Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors

IF 6.1 1区医学 Q1 ONCOLOGY

Breast Cancer Research Pub Date : 2022-04-01 DOI:10.1186/s13058-022-01521-3

Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, A. Wulf‐Goldenberg, Joshua Alcaniz, Elodie Montaudon, E. Marangoni, W. Birchmeier

引用次数: 1

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靶向SHP2磷酸酶治疗乳腺癌克服了rtk介导的对PI3K抑制剂的耐药

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来源期刊

Breast Cancer Research 医学-肿瘤学

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期刊介绍： Breast Cancer Research is an international, peer-reviewed online journal, publishing original research, reviews, editorials and reports. Open access research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal publishes preclinical, translational and clinical studies with a biological basis, including Phase I and Phase II trials.