Journal of cancer research and oncobiology最新文献

Therapeutic Potential of Ceramide in Cancer Treatment. 神经酰胺在癌症治疗中的治疗潜力。

Journal of cancer research and oncobiology Pub Date : 2024-01-01 Epub Date: 2024-09-30

Weiyuan Wang, Bert F Prince, Alexander J Thorpe, Timothy J Brown, Brian M Barth

引用次数: 0

Lactation Effect on Findings of Contrast-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging in Patients with Idiopathic Granulomatous Mastitis 乳汁对特发性肉芽肿性乳腺炎磁共振增强和弥散加权成像的影响

Journal of cancer research and oncobiology Pub Date : 2019-04-30 DOI: 10.31021/JCRO.20192120

A. Altunkeser, F. Arslan, M. Eryılmaz, Kazım Körez

{"title":"Lactation Effect on Findings of Contrast-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging in Patients with Idiopathic Granulomatous Mastitis","authors":"A. Altunkeser, F. Arslan, M. Eryılmaz, Kazım Körez","doi":"10.31021/JCRO.20192120","DOIUrl":"https://doi.org/10.31021/JCRO.20192120","url":null,"abstract":"Introduction: Idiopathic granulomatous mastitis is a benign chronic inflammatory disease of the breast. Lactation is considered as one of the most important risk factors. We investigated the effect of lactation on the findings of contrast-enhanced and diffusionweighted magnetic resonance imaging (DW-MRI) in IGM and aimed to identify the most observed findings. Methods: Contrast-enhancedand DW-MRI of 40 patients with lactation history in the last 5 years and 35 patients reporting no lactation history had been reevaluated retrospectively. Morphological features, enhancement pattern and kinetics of lesions were assessed based on BI-RADS. The presence of diffusion restriction was evaluated and apparent diffusion coefficient (ADC) values were obtained. MRI findings with lactation status were compared. Results: Non-mass contrast enhancement (p<0.02), cluster pattern (p<0.008) and fistula formation (p<0.035) were more frequently seen in patients with a lactation history than in patients reporting no lactation history. On MRI most common observed findings were concomittantly mass and non-mass contrast enhancement and abscess formation. Diffusion restriction was present in all of the lesions and the mean ADC values were 0.93 ± 0.25 x 10-3 mm2/s. Conclusion: Lactation status increases the incidence of non-mass contrast enhancement, cluster pattern and fistula formation on MRI.","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89293131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Improved Lung Cancer Diagnosis Model Based on Vocs and CT Data with Transcriptome Analysis 基于Vocs和CT数据的肺癌诊断模型及转录组分析

Journal of cancer research and oncobiology Pub Date : 2019-04-30 DOI: 10.31021/JCRO.20192119

Qian Wu, Sheng Jiajing, Y. Zou, Yanjie Hu, K. Ying, H. Wan, Ping Wang

引用次数: 0

Economic Impact of Cancer Diagnosis on Cancer Survivors: A survey of Colorectal, Breast and Prostate Cancer Survivors 癌症诊断对癌症幸存者的经济影响:结直肠癌、乳腺癌和前列腺癌幸存者的调查

Journal of cancer research and oncobiology Pub Date : 2018-12-24 DOI: 10.31021/jcro.20181118

Bosu Seo, A. Demers, Z. Nugent, Harminder Singh

{"title":"Economic Impact of Cancer Diagnosis on Cancer Survivors: A survey of Colorectal, Breast and Prostate Cancer Survivors","authors":"Bosu Seo, A. Demers, Z. Nugent, Harminder Singh","doi":"10.31021/jcro.20181118","DOIUrl":"https://doi.org/10.31021/jcro.20181118","url":null,"abstract":"Purpose: We investigated the economic impacts of breast, prostate and colorectal cancer (CRC) diagnosis on patients and compared them by cancer site. Methods: A self-administered survey was mailed to all 18 to 62 years old Manitobans with a history of non-metastic breast, prostate or CRC diagnosis within the prior one to three years. Cancer information was obtained from the provincial population-based Manitoba Cancer Registry. Fisher exact test was used to compare frequencies. Multivariate logistic regression models were used to determine independent predictors. Results: 704 (56%) returned the questionnaire of which 547 met the analysis inclusion criteria (employment at time of cancer diagnosis). One to three years after cancer diagnosis, there was a 4 to 9% increase in the number of cancer survivors earning less than $20,000 annually. There was a 13% (prostate), 23% (CRC) and 25% (breast) decrease in the number of survivors employed full-time. The most frequent financial consequence of a cancer diagnosis was using either registered retirement savings and/or other type of savings/investments (breast cancer: 38%, CRC: 35%, prostate cancer: 33%). Overall, 80% of survivors were able to return to the same number of hours worked pre cancer diagnosis. Conclusions: This study suggests that although most recently diagnosed non-metastatic cancer survivors are able to return to work, one fifth to one fourth are impacted adversely, even long term. The one to three year economic impact of cancer diagnosis varies among the most common cancer types, with prostate cancer survivors being the least affected. Implications: There is a need to identify and appraise effective strategies for restoring productive capabilities for cancer survivors currently unable to return to work but interested in doing so.","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81561333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Micro RNA (MiRNA) with Drug Resistance in Malignancies 微RNA (MiRNA)与恶性肿瘤耐药的关系

Journal of cancer research and oncobiology Pub Date : 2018-12-22 DOI: 10.31021/jcro.20181117

Y. Elshimali, M. E. Chatty, Yong Wu, J. Vadgama

引用次数: 0

Impact of Sarcopenia in the Prognostic of Ressectable Esophageal Cancer 肌少症对可切除食管癌预后的影响

Journal of cancer research and oncobiology Pub Date : 2018-11-30 DOI: 10.31021/JCRO.20181115

Sofía Pinheiro, T. Carneiro, Dina Lus, Antnio Gomes, A. Costa, Sandra F. Martins

{"title":"Impact of Sarcopenia in the Prognostic of Ressectable Esophageal Cancer","authors":"Sofía Pinheiro, T. Carneiro, Dina Lus, Antnio Gomes, A. Costa, Sandra F. Martins","doi":"10.31021/JCRO.20181115","DOIUrl":"https://doi.org/10.31021/JCRO.20181115","url":null,"abstract":"Background: Sarcopenia is an important prognostic factor in oncologic patients. In Esophageal Cancer, sarcopenia is associated with increased postoperative morbidity; however, there is no a clear association with mortality. Purpose: To assess the impact of sarcopenia on morbidity and mortality, and evaluate the survival rates of patients who underwent curative esophagectomy for Esophageal Cancer. Methods: Retrospective analysis of 71 patients with esophageal squamous cell carcinoma and esophageal adenocarcinoma, treated between 1st January 2004 and 30th September 2017. In order to obtain the skeletal muscle index, L3 muscle area was assessed through Computed Tomography. T test for independent samples, Mann-Whitney test, Qui-squared test and Fisher’s test were used when pertinent, to compare the data from sarcopenic and non-sarcopenic groups. Disease-free survival and overall survival rates were calculated using Kaplan-Meier method and Cox regression modeling. Results: Sarcopenia prevalence was 23.9% (17 patients). Patients with sarcopenia presented a mean muscle area of 138 cm2 (± 11.7), significantly lower than the nonsarcopenic group (t (64.02)=5.84, p<.001, d=1.29), and a median skeletal muscle index of 49.3 cm2/m2 (3.46), significantly lower than the non-sarcopenic patients (U=58.0, p<.001, r=-.64). Sarcopenia was associated with a lower disease-free survival; however, it has not been a significant predictor when confounders were controlled. Conclusions: In this study, sarcopenia was not associated with a higher postoperative morbimortality neither with a lower disease-free and overall survival.","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81125766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Urinary Bladder Leiomyoma: A Successful Long Term Conservative Treatment Based on Pre-operatory Magnetic Resonance Imaging Findingsr 偶发性膀胱平滑肌瘤:基于术前磁共振成像发现的一种成功的长期保守治疗

Journal of cancer research and oncobiology Pub Date : 2018-11-23 DOI: 10.31021/jcro.20181116

T. Prayer-Galetti, E. Scagliori, R. Stramare, A. Tregnaghi, F. Moro, F. Zattoni, M. Gardiman, M. Soligo

{"title":"Incidental Urinary Bladder Leiomyoma: A Successful Long Term Conservative Treatment Based on Pre-operatory Magnetic Resonance Imaging Findingsr","authors":"T. Prayer-Galetti, E. Scagliori, R. Stramare, A. Tregnaghi, F. Moro, F. Zattoni, M. Gardiman, M. Soligo","doi":"10.31021/jcro.20181116","DOIUrl":"https://doi.org/10.31021/jcro.20181116","url":null,"abstract":"Background: Leiomyomas are benign mesenchymal neoplasms which rarely occur in the urinary bladder, accounting for just 0.43% of all bladder tumours. Due to the paucity of data, very little is known about diagnosis, treatment and follow-up. Thus, despite their nonmalignant nature, they may be considered a true therapeutic challenge. Objective: Conservative management is paramount when assessing and managing benign neoplasms. It is the responsibility of the surgeon to tailor the most appropriate surgery for each patient, finding the best balance between oncologic and functional outcomes and future quality of life. Case report: We present a case report of a patient who was incidentally diagnosed with a large, asymptomatic intramural leiomyoma of the urinary bladder. Following abdominal imaging, biopsy specimens were obtained through cystoscopy, and a transurethral resection of the bladder (TURB) was eventually performed. Imaging findings including Ultrasonography (US), triple-phase Computed Tomography Urography (CTU) and Magnetic Resonance Urography (MRU) are reported, and the most representative images are shown. The patient has been successfully managed with staged TURB and then close outpatient follow-up, and she is currently recurrence-free 8 years after the last endoscopic treatment. Conclusion: Despite the benign nature of leiomyomas, the surgical options for these tumours range from TURB to radical cystectomy. Here, we underline how a conservative approach may be successful regardless of the size and site of the lesion, thus preserving the bladder and the patient’s quality of life without affecting the oncologic outcomes.","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88821478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Electrospun Linear and Branched Nanofibrous Scaffolds for Potential Therapeutic Application in Melanoma 电纺丝线性和分枝纳米纤维支架在黑色素瘤治疗中的潜在应用

Journal of cancer research and oncobiology Pub Date : 2018-08-31 DOI: 10.31021/JCRO.20181113

L. Naves, C. Dhand, S. T. Ong, Chinnasamy Gandhimathi, J. Venugopal, L. Almeida, N. Verma, R. Lakshminarayanan, S. Ramakrishna

{"title":"Electrospun Linear and Branched Nanofibrous Scaffolds for Potential Therapeutic Application in Melanoma","authors":"L. Naves, C. Dhand, S. T. Ong, Chinnasamy Gandhimathi, J. Venugopal, L. Almeida, N. Verma, R. Lakshminarayanan, S. Ramakrishna","doi":"10.31021/JCRO.20181113","DOIUrl":"https://doi.org/10.31021/JCRO.20181113","url":null,"abstract":"In this study, we present a potential alternate approach for the treatment of melanoma skin cancer and skin tissue regeneration, a comparison of polycaprolactone (PCL) and polycaprolactone blended with linear (LPEI) and branched polyethylenimine (BPEI). This research presents the biocompatibility and feasibility of PCL, PCL loaded with LPEI and PCL loaded with BPEI in different concentrations, producing electrospun scaffolds. SEM images show that the nanofibers developed between 74 ± 419 nm. Contact angle assay demonstrated high hydrophobicity for all mats, which could be overcome by surface modification, namely, plasma treatment, ameliorating the hydrophilicity of the mats, providing excellent cells adhesion to the scaffolds surface. We demonstrate the biocompatibility of the scaffolds developed by electrospinning techniques, followed by in vitro tests with Human Dermal Fibroblasts (HDFs) and murine melanoma cells (B16), by using MTT assay to determinate the biocompatibility with all cells, and confocal images to give as insights of cell morphology (nucleus and cellular membrane). Sirius red collagen assay was performed for HDFs to give the collagen release profile after 6 days of incubation, and the possibility of the mats to help in skin regeneration process by forming extra cellular matrix (ECM). The CFMDA dye suggested no cytotoxicity for HDFs to monitor the morphology of live cells. The results have shown that all the scaffolds developed have good cell adhesion and proliferation properties. We could also observe high cytotoxicity for B16 melanoma cells for PCL_BPEI nanofibers. This primary in vitro study suggests that the mats developed may increase the skin regeneration process and at the same time promote apoptosis of melanoma cells, therefore it can be an emerging technology for skin regeneration, wound healing process and treatment of melanoma through electrospun drugs delivery system. *Corresponding author:","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75378272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Who to Treat First: The Oncological Patient or the Oncological Disease? 先治疗谁:肿瘤患者还是肿瘤疾病?

Journal of cancer research and oncobiology Pub Date : 2018-07-31 DOI: 10.31021/jcro.20181114

J. Macedo, M. Machado

引用次数: 0

Treatment of Advanced Cancer-related Lymphocytopenia: Comparison among the Effects of Subcutaneous Low-dose Interleukin-2, High-dose Pineal Hormone Melatonin and Checkpoint Inhibitors 治疗晚期癌症相关淋巴细胞减少症:皮下低剂量白介素-2、高剂量松果体褪黑素和检查点抑制剂的效果比较

Journal of cancer research and oncobiology Pub Date : 2018-05-30 DOI: 10.31021/JCRO.20181112

P. Lissoni, F. Rovelli, G. Porro, F. Brivio, L. Fumagalli, A. Lissoni, G. Messina, Vezika Cenaj, G. Fede

{"title":"Treatment of Advanced Cancer-related Lymphocytopenia: Comparison among the Effects of Subcutaneous Low-dose Interleukin-2, High-dose Pineal Hormone Melatonin and Checkpoint Inhibitors","authors":"P. Lissoni, F. Rovelli, G. Porro, F. Brivio, L. Fumagalli, A. Lissoni, G. Messina, Vezika Cenaj, G. Fede","doi":"10.31021/JCRO.20181112","DOIUrl":"https://doi.org/10.31021/JCRO.20181112","url":null,"abstract":"Background: Despite the negative prognostic significance of lymphocytopenia is known for many years no clinical cancer study has been proposed up to now in an attempt to specifically correct the evidence of an abnormally low lymphocyte count. At present it is known that IL-2 is the main growth factor for T lymphocytes. Lymphocyte proliferation is also stimulated by the pineal indole hormone melatonin (MLT), which is provided by an anticancer activity, whereas it is inhibited by cortisol. Objective: On this basis a preliminary study was carried out to evaluate which may be the optimal therapeutic schedule of cancerrelated lymphocytopenia. Methods: The study included 40 advanced solid tumor patients who were treated by the best supportive care (BSC) (n=9), high-dose MLT alone (n=12) at 100 mg/day in the night, subcutaneous low-dose IL-2 alone (n=9) at 1.8 MIU/day for 5 days/week for 2 weeks followed by 2 weeks-rest period, or IL-2 plus MLT. The duration of study was 6 weeks. Results: The results were compared to those found in 10 advanced cancer patients treated by the checkpoint inhibitor Nivolumab (NVB) at 3 mg/kg/b.w. every 15 days. Lymphocyte count rapidly increased in a significant manner on IL-2 therapy, and a greater increase was reached by Il-2 + MLT. Lymphocyte mean count also increased on MLT alone and on NVB, without, however any statistically significant increase. Finally lymphocyte mean count progressively decreased on BSC alone. Conclusions: This preliminary study shows that S.C. low-dose IL-2 is the only drug able to rapidly correct cancer-related lymphocytopenia, whose efficacy may be further amplified by the concomitant endocrine therapy with the pineal hormone MLT. Further studies will be required to evaluate the impact of the lymphocytopenia correction on the survival of advanced cancer patients.","PeriodicalId":92396,"journal":{"name":"Journal of cancer research and oncobiology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89038672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2