Journal of diabetes, metabolic disorders & control最新文献

{"title":"Diabetes and heart failure: time for a new approach","authors":"Renato Kaufman","doi":"10.15406/jdmdc.2019.06.00186","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00186","url":null,"abstract":"1. Young LH, Wackers FJ, Chyun DA, et al. Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial. JAMA. 2009;301(15):1547–1555. 2. Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation. 2011;124(23):574–651.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73790026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of subacute thyroiditis associated with complete occlusion of right coronary artery","authors":"A. Nakanishi, Jouji Shunto, Reiko Shunto, M. Sata, H. Bando","doi":"10.15406/JDMDC.2019.06.00183","DOIUrl":"https://doi.org/10.15406/JDMDC.2019.06.00183","url":null,"abstract":"Case presentation: A case is a 72-year-old male, and developed fever, sore throat and immigrating neck pain, without shortness of breath (SOB). He showed pulse 96/min, Temp 38.8C, BP 146/90mmHg, respiration and SpO2 normal. Physicals were slight tenderness in thyroid, and laboratory data revealed free T3/T4 10.7pg/mL/5.4ng/dL. He was diagnosed as subacute thyroiditis. ECG showed incomplete right bundle block branch (RBBB) and Holter ECG showed pulse rate 70-144/min and the average was 95.8/min for 24 hours. HbA1c increased from 6.4% to 7.4% for 6 weeks. For the treatment, prednisolone 20mg/day was started and reduced gradually, and thyroid function was normalized. Consecutively, he developed chest discomfort and oppression with unremarkable ECG changes and chest CT showed only the calcification of coronary arteries. Coronary angiography showed occlusion of the right proximal coronary artery (RCA, #2:100%), left anterior descending (LAD, #6:75%, #7:90%). Coronary angioplasty was operated immediately. By placing a drug-eluting stent, RCA was re-opened successfully. His symptoms disappeared, and clinical course was improved.\u0000Discussion: Subacute thyroiditis may bring hyperthyroidism and tachycardia, increased metabolism for circulatory system. Then, subacute thyroiditis would give burden and stress for coronary heart function. It is suggested that hyperthyroidism would aggravate the coronary stenosis. We have to consider such complex pathophysiology for the diseased states in the clinical medical practice.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90205260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The artificial pancreas: Incremental improvements towards an automated closed-loop insulin delivery system in type 1 diabetes","authors":"Martina S Burn, Sabrina C Burn, P. Burn","doi":"10.15406/jdmdc.2019.06.00182","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00182","url":null,"abstract":"","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78468061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid hormone abnormalities in euthyroid type 2 diabetes mellitus with chronic kidney disease in Saudi community based hospital","authors":"Khalid S Aljabri, Ibrahim M Alnasser, Samia A Bokhari, Muneera A Alshareef, Patan M Khan, Abdulla M Mallosho, Hesham M Abu Elsaoud, Mohammad M Jalal, Rania F Safwat, Rehab El Boraie, Nawaf K Aljabri, Bandari K Aljabri, Arwa Y Alsuraihi MS, Amjad I Hawsawi","doi":"10.15406/jdmdc.2019.06.00180","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00180","url":null,"abstract":"Background and objective: The interactions between kidney and thyroid functions are known for years. The present retrospective study was conducted to find out the thyroid hormone abnormalities in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) in Saudi community based hospital. Design: We analyzed retrospectively 872 participants with T2DM whom are between the age 20 to 96 years. All patients were from the population of the Primary health centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. All data were collected on the basis of a review of electronic medical data. Participants were defined as having T2DM according to self-report, clinical reports, use of antidiabetic agents and HbA1c (≥6.5). HbA1c was expressed as percentage. High performance liquid chromatography was used. Serums FT4 were estimated by radioimmunoassay and Serum TSH was estimated by Immunoradiometric assey. All patients in the present study fulfilled the revised National Kidney Foundation criteria for the diagnosis of CKD. The total numbers of cohort were separated on basis of age values into four groups: <40 years, 40-49 years, 50-59 years and ≥60 years. Results: 872 subjects with T2DM were included. There were 273 (31.3%) male and 557 (68.7%) were female with mean age 54.5±13.0. The mean HbA1c, TSH and FT4 value were 8.1±2.2, 2.0±1.1 mIU/l and 15.8±2.8 pmol/l respectively. Among cases of T2DM and CKD, there were 239 (61.9 %) female and 147 (38.1 %) were male with female to male ration 1.6:1.0, p<0.0001. Patients with CKD were significantly older than patients without CKD, 57.3±2.9 vs. 52.3 ±12.6 respectively, p<0.0001. Patients with CKD were significantly have higher HbA1c than patients without CKD, 8.7±2.3 vs. 7.7±2.1 respectively, p<0.0001. Patients with CKD were significantly have higher TSH than patients without CKD, 2.1±1.0 vs. 1.9±1.1 respectively, p=0.001. Patients with CKD were significantly have lower FT4 than patients without CKD, 15.5±2.8 vs. 16.1±2.9 respectively, p=0.03. Patients with CKD have higher TSH than patients without CKD across all age groups. Patients with CKD have lower FT4 than patients without CKD across all age groups except patients older than 60years. Conclusion: We conclude that despite the limitations of this hospital-based retrospective study, high TSH and low FT4 levels are highly prevalent in cohort of Saudis with CKD and T2DM. The majority of our patients in our finding were predominantly females. These two observations remain to be validated by population-based studies. In the absence of registry data, larger cooperative studies involving diverse population samples from multiple centers could help to provide further information on the true thyroid hormone abnormalities.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78280764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of hypoglycemic episodes in diabetics in Africans","authors":"A. Ademolu","doi":"10.15406/jdmdc.2019.06.00179","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00179","url":null,"abstract":"Hypoglycemia as a management complication of diabetes mellitus is a worldwide experience.1 Though concerted efforts have been made by endocrinologist, health workers and patients to reduce hypoglycemic episodes yet its occurrence and recurrence despite these efforts cannot be overemphasized. The glycemic thresholds for symptoms of hypoglycemia (among other responses) shift to lower plasma glucose concentrations after recent antecedent hypoglycemia,2‒5 and to higher plasma glucose concentrations in patients with poorly controlled diabetes and infrequent hypoglycemia.6","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90655200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologically relevant drug interactions of α glucosidase inhibitors","authors":"Naina Mohamed Pakkir Maideen","doi":"10.15406/jdmdc.2019.06.00178","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00178","url":null,"abstract":"The α-glucosidase inhibitors are antidiabetic agents suppressing the postprandial hyperglycemia and they include Acarbose, Miglitol and Voglibose. These drugs could be used alone or as add-on therapy to treat patients with type 2 diabetes taking other antidiabetic drugs. The gastrointestinal motility is increased by the administration of Acarbose, which may lead to decreased absorption of Digoxin and Metronidazole. The glucose lowering effects of antidiabetic drugs such as Metformin, Glibenclamide, Rosiglitazone, Vildagliptin and Dapagliflozin might be enhanced by the coadministration of α-glucosidase inhibitors, though there were reports of little or no alterations in the pharmacokinetics properties of them.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79525737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily improvement of blood glucose profile by continuous glucose monitoring (CGM)","authors":"H. Bando, Y. Kato, S. Kanazawa, Mayumi Tanaka, E. Sueki, H. Kanagawa, T. Kawata, A. Kawahito, A. Aihara","doi":"10.15406/JDMDC.2019.06.00177","DOIUrl":"https://doi.org/10.15406/JDMDC.2019.06.00177","url":null,"abstract":"Background: The problem of glucose variability has been in focus for type 1 diabetes mellitus (T1DM) on insulin treatment. Daily profile of blood glucose was studied on Continuous Glucose Monitoring (CGM) using Free Style Libre. Case presentation and results: Patient is 54 year-old T1DM female, with HbA1c 7.8%. The blood glucose variability was measured by Free Style Libre. Insulin therapy included multiple daily insulin injection (MDI) of Insulin Glargin and Aspart. The result revealed unstable blood glucose profile in day 1 and 2. After that, the level and fluctuation of blood glucose gradually decreased from day 3 to 14. Average blood glucose in a day was 174mg/dL, 159mg/dL, 138mg/dL, 125mg/dL and 110mg/dL, in day 2, 4, 7, 9, 11, respectively. There was a discrepancy of HbA1c between 7.8% by laboratory measurement and 6.3% presumed value by Free Style Libre. Discussion and Conclusion: Free Style Libre showed satisfactory results as CGM. There was lower HbA1c value by presumed calculation, which would be possibly due to every 15minutes measurement and difficulty in checking abrupt glucose surges. CGM application would probably bring diabetic subjects behavioral change of life style, leading to better diabetic control. These results would become reference data in CGM study for future research.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75689348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where are we in the management of type 2 DM?","authors":"Mohamed Hassan Hatahet","doi":"10.15406/jdmdc.2019.06.00176","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00176","url":null,"abstract":"Efficacy a) Oral medications tend to be less effective in lowering HbA1c (< 1% reduction). b) Insulin and GLP1 RA reduce HbA1c more, alone or in combination. c) Basal insulin and GLP1 RA are similar in reducing HbA1c when used as 1st injectable. d) Adding an oral medication looks reasonable when HbA1c is still between 7-8%. e) Adding one of the injectable when HbA1c is 8% or above is the most reasonable to a patient on oral medication. f) Adding two or more oral medications can bring high HbA1c to goal.","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90839587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single and combinatorial herbal formulations reversed hyperglycemia and dyslipidemia in diabetic rats","authors":"C. Chikezie, Okey, A. Ojiako, A. Angela, Emejulu, PAUL CHIDOKA CHIKEZIE","doi":"10.15406/jdmdc.2019.06.00175","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00175","url":null,"abstract":"Acanthus montanus (Nees) T. Anderson is widespread in Africa, the Balkans, Romania, Greece and Eastern Mediterranean and belongs to the family of Acantheceae. The leaves are dark green and measure about 30 cm long. Common names of A. montanus are mountain thistle or Devil’s fig or Bear’s Breech. The leaf extracts of A. montanus have been previously reported to exhibit analgesics, antipyretic, antimicrobial, anti-inflammatory and immunological properties.1","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77548921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive dysfunction in diabetes mellitus","authors":"Raman Pg","doi":"10.15406/jdmdc.2019.06.00174","DOIUrl":"https://doi.org/10.15406/jdmdc.2019.06.00174","url":null,"abstract":"","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85960740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}