Breast Cancer Research最新文献

{"title":"CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome.","authors":"Ashvathi Raghavakaimal, Massimo Cristofanilli, Cha-Mei Tang, R K Alpaugh, Kirby P Gardner, Saranya Chumsri, Daniel L Adams","doi":"10.1186/s13058-022-01528-w","DOIUrl":"10.1186/s13058-022-01528-w","url":null,"abstract":"<p><strong>Background: </strong>CCR5 is a motility chemokine receptor implicated in tumor progression, whose activation and subsequent endocytosis may identify highly aggressive breast cancer cell subtypes likely to spread into the circulatory system.</p><p><strong>Methods: </strong>The MDA-MB-231 cell line was used to model and visualize CCR5 activation by stimulation with RANTES, in an effort to quantify CCR5 endocytosis from the cell surface to the perinuclear space. CCR5 expression was then examined in tumor-associated cells (TACs), consisting of circulating tumor cells and circulating stromal cells, isolated from the peripheral blood of 54 metastatic breast cancer (mBC) patients to evaluate these CCR5 pooling patterns as they relate to progression and survival over 2 years.</p><p><strong>Results: </strong>In MB231 experiments, it was observed that CCR5 formed ~ 1 micron clusters identified as \"CCR5 pools\" on the surface of the cell, which in the presence of RANTES were endocytosed and translocated to the cell cytoplasm. When TACs from patients were analyzed, CCR5 pools were observed on the cell surface and translocating to the nuclear area, with CCR5 also having a positive statistical correlation between increased numbers of TACs and increased CCR5 pools on the cells. Further, it was determined that patients with very high numbers of CCR5 (> 10 CCR5 pools), specifically in the circulating stromal cells, were associated with worse progression-free survival (hazard ratio = 4.5, p = 0.002) and worse overall survival (hazard ratio = 3.7, p = 0.014).</p><p><strong>Conclusions: </strong>Using a liquid biopsy approach, we evaluated two populations of tumor-associated cells emanating from primary tumors, with data suggesting that upregulation of the motility chemokine CCR5 in TACs provides clinically relevant opportunities for treating and tracking drug targetable receptors in mBC.</p>","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":"35"},"PeriodicalIF":6.1,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling","authors":"B. Rousseau, Sengottuvelan Murugan, Ajay Palagani, D. Sarkar","doi":"10.1186/s13058-022-01526-y","DOIUrl":"https://doi.org/10.1186/s13058-022-01526-y","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"39 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80577043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological interpretation of prognostic radiomic score by correlating with tumor heterogeneity and microenvironment","authors":"Jieling Zheng, Bin Zhang","doi":"10.1186/s13058-022-01527-x","DOIUrl":"https://doi.org/10.1186/s13058-022-01527-x","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases","authors":"W. Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E Castillo, A. Mawson, Moira K. O’Bryan, C. Goodnow, D. Gallego-Ortega, S. Oakes, C. Ormandy","doi":"10.1186/s13058-022-01525-z","DOIUrl":"https://doi.org/10.1186/s13058-022-01525-z","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":" ","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44167151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women.","authors":"Rachel Mintz, Mei Wang, Shuai Xu, Graham A Colditz, Chris Markovic, Adetunji T Toriola","doi":"10.1186/s13058-022-01522-2","DOIUrl":"10.1186/s13058-022-01522-2","url":null,"abstract":"<p><strong>Background: </strong>Hormones impact breast tissue proliferation. Studies investigating the associations of circulating hormone levels with mammographic breast density have reported conflicting results. Due to the limited number of studies, we investigated the associations of hormone gene expression as well as their downstream mediators within the plasma with mammographic breast density in postmenopausal women.</p><p><strong>Methods: </strong>We recruited postmenopausal women at their annual screening mammogram at Washington University School of Medicine, St. Louis. We used the NanoString nCounter platform to quantify gene expression of hormones (prolactin, progesterone receptor (PGR), estrogen receptor 1 (ESR1), signal transducer and activator of transcription (STAT1 and STAT5), and receptor activator of nuclear factor-kB (RANK) pathway markers (RANK, RANKL, osteoprotegerin, TNFRSF18, and TNFRSF13B) in plasma. We used Volpara to measure volumetric percent density, dense volume, and non-dense volume. Linear regression models, adjusted for confounders, were used to evaluate associations between gene expression (linear fold change) and mammographic breast density.</p><p><strong>Results: </strong>One unit increase in ESR1, RANK, and TNFRSF18 gene expression was associated with 8% (95% CI 0-15%, p value = 0.05), 10% (95% CI 0-20%, p value = 0.04) and % (95% CI 0-9%, p value = 0.04) higher volumetric percent density, respectively. There were no associations between gene expression of other markers and volumetric percent density. One unit increase in osteoprotegerin and PGR gene expression was associated with 12% (95% CI 4-19%, p value = 0.003) and 7% (95% CI 0-13%, p value = 0.04) lower non-dense volume, respectively.</p><p><strong>Conclusion: </strong>These findings provide new insight on the associations of plasma hormonal and RANK pathway gene expression with mammographic breast density in postmenopausal women and require confirmation in other studies.</p>","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"52 1","pages":"28"},"PeriodicalIF":6.2,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80366287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling","authors":"S. L. Foo, K. Sachaphibulkij, Corinne Lee, Gracemary L. R. Yap, Jianzhou Cui, T. Arumugam, L. Lim","doi":"10.1186/s13058-022-01514-2","DOIUrl":"https://doi.org/10.1186/s13058-022-01514-2","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM.","authors":"Anne-Laure Renault, James G Dowty, Jason A Steen, Shuai Li, Ingrid M Winship, Graham G Giles, John L Hopper, Melissa C Southey, Tú Nguyen-Dumont","doi":"10.1186/s13058-022-01518-y","DOIUrl":"10.1186/s13058-022-01518-y","url":null,"abstract":"<p><strong>Background: </strong>Multigene panel tests for breast cancer predisposition routinely include ATM as it is now a well-established breast cancer predisposition gene.</p><p><strong>Methods: </strong>We included ATM in a multigene panel test applied to the Australian Breast Cancer Family Registry (ABCFR), a population-based case-control-family study of breast cancer, with the purpose of estimating the prevalence and penetrance of heterozygous ATM pathogenic variants from the family data, using segregation analysis.</p><p><strong>Results: </strong>The estimated breast cancer hazard ratio for carriers of pathogenic ATM variants in the ABCFR was 1.32 (95% confidence interval 0.45-3.87; P = 0.6). The estimated cumulative risk of breast cancer to age 80 years for heterozygous ATM pathogenic variant carriers was estimated to be 13% (95% CI 4.6-30).</p><p><strong>Conclusions: </strong>Although ATM has been definitively identified as a breast cancer predisposition gene, further evidence, such as variant-specific penetrance estimates, are needed to inform risk management strategies for carriers of pathogenic variants to increase the clinical utility of population testing of this gene.</p>","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"24 1","pages":"24"},"PeriodicalIF":6.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors","authors":"Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, A. Wulf‐Goldenberg, Joshua Alcaniz, Elodie Montaudon, E. Marangoni, W. Birchmeier","doi":"10.1186/s13058-022-01521-3","DOIUrl":"https://doi.org/10.1186/s13058-022-01521-3","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"15 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87336096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of HER2-low expression in early breast cancer: a nationwide study from the Korean Breast Cancer Society","authors":"H. Won, J. Ahn, Y. Kim, Jin Sung Kim, J. Song, Hong-Kyu Kim, Jeeyeon Lee, H. Park, Yong-Seok Kim","doi":"10.1186/s13058-022-01519-x","DOIUrl":"https://doi.org/10.1186/s13058-022-01519-x","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"81 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88005552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics predicts the prognosis of patients with locally advanced breast cancer by reflecting the heterogeneity of tumor cells and the tumor microenvironment","authors":"Xuanyi Wang, Tiansong Xie, Ju-rui Luo, Zhengrong Zhou, Xiaoli Yu, Xiaomao Guo","doi":"10.1186/s13058-022-01516-0","DOIUrl":"https://doi.org/10.1186/s13058-022-01516-0","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"37 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78756858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}