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Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells 内分泌治疗的选择性压力通过NFκB信号在ER阳性乳腺癌细胞亚群中激活综合应激反应
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-03-09 DOI: 10.1186/s13058-022-01515-1
S. Semina, Purab Pal, Nidhi S. Kansara, R. Huggins, E. Alarid, G. Greene, J. Frasor
{"title":"Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells","authors":"S. Semina, Purab Pal, Nidhi S. Kansara, R. Huggins, E. Alarid, G. Greene, J. Frasor","doi":"10.1186/s13058-022-01515-1","DOIUrl":"https://doi.org/10.1186/s13058-022-01515-1","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"32 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80042185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer INHBA是HER2+基底乳腺癌侵袭性肿瘤行为的中介
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-03-05 DOI: 10.1186/s13058-022-01512-4
Moqing Liu, Rebecca B Smith, T. Liby, Kami E. Chiotti, C. Lopez, J. Korkola
{"title":"INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer","authors":"Moqing Liu, Rebecca B Smith, T. Liby, Kami E. Chiotti, C. Lopez, J. Korkola","doi":"10.1186/s13058-022-01512-4","DOIUrl":"https://doi.org/10.1186/s13058-022-01512-4","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"171 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89257359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer CDK4/6抑制剂在激素受体阳性乳腺癌治疗中的应答和耐药的细胞机制
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2022-03-05 DOI: 10.1186/s13058-022-01510-6
April C. Watt, S. Goel
{"title":"Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer","authors":"April C. Watt, S. Goel","doi":"10.1186/s13058-022-01510-6","DOIUrl":"https://doi.org/10.1186/s13058-022-01510-6","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"97 5","pages":""},"PeriodicalIF":7.4,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72410662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Li-Fraumeni syndrome: not a straightforward diagnosis anymore—the interpretation of pathogenic variants of low allele frequency and the differences between germline PVs, mosaicism, and clonal hematopoiesis Li-Fraumeni综合征:不再是一种简单的诊断——解释低等位基因频率的致病变异以及种系pv、嵌合体和克隆造血之间的差异
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2019-09-18 DOI: 10.1186/s13058-019-1193-1
Felipe Batalini, Ellie G. Peacock, Lindsey Stobie, Alison Robertson, J. Garber, J. Weitzel, N. Tung
{"title":"Li-Fraumeni syndrome: not a straightforward diagnosis anymore—the interpretation of pathogenic variants of low allele frequency and the differences between germline PVs, mosaicism, and clonal hematopoiesis","authors":"Felipe Batalini, Ellie G. Peacock, Lindsey Stobie, Alison Robertson, J. Garber, J. Weitzel, N. Tung","doi":"10.1186/s13058-019-1193-1","DOIUrl":"https://doi.org/10.1186/s13058-019-1193-1","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"41 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2019-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85057341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs 靶向髓源性抑制细胞联合原发乳腺肿瘤切除可减少肺转移性生长
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2019-09-05 DOI: 10.1186/s13058-019-1189-x
Momir Bosiljcic, Momir Bosiljcic, R. Cederberg, R. Cederberg, M. Hamilton, N. E. LePard, B. Harbourne, B. Harbourne, J. Collier, E. Halvorsen, E. Halvorsen, Rocky Shi, S. E. Franks, Ada Y. Kim, Ada Y. Kim, J. Banáth, M. Hamer, F. Rossi, K. Bennewith, K. Bennewith
{"title":"Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs","authors":"Momir Bosiljcic, Momir Bosiljcic, R. Cederberg, R. Cederberg, M. Hamilton, N. E. LePard, B. Harbourne, B. Harbourne, J. Collier, E. Halvorsen, E. Halvorsen, Rocky Shi, S. E. Franks, Ada Y. Kim, Ada Y. Kim, J. Banáth, M. Hamer, F. Rossi, K. Bennewith, K. Bennewith","doi":"10.1186/s13058-019-1189-x","DOIUrl":"https://doi.org/10.1186/s13058-019-1189-x","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"21 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-019-1189-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 52
Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2− breast cancer that had progressed during or after prior endocrine therapy dovitinib联合氟维司汀治疗绝经后HR+、HER2−乳腺癌患者，这些患者在既往内分泌治疗期间或之后发生进展，该研究是一项随机、安慰剂对照研究
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2017-02-10 DOI: 10.1186/s13058-017-0807-8
A. Musolino, M. Campone, P. Neven, N. Denduluri, C. Barrios, J. Cortés, K. Blackwell, H. Soliman, Z. Kahán, H. Bonnefoi, M. Squires, Yong Zhang, S. Deudon, M. Shi, F. André
{"title":"Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2− breast cancer that had progressed during or after prior endocrine therapy","authors":"A. Musolino, M. Campone, P. Neven, N. Denduluri, C. Barrios, J. Cortés, K. Blackwell, H. Soliman, Z. Kahán, H. Bonnefoi, M. Squires, Yong Zhang, S. Deudon, M. Shi, F. André","doi":"10.1186/s13058-017-0807-8","DOIUrl":"https://doi.org/10.1186/s13058-017-0807-8","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"25 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2017-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74326395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 84
Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer 基因组共扩增上调有丝分裂基因网络活性，预测乳腺癌有丝分裂蛋白抑制剂的结果和反应
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2017-02-09 DOI: 10.1186/s13058-017-0809-6
Zhi Hu, J. Mao, C. Curtis, Ge Huang, Shenda Gu, Laura M. Heiser, M. Lenburg, J. Korkola, N. Bayani, S. Samarajiwa, J. Seoane, Mark A. Dane, Amanda Esch, H. Feiler, Nicholas J. Wang, M. A. Hardwicke, S. Laquerre, J. Jackson, K. Wood, Barbara Weber, P. Spellman, S. Aparicio, R. Wooster, C. Caldas, Joe W. Gray
{"title":"Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer","authors":"Zhi Hu, J. Mao, C. Curtis, Ge Huang, Shenda Gu, Laura M. Heiser, M. Lenburg, J. Korkola, N. Bayani, S. Samarajiwa, J. Seoane, Mark A. Dane, Amanda Esch, H. Feiler, Nicholas J. Wang, M. A. Hardwicke, S. Laquerre, J. Jackson, K. Wood, Barbara Weber, P. Spellman, S. Aparicio, R. Wooster, C. Caldas, Joe W. Gray","doi":"10.1186/s13058-017-0809-6","DOIUrl":"https://doi.org/10.1186/s13058-017-0809-6","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"19 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-017-0809-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer NeoSphere研究的生物标志物分析:帕妥珠单抗、曲妥珠单抗和多西他赛与曲妥珠单抗加多西他赛、帕妥珠单抗加曲妥珠单抗或帕妥珠单抗加多西他赛用于her2阳性乳腺癌的新辅助治疗
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2017-02-09 DOI: 10.1186/s13058-017-0806-9
G. Bianchini, A. Kiermaier, G. Bianchi, Y. Im, T. Pieńkowski, Mei-Ching Liu, L. Tseng, M. Dowsett, L. Zabaglo, S. Kirk, T. Szado, J. Eng-Wong, L. Amler, P. Valagussa, L. Gianni
{"title":"Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer","authors":"G. Bianchini, A. Kiermaier, G. Bianchi, Y. Im, T. Pieńkowski, Mei-Ching Liu, L. Tseng, M. Dowsett, L. Zabaglo, S. Kirk, T. Szado, J. Eng-Wong, L. Amler, P. Valagussa, L. Gianni","doi":"10.1186/s13058-017-0806-9","DOIUrl":"https://doi.org/10.1186/s13058-017-0806-9","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"30 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80873385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 83
Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer 胸腺酶β 10是乳腺癌发生转移的关键调节因子和一种新的血清标志物
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2017-02-08 DOI: 10.1186/s13058-016-0785-2
Xin Zhang, Dong Ren, Ling Guo, Lan-Zeng Wang, Shu Wu, Chuyong Lin, L. Ye, Jinrong Zhu, Jun Yu Li, Libing Song, Huan-xin Lin, Zhen-Yu He
{"title":"Thymosin beta 10 is a key regulator of tumorigenesis and metastasis and a novel serum marker in breast cancer","authors":"Xin Zhang, Dong Ren, Ling Guo, Lan-Zeng Wang, Shu Wu, Chuyong Lin, L. Ye, Jinrong Zhu, Jun Yu Li, Libing Song, Huan-xin Lin, Zhen-Yu He","doi":"10.1186/s13058-016-0785-2","DOIUrl":"https://doi.org/10.1186/s13058-016-0785-2","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"19 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2017-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0785-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 82
Childhood body size and pubertal timing in relation to adult mammographic density phenotype 儿童体型和青春期时间与成人乳房x线摄影密度表型的关系
IF 7.4 1区 医学
Breast Cancer Research Pub Date : 2017-02-07 DOI: 10.1186/s13058-017-0804-y
M. Schoemaker, Michael E. Jones, S. Allen, J. Hoare, Alan Ashworth, M. Dowsett, A. Swerdlow
{"title":"Childhood body size and pubertal timing in relation to adult mammographic density phenotype","authors":"M. Schoemaker, Michael E. Jones, S. Allen, J. Hoare, Alan Ashworth, M. Dowsett, A. Swerdlow","doi":"10.1186/s13058-017-0804-y","DOIUrl":"https://doi.org/10.1186/s13058-017-0804-y","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"143 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2017-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78587773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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