在辐照骨髓细胞培养中刺激造血干细胞的增殖。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-03-01

K J Mori, H Izumi, A Seto

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引用次数: 0

摘要

在体外培养的骨髓细胞中建立了长期造血功能。这种培养被证明支持造血干细胞完全在体外照射后的恢复增殖。将正常骨髓细胞覆盖在辐照的贴壁细胞集落上，刺激造血干细胞增殖。这些结果表明造血干细胞的体外增殖和分化也受到基质-造血细胞相互作用的支持。

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Stimulation of the proliferation of hemopoietic stem cells in irradiated bone marrow cell culture.

Long-term hemopoiesis was established in bone marrow cell culture in vitro. This culture was shown to support the recovery proliferation of hemopoietic stem cells completely in vitro after irradiation. Hemopoietic stem cells were stimulated into proliferation in culture when normal bone marrow cells were overlayed on top of the irradiated adherent cell colonies. These results indicate that proliferation and differentiation of hemopoietic stem cells in vitro are also supported by stroma-hemopoietic cell interactions.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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