioning and abnormal WM microstructural integrity of fronto-limbic tracts in patients with remitted BD, providing further evidence of the neuronal disruption that underlies BD symptomatology.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88372858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two systems for empathy in obsessive-compulsive disorder: mentalizing and experience sharing 强迫症共情的两个系统:心智化和经验分享

Brazilian Journal of Psychiatry Pub Date : 2016-03-22 DOI: 10.1590/1516-4446-2015-1679

M. Pino, D. de Berardis, Melania Mariano, F. Vellante, N. Serroni, A. Valchera, M. Valenti, M. Mazza

{"title":"Two systems for empathy in obsessive-compulsive disorder: mentalizing and experience sharing","authors":"M. Pino, D. de Berardis, Melania Mariano, F. Vellante, N. Serroni, A. Valchera, M. Valenti, M. Mazza","doi":"10.1590/1516-4446-2015-1679","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1679","url":null,"abstract":"Objective: To investigate empathic abilities in patients with obsessive-compulsive disorder (OCD) compared to control subjects. OCD is characterized by persistent obsessions and compulsions. Previous studies have proposed specific emotion recognition deficits in patients with OCD. The ability to recognize emotion is part of the broad construct of empathy that incorporates mentalizing and experience-sharing dimensions. Methods: Twenty-four subjects with a diagnosis of OCD and 23 control subjects underwent empathic measures. Results: Patients with OCD compared to control subjects showed deficits in all mentalizing measures. They were incapable of understanding the mental and emotional states of other people. On the other hand, in the sharing experience measures, the OCD group was able to empathize with the emotional experience of other people when they expressed emotions with positive valence, but were not able to do when the emotional valence was negative. Conclusion: Our results suggest that patients with OCD show a difficulty in mentalizing ability, whereas the deficit in sharing ability is specific for the negative emotional valence.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83992720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Co-occurrence of communication disorder and psychiatric disorders in maltreated children and adolescents: relationship with global functioning. 受虐待儿童和青少年的沟通障碍和精神障碍并发症：与整体功能的关系。

Brazilian Journal of Psychiatry Pub Date : 2016-03-01 Epub Date: 2015-11-13 DOI: 10.1590/1516-4446-2014-1564

Luciene Stivanin, Christian C de Oliveira, Fernanda P Dos Santos, Bernardo Dos Santos, Sandra Scivoletto

{"title":"Co-occurrence of communication disorder and psychiatric disorders in maltreated children and adolescents: relationship with global functioning.","authors":"Luciene Stivanin, Christian C de Oliveira, Fernanda P Dos Santos, Bernardo Dos Santos, Sandra Scivoletto","doi":"10.1590/1516-4446-2014-1564","DOIUrl":"10.1590/1516-4446-2014-1564","url":null,"abstract":"Objective: To study the co-occurrence of psychiatric disorders (PD) and communication disorders (CD) and their relationship with global functioning in maltreated children and adolescents.Methods: The sample comprised 143 maltreated children and adolescents (55.8% male). All underwent clinical communication and psychiatric evaluations, as well as global functioning assessment using the Children's Global Assessment Scale (C-GAS).Results: Four groups emerged from evaluation: Group 1 (n=7, 4.9%) did not exhibit any disorders; Group 2 (n=26, 18.2%) exhibited PD; Group 3 (n=34, 23.8%) exhibited CD; and Group 4 (n=76, 53.1%) exhibited both PD and CD on evaluation. Significant differences in global functioning scores were found between G1 and G2, G1 and G4, G2 and G4, and G3 and G4, with the highest C-GAS scores found in G1 and the lowest in G4.Conclusion: Rates of PD and CD are high in this maltreated population. The presence of PD has a major impact on C-GAS score, and the simultaneous presence of CD increases the already impaired function of PD. Demonstration of the additive effects of PD and CD on youth functioning suggests that professionals should be alert to the presence of both disorders to better act preventively and therapeutically in a high-risk population.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75528468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington’s disease, Machado-Joseph disease, and familial amyloid polyneuropathy 中长期焦虑水平与亨廷顿氏病、马查多-约瑟夫病和家族性淀粉样多神经病变症状前检测相关

Brazilian Journal of Psychiatry Pub Date : 2016-02-05 DOI: 10.1590/1516-4446-2014-1617

S. Lêdo, Ângela Leite, Teresa Souto, M. Dinis, J. Sequeiros

{"title":"Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington’s disease, Machado-Joseph disease, and familial amyloid polyneuropathy","authors":"S. Lêdo, Ângela Leite, Teresa Souto, M. Dinis, J. Sequeiros","doi":"10.1590/1516-4446-2014-1617","DOIUrl":"https://doi.org/10.1590/1516-4446-2014-1617","url":null,"abstract":"Objective: To study anxiety as a variable of the mid- and long-term psychological impact of pre-symptomatic testing for three autosomal dominant late-onset disorders – Huntington’s disease (HD), Machado-Joseph disease (MJD) and familial amyloid polyneuropathy (FAP) TTR V30M – in a Portuguese sample. Methods: This cross-sectional study included 203 participants: 170 (83.7%) underwent pre-symptomatic testing for FAP, 29 (14.3%) for HD, and 4 (2%) for MJD. Of the 203 participants, 73 (36.0%) were asymptomatic carriers, 29 (14.5%) were symptomatic carriers, 9 (4.5%) were diagnosed with FAP and had a liver transplant, and 89 (44.5%) were non-carriers. Most were women (58.1%) and married (66.5%). The anxiety variable was assessed using the Zung Self-Rating Anxiety Scale (SAS). Results: The anxiety scores were higher for symptomatic carriers and for those who underwent psychological support consultations over the years. For symptomatic carriers, the mean scores were superior to 40 points, which reflects clinical anxiety. Conclusion: Although it was not possible to differentiate between the mid- and long-term psychological impacts, this study supports the conclusion that the proximity to the age of symptoms onset might be a trigger for anxiety.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83009813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study 终末期肾病患者的抑郁、生活质量和身体组成:一项队列研究

Brazilian Journal of Psychiatry Pub Date : 2016-02-05 DOI: 10.1590/1516-4446-2015-1681

Annerose Barros, B. E. D. da Costa, C. Mottin, D. D'avila

{"title":"Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study","authors":"Annerose Barros, B. E. D. da Costa, C. Mottin, D. D'avila","doi":"10.1590/1516-4446-2015-1681","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1681","url":null,"abstract":"Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants’ body composition was assessed by direct segmental multi-frequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups - depressive symptoms and no depressive symptoms - at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest. Results: Participants’ mean age was 55.3±15.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038). Conclusion: Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88853439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder 双相情感障碍患者未受影响的一级亲属血清BDNF水平

Brazilian Journal of Psychiatry Pub Date : 2016-02-05 DOI: 10.1590/1516-4446-2015-1801

F. Nery, A. D. Gigante, J. Amaral, Francy B. F. Fernandes, Mariangeles Berutti, K. M. Almeida, L. Stertz, G. Bristot, F. Kapczinski, B. Lafer

{"title":"Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder","authors":"F. Nery, A. D. Gigante, J. Amaral, Francy B. F. Fernandes, Mariangeles Berutti, K. M. Almeida, L. Stertz, G. Bristot, F. Kapczinski, B. Lafer","doi":"10.1590/1516-4446-2015-1801","DOIUrl":"https://doi.org/10.1590/1516-4446-2015-1801","url":null,"abstract":"Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease. Brain-derived neurotrophic factor (BDNF) is considered to be implicated in the pathophysiology of BD, but its role as an endophenotype has been poorly studied. We investigated abnormal serum BDNF levels in BD patients, in their unaffected relatives, and in healthy controls. Methods: BDNF levels were obtained from 25 DSM-IV bipolar I disorder patients, 23 unaffected relatives, and 27 healthy controls. All BD patients were in remission. The unaffected subjects were first-degree relatives of the proband who had no lifetime DSM-IV diagnosis of axis I disorder. BDNF serum levels were determined by sandwich ELISA using monoclonal BDNF-specific antibodies. Results: There were no statistical differences in BDNF levels among BD patients, relatives, and healthy controls. Conclusion: Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.","PeriodicalId":9246,"journal":{"name":"Brazilian Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84764888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8