Biomedicine / [publiee pour l'A.A.I.C.I.G.]最新文献_第6页

Effect of beta adrenergic agonists and beta blocking agents on hemopoiesis in human bone marrow. 肾上腺素能激动剂和阻滞剂对人骨髓造血的影响。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

C Dresch, J Minc, O Poirier, D Bouvet

{"title":"Effect of beta adrenergic agonists and beta blocking agents on hemopoiesis in human bone marrow.","authors":"C Dresch, J Minc, O Poirier, D Bouvet","doi":"","DOIUrl":"","url":null,"abstract":"The effect of propranolol (non specific blocking agent), acebutolol (beta 1 blocking agent), butoxamine (beta 2 blocking agent) and several beta adrenergic agonists was studied on 3H-thymidine (3H-TdR) incorporation and granulo-monocyte colony formation in agar by human bone marrow. Only butoxamine and propranolol decreased 3H-TdR incorporation by total normal bone marrow cells at concentrations above 10(-6) M for butoxamine and 10(-5) M for propranolol. Autoradiography showed that inhibition of 3H-TdR incorporation by butoxamine was slightly more pronounced on neutrophil precursors than on red cell precursors (neutrophil series LI..53 and erythroblasts .67 compared to control bone marrow cells at 10(-5) M concentration). The development of granulo-monocyte colonies in agar culture was delayed by preincubation with butoxamine at concentrations above 5 X 10(-6) M. Hydroxyurea suicide showed that this was due to a decrease in the number of CFU-C in S phase. beta 2 blocking agents are able to decrease the number of normal hematopoietic cells entering S phase. This effect is seen on both neutrophil and erythroblastic precursors and on granulo-monocyte progenitors. It could be used as a means of protecting bone marrow cells during cancer intensive chemotherapy.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"34 2","pages":"93-8"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17183510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal of glucose-induced hyperkalemia by sodium restriction in normaldosteronemic diabetes: evidence for elevated mineralocorticoid threshold. 正常固酮血症型糖尿病通过限钠逆转葡萄糖诱导的高钾血症:矿物质皮质激素阈值升高的证据。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

J P Rado

{"title":"Reversal of glucose-induced hyperkalemia by sodium restriction in normaldosteronemic diabetes: evidence for elevated mineralocorticoid threshold.","authors":"J P Rado","doi":"","DOIUrl":"","url":null,"abstract":"Acute glucose loading studies were performed on seven diabetic patients and 18 control subjects. In two normaldosteronemic insulin-dependent diabetic patients during high sodium intake and insulin withdrawal infusion of hypertonic glucose induced a paradoxical elevation of serum potassium levels, while no such abnormalities were found in two other diabetics despite of lower plasma aldosterone levels. Paradoxical glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g of glucose orally to further three patients with normaldosteronemic diabetes in whom a complete reversal of PGIH was obtained l glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g of glucose orally to further three patients with normaldosteronemic diabetes in whom a complete reversal of PGIH was obtained l glucose-induced hyperkalemia (PGIH) was abolished during insulin withdrawal by sodium restriction associated with a dramatic increase in plasma aldosterone. PGIH was elicited when given 100 g of glucose orally to further three patients with normaldosteronemic diabetes in whom a complete reversal of PGIH was obtained also by sodium restriction or by administering a large intravenous dose of desoxycorticosterone. These findings suggested an elevated mineralocorticoid threshold level for the normal cellular regulation of potassium distribution in normaldosteronemic diabetics with PGIH.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"35 4","pages":"109-11"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18307377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesizing activity and ultrastructural findings of human blood cells after incubation with cis-platinum "in vitro". 顺铂体外培养后人血细胞的合成活性及超微结构。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

P Fishman, J Levi, I Notti, M Djaldetti

引用次数: 0

L5H tryptophan in the cerebellar syndrome treatment. L5H色氨酸在小脑综合征治疗中的作用。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

A Rascol, M Clanet, J L Montastruc, W Delage, B Guiraud-Chaumeil

引用次数: 0

The radial distribution of fibroblastic colony-forming units in mouse femoral marrow. 小鼠股骨髓成纤维细胞集落形成单位的径向分布。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

C X Xu, J H Hendry

引用次数: 0

Hemopoiesis in cultures of the bone marrow cells from genetically anemic mice. 遗传性贫血小鼠骨髓细胞培养中的造血功能。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

K J Mori, Y Kitamura, A Seto

引用次数: 0

Interferons induced by Chlamydia trachomatis in human lymphocyte cultures. 沙眼衣原体在人淋巴细胞培养中诱导干扰素。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

P Duc-Goiran, L Zernicki

引用次数: 0

The role of macrophages and T-lymphocytes in glucan-mediated alteration of murine hemopoiesis. 巨噬细胞和t淋巴细胞在葡聚糖介导的小鼠造血功能改变中的作用。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

M L Patchen, E Lotzová

引用次数: 0

Monosaccharide composition of human monoclonal (18) and normal (8) IGM immunoglobulins: proposed structural models for their glycan chains. 人单克隆(18)和正常(8)IGM免疫球蛋白的单糖组成:其糖链的结构模型

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

A Cahour, M P Ollier-Hartmann, C Mihaesco, L Hartmann

引用次数: 0

[Nonspecific phosphodiesterases of human leukocytes, blood platelets and serum]. [人白细胞、血小板和血清的非特异性磷酸二酯酶]。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

A Négre, R Salvayre, A Maret, L Douste-Blazy

{"title":"[Nonspecific phosphodiesterases of human leukocytes, blood platelets and serum].","authors":"A Négre, R Salvayre, A Maret, L Douste-Blazy","doi":"","DOIUrl":"","url":null,"abstract":"Phosphodiesterases from blood cells and serum can be subdivided in several groups according to substrate specificity, optimum pH and effects of inhibitors: 1) Acidic phosphodiesterase activities were not inhibited by EDTA, represented the whole p3'T hydrolysing activity, but only a part of the activity hydrolysing the other substrates (p5'T was not hydrolysed at acidic pH). This acid phosphodiesterase activity was high in white blood cells and platelets but very low in serum. 2) Neutral phosphodiesterase activity was prevalent in leucocytes when BpP and BMP were used as substrates. 3) Alkaline phosphodiesterase activity was characterized by substrate specificity at optimum pH and distribution in cells and serum: in serum there are phosphodiesterases hydrolysing all checked substrates (p3'T excepted) at optimum pH 9.0, whereas in blood cells alkaline phosphodiesterase activities are very low for all substrates (excepted for p Phi Pn and p5'T). In each cell and serum we have determined, for all phosphodiesterase activities, the linearity of activity of versus time and versus protein concentration, the effect of substrate and effector concentration and the heat stability.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"35 4","pages":"128-32"},"PeriodicalIF":0.0,"publicationDate":"1981-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17333257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0