Breast Cancer Research最新文献

{"title":"An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers","authors":"G. Bottai, Carlotta Raschioni, A. Losurdo, L. di Tommaso, C. Tinterri, R. Torrisi, J. Reis-Filho, M. Roncalli, C. Sotiriou, A. Santoro, A. Mantovani, S. Loi, L. Santarpia","doi":"10.1186/s13058-016-0783-4","DOIUrl":"https://doi.org/10.1186/s13058-016-0783-4","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0783-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of vinorelbine in combination with pertuzumab and trastuzumab for first-line treatment of patients with HER2-positive locally advanced or metastatic breast cancer: VELVET Cohort 1 final results","authors":"E. Perez, J. López-Vega, T. Petit, C. Zamagni, V. Easton, Julia Kamber, E. Restuccia, M. Andersson","doi":"10.1186/s13058-016-0773-6","DOIUrl":"https://doi.org/10.1186/s13058-016-0773-6","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0773-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers","authors":"C. Selli, J. Dixon, A. Sims","doi":"10.1186/s13058-016-0779-0","DOIUrl":"https://doi.org/10.1186/s13058-016-0779-0","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0779-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib","authors":"Adelaide I J Young, Andrew M. K. Law, Lesley E Castillo, Sabrina Chong, H. Cullen, M. Koehler, S. Herzog, T. Brummer, Erinna F. Lee, W. Fairlie, M. Lucas, D. Herrmann, A. Allam, P. Timpson, D. Watkins, E. Millar, S. O'toole, D. Gallego-Ortega, C. Ormandy, S. Oakes","doi":"10.1186/s13058-016-0781-6","DOIUrl":"https://doi.org/10.1186/s13058-016-0781-6","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0781-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop “Methods in Mammary Gland Development and Cancer”","authors":"Bethan Lloyd-Lewis, A. A. A. van de Moosdijk, M. Bentires-Alj, R. Clarke, Renée van Amerongen","doi":"10.1186/s13058-016-0777-2","DOIUrl":"https://doi.org/10.1186/s13058-016-0777-2","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0777-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complexities and caveats of lineage tracing in the mammary gland","authors":"Anne C. Rios, Nai-yang Fu, Joseph Cursons, G. Lindeman, J. Visvader","doi":"10.1186/s13058-016-0774-5","DOIUrl":"https://doi.org/10.1186/s13058-016-0774-5","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0774-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI","authors":"Li-Liang Li, Ai-min Xue, Bei-xu Li, Yi-wen Shen, Yuhua Li, Cheng-Liang Luo, Mingchun Zhang, Jieqing Jiang, Zu-de Xu, Jian-hui Xie, Zi-qin Zhao","doi":"10.1186/s13058-016-0776-3","DOIUrl":"https://doi.org/10.1186/s13058-016-0776-3","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0776-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC","authors":"N. Griffin, G. Sharma, Xiangshan Zhao, S. Mirza, Shashank Srivastava, B. Dave, M. Aleskandarany, E. Rakha, Shakur Mohibi, H. Band, V. Band","doi":"10.1186/s13058-016-0770-9","DOIUrl":"https://doi.org/10.1186/s13058-016-0770-9","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0770-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.","authors":"Timothy R Rebbeck, Tara M Friebel, Nandita Mitra, Fei Wan, Stephanie Chen, Irene L Andrulis, Paraskevi Apostolou, Norbert Arnold, Banu K Arun, Daniel Barrowdale, Javier Benitez, Raanan Berger, Pascaline Berthet, Ake Borg, Saundra S Buys, Trinidad Caldes, Jonathan Carter, Jocelyne Chiquette, Kathleen B M Claes, Fergus J Couch, Cezary Cybulski, Mary B Daly, Miguel de la Hoya, Orland Diez, Susan M Domchek, Katherine L Nathanson, Katarzyna Durda, Steve Ellis, D Gareth Evans, Lenka Foretova, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Gord Glendon, Andrew K Godwin, Mark H Greene, Jacek Gronwald, Eric Hahnen, Emily Hallberg, Ute Hamann, Thomas V O Hansen, Evgeny N Imyanitov, Claudine Isaacs, Anna Jakubowska, Ramunas Janavicius, Katarzyna Jaworska-Bieniek, Esther M John, Beth Y Karlan, Bella Kaufman, KConFab Investigators, Ava Kwong, Yael Laitman, Christine Lasset, Conxi Lazaro, Jenny Lester, Niklas Loman, Jan Lubinski, Siranoush Manoukian, Gillian Mitchell, Marco Montagna, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Sue Kyung Park, Marion Piedmonte, Paolo Radice, Christine Rappaport-Fuerhauser, Matti A Rookus, Caroline Seynaeve, Jacques Simard, Christian F Singer, Penny Soucy, Melissa Southey, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Csilla I Szabo, Mariella Tancredi, Manuel R Teixeira, Soo-Hwang Teo, Mary Beth Terry, Mads Thomassen, Laima Tihomirova, Marc Tischkowitz, Amanda Ewart Toland, Aleksandra Toloczko-Grabarek, Nadine Tung, Elizabeth J van Rensburg, Danylo Villano, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Jamal Zidan, Kristin K Zorn, Lesley McGuffog, Douglas Easton, Georgia Chenevix-Trench, Antonis C Antoniou, Susan J Ramus","doi":"10.1186/s13058-016-0768-3","DOIUrl":"10.1186/s13058-016-0768-3","url":null,"abstract":"<p><strong>Background: </strong>Most BRCA1 or BRCA2 mutation carriers have inherited a single (heterozygous) mutation. Transheterozygotes (TH) who have inherited deleterious mutations in both BRCA1 and BRCA2 are rare, and the consequences of transheterozygosity are poorly understood.</p><p><strong>Methods: </strong>From 32,295 female BRCA1/2 mutation carriers, we identified 93 TH (0.3 %). \"Cases\" were defined as TH, and \"controls\" were single mutations at BRCA1 (SH1) or BRCA2 (SH2). Matched SH1 \"controls\" carried a BRCA1 mutation found in the TH \"case\". Matched SH2 \"controls\" carried a BRCA2 mutation found in the TH \"case\". After matching the TH carriers with SH1 or SH2, 91 TH were matched to 9316 SH1, and 89 TH were matched to 3370 SH2.</p><p><strong>Results: </strong>The majority of TH (45.2 %) involved the three common Jewish mutations. TH were more likely than SH1 and SH2 women to have been ever diagnosed with breast cancer (BC; p = 0.002). TH were more likely to be diagnosed with ovarian cancer (OC) than SH2 (p = 0.017), but not SH1. Age at BC diagnosis was the same in TH vs. SH1 (p = 0.231), but was on average 4.5 years younger in TH than in SH2 (p < 0.001). BC in TH was more likely to be estrogen receptor (ER) positive (p = 0.010) or progesterone receptor (PR) positive (p = 0.013) than in SH1, but less likely to be ER positive (p < 0.001) or PR positive (p = 0.012) than SH2. Among 15 tumors from TH patients, there was no clear pattern of loss of heterozygosity (LOH) for BRCA1 or BRCA2 in either BC or OC.</p><p><strong>Conclusions: </strong>Our observations suggest that clinical TH phenotypes resemble SH1. However, TH breast tumor marker characteristics are phenotypically intermediate to SH1 and SH2.</p>","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":"112"},"PeriodicalIF":7.4,"publicationDate":"2016-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PALB2 p.Leu939Trp mutation is not associated with breast cancer risk","authors":"Irene Catucci, P. Radice, R. Milne, F. Couch, M. Southey, P. Peterlongo","doi":"10.1186/s13058-016-0762-9","DOIUrl":"https://doi.org/10.1186/s13058-016-0762-9","url":null,"abstract":"","PeriodicalId":9222,"journal":{"name":"Breast Cancer Research","volume":"18 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13058-016-0762-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}