发布求助
文献互助 智能选刊 最新文献

Biotarget最新文献

筛选
英文 中文
Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity 靶向BECN1-BCL2自噬调控复合体促进长寿
Biotarget Pub Date : 2018-10-01 DOI: 10.21037/BIOTARGET.2018.10.01
B. Stork, N. Ventura
{"title":"Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity","authors":"B. Stork, N. Ventura","doi":"10.21037/BIOTARGET.2018.10.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.10.01","url":null,"abstract":"Several studies in the past two decades established an evolutionarily conserved and tight relationship between autophagy and ageing. Model organisms such as the budding yeast Saccharomyces cerevisiae , the soil dueling worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster , have been instrumental for the identification of key genes regulating a variety of pathophysiological processes and signaling, including ageing and associated pathologies (1).","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2018.10.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41711124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous profiling of multiple genomic variations using a CRISPR-Cas9 high-throughput strategy 使用CRISPR-Cas9高通量策略同时分析多种基因组变异
Biotarget Pub Date : 2018-09-11 DOI: 10.21037/BIOTARGET.2018.10.02
P. Cordelier
{"title":"Simultaneous profiling of multiple genomic variations using a CRISPR-Cas9 high-throughput strategy","authors":"P. Cordelier","doi":"10.21037/BIOTARGET.2018.10.02","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.10.02","url":null,"abstract":"In the paper untitled “high-throughput creation and functional profiling of DNA sequence variant libraries using CRISP-Cas9 in yeast” (1) published online in May 2018 in Nature Biotechnology, George M. Church, an eminent expert in CRISPR-Cas9 biology and technology, makes, yet another, giant step in the field of genomics.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46357703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The complexity of the ubiquitination code is driven by bacteria 泛素化代码的复杂性是由细菌驱动的
Biotarget Pub Date : 2018-09-01 DOI: 10.21037/BIOTARGET.2018.08.04
F. Nazio, F. Cecconi
{"title":"The complexity of the ubiquitination code is driven by bacteria","authors":"F. Nazio, F. Cecconi","doi":"10.21037/BIOTARGET.2018.08.04","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.08.04","url":null,"abstract":"Protein ubiquitination is a post-translational modification dynamically regulated, and is involved in many processes to maintain a balanced functioning of cellular pathways.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45595558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENL YEATS domain: targeting the acute myeloid leukemia epigenome ENL YEATS结构域:靶向急性髓系白血病表观基因组
Biotarget Pub Date : 2018-08-01 DOI: 10.21037/BIOTARGET.2018.08.01
F. Loscocco, G. Visani, A. Isidori
{"title":"ENL YEATS domain: targeting the acute myeloid leukemia epigenome","authors":"F. Loscocco, G. Visani, A. Isidori","doi":"10.21037/BIOTARGET.2018.08.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.08.01","url":null,"abstract":"Acute myeloid leukemia (AML) is a hematological cancer characterized by the quick proliferation and accumulation of immature myeloid cells in the bone marrow, with an impaired differentiation program.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46120511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes NKX3.2在调节HIF1α诱导的软骨细胞血管生成中起关键作用
Biotarget Pub Date : 2018-07-01 DOI: 10.21037/BIOTARGET.2018.07.01
T. Welting, M. Karperien, J. Post
{"title":"NKX3.2 plays a key role in regulating HIF1α-directed angiogenesis in chondrocytes","authors":"T. Welting, M. Karperien, J. Post","doi":"10.21037/BIOTARGET.2018.07.01","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.07.01","url":null,"abstract":"The cellular fraction of cartilage is mainly composed of one single cell type, the chondrocyte, which secretes, shapes and maintains the cartilaginous matrix that functions, in the case of epiphyseal cartilage, as the template for bone elongation. The biomechanical properties of cartilage are dependent mainly on the composition, as well as the macromolecular integrity of its matrix contributing to the functional and phenotypic differences between cartilage subtypes (1). For example, articular cartilage (AC) is a highly resilient tissue that allows low-friction joint articulation. In contrast, growth plate (GP) cartilage is populated by highly proliferative chondrocytes that undergo hypertrophic differentiation in an angiogenesis-promoting spatiotemporal manner, serving as a mold for longitudinal bone growth. As such, an in sharp contrast to AC, GP cartilage is a transient tissue and is replaced by bone in a process known as endochondral ossification (2).","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2018.07.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49474895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Regulation of SCF E3 ligase activity by Cand1 Cand1对scfe3连接酶活性的调控
Biotarget Pub Date : 2018-06-01 DOI: 10.21037/biotarget.2018.05.03
Maryna Gorelik, S. Sidhu
{"title":"Regulation of SCF E3 ligase activity by Cand1","authors":"Maryna Gorelik, S. Sidhu","doi":"10.21037/biotarget.2018.05.03","DOIUrl":"https://doi.org/10.21037/biotarget.2018.05.03","url":null,"abstract":"Ubiquitination, which targets proteins for degradation or modifies their activity, is central to cellular function. Proteins controlling ubiquitination have attracted a lot of attention as potential therapeutic targets for a variety of diseases.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/biotarget.2018.05.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41625061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New function of Tip60 in controlling triacylglycerol synthesis Tip60在控制三酰基甘油合成中的新功能
Biotarget Pub Date : 2018-04-09 DOI: 10.21037/biotarget.2018.08.03
T. Hattori
{"title":"New function of Tip60 in controlling triacylglycerol synthesis","authors":"T. Hattori","doi":"10.21037/biotarget.2018.08.03","DOIUrl":"https://doi.org/10.21037/biotarget.2018.08.03","url":null,"abstract":"The HIV Tat-interactive protein, 60 kDa (Tip60) was originally identified as a cellular acetyltransferase belonging to the MYST (MOZ, Ybf2/Sas3, Sas2 and Tip60) family.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44396038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wnt7a and miR-370-3p: new contributors to bladder cancer invasion. Wnt7a和miR-370-3p：膀胱癌症侵袭的新贡献者。
Biotarget Pub Date : 2018-04-09 DOI: 10.21037/BIOTARGET.2018.08.02
D. Scheunemann, A. Pradhan, Swadesh K. Das, D. Sarkar, L. Emdad, P. Fisher
{"title":"Wnt7a and miR-370-3p: new contributors to bladder cancer invasion.","authors":"D. Scheunemann, A. Pradhan, Swadesh K. Das, D. Sarkar, L. Emdad, P. Fisher","doi":"10.21037/BIOTARGET.2018.08.02","DOIUrl":"https://doi.org/10.21037/BIOTARGET.2018.08.02","url":null,"abstract":"In eukaryotes, microRNAs (miRNAs) are central regulators of gene expression. These small noncoding RNAs are about 19–24 nucleotides long (1). miRNAs can silence gene expression by binding to a complementary sequence in the 3'-UTR of the target gene, which then triggers mRNA degradation.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/BIOTARGET.2018.08.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43703723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Vacuolar H+-ATPases (V-ATPases) as therapeutic targets: a brief review and recent developments. 液泡H+- atp酶(v - atp酶)作为治疗靶点:简要回顾和最新进展。
Biotarget Pub Date : 2017-12-01 Epub Date: 2017-12-13 DOI: 10.21037/biotarget.2017.12.01
L Shannon Holliday
{"title":"Vacuolar H<sup>+</sup>-ATPases (V-ATPases) as therapeutic targets: a brief review and recent developments.","authors":"L Shannon Holliday","doi":"10.21037/biotarget.2017.12.01","DOIUrl":"https://doi.org/10.21037/biotarget.2017.12.01","url":null,"abstract":"<p><p>Vacuolar H<sup>+</sup>-ATPases (V-ATPases) are multi-subunit enzymes that play housekeeping roles in eukaryotic cells by acidifying lysosomes, late endosomes, Golgi, and other membrane-bounded compartments. Beyond that, V-ATPases have specialized functions in certain cell types linked to diseases including osteoporosis and cancer. Efforts to identify strategies to develop inhibitors selective for V-ATPases that are involved in disease progression have been ongoing for more than two decades, but so far have not yielded a therapeutic agent that has been translated to the clinic. Recent basic science studies have identified unexpected roles for V-ATPases in nutrient and energy sensing, and renin/angiotensin signaling, which offer additional incentives for considering V-ATPases as therapeutic targets. This article briefly reviews efforts to utilize inhibitors of V-ATPases as drugs. Primary focus is on recent \"rational\" efforts to identify small molecule inhibitors of the V-ATPases that are selectively expressed in osteoclasts and cancer cells. Enoxacin and bis-enoxacin are two molecules that emerged from these efforts. These molecules block a binding interaction between V-ATPases and microfilaments that occurs in osteoclasts, but not most other cell types, which relates to the specialized function of V-ATPases in bone resorption. Enoxacin and bis-enoxacin have proven useful in the treatment of bone diseases and cancer in animal models and display therapeutic effects that are different, and perhaps better, than current drugs. These results provide evidence that agents targeting subsets of V-ATPases may prove useful in the clinic.</p>","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/biotarget.2017.12.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37128906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury. 间充质干细胞衍生的细胞外囊泡:一种治疗肝损伤的新方法。
Biotarget Pub Date : 2017-09-01 Epub Date: 2017-09-19 DOI: 10.21037/biotarget.2017.08.04
Anuradha Moirangthem, Tushar Patel
{"title":"Mesenchymal stem cell derived extracellular vesicles: a promising new therapeutic approach for hepatic injury.","authors":"Anuradha Moirangthem,&nbsp;Tushar Patel","doi":"10.21037/biotarget.2017.08.04","DOIUrl":"https://doi.org/10.21037/biotarget.2017.08.04","url":null,"abstract":"Liver injury is a serious condition which may often lead to hepatic failure. It can occur as a consequence of insults and toxicity related to viral hepatitis, drugs, ischemia, alcohol, drugs, metabolic diseases or autoimmune disease. Liver transplantation may be required in cases of acute or fulminant liver failure beyond the capacity of the liver to repair and regenerate. While this is an effective treatment option, the scarcity of organ donors, and the medical, financial and socioeconomic factors limit its utility. New approaches to ameliorate liver injury are needed.","PeriodicalId":92338,"journal":{"name":"Biotarget","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/biotarget.2017.08.04","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36488760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信