Association of Micro RNA (MiRNA) with Drug Resistance in Malignancies

Abstract

The resistance against chemotherapy in malignancies is a major challenge in clinical oncology and remarkable successes related to this field have been achieved. Many mechanisms such as gene mutation, oxidative stress, tumor hypoxia, multidrug efflux pumps, DNA methylation and histone modification have important roles in the resistance of cancer cells to chemotherapeutic agents. Recent researches in molecular oncology raised the role of miRNAs on the development of drug resistance in cancers. In this review, we will focus on the updated findings about the interaction between a variety of miRNAs and other cellular molecules that result in drug resistance.