Journal of analytical & pharmaceutical research最新文献

{"title":"A gas chromatographic analysis method development and validation for determination of common plasticizers in delayed release tablet dosage forms","authors":"P. Panzade, Jessie Wang, Y. Wang","doi":"10.15406/japlr.2019.08.00340","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00340","url":null,"abstract":"Various polymers (MW>100,000) are widely used materials to retard the drug release from controlled release pharmaceutical preparations. Polymers present in film coated delayed release (DR) tablets are typically used together with plasticizers such as Dibutyl Sebacate (DBS), Tributyl Phosphate (TBP) and Tributyl Acetyl Citrate (TBAC). Plasticizers are recognized as a critical aspect for drug delivery. They are relatively small lubricating molecules (MW 200400) that can modify physico-chemical properties and process ability of the polymers, improve the mechanical properties of a polymer matrix, and increase the workability, flexibility or extensibility of the polymer. Also, plasticizers are generally used to modify the thermal properties, water absorption behavior, and adhesive properties of polymeric films. The concentration of plasticizer affects the strength of coating films, overall integrity of drug products and drug release characteristics in therapeutic pharmaceutical dosage forms.1,2","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the main electrolytes concentrations in the prostate fluid of normal gland","authors":"V. Zaichick","doi":"10.15406/japlr.2019.08.00341","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00341","url":null,"abstract":"The prostate gland is subject to various disorders and of them chronic prostatitis, benign prostatic hyperplasia, and prostate cancer are the extremely common diseases of ageing men.1–3 The etiology and pathogenesis of these diseases are not well understood. Moreover, despite technological advancements, the differential diagnostics of prostate disorders has become progressively more complex and controversial. This is particularly concerned with prostate cancer where the limitations and potential harms associated with the use of prostate-specific antigen (PSA) as a diagnostic marker. The situation stimulates significant investigation of numerous novel biomarkers that demonstrate varying capacities to detect prostate cancer and can decrease unnecessary biopsies.4 In our previous studies the significant involvement of zinc (Zn), calcium (Ca), magnesium (Mg), rubidium (Rb) and some other main electrolytes (MEs) and trace elements (TEs) in the normal physiology of the prostate was found.5–30 It was also found a great deformation of chemical element concentrations in affected prostate and was demonstrated that the changes of some MEs and TEs content, as well as levels of some ME/TE ratios in the prostate tissue can be used as the biomarkers of prostate diseases,31–41 and global environmental contamination.42 Moreover, it was shown that levels of some MEs and TEs in prostate tissue play a very important role in carcinogenesis of the gland.43–45 One of the main functions of the prostate gland is the production of prostatic fluid.46 It contains a high concentration of Ca, Mg, Rb, Zn and some other TEs, in comparison with levels in blood serum and other human body fluids. The first finding of remarkably high levels of Zn in human expressed prostatic fluid (EPF) was reported in the early 1960s.47 After analyzing EPF expressed from the prostates of 8 apparently healthy men, aged 25-55years, it was found that Zn concentrations varied from 300 to 730mg/L. After this finding several investigators suggested that the measurement of Zn levels in EPF may be useful as a marker of abnormal prostate secretory function.48,49 This suggestion promoted more detailed studies of the MEs and TEs concentrations in the EPF of healthy subjects and in those with different prostatic diseases, including PCa.49–69 MEs, such as Ca, chlorine (Cl), potassium (K), Mg, and sodium (Na) are vital for the normal functioning of the human body,70 there are a lot of data on the subject. However, the exact role of MEs in normal and pathophysiology of the prostate gland, specifically the prostatic fluid, is until now unknown.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of selected metal ions using powder of seeds of Ajwaa dates from aqueous solution","authors":"A. A. J. Mohamed, Lila Ali Vuai, M. Kombo, O. Chukwuma","doi":"10.15406/japlr.2019.08.00343","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00343","url":null,"abstract":"Toxic metals are those metals known to cause toxicity to living organisms. These metals can be either light metals or heavy metals.1 The presence of these metals in our environments is of major concern due to their toxicity, bio-accumulation, and threat to human life and environment.2,3 Toxic metals such as chromium, copper, lead, zinc, mercury, cadmium etc., are omnipresent in our environment. Possible anthropogenic sources of toxic metals in our environment include activities, such as metal cleaning and plating baths, refineries, paper and pulp, tanning, and chemical manufacturing processes.4 The toxic metals are transported by runoff water and contaminated water sources downstream from the contaminant sources.5 These metals are non-degradable and are very resistant to biodegradation. In living organisms, toxic metal ions mainly bind to nucleic acids, proteins and small metabolites. The cells biological functions are hampered as they lose their homeostatic control of essential metals, resulting in fatal health problems.6","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and evaluation of an anti-asthmatic gel of theophylline with diclofenac sodium","authors":"J. Fardous, F. Perveen, A. Saifuddin, M. Akter, S. Sultana","doi":"10.15406/japlr.2019.08.00314","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00314","url":null,"abstract":"Asthma is defined as a chronic inflammatory disease of the airways and is most common respiratory disease in the whole world. This chronic inflammation is associated with airway hyper-responsiveness like to triggers, such as allergens and exercise.1 This is followed by constriction of bronchial smooth muscles, hyper secretion of mucus that leads to narrowing of airways.2 As a result patients suffer from the characteristic symptoms of asthma like breathlessness, chest tightness, wheezing etc. particularly in night or early in the morning (Figure 1).3,4","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodometric determination of glucose and ribose using potassium iodate as novel reagent in acetic acid medium","authors":"Lokanatha Rai Km, K PrakruthiAiyappa, Harshitha Bl, C. Ks","doi":"10.15406/japlr.2019.08.00336","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00336","url":null,"abstract":"Glucose is the major carbohydrate found in blood and a chief source of energy in human body. The blood glucose levels are perfectly maintained under the influence of hormones like insulin. However the hormonal imbalance sometimes may result in abnormalities of glucose metabolism and results in diseased condition.1 Thus the detection of blood glucose levels can provide a basic understanding of the malfunctioning of the tissues and body. Although various methods are reported in the literature for the determination of glucose, few are commonly used via, colorimetric method, Benedict’s method,2 Bertrand’s method,3 Hagedorn-Jenson method,4 chloramine-T5 method etc.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid dispersions: A technology for improving bioavailability","authors":"K. Sharma, Jagannath Sahoo, S. Agrawal, A. Kumari","doi":"10.15406/japlr.2019.08.00326","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00326","url":null,"abstract":"Modern drug discovery techniques, with advances in combinatorial chemistry and high throughput screening, continue to fill drug development pipelines with a high number of poorly soluble New Chemical Entities (NCEs). It is estimated that over the years about 40%–70% of NCEs are poorly water soluble and large number of scientists are engage in invention of NCEs and the success rate is poor. A drug with poor aqueous solubility will typically exhibit dissolution rate limited absorption, and a drug with poor membrane permeability will typically exhibit permeation rate limited absorption. Hence, two areas of pharmaceutical research that focus on improving the oral bioavailability of active agents include: enhancing solubility and dissolution rate of poorly water soluble drug and enhancing permeability of poorly permeable drugs.1","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the definition of distribution equilibrium potentials in the distribution systems with simple salts","authors":"Yoshihiro Kudo ","doi":"10.15406/japlr.2019.08.00333","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00333","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67073503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-hypertensive activity of aqueous and methanolic leaf extracts of Schleichera oleosa (Lour.) Merr","authors":"Sukumar Dandapat, Sophy Jose, M. Sinha","doi":"10.15406/japlr.2019.08.00320","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00320","url":null,"abstract":"Diseases related to heart and circulatory systems are the reasons for 12 million deaths every year globally and are known to be the major group of killer disease.1 Hypertension is the most common problem associated with cardiovascular disease and constituents a major factor for several cardiovascular pathologies including atherosclerosis, coronary artery disease, myocardial infract heart failure, renal insufficiency, stroke and dissecting aneurysm of aorta and is one of the leading causes of disability, mortality and morbidity along the population and it is the most common chronic illness faced in the world specially developing countries.2,3","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and determination of antimicrobial and metal resistant profiles of Xanthomonas strains isolated from natural environments","authors":"C. Velásquez, M. Rojas, M. Peña, María Peña-Vera, M. Sulbarán, E. Pérez","doi":"10.15406/japlr.2019.08.00312","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00312","url":null,"abstract":"Three Xanthomonas strains were isolated from natural environments in Venezuela and studied morphologically, subjected to biochemical characterization and microbiologically and molecularly identified. In order to reconfirm the identity of these strains, the production of xanthan was induced for Xanthomonas campestris and Xanthomonas vesicatoria isolates, obtaining a yield of 7 and 35mg/100mL of culture, respectively; the characterization by FTIR spectroscopy of the obtained products confirmed the formation of xanthan during the growth of the strains. Characterized strains were submitted to resistance studies to 14 commercial antibiotics of clinical use as well as to 10 metal salts were carried out in Luria Bertani (LB) medium, which disturbingly confirmed these Xantho-monas strains present important percentages of resistance to the antibiotics (79%) and to the salts (50%) tested.","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of natural magnesium-containing solution in correction heart failure in experiment","authors":"Gushcha Sergey G, Nasibullin Boris A, Polshakova Tatyana V, Volyanska Veronika S, Balashova Irina V, Bondar Yulia P","doi":"10.15406/japlr.2019.08.00323","DOIUrl":"https://doi.org/10.15406/japlr.2019.08.00323","url":null,"abstract":"","PeriodicalId":92063,"journal":{"name":"Journal of analytical & pharmaceutical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}