Breast Cancer Research最新文献

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CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome. 从乳腺癌患者血液中分离出的循环肿瘤衍生细胞中的 CCR5 激活和内吞作用可提供有关临床结果的信息。
IF 6.1 1区 医学
Breast Cancer Research Pub Date : 2022-05-23 DOI: 10.1186/s13058-022-01528-w
Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R K Alpaugh, Kirby P Gardner, Saranya Chumsri, Daniel L Adams
{"title":"CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome.","authors":"Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R K Alpaugh, Kirby P Gardner, Saranya Chumsri, Daniel L Adams","doi":"10.1186/s13058-022-01528-w","DOIUrl":"10.1186/s13058-022-01528-w","url":null,"abstract":"<p><strong>Background: </strong>CCR5 is a motility chemokine receptor implicated in tumor progression, whose activation and subsequent endocytosis may identify highly aggressive breast cancer cell subtypes likely to spread into the circulatory system.</p><p><strong>Methods: </strong>The MDA-MB-231 cell line was used to model and visualize CCR5 activation by stimulation with RANTES, in an effort to quantify CCR5 endocytosis from the cell surface to the perinuclear space. CCR5 expression was then examined in tumor-associated cells (TACs), consisting of circulating tumor cells and circulating stromal cells, isolated from the peripheral blood of 54 metastatic breast cancer (mBC) patients to evaluate these CCR5 pooling patterns as they relate to progression and survival over 2 years.</p><p><strong>Results: </strong>In MB231 experiments, it was observed that CCR5 formed ~ 1 micron clusters identified as \"CCR5 pools\" on the surface of the cell, which in the presence of RANTES were endocytosed and translocated to the cell cytoplasm. When TACs from patients were analyzed, CCR5 pools were observed on the cell surface and translocating to the nuclear area, with CCR5 also having a positive statistical correlation between increased numbers of TACs and increased CCR5 pools on the cells. Further, it was determined that patients with very high numbers of CCR5 (> 10 CCR5 pools), specifically in the circulating stromal cells, were associated with worse progression-free survival (hazard ratio = 4.5, p = 0.002) and worse overall survival (hazard ratio = 3.7, p = 0.014).</p><p><strong>Conclusions: </strong>Using a liquid biopsy approach, we evaluated two populations of tumor-associated cells emanating from primary tumors, with data suggesting that upregulation of the motility chemokine CCR5 in TACs provides clinically relevant opportunities for treating and tracking drug targetable receptors in mBC.</p>","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":"35"},"PeriodicalIF":6.1,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling β 2肾上腺素能受体和mu阿片受体相互作用,通过激活糖原合成酶激酶3信号通路增强人乳腺癌细胞的侵袭性
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-05-14 DOI: 10.1186/s13058-022-01526-y
B. Rousseau, Sengottuvelan Murugan, Ajay Palagani, D. Sarkar
{"title":"Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling","authors":"B. Rousseau, Sengottuvelan Murugan, Ajay Palagani, D. Sarkar","doi":"10.1186/s13058-022-01526-y","DOIUrl":"https://doi.org/10.1186/s13058-022-01526-y","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"39 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80577043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological interpretation of prognostic radiomic score by correlating with tumor heterogeneity and microenvironment 与肿瘤异质性和微环境相关的预后放射学评分的生物学解释
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-05-09 DOI: 10.1186/s13058-022-01527-x
Jieling Zheng, Bin Zhang
{"title":"Biological interpretation of prognostic radiomic score by correlating with tumor heterogeneity and microenvironment","authors":"Jieling Zheng, Bin Zhang","doi":"10.1186/s13058-022-01527-x","DOIUrl":"https://doi.org/10.1186/s13058-022-01527-x","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases 激活病毒传感器低聚腺苷酸合成酶2 (Oas2)可预防妊娠驱动的乳腺癌转移
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-05-03 DOI: 10.1186/s13058-022-01525-z
W. Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E Castillo, A. Mawson, Moira K. O’Bryan, C. Goodnow, D. Gallego-Ortega, S. Oakes, C. Ormandy
{"title":"Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases","authors":"W. Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E Castillo, A. Mawson, Moira K. O’Bryan, C. Goodnow, D. Gallego-Ortega, S. Oakes, C. Ormandy","doi":"10.1186/s13058-022-01525-z","DOIUrl":"https://doi.org/10.1186/s13058-022-01525-z","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44167151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women 绝经后妇女血浆和乳腺密度中NF-κB (RANK)通路激素和受体激活因子基因表达
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-04-14 DOI: 10.1186/s13058-022-01522-2
Rachel L. Mintz, Mei Wang, Shuaili Xu, G. Colditz, C. Markovic, Adetunji T. Toriola
{"title":"Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women","authors":"Rachel L. Mintz, Mei Wang, Shuaili Xu, G. Colditz, C. Markovic, Adetunji T. Toriola","doi":"10.1186/s13058-022-01522-2","DOIUrl":"https://doi.org/10.1186/s13058-022-01522-2","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"52 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80366287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling 乳腺癌脑转移通过膜联蛋白a1 /甲酰基肽受体信号通路募集和激活小胶质细胞
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-04-05 DOI: 10.1186/s13058-022-01514-2
S. L. Foo, K. Sachaphibulkij, Corinne Lee, Gracemary L. R. Yap, Jianzhou Cui, T. Arumugam, L. Lim
{"title":"Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling","authors":"S. L. Foo, K. Sachaphibulkij, Corinne Lee, Gracemary L. R. Yap, Jianzhou Cui, T. Arumugam, L. Lim","doi":"10.1186/s13058-022-01514-2","DOIUrl":"https://doi.org/10.1186/s13058-022-01514-2","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM 基于人群的ATM致病性变异的年龄特异性乳腺癌累积风险评估
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-04-01 DOI: 10.1186/s13058-022-01518-y
Anne-Laure Renault, J. Dowty, Jason A. Steen, Shuai Li, I. Winship, G. Giles, J. Hopper, M. Southey, T. Nguyen-Dumont
{"title":"Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM","authors":"Anne-Laure Renault, J. Dowty, Jason A. Steen, Shuai Li, I. Winship, G. Giles, J. Hopper, M. Southey, T. Nguyen-Dumont","doi":"10.1186/s13058-022-01518-y","DOIUrl":"https://doi.org/10.1186/s13058-022-01518-y","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors 靶向SHP2磷酸酶治疗乳腺癌克服了rtk介导的对PI3K抑制剂的耐药
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-04-01 DOI: 10.1186/s13058-022-01521-3
Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, A. Wulf‐Goldenberg, Joshua Alcaniz, Elodie Montaudon, E. Marangoni, W. Birchmeier
{"title":"Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors","authors":"Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, A. Wulf‐Goldenberg, Joshua Alcaniz, Elodie Montaudon, E. Marangoni, W. Birchmeier","doi":"10.1186/s13058-022-01521-3","DOIUrl":"https://doi.org/10.1186/s13058-022-01521-3","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"15 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87336096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical significance of HER2-low expression in early breast cancer: a nationwide study from the Korean Breast Cancer Society her2低表达在早期乳腺癌中的临床意义:韩国乳腺癌协会的一项全国性研究
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-03-21 DOI: 10.1186/s13058-022-01519-x
H. Won, J. Ahn, Y. Kim, Jin Sung Kim, J. Song, Hong-Kyu Kim, Jeeyeon Lee, H. Park, Yong-Seok Kim
{"title":"Clinical significance of HER2-low expression in early breast cancer: a nationwide study from the Korean Breast Cancer Society","authors":"H. Won, J. Ahn, Y. Kim, Jin Sung Kim, J. Song, Hong-Kyu Kim, Jeeyeon Lee, H. Park, Yong-Seok Kim","doi":"10.1186/s13058-022-01519-x","DOIUrl":"https://doi.org/10.1186/s13058-022-01519-x","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"81 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88005552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Radiomics predicts the prognosis of patients with locally advanced breast cancer by reflecting the heterogeneity of tumor cells and the tumor microenvironment 放射组学通过反映肿瘤细胞和肿瘤微环境的异质性来预测局部晚期乳腺癌患者的预后
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-03-15 DOI: 10.1186/s13058-022-01516-0
Xuanyi Wang, Tiansong Xie, Ju-rui Luo, Zhengrong Zhou, Xiaoli Yu, Xiaomao Guo
{"title":"Radiomics predicts the prognosis of patients with locally advanced breast cancer by reflecting the heterogeneity of tumor cells and the tumor microenvironment","authors":"Xuanyi Wang, Tiansong Xie, Ju-rui Luo, Zhengrong Zhou, Xiaoli Yu, Xiaomao Guo","doi":"10.1186/s13058-022-01516-0","DOIUrl":"https://doi.org/10.1186/s13058-022-01516-0","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"37 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78756858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
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