Biomedicine / [publiee pour l'A.A.I.C.I.G.]最新文献_第10页

Oxygen enhancement of radiation induced lethality is greatly reduced in glutathione deficient human fibroblasts. 在缺乏谷胱甘肽的人成纤维细胞中，辐射致死性的氧增强大大降低。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

P J Deschavanne, J Midander, M Edgren, A Larsson, E P Malaise, L Révész

引用次数: 0

Mycoplasma-induced lesions of RIII mouse uterus. 支原体诱导的RIII小鼠子宫病变。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

G Seman

引用次数: 0

Mercuric chloride and ethacrynic acid binding to uromucoid or Tamm-Horsfall protein. 氯化汞和乙酸与尿黏液或Tamm-Horsfall蛋白的结合。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

L Hartmann, J P Ambert, M P Ollier-Hartmann, G Richet, C Raynaud

引用次数: 0

A new method in differential diagnosis of the liver: identification of liver pulsating activities by spectral analysis of radio-isotope counts during liver scan. Comparative studies by ultrasonography. 肝脏鉴别诊断的新方法:通过肝脏扫描期间放射性同位素计数的频谱分析来识别肝脏脉动活动。超声比较研究。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

M Ram, A Rohner, W Curati

引用次数: 0

Influence of antitumor drugs of natural origin on the intramuscular and subcutaneous form of five transplantable tumor models. 天然来源的抗肿瘤药物对5种可移植肿瘤模型肌内和皮下形态的影响。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

K Maneva, M Ilarionova, D Todorov, K Silyanovska

引用次数: 0

Myosin ATPase in swine heart, "soleus" and "gastrocnemius". 猪心脏、“比目鱼肌”和“腓肠肌”中的肌球蛋白atp酶。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

A W Taylor, F Cerny, J Keul

引用次数: 0

Stimulation of the proliferation of hemopoietic stem cells in irradiated bone marrow cell culture. 在辐照骨髓细胞培养中刺激造血干细胞的增殖。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

K J Mori, H Izumi, A Seto

引用次数: 0

Human T lymphocyte colonies. I. Surface markers and cytotoxic potential of colony cells. 人T淋巴细胞菌落。1 .集落细胞的表面标记物和细胞毒性潜能。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-02-01

B Klein, J Caraux, A Causse, C Thierry, B Serrou

{"title":"Human T lymphocyte colonies. I. Surface markers and cytotoxic potential of colony cells.","authors":"B Klein, J Caraux, A Causse, C Thierry, B Serrou","doi":"","DOIUrl":"","url":null,"abstract":"Colonies were obtained from peripheral blood lymphocytes (PBL) grown in soft agar in the presence of PHAM or PHAp mitogens. One out of 130 PBL was able to generate a colony. Colony cells were mass harvested and assayed for surface markers and cytotoxic potential. Most of the colony cells (83%) form spontaneous rosettes with sheep-red blood cells (RBC) and bear the human T lymphocyte antigens (HTLA) (92%). A significant amount of colony cells able to bind autologous RBC was detected (24%). The capacity of PBL and colony cells to bind Ox-RBC sensitized with rabbit anti-Ox-RBC IgM (EAM complexes) was measured: only 15% of colony cells compared to 49% of the PBL formed EAM rosettes. The capacity of cells to bind the Fc portion of antigen-complexed IgG was investigated by two rosette assays: using Chicken or Ox-RBC sensitized with a rabbit anti-Chicken-RBC or Ox-RBC IgG (Chicken EAG or Ox-EAG complexes). The percentage of colony cells forming Chicken EAG rosettes was low (3.6%) compared to PBL (12%). This percentage was significantly increased with PHAp, and not PHAM stimulation (11%). Using Ox-EAG complexes, we confirmed the low percentage of EAG rosettes in colony cells under PHAM stimulation (4.7%) compared to PBL (21%). A significant cytotoxic capacity (spontaneous or antibody dependent) was found in colony cells after PHAM stimulation. This method of culture is able to generate clones of T cells and conserve T cell subsets and cytotoxic potential usually found in a T purified population. In further studies, it will be interesting to investigate if each clone possesses specific markers and cytotoxic potential and is able to maintain this differentiation step in long term culture.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"34 1","pages":"34-9"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18021478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histocompatibility influence in allogeneic marrow transplantation therapy of murine viral leukemia. I.--Studies of the relative influence of major versus minor histocompatibility determinants. 同种异体骨髓移植治疗小鼠病毒性白血病的组织相容性影响。主要组织相容性决定因素与次要组织相容性决定因素的相对影响研究。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-02-01

R F Meredith, J P Okunewick, R B Raikow, B J Brozovich, P R Seeman, K C Magliere

{"title":"Histocompatibility influence in allogeneic marrow transplantation therapy of murine viral leukemia. I.--Studies of the relative influence of major versus minor histocompatibility determinants.","authors":"R F Meredith, J P Okunewick, R B Raikow, B J Brozovich, P R Seeman, K C Magliere","doi":"","DOIUrl":"","url":null,"abstract":"The anti-leukemic effectiveness (GvL activity) and anti-host response (GvH response) of several allogeneic donor marrows were compared in lethally irradiated normal and Rauscher leukemia SJL/J recipients. Although both types of effects could be demonstrated, the degree of GvL activity did not parallel the severity of GvH response. The level of GvL activity of the donor marrow also appeared to be independent of sensitivity of the donors to the leukemia inducing Rauscher virus (RLV), as a high level of leukemia recurrence was found using marrow from RLV-resistant RF/J donors, while a lesser degree of recurrence occurred with the use of RLV-sensitive DBA-2J marrow. Analysis of the possible influence of major (MHC) and Minor (MiHL) histocompatibility loci suggested that GvL activity may be independent of the H-2 locus, and that the \"a\" alleles of the H-4 and H-13 loci may not be contributing to GvL effect. Likewise the \"a\" alleles of the H-7 and H-12 loci did not appear to affect the severity of GvH response. The possibly that GvL activity may be independent of th MHC, but governed by MiHL possibility different from those regulating GvH response might explain why in this and previous studies GvL activity could only be demonstrated following allogeneic marrow transplantation but did not appear to correlate with severity of GvH response.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"34 1","pages":"11-7"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18060192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the altered nucleocytoplasmic transport "in vitro" of rapidly labelled RNA, in the presence of cytosol or serum from tumor-bearing rats. 在荷瘤大鼠细胞液或血清的存在下，快速标记RNA在体外的核细胞质转运的改变。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-02-01

M Lemaire, W Baeyens, L Baugnet-Mahieu

{"title":"On the altered nucleocytoplasmic transport \"in vitro\" of rapidly labelled RNA, in the presence of cytosol or serum from tumor-bearing rats.","authors":"M Lemaire, W Baeyens, L Baugnet-Mahieu","doi":"","DOIUrl":"","url":null,"abstract":"Enhanced nucleocytoplasmic RNA transport has been demonstrated by incubating normal rat liver nuclei in presence of cytosols originating from the poorly differentiated, fast-growing hepatoma HW-165, in the linear phase of tumor growth. The effect of hepatoma HW-165 cytosol was reduced or suppressed in presence of small amounts of normal liver cytosol: on the other hand, several polypeptides of molecular weight 20,000 to 40,000 daltons were hardly detectable in hepatoma HW-165 cytosol, both arguments indicating that potentially regulatory proteins should be absent or present in reduced concentration in hepatoma HW-165 cytosol. No modification of RNA release was observed in presence of cytosols originating from the thymus of RNA virus (BL/F)-infected rats, whatever be the time after inoculation. Attempts were made to use the nuclear restriction assay, supplemented with plasma or serum of various origins, as a biochemical marker of neoplasia. In a first series of assays, including 80 cancer patients and 12 healthy controls, the RNA transport activity was stimulated by the serum of patients bearing various tumors (lung cancer, cancer of the respiratory tract, uterine cervix...), except in a few cases of mammary carcinoma, where values equivalent to or lower than the controls were obtained.","PeriodicalId":9217,"journal":{"name":"Biomedicine / [publiee pour l'A.A.I.C.I.G.]","volume":"34 1","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"1981-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17229582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0